BR112015021677A2 - inibidores de tirosina quinase de bruton - Google Patents
inibidores de tirosina quinase de brutonInfo
- Publication number
- BR112015021677A2 BR112015021677A2 BR112015021677A BR112015021677A BR112015021677A2 BR 112015021677 A2 BR112015021677 A2 BR 112015021677A2 BR 112015021677 A BR112015021677 A BR 112015021677A BR 112015021677 A BR112015021677 A BR 112015021677A BR 112015021677 A2 BR112015021677 A2 BR 112015021677A2
- Authority
- BR
- Brazil
- Prior art keywords
- tyrosine kinase
- kinase inhibitors
- compounds
- bruton tyrosine
- diseases associated
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1/1 resumo inibidores de tirosina quinase de bruton o presente pedido expõe compostos de acordo com a fórmula i genérica: nnnnhnhx1x2x3a1x4a2i em que todas as variáveis são definidas da forma que se encontram descritas neste contexto, que inibe a btk. os compostos aqui descritos são de utilidade para modular a atividade da btk e tartar as enfermidades associadas com a atividade excessiva da btk. os compostos são ainda de utilidade para o tratamento de enfermidades inflamatórias e auto-imunes associadas com a proliferação anômala das células b-cell tais como artrite reumatóide. encontram-se igualmente expostas as composições que contêm compostos da fórmula i e pelo menos um carreador, diluente ou excipiente.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361772938P | 2013-03-05 | 2013-03-05 | |
PCT/EP2014/054017 WO2014135473A1 (en) | 2013-03-05 | 2014-03-03 | Inhibitors of bruton's tyrosine kinase |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112015021677A2 true BR112015021677A2 (pt) | 2017-07-18 |
Family
ID=50272581
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015021677A BR112015021677A2 (pt) | 2013-03-05 | 2014-03-03 | inibidores de tirosina quinase de bruton |
Country Status (11)
Country | Link |
---|---|
US (1) | US9469644B2 (pt) |
EP (1) | EP2964647A1 (pt) |
JP (1) | JP2016513621A (pt) |
KR (1) | KR20150113195A (pt) |
CN (1) | CN105073750A (pt) |
BR (1) | BR112015021677A2 (pt) |
CA (1) | CA2902375A1 (pt) |
HK (1) | HK1217695A1 (pt) |
MX (1) | MX2015010466A (pt) |
RU (1) | RU2015137298A (pt) |
WO (1) | WO2014135473A1 (pt) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20180305348A1 (en) * | 2015-06-02 | 2018-10-25 | Pharmacyclics Llc | Inhibitors of brutons tyrosine kinase |
KR102048719B1 (ko) * | 2015-08-13 | 2019-11-26 | 베이징 한미 파마슈티컬 컴퍼니 리미티드 | Irak4억제제 및 이의 용도 |
US10023579B2 (en) | 2015-12-16 | 2018-07-17 | Southern Research Institute | Pyrrolopyrimidine compounds, use as inhibitors of the kinase LRRK2, and methods for preparation thereof |
WO2017205762A1 (en) * | 2016-05-27 | 2017-11-30 | Pharmacyclics Llc | Inhibitors of interleukin-1 receptor-associated kinase |
MY191110A (en) | 2016-06-30 | 2022-05-30 | Daewoong Pharmaceutical Co Ltd | Pyrazolopyrimidine derivatives as kinase inhibitor |
WO2018119395A1 (en) * | 2016-12-23 | 2018-06-28 | Aquinnah Pharmaceuticals, Inc. | Compouns, compositions and methods of use |
WO2018139883A1 (ko) * | 2017-01-26 | 2018-08-02 | 부광약품 주식회사 | 다중 표적 키나아제 저해제로서 융합피리미딘 유도체 |
HRP20221043T1 (hr) | 2017-12-28 | 2022-11-11 | Daewoong Pharmaceutical Co., Ltd. | Derivat oksi-fluoropiperidina kao inhibitor kinaze |
US20240100172A1 (en) | 2020-12-21 | 2024-03-28 | Hangzhou Jijing Pharmaceutical Technology Limited | Methods and compounds for targeted autophagy |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2550000A1 (de) * | 1975-11-07 | 1977-05-12 | Boehringer Mannheim Gmbh | Neue purin-derivate und verfahren zu ihrer herstellung |
