BR112015025208A2 - método para detectar anticorpos alfa-sinucleína específicos, uso de um método, e, kit - Google Patents

método para detectar anticorpos alfa-sinucleína específicos, uso de um método, e, kit

Info

Publication number
BR112015025208A2
BR112015025208A2 BR112015025208A BR112015025208A BR112015025208A2 BR 112015025208 A2 BR112015025208 A2 BR 112015025208A2 BR 112015025208 A BR112015025208 A BR 112015025208A BR 112015025208 A BR112015025208 A BR 112015025208A BR 112015025208 A2 BR112015025208 A2 BR 112015025208A2
Authority
BR
Brazil
Prior art keywords
asyn
antibodies
kit
aggregates
detecting specific
Prior art date
Application number
BR112015025208A
Other languages
English (en)
Inventor
Mairhofer Andreas
Von Bonin Arne
Staffler Günther
Mandler Markus
Original Assignee
Affiris Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affiris Ag filed Critical Affiris Ag
Publication of BR112015025208A2 publication Critical patent/BR112015025208A2/pt

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Rehabilitation Therapy (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Organic Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Zoology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

1 / 1 resumo “mã‰todo para detectar anticorpos alfa-sinucleãna especãficos, uso de um mã‰todo, e, kit ” ㉠descrito um mã©todo para detectar anticorpos asyn especã­ficos em uma amostra biolã³gica, compreendendo as seguintes etapas: - contactar a amostra com agregados que compreendem asyn e permitir que os anticorpos asyn especã­ficos se liguem aos agregados que compreendem asyn, e - detectar os anticorpos asyn especã­ficos ligados aos agregados que compreendem asyn por uma ãºnica tã©cnica de detecã§ã£o de partã­cula, preferivelmente, por separaã§ã£o de cã©lulas ativadas por fluorescãªncia (facs).
BR112015025208A 2013-04-03 2014-04-02 método para detectar anticorpos alfa-sinucleína específicos, uso de um método, e, kit BR112015025208A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13162107.0A EP2787348A1 (en) 2013-04-03 2013-04-03 Method for detecting aSyn-specific antibodies in a biological sample
PCT/EP2014/056588 WO2014161879A1 (en) 2013-04-03 2014-04-02 Method for detecting asyn-specific antibodies in a biological sample

Publications (1)

Publication Number Publication Date
BR112015025208A2 true BR112015025208A2 (pt) 2017-07-18

Family

ID=47998336

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015025208A BR112015025208A2 (pt) 2013-04-03 2014-04-02 método para detectar anticorpos alfa-sinucleína específicos, uso de um método, e, kit

Country Status (14)

Country Link
US (1) US9964547B2 (pt)
EP (2) EP2787348A1 (pt)
JP (1) JP6416871B2 (pt)
KR (1) KR20150137114A (pt)
CN (1) CN105247368B (pt)
AR (1) AR095994A1 (pt)
AU (1) AU2014247129A1 (pt)
BR (1) BR112015025208A2 (pt)
CA (1) CA2908607A1 (pt)
DK (1) DK2981824T3 (pt)
ES (1) ES2657093T3 (pt)
PL (1) PL2981824T3 (pt)
TW (1) TW201514496A (pt)
WO (1) WO2014161879A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7136790B2 (ja) 2017-02-17 2022-09-13 ブリストル－マイヤーズ スクイブ カンパニー アルファ－シヌクレインに対する抗体およびその使用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69638321D1 (de) * 1995-10-11 2011-03-03 Luminex Corp Gleichzeitige mehrfachanalyse klinischer proben
SI2370466T1 (sl) * 2008-12-19 2015-11-30 Biogen International Neuroscience Gmbh Človeška avtoprotitelesa proti alfa-sinukleinu
CA2753586A1 (en) 2009-02-24 2010-09-02 Winton G. Gibbons Detection of complexes of tau and amyloid
US8956589B2 (en) * 2009-02-27 2015-02-17 Shiga University Of Medical Science Imaging diagnostic agent and extracorporeal diagnostic agent for incurable neurological diseases
WO2010128139A1 (en) 2009-05-08 2010-11-11 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin Biomarkers and methods for diagnosing alzheimer's disease and/ or mild cognitive impairment
EP2366714A1 (en) * 2010-03-03 2011-09-21 Dr. Rentschler Holding GmbH & Co. KG Naturally occuring autoantibodies against alpha-synuclein that inhibit the aggregation and cytotoxicity of alpha-synuclein
WO2012099576A1 (en) * 2011-01-18 2012-07-26 Baxter International Inc. Measurement of anti-amyloid antibodies in human blood

Also Published As

Publication number Publication date
ES2657093T3 (es) 2018-03-01
US20160054333A1 (en) 2016-02-25
EP2787348A1 (en) 2014-10-08
AR095994A1 (es) 2015-11-25
PL2981824T3 (pl) 2018-04-30
CA2908607A1 (en) 2014-10-09
CN105247368B (zh) 2018-04-27
US9964547B2 (en) 2018-05-08
JP6416871B2 (ja) 2018-10-31
EP2981824A1 (en) 2016-02-10
EP2981824B1 (en) 2017-11-22
KR20150137114A (ko) 2015-12-08
TW201514496A (zh) 2015-04-16
JP2016514842A (ja) 2016-05-23
CN105247368A (zh) 2016-01-13
AU2014247129A1 (en) 2015-10-29
WO2014161879A1 (en) 2014-10-09
DK2981824T3 (en) 2018-01-15

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]