BR112015022558A2 - sequência isolada de ácidos nucleicos do promotor pcs1, construção de expressão ou célula hospedeira recombinante compreendendo a sequência de ácidos nucleicos, cultura celular estável de uma pluralidade das referidas células hospedeiras, método para a produção de uma proteína de interesse e utilização de uma sequência isolada de ácidos nucleicos compreendendo um promotor em um método para a produção de uma proteína de interesse - Google Patents
sequência isolada de ácidos nucleicos do promotor pcs1, construção de expressão ou célula hospedeira recombinante compreendendo a sequência de ácidos nucleicos, cultura celular estável de uma pluralidade das referidas células hospedeiras, método para a produção de uma proteína de interesse e utilização de uma sequência isolada de ácidos nucleicos compreendendo um promotor em um método para a produção de uma proteína de interesseInfo
- Publication number
- BR112015022558A2 BR112015022558A2 BR112015022558A BR112015022558A BR112015022558A2 BR 112015022558 A2 BR112015022558 A2 BR 112015022558A2 BR 112015022558 A BR112015022558 A BR 112015022558A BR 112015022558 A BR112015022558 A BR 112015022558A BR 112015022558 A2 BR112015022558 A2 BR 112015022558A2
- Authority
- BR
- Brazil
- Prior art keywords
- promoter
- nucleic acid
- acid sequence
- protein
- interest
- Prior art date
Links
- 150000007523 nucleic acids Chemical group 0.000 title abstract 9
- 108091028043 Nucleic acid sequence Proteins 0.000 title abstract 7
- 108090000623 proteins and genes Proteins 0.000 title abstract 6
- 102000004169 proteins and genes Human genes 0.000 title abstract 6
- 238000004519 manufacturing process Methods 0.000 title abstract 5
- 101100028900 Caenorhabditis elegans pcs-1 gene Proteins 0.000 title abstract 3
- 238000004113 cell culture Methods 0.000 title abstract 2
- 108020004707 nucleic acids Proteins 0.000 title abstract 2
- 102000039446 nucleic acids Human genes 0.000 title abstract 2
- 210000004027 cell Anatomy 0.000 abstract 4
- 241000235058 Komagataella pastoris Species 0.000 abstract 1
- 210000003527 eukaryotic cell Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/835,589 US9150870B2 (en) | 2013-03-15 | 2013-03-15 | Constitutive promoter |
| EP13159527 | 2013-03-15 | ||
| PCT/EP2013/077144 WO2014139608A1 (en) | 2013-03-15 | 2013-12-18 | Constitutive promoter |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112015022558A2 true BR112015022558A2 (pt) | 2017-10-24 |
Family
ID=49841670
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112015022558A BR112015022558A2 (pt) | 2013-03-15 | 2013-12-18 | sequência isolada de ácidos nucleicos do promotor pcs1, construção de expressão ou célula hospedeira recombinante compreendendo a sequência de ácidos nucleicos, cultura celular estável de uma pluralidade das referidas células hospedeiras, método para a produção de uma proteína de interesse e utilização de uma sequência isolada de ácidos nucleicos compreendendo um promotor em um método para a produção de uma proteína de interesse |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US11168117B2 (enExample) |
| EP (2) | EP2970994B1 (enExample) |
| JP (2) | JP6698352B2 (enExample) |
| KR (1) | KR102128959B1 (enExample) |
| CN (1) | CN105229154B (enExample) |
| AU (1) | AU2013382370B2 (enExample) |
| BR (1) | BR112015022558A2 (enExample) |
| CA (1) | CA2903568C (enExample) |
| DK (1) | DK2970994T3 (enExample) |
| ES (2) | ES2751336T3 (enExample) |
| HK (1) | HK1213292A1 (enExample) |
| IL (1) | IL241340B (enExample) |
| PL (1) | PL2970994T3 (enExample) |
| SG (2) | SG11201507557UA (enExample) |
| WO (1) | WO2014139608A1 (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2970994B1 (en) * | 2013-03-15 | 2019-07-17 | Lonza Ltd | Constitutive promoter |