JPS606616A (ja) * | 1983-06-24 | 1985-01-14 | Ishihara Sangyo Kaisha Ltd | 血管拡張剤 |
ZA858154B (en) * | 1984-10-26 | 1986-06-25 | Warner Lambert Co | N6-substituted deoxyribose analogs of adenosines |
JPS61256346A (ja) * | 1985-05-10 | 1986-11-13 | Konishiroku Photo Ind Co Ltd | ハロゲン化銀写真感光材料 |
JPH0642039B2 (ja) * | 1985-09-05 | 1994-06-01 | コニカ株式会社 | 直接ポジ画像の形成方法 |
IL86007A0 (en) * | 1987-04-09 | 1988-09-30 | Wellcome Found | 6-substituted purine nucleosides,their preparation and pharmaceutical compositions containing them |
JPH0196644A (ja) * | 1987-10-07 | 1989-04-14 | Konica Corp | 直接ポジ型ハロゲン化銀写真感光材料 |
PT95516A (pt) * | 1989-10-06 | 1991-08-14 | Wellcome Found | Processo para a preparacao de derivados de 2',3'-didesoxi nucleosidos 6-substituidos |
JP2010522720A (ja) * | 2007-03-28 | 2010-07-08 | ノイロサーチ アクティーゼルスカブ | プリニル誘導体及びカリウムチャネルモジュレーターとしてのそれらの使用 |
AU2008345225A1 (en) * | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
WO2010068806A1 (en) * | 2008-12-10 | 2010-06-17 | Cgi Pharmaceuticals, Inc. | Amide derivatives as btk inhibitors in the treatment of allergic, autoimmune and inflammatory disorders as well as cancer |
WO2010111406A2 (en) * | 2009-03-24 | 2010-09-30 | Myriad Pharmaceuticals, Inc. | Compounds and therapeutic uses thereof |
EP2616474A1 (en) * | 2010-09-14 | 2013-07-24 | Centre National De La Recherche Scientifique | Novel antiviral acyclic nucleoside phosphonates |
EP2632898A4 (en) * | 2010-10-29 | 2014-04-02 | Biogen Idec Inc | HETEROCYCLIC TYROSINE KINASE HEMMER |
SG194219A1 (en) * | 2011-06-10 | 2013-11-29 | Merck Patent Gmbh | Compositions and methods for the production of pyrimidine and pyridine compounds with btk inhibitory activity |
-
2014
- 2014-03-03 CA CA2902375A patent/CA2902375A1/en not_active Abandoned
- 2014-03-03 KR KR1020157023989A patent/KR20150113195A/ko active IP Right Grant
- 2014-03-03 BR BR112015021677A patent/BR112015021677A2/pt not_active IP Right Cessation
- 2014-03-03 RU RU2015137298A patent/RU2015137298A/ru not_active Application Discontinuation
- 2014-03-03 JP JP2015560641A patent/JP2016513621A/ja active Pending
- 2014-03-03 US US14/768,688 patent/US9469644B2/en not_active Expired - Fee Related
- 2014-03-03 MX MX2015010466A patent/MX2015010466A/es unknown
- 2014-03-03 EP EP14709585.5A patent/EP2964647A1/en not_active Withdrawn
- 2014-03-03 CN CN201480011832.1A patent/CN105073750A/zh active Pending
- 2014-03-03 WO PCT/EP2014/054017 patent/WO2014135473A1/en active Application Filing
-
2016
- 2016-05-16 HK HK16105564.7A patent/HK1217695A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
RU2015137298A (ru) | 2017-04-10 |
JP2016513621A (ja) | 2016-05-16 |
CN105073750A (zh) | 2015-11-18 |
MX2015010466A (es) | 2015-10-30 |
US9469644B2 (en) | 2016-10-18 |
WO2014135473A1 (en) | 2014-09-12 |
HK1217695A1 (zh) | 2017-01-20 |
KR20150113195A (ko) | 2015-10-07 |
CA2902375A1 (en) | 2014-09-12 |
EP2964647A1 (en) | 2016-01-13 |
US20160002243A1 (en) | 2016-01-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law | ||
B08F | Application fees: dismissal - article 86 of industrial property law |
Free format text: REFERENTE A 5A ANUIDADE. |
|
B08K | Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87) |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2504 DE 02-01-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |