BR112015025599A2 - processo para a preparação diastereosseletiva de complexos de rutênio - Google Patents
processo para a preparação diastereosseletiva de complexos de rutênioInfo
- Publication number
- BR112015025599A2 BR112015025599A2 BR112015025599A BR112015025599A BR112015025599A2 BR 112015025599 A2 BR112015025599 A2 BR 112015025599A2 BR 112015025599 A BR112015025599 A BR 112015025599A BR 112015025599 A BR112015025599 A BR 112015025599A BR 112015025599 A2 BR112015025599 A2 BR 112015025599A2
- Authority
- BR
- Brazil
- Prior art keywords
- formula
- compound
- preparation
- ruthenium complexes
- nitrogen
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 238000002360 preparation method Methods 0.000 title abstract 3
- 150000003303 ruthenium Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- 125000001931 aliphatic group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052751 metal Inorganic materials 0.000 abstract 2
- 239000002184 metal Substances 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 229910052717 sulfur Chemical group 0.000 abstract 2
- 239000011593 sulfur Chemical group 0.000 abstract 2
- 101100516568 Caenorhabditis elegans nhr-7 gene Proteins 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000005922 Phosphane Substances 0.000 abstract 1
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 abstract 1
- KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical class [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 abstract 1
- 150000001345 alkine derivatives Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 238000009835 boiling Methods 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 229910000064 phosphane Inorganic materials 0.000 abstract 1
- 229910052707 ruthenium Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0046—Ruthenium compounds
- C07F15/0053—Ruthenium compounds without a metal-carbon linkage
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
- B01J31/2404—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring
- B01J31/2409—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring with more than one complexing phosphine-P atom
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
- B01J2231/60—Reduction reactions, e.g. hydrogenation
- B01J2231/64—Reductions in general of organic substrates, e.g. hydride reductions or hydrogenations
- B01J2231/641—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes
- B01J2231/643—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes of R2C=O or R2C=NR (R= C, H)
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
- B01J2531/80—Complexes comprising metals of Group VIII as the central metal
- B01J2531/82—Metals of the platinum group
- B01J2531/821—Ruthenium
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Quinoline Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
resumo patente de invenção: "processo para a preparação diastereosseletiva de complexos de rutênio". a invenção refere-se a um processo para a preparação de um composto da fórmula (i) (i) em que x é -ch2-, -ch2-ch2-, -ch2-ch2-ch2- ou -ch2-ch2-ch2-ch2-;y1 é -ch2-; -ch2-ch2- ou -nh-; y2 é nhr7 ou sh; em que r7 é hidrogênio, alquila c1-c4 ou fenila; r1 e r2, independentemente um do outro, representam grupos alifáticos ou aromáticos;r3 e r4, independentemente um do outro, representam grupos alifáticos ou aromáticos; r5 e r6 são cada um hidrogênio ou representam em conjunto com os átomos de carbono aos quais estão ligados um anel de fenila; cujo processo compreende reação de um composto da fórmula ii [rucl2(r8)n]m (ii), em que n é 1 e m é > 1 que representa uma estrutura polimérica se r8 for uma molécula contendo duas frações de alqueno ou alquino se coordenando em um modo de coordenação hapto-2 ao metal; ou n é 4 e m é 1 se r8 for uma molécula contendo nitrogênio, oxigênio ou enxofre na qual o referido nitrogênio, oxigênio ou enxofre se coordena ao metal;na presença de um solvente inerte cujo ponto de ebulição é de 112 ºc a 165 ºc com um composto da fórmula (iii) (iii), em que r5, r6, y1 e y2 são como definidos sob a fórmula i, e um fosfano da fórmula iv r3r4p-x-pr1r2 (iv), em que r1, r2, r3, r4 e x são como definidos sob a fórmula i.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13162679.8A EP2789623A1 (en) | 2013-04-08 | 2013-04-08 | Process for the diastereoselective preparation of ruthenium complexes |
| EP13162679.8 | 2013-04-08 | ||
| PCT/EP2014/056495 WO2014166777A1 (en) | 2013-04-08 | 2014-04-01 | Process for the diastereoselective preparation of ruthenium complexes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112015025599A2 true BR112015025599A2 (pt) | 2017-07-18 |
| BR112015025599B1 BR112015025599B1 (pt) | 2020-10-13 |
Family
ID=48045333
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112015025599-0A BR112015025599B1 (pt) | 2013-04-08 | 2014-04-01 | processo para a preparação diastereosseletiva de complexos de rutênio |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9303054B2 (pt) |
| EP (2) | EP2789623A1 (pt) |
| JP (1) | JP6470256B2 (pt) |
| CN (1) | CN105143239B (pt) |
