BR112015032732B1 - Sistema para tratamento ultrassônico de acidente vascular cerebral - Google Patents
Sistema para tratamento ultrassônico de acidente vascular cerebral Download PDFInfo
- Publication number
- BR112015032732B1 BR112015032732B1 BR112015032732-0A BR112015032732A BR112015032732B1 BR 112015032732 B1 BR112015032732 B1 BR 112015032732B1 BR 112015032732 A BR112015032732 A BR 112015032732A BR 112015032732 B1 BR112015032732 B1 BR 112015032732B1
- Authority
- BR
- Brazil
- Prior art keywords
- site
- occlusion
- acoustic
- pressure
- acoustic pressure
- Prior art date
Links
- 208000006011 Stroke Diseases 0.000 title claims abstract description 22
- 238000011282 treatment Methods 0.000 title description 45
- 238000002560 therapeutic procedure Methods 0.000 claims abstract description 54
- 230000010410 reperfusion Effects 0.000 claims abstract description 34
- 230000009089 cytolysis Effects 0.000 claims abstract description 25
- 238000009210 therapy by ultrasound Methods 0.000 claims abstract description 19
- 238000002604 ultrasonography Methods 0.000 claims description 117
- 230000005540 biological transmission Effects 0.000 claims description 38
- 230000003447 ipsilateral effect Effects 0.000 claims description 29
- 230000001225 therapeutic effect Effects 0.000 claims description 29
- 230000002792 vascular Effects 0.000 claims description 27
- 230000005855 radiation Effects 0.000 claims description 24
- 239000000523 sample Substances 0.000 claims description 19
- 239000011159 matrix material Substances 0.000 claims description 13
- 230000000638 stimulation Effects 0.000 claims description 5
- 230000002490 cerebral effect Effects 0.000 claims 12
- 206010008190 Cerebrovascular accident Diseases 0.000 claims 1
- 208000026106 cerebrovascular disease Diseases 0.000 claims 1
- 208000007536 Thrombosis Diseases 0.000 abstract description 36
- 230000001404 mediated effect Effects 0.000 abstract description 3
- 238000000034 method Methods 0.000 description 28
- 238000003491 array Methods 0.000 description 21
- 210000004556 brain Anatomy 0.000 description 20
- 238000003384 imaging method Methods 0.000 description 20
- 239000007789 gas Substances 0.000 description 16
- 210000003657 middle cerebral artery Anatomy 0.000 description 14
- 210000001519 tissue Anatomy 0.000 description 14
- 150000003904 phospholipids Chemical class 0.000 description 13
- 210000003582 temporal bone Anatomy 0.000 description 13
- 230000000694 effects Effects 0.000 description 12
- 230000017531 blood circulation Effects 0.000 description 11
- 230000008569 process Effects 0.000 description 10
- 210000004204 blood vessel Anatomy 0.000 description 9
- 239000000203 mixture Substances 0.000 description 8
- 210000003625 skull Anatomy 0.000 description 8
- 230000010355 oscillation Effects 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 6
- 239000008280 blood Substances 0.000 description 6
- 238000012285 ultrasound imaging Methods 0.000 description 6
- 210000001367 artery Anatomy 0.000 description 5
- 230000033001 locomotion Effects 0.000 description 5
- 230000004044 response Effects 0.000 description 5
- 230000000087 stabilizing effect Effects 0.000 description 5
- 230000002123 temporal effect Effects 0.000 description 5
- 208000032382 Ischaemic stroke Diseases 0.000 description 4
- 206010053648 Vascular occlusion Diseases 0.000 description 4
- 230000006378 damage Effects 0.000 description 4
- 238000001228 spectrum Methods 0.000 description 4
- 208000021331 vascular occlusion disease Diseases 0.000 description 4
- 206010061216 Infarction Diseases 0.000 description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 3
- 238000002059 diagnostic imaging Methods 0.000 description 3
- 230000008034 disappearance Effects 0.000 description 3
- 238000009826 distribution Methods 0.000 description 3
- 230000009977 dual effect Effects 0.000 description 3
- 238000002592 echocardiography Methods 0.000 description 3
- 230000007574 infarction Effects 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 230000000302 ischemic effect Effects 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 102000003978 Tissue Plasminogen Activator Human genes 0.000 description 2
- 108090000373 Tissue Plasminogen Activator Proteins 0.000 description 2
- 230000008081 blood perfusion Effects 0.000 description 2
