BR112016000825B1 - Compostos moduladores de sulfonamidas dos canais de sódio, composição farmacêutica, e uso dos mesmos - Google Patents

Info

Publication number

BR112016000825B1

BR112016000825B1 BR112016000825-1A BR112016000825A BR112016000825B1 BR 112016000825 B1 BR112016000825 B1 BR 112016000825B1 BR 112016000825 A BR112016000825 A BR 112016000825A BR 112016000825 B1 BR112016000825 B1 BR 112016000825B1

Authority

BR

Brazil

Prior art keywords

benzamide

sulfamoylphenyl

pain

trifluoromethyl

fluoro

Prior art date

2013-07-19

Links

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• 150000001875 compounds Chemical class 0.000 title claims abstract description 282
• 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 44
• 108010052164 Sodium Channels Proteins 0.000 title abstract description 26
• 102000018674 Sodium Channels Human genes 0.000 title abstract description 25
• 208000002193 Pain Diseases 0.000 claims abstract description 205
• 230000036407 pain Effects 0.000 claims abstract description 173
• 150000003839 salts Chemical class 0.000 claims abstract description 100
• 238000000034 method Methods 0.000 claims abstract description 63
• 238000011282 treatment Methods 0.000 claims abstract description 11
• 229910052731 fluorine Inorganic materials 0.000 claims description 72
• 229910052801 chlorine Inorganic materials 0.000 claims description 69
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 65
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 63
• 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims description 59
• 208000004296 neuralgia Diseases 0.000 claims description 58
• 125000004786 difluoromethoxy group Chemical group [H]C(F)(F)O* 0.000 claims description 51
• 239000003814 drug Substances 0.000 claims description 39
• 208000021722 neuropathic pain Diseases 0.000 claims description 35
• 229910052739 hydrogen Inorganic materials 0.000 claims description 27
• 125000006340 pentafluoro ethyl group Chemical group FC(F)(F)C(F)(F)* 0.000 claims description 24
• 206010065390 Inflammatory pain Diseases 0.000 claims description 20
• 230000006378 damage Effects 0.000 claims description 19
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• 208000014674 injury Diseases 0.000 claims description 18
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• 229940124597 therapeutic agent Drugs 0.000 claims description 17
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• 102000016913 Voltage-Gated Sodium Channels Human genes 0.000 claims description 15
• 208000005298 acute pain Diseases 0.000 claims description 15
• 239000003981 vehicle Substances 0.000 claims description 15
• 238000004519 manufacturing process Methods 0.000 claims description 14
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• 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 13
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• 208000023890 Complex Regional Pain Syndromes Diseases 0.000 claims description 12
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• ILPVYHZNNPCAAY-UHFFFAOYSA-N 2-(4-fluoro-2-methylphenoxy)-n-(3-sulfamoylphenyl)-5-(trifluoromethyl)benzamide Chemical compound CC1=CC(F)=CC=C1OC1=CC=C(C(F)(F)F)C=C1C(=O)NC1=CC=CC(S(N)(=O)=O)=C1 ILPVYHZNNPCAAY-UHFFFAOYSA-N 0.000 claims description 5
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