BR112015029724A2 - derivados de etinila como antagonistas do receptor de glutamato metabotrópico - Google Patents
derivados de etinila como antagonistas do receptor de glutamato metabotrópicoInfo
- Publication number
- BR112015029724A2 BR112015029724A2 BR112015029724A BR112015029724A BR112015029724A2 BR 112015029724 A2 BR112015029724 A2 BR 112015029724A2 BR 112015029724 A BR112015029724 A BR 112015029724A BR 112015029724 A BR112015029724 A BR 112015029724A BR 112015029724 A2 BR112015029724 A2 BR 112015029724A2
- Authority
- BR
- Brazil
- Prior art keywords
- receptor antagonists
- glutamate receptor
- metabotropic glutamate
- ethinyl
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
resumo patente de invenção: "derivados de etinila como antagonistas do receptor de glutamato metabotrópico". a presente invenção refere-se aos derivados de etinila de fórmula (i), em que y é n ou ch; r1 é hidrogênio, flúor ou cloro; e r2 é hidrogênio ou alquila inferior; ou a um seu sal de adição de ácido farmaceuticamente aceitável. foi agora surpreendentemente verificado que os compostos de fórmula geral (i) são antagonistas do receptor de glutamato metabotrópico (moduladores alostéricos negativos) para uso no tratamento de ansiedade e dor, depressão, síndrome do x frágil, transtornos do espectro autista, doença de parkinson, e doença do refluxo gastroesofágico (gerd).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13175535 | 2013-07-08 | ||
PCT/EP2014/064272 WO2015004007A1 (en) | 2013-07-08 | 2014-07-04 | Ethynyl derivatives as metabotropic glutamate receptor antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112015029724A2 true BR112015029724A2 (pt) | 2017-07-25 |
Family
ID=48745843
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015029724A BR112015029724A2 (pt) | 2013-07-08 | 2014-07-04 | derivados de etinila como antagonistas do receptor de glutamato metabotrópico |
Country Status (28)
Country | Link |
---|---|
US (2) | US9682959B2 (pt) |
EP (1) | EP3019486B1 (pt) |
JP (1) | JP6116761B2 (pt) |
KR (1) | KR101767348B1 (pt) |
CN (1) | CN105358543B (pt) |
AR (1) | AR096824A1 (pt) |
AU (1) | AU2014289398B2 (pt) |
BR (1) | BR112015029724A2 (pt) |
CA (1) | CA2914282A1 (pt) |
CL (1) | CL2015003761A1 (pt) |
CR (1) | CR20150650A (pt) |
DK (1) | DK3019486T3 (pt) |
EA (1) | EA027882B1 (pt) |
ES (1) | ES2628206T3 (pt) |
HK (1) | HK1215573A1 (pt) |
HU (1) | HUE033270T2 (pt) |
IL (1) | IL242682B (pt) |
MA (1) | MA38659B1 (pt) |
MY (1) | MY181847A (pt) |
PE (1) | PE20160604A1 (pt) |
PH (1) | PH12015502692A1 (pt) |
PL (1) | PL3019486T3 (pt) |
SG (1) | SG11201510607RA (pt) |
SI (1) | SI3019486T1 (pt) |
TW (1) | TWI527808B (pt) |
UA (1) | UA116023C2 (pt) |
WO (1) | WO2015004007A1 (pt) |
ZA (1) | ZA201508410B (pt) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107849006B (zh) | 2015-06-03 | 2020-11-13 | 豪夫迈·罗氏有限公司 | 乙炔基衍生物 |
US10034861B2 (en) | 2016-07-04 | 2018-07-31 | H. Lundbeck A/S | 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors |
HUE057202T2 (hu) | 2017-12-14 | 2022-04-28 | H Lundbeck As | Kombinációs kezelések 1H-pirazolo[4,3-b]piridinek alkalmazásával |
AR113926A1 (es) | 2017-12-14 | 2020-07-01 | H Lundbeck As | Derivados de 1h-pirazolo[4,3-b]piridinas |
US11535611B2 (en) | 2017-12-20 | 2022-12-27 | H. Lundbeck A/S | Pyrazolo[3,4-B]pyridines and imidazo[1,5-B]pyridazines as PDE1 inhibitors |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IN153523B (pt) * | 1980-06-02 | 1984-07-21 | American Cyanamid Co | |