- 230000036772 blood pressure Effects 0.000 description 2
- 230000036770 blood supply Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000009560 cranial ultrasound Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000006073 displacement reaction Methods 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 210000005069 ears Anatomy 0.000 description 2
- 150000004665 fatty acids Chemical group 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- -1 glycerol-phosphoric acid diesters Chemical class 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 208000010125 myocardial infarction Diseases 0.000 description 2
- 238000001208 nuclear magnetic resonance pulse sequence Methods 0.000 description 2
- 238000005457 optimization Methods 0.000 description 2
- 230000037361 pathway Effects 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 229960000187 tissue plasminogen activator Drugs 0.000 description 2
- 238000011277 treatment modality Methods 0.000 description 2
- 210000005166 vasculature Anatomy 0.000 description 2
- PORPENFLTBBHSG-MGBGTMOVSA-N 1,2-dihexadecanoyl-sn-glycerol-3-phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=O)OC(=O)CCCCCCCCCCCCCCC PORPENFLTBBHSG-MGBGTMOVSA-N 0.000 description 1
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 description 1
- 206010008111 Cerebral haemorrhage Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 description 1
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- ATBOMIWRCZXYSZ-XZBBILGWSA-N [1-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-3-hexadecanoyloxypropan-2-yl] (9e,12e)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C\C\C=C\CCCCC ATBOMIWRCZXYSZ-XZBBILGWSA-N 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 239000003570 air Substances 0.000 description 1
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 239000007900 aqueous suspension Substances 0.000 description 1
- 239000008135 aqueous vehicle Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 239000002872 contrast media Substances 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 230000001066 destructive effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 150000005690 diesters Chemical class 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 239000002961 echo contrast media Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 239000003527 fibrinolytic agent Substances 0.000 description 1
- 239000002657 fibrous material Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 150000002314 glycerols Chemical class 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000004941 influx Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 208000020658 intracerebral hemorrhage Diseases 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000003094 microcapsule Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000000440 neutrophil Anatomy 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 150000008103 phosphatidic acids Chemical class 0.000 description 1
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 description 1
- 150000008104 phosphatidylethanolamines Chemical class 0.000 description 1
- 150000003905 phosphatidylinositols Chemical class 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000000541 pulsatile effect Effects 0.000 description 1
- 230000010349 pulsation Effects 0.000 description 1
- 238000009877 rendering Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000009424 thromboembolic effect Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
- A61B17/22004—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/08—Clinical applications
- A61B8/0833—Clinical applications involving detecting or locating foreign bodies or organic structures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
- A61B17/22004—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
- A61B2017/22005—Effects, e.g. on tissue
- A61B2017/22007—Cavitation or pseudocavitation, i.e. creation of gas bubbles generating a secondary shock wave when collapsing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
- A61B17/22004—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
- A61B2017/22005—Effects, e.g. on tissue
- A61B2017/22007—Cavitation or pseudocavitation, i.e. creation of gas bubbles generating a secondary shock wave when collapsing