| KR102593407B1 (ko) * | 2016-03-02 | 2023-10-24 | 론자 리미티드 | 개선된 발효 공정 |
| US12404309B2 (en) | 2018-02-12 | 2025-09-02 | Lonza Ltd | Host cell for producing a protein of interest |
| EP3536784A1 (en) | 2018-03-05 | 2019-09-11 | ACIB GmbH | Host cell engineered for improved metabolite production |
| SI3802820T1 (sl) * | 2018-06-07 | 2023-05-31 | Basf Se | Postopek za prepoznavanje promotorjev za proizvodnjo proteinov v kvasovkah |
| JP2020146308A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146307A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146311A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146301A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146304A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146303A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146298A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146300A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146318A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146297A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146312A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146299A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146306A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146313A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146317A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146305A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146315A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146302A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146309A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146316A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146314A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| HUE064229T2 (hu) | 2019-04-01 | 2024-02-28 | Univ Wien Bodenkultur | Mut-metilotróf élesztõ |
| WO2020200414A1 (en) | 2019-04-01 | 2020-10-08 | Lonza Ltd | Protein production in mut-methylotrophic yeast |
| WO2020200415A1 (en) | 2019-04-01 | 2020-10-08 | Lonza Ltd | Mut- methylotrophic yeast |
| WO2021014470A1 (en) * | 2019-07-25 | 2021-01-28 | Council Of Scientific And Industrial Research | Recombinant vector for high-expression of proteins in yeasts |
| EP4127185B1 (en) | 2020-04-01 | 2025-06-04 | Lonza Ltd. | Helper factors for expressing proteins in yeast |
| JP7808097B2 (ja) * | 2020-09-22 | 2026-01-28 | ブリストル－マイヤーズ スクイブ カンパニー | 治療タンパク質を生産するための方法 |
| EP4222266A1 (en) | 2020-09-30 | 2023-08-09 | Lonza Ltd. | Host cells overexpressing translational factors |
| US20250277248A1 (en) * | 2020-12-14 | 2025-09-04 | Indian Institute Of Science | Nucleotide sequence, expression vectors, recombinant yeast cells and applications thereof |
| CN117120618A (zh) | 2021-02-12 | 2023-11-24 | 勃林格殷格翰 Rcv 两合公司 | 用于增加蛋白质分泌的信号肽 |
| WO2024133538A1 (en) | 2022-12-20 | 2024-06-27 | Lonza Ltd | Host cells with pat1 knockout for increased specific protein productivity |
| CN118308361B (zh) * | 2024-06-07 | 2024-09-17 | 中国人民解放军军事科学院军事医学研究院 | 表达人血清白蛋白的重组序列、生物材料及其应用与方法 |
| WO2026027251A1 (en) | 2024-08-01 | 2026-02-05 | Boehringer Ingelheim Rcv Gmbh & Co Kg | Signal peptides for increased protein secretion |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU577259B2 (en) | 1982-08-13 | 1988-09-22 | Zymogenetics Inc. | Glycolytic promters for regulated protein expression protease inhibitor |
| US4808537A (en) | 1984-10-30 | 1989-02-28 | Phillips Petroleum Company | Methanol inducible genes obtained from pichia and methods of use |
| US4855231A (en) | 1984-10-30 | 1989-08-08 | Phillips Petroleum Company | Regulatory region for heterologous gene expression in yeast |