FI90869C (fi) * | 1986-11-14 | 1994-04-11 | Tanabe Seiyaku Co | Menetelmä lääkeaineena käyttökelpoisten imidatsolidinonijohdannaisten valmistamiseksi |
TW544448B (en) * | 1997-07-11 | 2003-08-01 | Novartis Ag | Pyridine derivatives |
TWI292318B (en) | 2003-03-10 | 2008-01-11 | Hoffmann La Roche | Imidazol-4-yl-ethynyl-pyridine derivatives |
EP2380889B1 (en) * | 2004-10-07 | 2013-06-26 | Merck Sharp & Dohme Corp. | Thiazolyl MGLUR5 antagonists and methods for their use |
US8389536B2 (en) * | 2009-10-27 | 2013-03-05 | Hoffmann-La Roche Inc. | Positive allosteric modulators (PAM) |
US8420661B2 (en) | 2010-04-13 | 2013-04-16 | Hoffmann-La Roche Inc. | Arylethynyl derivatives |
EP2702050B1 (en) | 2011-04-26 | 2016-05-18 | F.Hoffmann-La Roche Ag | Pyrazolidin-3-one derivatives |
HUE025031T2 (en) * | 2011-04-26 | 2016-02-29 | Hoffmann La Roche | Ethinyl derivatives as positive allosteric modulators of MGLUR5 |
UA110862C2 (uk) * | 2011-10-07 | 2016-02-25 | Ф. Хоффманн-Ля Рош Аг | Похідні етинілу як алостеричні модулятори метаботропного рецептора глутамату mglur 5 |
-
2014
- 2014-04-07 UA UAA201600580A patent/UA116023C2/uk unknown
- 2014-07-04 PL PL14739714T patent/PL3019486T3/pl unknown
- 2014-07-04 BR BR112015029724A patent/BR112015029724A2/pt not_active Application Discontinuation
- 2014-07-04 SI SI201430233A patent/SI3019486T1/sl unknown
- 2014-07-04 DK DK14739714.5T patent/DK3019486T3/en active
- 2014-07-04 JP JP2016524753A patent/JP6116761B2/ja active Active
- 2014-07-04 EA EA201690162A patent/EA027882B1/ru not_active IP Right Cessation
- 2014-07-04 EP EP14739714.5A patent/EP3019486B1/en active Active
- 2014-07-04 SG SG11201510607RA patent/SG11201510607RA/en unknown
- 2014-07-04 WO PCT/EP2014/064272 patent/WO2015004007A1/en active Application Filing
- 2014-07-04 TW TW103123204A patent/TWI527808B/zh not_active IP Right Cessation
- 2014-07-04 CN CN201480038739.XA patent/CN105358543B/zh active Active
- 2014-07-04 ES ES14739714.5T patent/ES2628206T3/es active Active
- 2014-07-04 CA CA2914282A patent/CA2914282A1/en not_active Abandoned
- 2014-07-04 KR KR1020167000013A patent/KR101767348B1/ko active IP Right Grant
- 2014-07-04 HU HUE14739714A patent/HUE033270T2/en unknown
- 2014-07-04 AU AU2014289398A patent/AU2014289398B2/en not_active Ceased
- 2014-07-04 MY MYPI2015003036A patent/MY181847A/en unknown
- 2014-07-04 PE PE2015002663A patent/PE20160604A1/es not_active Application Discontinuation
- 2014-07-07 AR ARP140102508A patent/AR096824A1/es unknown
-
2015
- 2015-11-13 ZA ZA2015/08410A patent/ZA201508410B/en unknown
- 2015-11-19 IL IL242682A patent/IL242682B/en not_active IP Right Cessation
- 2015-12-02 PH PH12015502692A patent/PH12015502692A1/en unknown
- 2015-12-08 CR CR20150650A patent/CR20150650A/es unknown
- 2015-12-10 MA MA38659A patent/MA38659B1/fr unknown
- 2015-12-30 CL CL2015003761A patent/CL2015003761A1/es unknown
-
2016
- 2016-01-08 US US14/991,748 patent/US9682959B2/en active Active
- 2016-03-24 HK HK16103513.4A patent/HK1215573A1/zh unknown
-
2017
- 2017-04-17 US US15/489,295 patent/US9751856B2/en active Active
Also Published As
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Legal Events
Date | Code | Title | Description |
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B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements | ||
B350 | Update of information on the portal [chapter 15.35 patent gazette] |