- A61B2017/22008—Cavitation or pseudocavitation, i.e. creation of gas bubbles generating a secondary shock wave when collapsing used or promoted
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/48—Diagnostic techniques
- A61B8/483—Diagnostic techniques involving the acquisition of a 3D volume of data
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/52—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/5215—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data
- A61B8/5238—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data for combining image data of patient, e.g. merging several images from different acquisition modes into one image
- A61B8/5246—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data for combining image data of patient, e.g. merging several images from different acquisition modes into one image combining images from the same or different imaging techniques, e.g. color Doppler and B-mode
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0004—Applications of ultrasound therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0039—Ultrasound therapy using microbubbles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0052—Ultrasound therapy using the same transducer for therapy and imaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0078—Ultrasound therapy with multiple treatment transducers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0086—Beam steering
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Surgery (AREA)
- Radiology & Medical Imaging (AREA)
- Medical Informatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Mechanical Engineering (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Surgical Instruments (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Percussion Or Vibration Massage (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361842404P | 2013-07-03 | 2013-07-03 | |
| US201361842402P | 2013-07-03 | 2013-07-03 | |
| US61/842,404 | 2013-07-03 | ||
| US61/842,402 | 2013-07-03 | ||
| EP13182062.3 | 2013-08-28 | ||
| EP13182062 | 2013-08-28 | ||
| PCT/EP2014/064052 WO2015000953A1 (en) | 2013-07-03 | 2014-07-02 | Devices and methods for the ultrasound treatment of ischemic stroke |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112015032732A2 BR112015032732A2 (pt) | 2017-07-25 |
| BR112015032732B1 true BR112015032732B1 (pt) | 2022-05-17 |
Family
ID=49036479
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112015032732-0A BR112015032732B1 (pt) | 2013-07-03 | 2014-07-02 | Sistema para tratamento ultrassônico de acidente vascular cerebral |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10926112B2 (enExample) |
| EP (1) | EP3016713B1 (enExample) |
| JP (1) | JP6568057B2 (enExample) |
| CN (1) | CN105407968B (enExample) |
| BR (1) | BR112015032732B1 (enExample) |
| CA (1) | CA2917095C (enExample) |
| WO (1) | WO2015000953A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9630028B2 (en) * | 2006-08-11 | 2017-04-25 | Koninklijke Philips N.V. | Ultrasound system for cerebral blood flow imaging and microbubble-enhanced blood clot lysis |
| EP2903688A4 (en) | 2012-10-05 | 2016-06-15 | Univ Michigan | BLADE-INDUCED COLOR DOPPLER FEEDBACK DURING A HISTOTRIPSIA |
| WO2015003154A1 (en) | 2013-07-03 | 2015-01-08 | Histosonics, Inc. | Articulating arm limiter for cavitational ultrasound therapy system |
| JP6600304B2 (ja) | 2013-07-03 | 2019-10-30 | ヒストソニックス，インコーポレーテッド | 衝撃散乱を使用した気泡雲形成のために最適化されたヒストトリプシ励起シーケンス |
| US10780298B2 (en) | 2013-08-22 | 2020-09-22 | The Regents Of The University Of Michigan | Histotripsy using very short monopolar ultrasound pulses |
| JP6810037B2 (ja) | 2014-12-11 | 2021-01-06 | コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． | 超音波出力パワー調整方法、装置及び記憶媒体 |
| EP3313517B1 (en) | 2015-06-24 | 2023-06-07 | The Regents Of The University Of Michigan | Histotripsy therapy systems for the treatment of brain tissue |
| CN108601948B (zh) * | 2015-12-09 | 2021-04-20 | 皇家飞利浦有限公司 | 超声系统 |
| US10589129B2 (en) * | 2016-09-14 | 2020-03-17 | Insightec, Ltd. | Therapeutic ultrasound with reduced interference from microbubbles |
| US11259781B2 (en) | 2016-12-16 | 2022-03-01 | Koninklijke Philips N.V. | Adaptive pulsing for sonothrombolysis treatment |
| US11369810B2 (en) * | 2016-12-19 | 2022-06-28 | Michalakis Averkiou | Method and apparatus for ultrasonic mediation of drug delivery using microbubbles |