| AU2887897A (en) | 1996-05-21 | 1997-12-09 | Novo Nordisk A/S | Novel yeast promoters suitable for expression cloning in yeast and heterologous expression of proteins in yeast |
| US6730499B1 (en) | 1998-07-03 | 2004-05-04 | Research Corporation Technologies, Inc. | Promoter for the Pichia pastoris formaldehyde dehydrogenase gene FLD1 |
| US7259255B2 (en) | 2003-06-25 | 2007-08-21 | E. I. Du Pont De Nemours And Company | Glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate mutase promoters for gene expression in oleaginous yeast |
| AT501955B1 (de) | 2005-02-23 | 2007-08-15 | Univ Graz Tech | Mutierte aox1-promotoren |
| KR20070009269A (ko) * | 2005-07-15 | 2007-01-18 | 한국생명공학연구원 | 재조합단백질 생산용 단백질융합인자 라이브러리 및이로부터 획득된 단백질융합인자 |
| DE602006018054D1 (de) | 2005-11-16 | 2010-12-16 | Korea Res Inst Of Bioscience | Translationselongationsfaktor-promotor aus pichia pastoris und verfahren zur herstellung von rekombinantem protein unter verwendung davon |
| US8440456B2 (en) * | 2009-05-22 | 2013-05-14 | Vib, Vzw | Nucleic acids of Pichia pastoris and use thereof for recombinant production of proteins |
| CN102180954B (zh) | 2011-03-01 | 2013-04-17 | 华南理工大学 | 一种毕赤酵母壁蛋白及其构建的表面展示系统和构建方法 |
| CN102994501B (zh) | 2012-10-15 | 2018-04-27 | 华南理工大学 | 具有组成型启动子活性的dna及其应用和巴斯德毕赤酵母表达载体 |
| US20150293076A1 (en) * | 2012-10-22 | 2015-10-15 | Bolt Threads, Inc. | Cellular Reprogramming for Product Optimization |
| PL2964765T3 (pl) * | 2013-03-08 | 2019-10-31 | Keck Graduate Inst Of Applied Life Sciences | Promotory drożdżowe z pichia pastoris |
| EP2970994B1 (en) * | 2013-03-15 | 2019-07-17 | Lonza Ltd | Constitutive promoter |
-
2013
- 2013-12-18 EP EP13811203.2A patent/EP2970994B1/en active Active
- 2013-12-18 WO PCT/EP2013/077144 patent/WO2014139608A1/en not_active Ceased
- 2013-12-18 CN CN201380076047.XA patent/CN105229154B/zh active Active
- 2013-12-18 JP JP2015561962A patent/JP6698352B2/ja active Active
- 2013-12-18 HK HK16101211.3A patent/HK1213292A1/zh unknown
- 2013-12-18 KR KR1020157028747A patent/KR102128959B1/ko active Active
- 2013-12-18 SG SG11201507557UA patent/SG11201507557UA/en unknown
- 2013-12-18 ES ES13811203T patent/ES2751336T3/es active Active
- 2013-12-18 DK DK13811203T patent/DK2970994T3/da active
- 2013-12-18 AU AU2013382370A patent/AU2013382370B2/en not_active Ceased
- 2013-12-18 CA CA2903568A patent/CA2903568C/en active Active
- 2013-12-18 PL PL13811203T patent/PL2970994T3/pl unknown
- 2013-12-18 EP EP19186013.9A patent/EP3584322B1/en active Active
- 2013-12-18 BR BR112015022558A patent/BR112015022558A2/pt not_active Application Discontinuation
- 2013-12-18 SG SG10201804002PA patent/SG10201804002PA/en unknown
- 2013-12-18 ES ES19186013T patent/ES3013464T3/es active Active
-
2015
- 2015-09-08 IL IL241340A patent/IL241340B/en unknown
-
2018
- 2018-11-05 JP JP2018208031A patent/JP2019047804A/ja not_active Withdrawn
-
2019
- 2019-07-16 US US16/513,022 patent/US11168117B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2013382370A1 (en) | 2015-09-24 |
| DK2970994T3 (da) | 2019-10-28 |
| CA2903568C (en) | 2022-07-12 |
| WO2014139608A1 (en) | 2014-09-18 |
| JP6698352B2 (ja) | 2020-05-27 |
| JP2016508742A (ja) | 2016-03-24 |
| CN105229154B (zh) | 2026-03-03 |
| PL2970994T3 (pl) | 2020-03-31 |
| SG10201804002PA (en) | 2018-07-30 |
| ES2751336T3 (es) | 2020-03-31 |
| EP2970994A1 (en) | 2016-01-20 |
| SG11201507557UA (en) | 2015-10-29 |
| EP2970994B1 (en) | 2019-07-17 |
| KR102128959B1 (ko) | 2020-07-02 |
| EP3584322A1 (en) | 2019-12-25 |
| US11168117B2 (en) | 2021-11-09 |
| ES3013464T3 (en) | 2025-04-14 |
| JP2019047804A (ja) | 2019-03-28 |
| IL241340B (en) | 2022-02-01 |
| CN105229154A (zh) | 2016-01-06 |
| EP3584322C0 (en) | 2024-12-04 |