| BR (1) | BR112015025599B1 (pt) |
| ES (1) | ES2807579T3 (pt) |
| HU (1) | HUE050085T2 (pt) |
| WO (1) | WO2014166777A1 (pt) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201320869D0 (en) | 2013-11-26 | 2014-01-08 | Johnson Matthey Plc | Process |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITPD20040115A1 (it) | 2004-05-04 | 2004-08-04 | Univ Degli Studi Udine | Complessi di rutenio con 2-(amminometil)piridine e fosfine, loro preparazione ed uso come catalizzatori |
| JP5283931B2 (ja) * | 2007-03-16 | 2013-09-04 | 高砂香料工業株式会社 | アルコール類の製造方法 |
| ITPD20070237A1 (it) * | 2007-07-11 | 2009-01-12 | Univ Degli Studi Udine | Nuovi leganti della classe della benzo[h]chinolina e complessi di metalli di transizione che li contengono e uso di tali complessi come catalizzatori |
| EP2215101A4 (en) * | 2007-10-30 | 2013-04-24 | Kanata Chemical Technologies Inc | CATIONIC TRANSITION METAL CATALYSTS |
| JP2012504596A (ja) * | 2008-10-02 | 2012-02-23 | フイルメニツヒ ソシエテ アノニム | ホスフィノオキシドベースのルテニウム錯体を有するエステル基又はカルボニル基の水素化 |
| CN102227261A (zh) * | 2008-11-28 | 2011-10-26 | 弗门尼舍有限公司 | 用具有二胺和磷-氮二齿配体的钌络合物进行的酯、酮或醛基的氢化 |
| GB201116057D0 (en) * | 2011-09-16 | 2011-11-02 | Univ York | Synthesis and anticancer activity of ruthenium (II) cis-cis-1,3,5-triaminocyclohexane complexes |
-
2013
- 2013-04-08 EP EP13162679.8A patent/EP2789623A1/en not_active Ceased
-
2014
- 2014-04-01 HU HUE14714273A patent/HUE050085T2/hu unknown
- 2014-04-01 JP JP2016506849A patent/JP6470256B2/ja active Active
- 2014-04-01 US US14/781,980 patent/US9303054B2/en active Active
- 2014-04-01 ES ES14714273T patent/ES2807579T3/es active Active
- 2014-04-01 BR BR112015025599-0A patent/BR112015025599B1/pt active IP Right Grant
- 2014-04-01 CN CN201480020118.9A patent/CN105143239B/zh active Active
- 2014-04-01 WO PCT/EP2014/056495 patent/WO2014166777A1/en active Application Filing
- 2014-04-01 EP EP14714273.1A patent/EP2984094B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2789623A1 (en) | 2014-10-15 |
| EP2984094B1 (en) | 2020-05-13 |
| EP2984094A1 (en) | 2016-02-17 |
| JP2016517847A (ja) | 2016-06-20 |
| ES2807579T3 (es) | 2021-02-23 |
| CN105143239A (zh) | 2015-12-09 |
| BR112015025599B1 (pt) | 2020-10-13 |
| US9303054B2 (en) | 2016-04-05 |
| JP6470256B2 (ja) | 2019-02-13 |
| HUE050085T2 (hu) | 2020-11-30 |
| US20160046658A1 (en) | 2016-02-18 |
| WO2014166777A1 (en) | 2014-10-16 |
| CN105143239B (zh) | 2018-07-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR112015005331B8 (pt) | Eletrólito de polímero em gel e dispositivo eletroquímico incluindo o mesmo | |
| AR057044A1 (es) | Composiciones con modificadores de reologia hase | |
| JP2013010731A5 (ja) | 複素環化合物 | |
| UA113643C2 (xx) | N-цикліламіди як нематоциди | |
| EP4329431A3 (en) | Novel heteroleptic iridium complexes | |
| AR049401A1 (es) | Aza-biciclononanos | |
| EA201070872A1 (ru) | Производные азабициклических карбоксамидов, их получение и их применение в терапии | |
| BR112014010644A2 (pt) | novos derivados de aril-quinolina | |
| EA201490709A1 (ru) | Адъювантное соединение | |
| BR112014029972A2 (pt) | reagentes de conjugação | |
| BR112017018305A2 (pt) | desacetoxitubulisina h e análogos da mesma | |
| BR112014004144B1 (pt) | composição de ionômero antimicrobiana compreendendo um composto de polímero catiônico de funcionalidade amina e halogeneto de prata, método de produção da composição e usos da mesma | |
| EP3670496A3 (en) | Acc2 inhibitors | |
| ATE477234T1 (de) | Synthese von phenolischen estern von hydroxymethylphenolen | |
| RS53903B1 (en) | ETHINYL DERIVATIVES AS POSITIVE MGLUR5 MODULATORS | |
| EA201001087A1 (ru) | Новые дигидроиндолоновые соединения, способ их получения и фармацевтические композиции, содержащие их | |
| BR112016000968A2 (pt) | Processo para a preparação de bifenilanilidas halogenadas | |
| CY1117560T1 (el) | Νεο υποκατασταθεν παραγωγο ισοκινολινης | |
| PH12015502851B1 (en) | Curable composition | |
| BR112013024957A2 (pt) | derviado de furanona ou um sal farmaceuticamente aceitável do mesmo | |
| BR112013001534A2 (pt) | derivados de oxadiazol e piridazina, suas preparações e suas aplicações em terapêutica | |
| BR112015025599A2 (pt) | processo para a preparação diastereosseletiva de complexos de rutênio | |
| BR112013025510A2 (pt) | formulação e composto catalisador de oxo-quelato de titânio, usos de uma formulação de catalisador de oxo-quelato de titânio, e de uma composição polimerizável, composição, substrato revestido, e, processo para polimerizar compostos | |
| EA201590557A1 (ru) | Производные арилэтинила | |
| EP2644688A3 (en) | Novel pyrimidine derivatives and their use in perfume compositions |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06U | Preliminary requirement: requests with searches performed by other patent offices: suspension of the patent application procedure | ||
| B09A | Decision: intention to grant | ||
| B16A | Patent or certificate of addition of invention granted |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 01/04/2014, OBSERVADAS AS CONDICOES LEGAIS. |