| WO2020039258A1 (en) * | 2018-08-24 | 2020-02-27 | Neuravi Limited | Apparatus for managing acute ischemic events |
| WO2020039082A1 (en) * | 2018-08-24 | 2020-02-27 | Neuravi Limited | Apparatus for managing acute ischemic events |
| EP3886737A4 (en) | 2018-11-28 | 2022-08-24 | Histosonics, Inc. | HISTOTRIPSY SYSTEMS AND METHODS |
| EP3669802A1 (en) * | 2018-12-19 | 2020-06-24 | Neuravi Limited | Apparatus for managing acute ischemic events |
| US11813485B2 (en) | 2020-01-28 | 2023-11-14 | The Regents Of The University Of Michigan | Systems and methods for histotripsy immunosensitization |
| JP2023538245A (ja) * | 2020-08-11 | 2023-09-07 | アミール・イー・ハサン | 術者非依存ヒストトリプシデバイス |
| EP4204084A4 (en) | 2020-08-27 | 2024-10-09 | The Regents Of The University Of Michigan | ULTRASONIC TRANSDUCER WITH TRANSMIT-RECEIVE CAPABILITY FOR HISTOTRIPSY |
| EP3970653B8 (en) * | 2020-09-21 | 2024-01-10 | Servicio Andaluz De Salud | Device for non-invasive preventive cleaning of cerebrospinal fluid shunt systems |
| CN113974765B (zh) * | 2021-10-22 | 2022-09-06 | 北京荷清和创医疗科技有限公司 | 介入式除栓装置及促溶栓模块 |
| CN115105123A (zh) * | 2022-05-31 | 2022-09-27 | 深圳迈瑞生物医疗电子股份有限公司 | 一种超声成像系统和方法 |
| KR20250102047A (ko) | 2022-10-28 | 2025-07-04 | 히스토소닉스, 인크. | 히스토트립시 시스템들 및 방법들 |
| USD1037522S1 (en) | 2022-11-30 | 2024-07-30 | Eaton Intelligent Power Limited | Floodlight |
| WO2024221001A2 (en) | 2023-04-20 | 2024-10-24 | Histosonics, Inc. | Histotripsy systems and associated methods including user interfaces and workflows for treatment planning and therapy |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN172208B (enExample) | 1990-04-02 | 1993-05-01 | Sint Sa | |
| US5445813A (en) | 1992-11-02 | 1995-08-29 | Bracco International B.V. | Stable microbubble suspensions as enhancement agents for ultrasound echography |
| US5556610A (en) | 1992-01-24 | 1996-09-17 | Bracco Research S.A. | Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method |
| AU636481B2 (en) | 1990-05-18 | 1993-04-29 | Bracco International B.V. | Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography |
| IL104084A (en) | 1992-01-24 | 1996-09-12 | Bracco Int Bv | Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them |
| US6333021B1 (en) | 1994-11-22 | 2001-12-25 | Bracco Research S.A. | Microcapsules, method of making and their use |
| US5558092A (en) * | 1995-06-06 | 1996-09-24 | Imarx Pharmaceutical Corp. | Methods and apparatus for performing diagnostic and therapeutic ultrasound simultaneously |
| US6013032A (en) | 1998-03-13 | 2000-01-11 | Hewlett-Packard Company | Beamforming methods and apparatus for three-dimensional ultrasound imaging using two-dimensional transducer array |
| US5997479A (en) | 1998-05-28 | 1999-12-07 | Hewlett-Packard Company | Phased array acoustic systems with intra-group processors |
| US6530885B1 (en) | 2000-03-17 | 2003-03-11 | Atl Ultrasound, Inc. | Spatially compounded three dimensional ultrasonic images |
| US6468216B1 (en) | 2000-08-24 | 2002-10-22 | Kininklijke Philips Electronics N.V. | Ultrasonic diagnostic imaging of the coronary arteries |
| US6723050B2 (en) | 2001-12-19 | 2004-04-20 | Koninklijke Philips Electronics N.V. | Volume rendered three dimensional ultrasonic images with polar coordinates |
| JP4139916B2 (ja) * | 2002-07-03 | 2008-08-27 | 株式会社東京大学Ｔｌｏ | 超音波照射方法及び超音波照射装置 |
| WO2004069284A2 (en) | 2003-02-04 | 2004-08-19 | Bracco International B.V. | Ultrasound contrast agents and process for the preparation thereof |
| US8038616B2 (en) * | 2003-05-30 | 2011-10-18 | Surf Technology As | Acoustic imaging by nonlinear low frequency manipulation of high frequency scattering and propagation properties |
| US20050019744A1 (en) | 2003-07-25 | 2005-01-27 | La Jolla Bioengineering Institute | Ultrasound-assisted ischemic reperfusion |
| WO2005074805A1 (en) | 2004-02-05 | 2005-08-18 | Koninklijke Philips Electronics N.V. | Ultrasonic imaging of perfusion and blood flow with harmonic contrast agents |
| US20120016239A1 (en) * | 2004-10-06 | 2012-01-19 | Guided Therapy Systems, Llc | Systems for cosmetic treatment |
| CN100386057C (zh) | 2005-10-31 | 2008-05-07 | 西安交通大学 | 基于包膜微泡的灌注成像与超声控制释放的系统和方法 |
| WO2007058668A1 (en) * | 2005-11-18 | 2007-05-24 | Imarx Therapeutics, Inc. | Ultrasound apparatus and method to treat an ischemic stroke |