| KR20160002763A (ko) | 2016-01-08 |
| AU2013382370B2 (en) | 2020-01-23 |
| US20190337998A1 (en) | 2019-11-07 |
| IL241340A0 (en) | 2015-11-30 |
| EP3584322B1 (en) | 2024-12-04 |
| HK1213292A1 (zh) | 2016-06-30 |
| CA2903568A1 (en) | 2014-09-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR112015022558A2 (pt) | sequência isolada de ácidos nucleicos do promotor pcs1, construção de expressão ou célula hospedeira recombinante compreendendo a sequência de ácidos nucleicos, cultura celular estável de uma pluralidade das referidas células hospedeiras, método para a produção de uma proteína de interesse e utilização de uma sequência isolada de ácidos nucleicos compreendendo um promotor em um método para a produção de uma proteína de interesse | |
| BR112015022971A2 (pt) | métodos de fabricação para controlar o teor de lisina c-terminal, galactose e ácido siálico em proteínas recombinantes | |
| BR112021025359A2 (pt) | Composições de proteína anti-vegf e métodos para a produção das mesmas | |
| BR112017008108A2 (pt) | incorporação de aminoácidos não naturais em proteínas | |
| CY1122800T1 (el) | Συνθεσεις του παραγοντα viii και μεθοδοι δημιουργιας και χρησης αυτων | |
| EA201170993A1 (ru) | Удлиненные рекомбинантные полипептиды и содержащие их композиции | |
| EA201690600A1 (ru) | Метаболически оптимизированная клеточная культура | |
| BR112015031639A2 (pt) | integração alvo | |
| BRPI0806578A8 (pt) | Promotores de lactococcus e usos dos mesmos | |
| EP2536821A4 (en) | IMPROVING THE EFFECT OF FE-S-BUNDLE REQUIRING PROTEINS | |
| BR112015004701A2 (pt) | polipeptídeo isolado, polipeptídeo variante, composição, uso de um polipeptídeo isolado, polinucleotídeo isolado, construção de ácido nucleico ou vetor de expressão, célula hospedeira de expressão recombinante, métodos para produção de um polipeptídeo, para melhorar o valor nutricional de uma ração animal, e para tratamento de proteínas, planta, parte de planta ou célula de planta transgênica, composição de ração animal, aditivo de ração animal, e, ração animal | |
| WO2013093760A3 (en) | Compositions, methods, and kits for preparing sialylated recombinant proteins | |
| NZ705575A (en) | Recombinant clostridium botulinum neurotoxins | |
| AR116615A2 (es) | Operaciones de cosecha mejoradas para proteínas recombinadas | |
| BR112015021785A2 (pt) | Promotores de levedura para expressão de proteína | |
| WO2014097113A3 (en) | Production of therapeutic proteins in genetically modified mammalian cells | |
| MX2019003360A (es) | Vectores de expresion para una secrecion de proteina mejorada. | |
| BR112018011896A2 (pt) | promotor, ácido nucleico, célula hospedeira procariótica, método de fermentação, e, método para aumentar a expressão ou atividade de catalase em uma célula hospedeira procariótica | |
| MX2016007207A (es) | Metodos mejorados para la produccion de polipeptidos recombinantes. | |
| AR097805A1 (es) | Células de cambio de temperatura para la expresión de alto rendimiento de polipéptidos en levadura y otros transformados | |
| MX370305B (es) | Proteína estructurante de hielo. | |
| BR112017022076A2 (pt) | fusões de mesotelina-variante iii de receptor de fator de crescimento epidérmico e métodos de uso das mesmas | |
| BR112015031236A2 (pt) | Produção de proteína em plantas | |
| EA201000945A1 (ru) | Конструирование системы секреции на основе sm-белков | |
| BR112013004396A2 (pt) | alimentação alcalina |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06I | Publication of requirement cancelled [chapter 6.9 patent gazette] |
Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2462 DE 13/03/2018 POR TER SIDO INDEVIDA. |
|
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |