BR112015019669A2 - método de produção de um composto - Google Patents

método de produção de um composto

Info

Publication number
BR112015019669A2
BR112015019669A2 BR112015019669A BR112015019669A BR112015019669A2 BR 112015019669 A2 BR112015019669 A2 BR 112015019669A2 BR 112015019669 A BR112015019669 A BR 112015019669A BR 112015019669 A BR112015019669 A BR 112015019669A BR 112015019669 A2 BR112015019669 A2 BR 112015019669A2
Authority
BR
Brazil
Prior art keywords
compound
producing
production method
octan
oxabicyclo
Prior art date
Application number
BR112015019669A
Other languages
English (en)
Inventor
Takayanagi Yoshihiro
Nakamura Yoshitaka
Furuya Yukito
Original Assignee
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Publication of BR112015019669A2 publication Critical patent/BR112015019669A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/10—Preparation of carboxylic acid amides from compounds not provided for in groups C07C231/02 - C07C231/08
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Abstract

1 / 1 resumo “mã‰todo de produã‡ãƒo de um composto” a presente invenã§ã£o trata o problema de fornecer um mã©todo de produã§ã£o de (1s,4s,5s)-4-bromo-6-oxabiciclo[3,2,1]octan-7-ona (1), que ã© importante como um composto intermediã¡rio para a produã§ã£o de um composto inibidor de fxa, com alta eficiãªncia. um mã©todo de produã§ã£o de (1s,4s,5s)-4-bromo-6-oxabiciclo[3,2,1]octan-7-ona (1), o dito mã©todo sendo caracterizado pelo tratamento de um sal de (r)-î±-feniletilamina do ã¡cido (s)- 3-cicloexeno-1-carboxã­lico com 1,3-dibromo-5,5-dimetilidantoã­na ou n- bromossuccinimida em um solvente.
BR112015019669A 2013-03-29 2014-03-28 método de produção de um composto BR112015019669A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2013072896 2013-03-29
PCT/JP2014/059101 WO2014157612A1 (ja) 2013-03-29 2014-03-28 （１ｓ，４ｓ，５ｓ）－４－ブロモ－６－オキサビシクロ［３．２．１］オクタン－７－オンの製造方法

Publications (1)

Publication Number Publication Date
BR112015019669A2 true BR112015019669A2 (pt) 2017-07-18

Family

ID=51624568

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015019669A BR112015019669A2 (pt) 2013-03-29 2014-03-28 método de produção de um composto

Country Status (9)

Country Link
US (1) US20150353577A1 (pt)
EP (1) EP2980090A4 (pt)
JP (1) JPWO2014157612A1 (pt)
KR (1) KR20150138214A (pt)
CN (1) CN104936961B (pt)
BR (1) BR112015019669A2 (pt)
CA (1) CA2896338A1 (pt)
HK (1) HK1220977A1 (pt)
WO (1) WO2014157612A1 (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105777779B (zh) * 2014-12-16 2019-03-26 四川海思科制药有限公司 一种对甲苯磺酸依度沙班化合物
CN104761571B (zh) * 2015-03-10 2017-03-08 山东科兴生物制品有限公司 一种依度沙班的合成方法
CN106316889B (zh) * 2015-06-15 2020-07-10 上海阳帆医药科技有限公司 依度沙班中间体的制备方法
CN107033163A (zh) * 2015-07-16 2017-08-11 浙江海正药业股份有限公司 一种依度沙班对苯甲磺酸盐新晶型及其制备方法和应用
CN105399667A (zh) * 2015-12-15 2016-03-16 南京艾德凯腾生物医药有限责任公司 一种依度沙班中间体的制备方法
CN107641131B (zh) * 2016-07-22 2019-06-18 江苏威凯尔医药科技有限公司 一种抗血栓药物的制备方法
KR20180022125A (ko) * 2016-08-23 2018-03-06 동화약품주식회사 디아민 유도체의 산부가염 및 이의 제조 방법
CN113045442B (zh) * 2019-12-27 2022-09-16 上海化学试剂研究所有限公司 一种利用微通道反应器制备草酰胺的方法
CN111763157B (zh) * 2020-04-26 2021-10-26 中山大学 一种手性氨基化合物及其制备方法和应用、及由其制备依度沙班中间体的制备方法
KR102513519B1 (ko) 2020-06-08 2023-03-23 주식회사 파마코스텍 신규한 에독사반 벤젠술폰산염 1 수화물의 제조방법
CN111606827B (zh) * 2020-06-23 2022-10-25 内蒙古京东药业有限公司 一种制备依度沙班手性胺中间体的方法
CN111763222B (zh) * 2020-08-03 2021-05-25 珠海市海瑞德新材料科技有限公司 用于制备依度沙班游离碱的中间体及其制备方法和应用
CN112321613B (zh) * 2020-11-06 2022-04-12 江苏华阳制药有限公司 甲苯磺酸艾多沙班及其异构体的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI290136B (en) 2000-04-05 2007-11-21 Daiichi Seiyaku Co Ethylenediamine derivatives
GB0112834D0 (en) * 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
WO2003000657A1 (fr) * 2001-06-20 2003-01-03 Daiichi Pharmaceutical Co., Ltd. Derives de diamine
WO2003016302A1 (fr) 2001-08-09 2003-02-27 Daiichi Pharmaceutical Co., Ltd. Derives de diamine
WO2003000680A1 (fr) 2001-06-20 2003-01-03 Daiichi Pharmaceutical Co., Ltd. Derives de diamine
AR040335A1 (es) * 2002-06-26 2005-03-30 Glaxo Group Ltd Compuesto de ciclohexano o ciclohexeno, uso del mismo para preparar un medicamento, composicion farmaceutica que lo comprende, procedimiento y compuestos intermediarios de utilidad para preparar dicho compuesto
CA2511493A1 (en) 2002-12-25 2004-07-15 Daiichi Pharmaceutical Co., Ltd. Diamine derivatives
HUE029336T2 (en) 2005-09-16 2017-02-28 Daiichi Sankyo Co Ltd For the preparation of an optically active diamine derivative and process
JP2007238476A (ja) * 2006-03-07 2007-09-20 Sumitomo Chemical Co Ltd ブテノリド化合物及びその植物生長促進用途、並びにその製造中間体
WO2010021093A1 (ja) * 2008-08-18 2010-02-25 第一三共株式会社 不斉有機触媒
WO2012002538A1 (ja) * 2010-07-02 2012-01-05 第一三共株式会社 光学活性ジアミン誘導体の塩の製造方法

Also Published As

Publication number Publication date
KR20150138214A (ko) 2015-12-09
HK1220977A1 (zh) 2017-05-19
JPWO2014157612A1 (ja) 2017-02-16
EP2980090A4 (en) 2016-11-09
EP2980090A1 (en) 2016-02-03
CN104936961A (zh) 2015-09-23
CA2896338A1 (en) 2014-10-02
WO2014157612A1 (ja) 2014-10-02
US20150353577A1 (en) 2015-12-10
CN104936961B (zh) 2016-10-26

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]