| US9630028B2 (en) | 2006-08-11 | 2017-04-25 | Koninklijke Philips N.V. | Ultrasound system for cerebral blood flow imaging and microbubble-enhanced blood clot lysis |
| WO2008017998A2 (en) * | 2006-08-11 | 2008-02-14 | Koninklijke Philips Electronics, N.V. | Ultrasound system for cerebral blood flow imaging and microbubble-enhanced blood clot lysis |
| US20080097206A1 (en) | 2006-09-27 | 2008-04-24 | Chomas James E | Enhanced contrast agent augmented ultrasound thrombus treatment |
| US8425424B2 (en) * | 2008-11-19 | 2013-04-23 | Inightee Ltd. | Closed-loop clot lysis |
| EP2480127A4 (en) * | 2009-09-22 | 2015-06-24 | Targeson Inc | Contrast agents for optical imaging and uses thereof |
| US20120296241A1 (en) * | 2011-05-22 | 2012-11-22 | Mishelevich David J | Ultrasound neuromodulation for treatment of autism spectrum disorder and alzheimers disease and other dementias |
| US8715186B2 (en) * | 2009-11-24 | 2014-05-06 | Guided Therapy Systems, Llc | Methods and systems for generating thermal bubbles for improved ultrasound imaging and therapy |
| JP5541946B2 (ja) | 2010-02-26 | 2014-07-09 | オリンパス株式会社 | 超音波治療装置 |
| US20110251489A1 (en) | 2010-04-07 | 2011-10-13 | Physiosonics, Inc. | Ultrasound monitoring systems, methods and components |
| WO2012042423A1 (en) | 2010-09-30 | 2012-04-05 | Koninklijke Philips Electronics N.V. | Monitoring and control of microbubble cavitation in therapeutic ultrasound |
| US8603014B2 (en) | 2010-10-05 | 2013-12-10 | Cerevast Therapeutics, Inc. | Hands-free operator-independent transcranial ultrasound apparatus and methods |
-
2014
- 2014-07-02 JP JP2016522596A patent/JP6568057B2/ja active Active
- 2014-07-02 WO PCT/EP2014/064052 patent/WO2015000953A1/en not_active Ceased
- 2014-07-02 EP EP14736729.6A patent/EP3016713B1/en active Active
- 2014-07-02 CN CN201480038085.0A patent/CN105407968B/zh active Active
- 2014-07-02 BR BR112015032732-0A patent/BR112015032732B1/pt active IP Right Grant
- 2014-07-02 US US14/902,012 patent/US10926112B2/en active Active
- 2014-07-02 CA CA2917095A patent/CA2917095C/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3016713B1 (en) | 2023-03-01 |
| CA2917095C (en) | 2021-11-02 |
| BR112015032732A2 (pt) | 2017-07-25 |
| US10926112B2 (en) | 2021-02-23 |
| CN105407968A (zh) | 2016-03-16 |
| EP3016713A1 (en) | 2016-05-11 |
| JP6568057B2 (ja) | 2019-08-28 |
| JP2016526976A (ja) | 2016-09-08 |
| US20160279449A1 (en) | 2016-09-29 |
| CN105407968B (zh) | 2019-09-03 |
| CA2917095A1 (en) | 2015-01-08 |
| WO2015000953A1 (en) | 2015-01-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR112015032732B1 (pt) | Sistema para tratamento ultrassônico de acidente vascular cerebral | |
| US12303152B2 (en) | Histotripsy for thrombolysis | |
| US6733450B1 (en) | Therapeutic methods and apparatus for use of sonication to enhance perfusion of tissue | |
| Vignon et al. | Microbubble cavitation imaging | |
| EP1711109B1 (en) | Localized production of microbubbles and control of cavitational and heating effects by use of enhanced ultrasound | |
| US20120116221A1 (en) | Methods and systems for image-guided treatment of blood vessels | |
| CN101829326B (zh) | 微泡在制备用于联合超声产生高强度空化作为抗肿瘤新生血管药物的用途 | |
| Porter et al. | Effectiveness of transcranial and transthoracic ultrasound and microbubbles in dissolving intravascular thrombi. | |
| JP7534839B2 (ja) | 超音波血栓溶解用及び血管音響共振器を介した他の治療用のインターリーブビームパターン | |
| Alkins et al. | Cavitation-based third ventriculostomy using MRI-guided focused ultrasound | |
| US20230381546A1 (en) | Non-Cavitational Mechanical Pulsed Ultrasound Therapy | |
| KR20120136273A (ko) | 초음파 캐비테이션을 사용하는 종양 치료 | |
| Peng et al. | Intracranial non-thermal ablation mediated by transcranial focused ultrasound and phase-shift nanoemulsions | |
| Papadopoulos et al. | In vitro evaluation of focused ultrasound-enhanced TNK-tissue plasminogen activator-mediated thrombolysis | |
| US20250235536A1 (en) | Composition for ultrasound ablation | |
| Vignon et al. | Real-time two-dimensional imaging of microbubble cavitation | |
| Vignon et al. | In vivo microbubble cavitation imaging | |
| Lin et al. | A noninvasive approach for metastatic lymph node ablation using histotripsy tissue fractionation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 02/07/2014, OBSERVADAS AS CONDICOES LEGAIS |