BR112016004375A2 - acylamino acids production method - Google Patents
acylamino acids production methodInfo
- Publication number
- BR112016004375A2 BR112016004375A2 BR112016004375A BR112016004375A BR112016004375A2 BR 112016004375 A2 BR112016004375 A2 BR 112016004375A2 BR 112016004375 A BR112016004375 A BR 112016004375A BR 112016004375 A BR112016004375 A BR 112016004375A BR 112016004375 A2 BR112016004375 A2 BR 112016004375A2
- Authority
- BR
- Brazil
- Prior art keywords
- amino acid
- acyltransferase
- recombinant
- production method
- acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y203/00—Acyltransferases (2.3)
- C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
- C12Y203/01065—Bile acid-CoA:amino acid N-acyltransferase (2.3.1.65)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y203/00—Acyltransferases (2.3)
- C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
- C12Y203/01086—Fatty-acyl-CoA synthase (2.3.1.86)
Abstract
resumo da patente de invenção para: "método de produção de acilaminoácidos". a presente invenção refere-se a uma célula que expressa uma aminoácido n-aciltransferase, a qual é de preferência recombinante, e uma acil-coa sintetase, a qual é preferencialmente recombinante, tendo a célula uma capacidade de degradação de ácidos gordos reduzida, a um método de produção de acilaminoácidos que compreende a etapa de pôr em contato um aminoácido e um acil-coa na presença de uma aminoácido n-aciltransferase, a qual é de preferência isolada e/ou recombinante, em que a aminoácido n-aciltransferase é de preferência uma aminoácido n-aciltransferase humana, ou a cultura da célula e uma mistura reacional composta por uma aminoácido n-aciltransferase, a qual é de preferência isolada e/ou recombinante, uma acil-coa sintetase, a qual é de preferência isolada e/ou recombinante, um aminoácido e quer ácido gordo-coa ou um ácido gordo e uma acil-coa sintetase.Patent Summary for: "Acylamino Acid Production Method". The present invention relates to a cell expressing an amino acid n-acyltransferase, which is preferably recombinant, and an acylcoacetetase, which is preferably recombinant, the cell having a reduced fatty acid degradation capacity. an acylamino acid production method comprising the step of contacting an amino acid and an acylco in the presence of an amino acid n-acyltransferase, which is preferably isolated and / or recombinant, wherein the amino acid n-acyltransferase is preferably a human n-acyltransferase amino acid, or cell culture and a reaction mixture composed of an n-acyltransferase amino acid, which is preferably isolated and / or recombinant, an acylcoacetetase, which is preferably isolated and / or recombinant, an amino acid and either fatty acid or a fatty acid and an acylco synthetase.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP20130181841 EP2843043A1 (en) | 2013-08-27 | 2013-08-27 | A method for producing acyl amino acids |
EP20140169650 EP2842542A1 (en) | 2013-08-27 | 2014-05-23 | A method for producing acyl amino acids |
PCT/EP2014/067990 WO2015028423A1 (en) | 2013-08-27 | 2014-08-25 | A method for producing acyl amino acids |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112016004375A2 true BR112016004375A2 (en) | 2017-10-17 |
Family
ID=49029032
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112016004375A BR112016004375A2 (en) | 2013-08-27 | 2014-08-25 | acylamino acids production method |
Country Status (6)
Country | Link |
---|---|
US (1) | US20160272950A1 (en) |
EP (3) | EP2843043A1 (en) |
JP (1) | JP2016528904A (en) |
CN (1) | CN105813625A (en) |
BR (1) | BR112016004375A2 (en) |
WO (1) | WO2015028423A1 (en) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8647642B2 (en) | 2008-09-18 | 2014-02-11 | Aviex Technologies, Llc | Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment |
EP2746400A1 (en) | 2012-12-21 | 2014-06-25 | Evonik Industries AG | Preparation of amines and diamines from a carboxylic acid or dicarboxylic acid or a monoester thereof |
EP2759598A1 (en) | 2013-01-24 | 2014-07-30 | Evonik Industries AG | Process for preparing alpha, omega alkanediols |
EP2944697A1 (en) | 2014-05-13 | 2015-11-18 | Evonik Degussa GmbH | Method of producing nylon |
DK3155102T3 (en) | 2014-06-11 | 2023-01-30 | Univ Duke | COMPOSITIONS AND METHODS FOR RAPID AND DYNAMIC FLOW REGULATION USING SYNTHETIC METABOLIC VALVES |
EP3081639A1 (en) * | 2015-04-14 | 2016-10-19 | Evonik Degussa GmbH | Acyl amino acid production |
EP3091080A1 (en) * | 2015-05-05 | 2016-11-09 | Evonik Degussa GmbH | Process for producing acyl amino acids employing lipases |
CN108138121B (en) * | 2015-07-22 | 2022-04-19 | 纳幕尔杜邦公司 | High-level production of long-chain dicarboxylic acids by microorganisms |
WO2017102952A1 (en) | 2015-12-17 | 2017-06-22 | Evonik Degussa Gmbh | A genetically modified acetogenic cell |
JP2019523271A (en) | 2016-07-27 | 2019-08-22 | エボニック デグサ ゲーエムベーハーEvonik Degussa GmbH | N-acetylhomoserine |
US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
MY193581A (en) | 2017-02-21 | 2022-10-19 | Univ Duke | Compositions and methods for robust dynamic metabolic control |
WO2018157150A1 (en) | 2017-02-27 | 2018-08-30 | Duke University | In vivo protein n-acylation |
EP3778912A4 (en) | 2018-04-13 | 2022-01-26 | Ajinomoto Co., Inc. | Method for producing n-acyl-amino group-containing compound |
US11203744B2 (en) | 2018-06-21 | 2021-12-21 | Duke University | Compositions and methods for the production of pyruvic acid and related products using dynamic metabolic control |
CN114761554A (en) | 2019-10-10 | 2022-07-15 | 味之素株式会社 | Modified enzyme having N-acylation activity |
KR102207867B1 (en) * | 2020-01-21 | 2021-01-26 | 씨제이제일제당 주식회사 | Method for producing L-amino acids using microorganisms containing NADP dependent glyceraldehyde-3-phosphate dehydrogenase |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5141602B2 (en) | 1973-12-12 | 1976-11-11 | ||
GB8918709D0 (en) * | 1989-08-16 | 1989-09-27 | Unilever Plc | Cosmetic composition |
EP0500332B1 (en) * | 1991-02-19 | 1998-05-27 | National Food Research Institute Ministry Of Agriculture, Forestry And Fisheries | Novel acylamino acid compounds and a method for their production |
US5734070A (en) | 1994-02-17 | 1998-03-31 | Degussa Aktiengesellschaft | Hardening of unsaturated fats, fatty acids or fatty acid esters |
US7217856B2 (en) * | 1999-01-14 | 2007-05-15 | Martek Biosciences Corporation | PUFA polyketide synthase systems and uses thereof |
RU2212447C2 (en) | 2000-04-26 | 2003-09-20 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" | Strain escherichia coli as producer of amino acid (variants) and method for preparing amino acid (variants) |
US7981685B2 (en) * | 2007-04-16 | 2011-07-19 | Modular Genetics, Inc. | Generation of acyl amino acids |
WO2010127318A2 (en) * | 2009-05-01 | 2010-11-04 | The Regents Of The University Of California | Product of fatty acid esters from biomass polymers |
EP2415451A1 (en) * | 2010-08-05 | 2012-02-08 | KPSS-Kao Professional Salon Services GmbH | Cleansing composition |
AU2011294798B2 (en) * | 2010-08-24 | 2015-06-11 | North-West University | Recombinant therapeutic glycine N-acyltransferase |
SG11201501013PA (en) | 2012-08-10 | 2015-04-29 | Opx Biotechnologies Inc | Microorganisms and methods for the production of fatty acids and fatty acid derived products |
EP2970928A4 (en) * | 2013-03-15 | 2017-02-15 | Modular Genetics, Inc. | Generation of acyl amino acids |
-
2013
- 2013-08-27 EP EP20130181841 patent/EP2843043A1/en not_active Withdrawn
-
2014
- 2014-05-23 EP EP20140169650 patent/EP2842542A1/en not_active Withdrawn
- 2014-08-25 EP EP14755659.1A patent/EP3038595B1/en active Active
- 2014-08-25 WO PCT/EP2014/067990 patent/WO2015028423A1/en active Application Filing
- 2014-08-25 US US14/915,012 patent/US20160272950A1/en not_active Abandoned
- 2014-08-25 BR BR112016004375A patent/BR112016004375A2/en not_active IP Right Cessation
- 2014-08-25 JP JP2016537248A patent/JP2016528904A/en not_active Withdrawn
- 2014-08-25 CN CN201480059039.9A patent/CN105813625A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2016528904A (en) | 2016-09-23 |
US20160272950A1 (en) | 2016-09-22 |
WO2015028423A1 (en) | 2015-03-05 |
EP3038595A1 (en) | 2016-07-06 |
CN105813625A (en) | 2016-07-27 |
EP2843043A1 (en) | 2015-03-04 |
EP2842542A1 (en) | 2015-03-04 |
EP3038595B1 (en) | 2019-08-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112016004375A2 (en) | acylamino acids production method | |
CL2017002184A1 (en) | Composition comprising sialillactose for use in improving learning skills and memory function. | |
BR112015013525A2 (en) | a method for producing a fusion protein as well as a composition comprising a fusion protein | |
PE20151765A1 (en) | FORMULAS BASED ON HYDROLYZED AMINO ACID AND PROTEIN WITH A STABLE EMULSION SYSTEM | |
BR112019006706A2 (en) | improved methods for assessing gfap status in patient samples | |
BR112013016447A2 (en) | Production method of recombinant glycoproteins with increased circulatory half-life in mammalian cells | |
BR112014030682A2 (en) | differentiation of human embryonic stem cells into endocrine pancreatic cells | |
BR112015017307A2 (en) | compositions of low acid species and methods for their production and use | |
BR112012020372A2 (en) | "human csf-1r binding body, pharmaceutical composition nucleic acid expression vectors, host cell and method for producing a recombinant antibody | |
BR112015021495A2 (en) | integrated continuous manufacturing of therapeutic protein drug substances | |
CL2014003110A1 (en) | Anti-fcrn antibody; sequences that encode it; vector; host cell; production process; pharmaceutical composition comprising it; use for the treatment of autoimmune disease; and assay to test the ability of an antibody to block human fcrn activity. | |
CL2015000757A1 (en) | A protein | |
BR112014018630A2 (en) | bleaching of chondroitin sulfate glycans | |
BR112015003591A8 (en) | USES OF LYS-C AND METHODS FOR MANUFACTURING A PROTEOLYTHICALLY PROCESSED POLYPEPTIDE | |
BR112015022443A2 (en) | method for the extraction of protein from oilseeds | |
BR112014023792A2 (en) | loaded nutrient proteins and methods | |
BR112017011542A2 (en) | oleic acid production in yeast | |
CL2011003003A1 (en) | Reconstituted surfactant composition comprising a native surfactant protein c-analog polypeptide, a native surfactant protein-b-analog polypeptide, a monounsaturated phospholipid, and a saturated phospholipid, useful for the treatment of respiratory distress syndrome. | |
BR112016014756A8 (en) | sealant formulation comprising fibrinogen and zymogens, their method of manufacture, container and use | |
AR084760A1 (en) | PROCESS FOR ISOLATING A PROTEIN COMPOSITION AND A FAT COMPOSITION FROM MEAT CUTS | |
BR112015021681A2 (en) | binding proteins for pcsk9 | |
BR112016027871A2 (en) | composition to improve memory, learning function and / or cognitive function | |
BR112014028588A8 (en) | polypeptide, method of producing a polypeptide comprising the bcn group, method of producing a polypeptide comprising a tetrazine group, amino acid, bcn lysine, and pyirs trna synthetase | |
GT201200252A (en) | OPTIMIZED MONOCLONAL ANTIBODIES AGAINST THE INHIBITOR OF THE TISSULAR FACTOR ROUTE (TFPI) | |
BR112019002505A2 (en) | method for producing a recombinant protein aggregate, and recombinant protein aggregate. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application fees: application dismissed [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2529 DE 25-06-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |
|
B350 | Update of information on the portal [chapter 15.35 patent gazette] |