BR112016023607A2 - uso médico de compostos de artemisinina e agonistas de gefirina - Google Patents

uso médico de compostos de artemisinina e agonistas de gefirina

Info

Publication number
BR112016023607A2
BR112016023607A2 BR112016023607A BR112016023607A BR112016023607A2 BR 112016023607 A2 BR112016023607 A2 BR 112016023607A2 BR 112016023607 A BR112016023607 A BR 112016023607A BR 112016023607 A BR112016023607 A BR 112016023607A BR 112016023607 A2 BR112016023607 A2 BR 112016023607A2
Authority
BR
Brazil
Prior art keywords
gephyrin
medical use
agonists
artemisinin compounds
artemisinin
Prior art date
Application number
BR112016023607A
Other languages
English (en)
Inventor
Li Jin
Kubicek Stefan
Original Assignee
Cemm Forschungszentrum Fuer Molekulare Medizin Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cemm Forschungszentrum Fuer Molekulare Medizin Gmbh filed Critical Cemm Forschungszentrum Fuer Molekulare Medizin Gmbh
Publication of BR112016023607A2 publication Critical patent/BR112016023607A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4748—Quinolines; Isoquinolines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/507—Pancreatic cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9406—Neurotransmitters
    • G01N33/9426—GABA, i.e. gamma-amino-butyrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

a invenção refere-se a ligantes de btbd9 e ligantes de gefirina para uso médico e, em particular, um composto de artemisinina de fórmula geral i para uso no tratamento de um paciente com diabetes, bem como um método de identificação de candidatos principais adequados.
BR112016023607A 2014-04-11 2015-04-09 uso médico de compostos de artemisinina e agonistas de gefirina BR112016023607A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14164471.6A EP2929881A1 (en) 2014-04-11 2014-04-11 Medical use of artemisinin compounds and gephyrin agonists
PCT/EP2015/057755 WO2015155303A2 (en) 2014-04-11 2015-04-09 Medical use of artemisinin compounds and gephyrin agonists

Publications (1)

Publication Number Publication Date
BR112016023607A2 true BR112016023607A2 (pt) 2017-12-26

Family

ID=50513025

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016023607A BR112016023607A2 (pt) 2014-04-11 2015-04-09 uso médico de compostos de artemisinina e agonistas de gefirina

Country Status (22)

Country Link
US (1) US9999621B2 (pt)
EP (2) EP2929881A1 (pt)
JP (1) JP6680759B2 (pt)
KR (1) KR20160136452A (pt)
CN (1) CN106459079B (pt)
AU (1) AU2015245523A1 (pt)
BR (1) BR112016023607A2 (pt)
CA (1) CA2945046A1 (pt)
CY (1) CY1122185T1 (pt)
DK (1) DK3129019T3 (pt)
ES (1) ES2749074T3 (pt)
HR (1) HRP20191795T1 (pt)
HU (1) HUE046397T2 (pt)
IL (1) IL248259A0 (pt)
LT (1) LT3129019T (pt)
MX (1) MX2016013323A (pt)
PL (1) PL3129019T3 (pt)
PT (1) PT3129019T (pt)
RS (1) RS59476B1 (pt)
RU (1) RU2016144173A (pt)
SI (1) SI3129019T1 (pt)
WO (1) WO2015155303A2 (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107349198A (zh) * 2016-05-10 2017-11-17 复旦大学 蒿甲醚在制备促进脂肪分解和改善糖代谢制剂中的用途
CN108383851A (zh) * 2016-12-09 2018-08-10 新乡学院 一种具有心脑血管疾病防治活性的青蒿素酯类化合物、其制备方法及其应用
WO2018115012A1 (en) * 2016-12-20 2018-06-28 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of neurodegeneration with brain iron accumulation
WO2019153325A1 (zh) * 2018-02-12 2019-08-15 深圳市中医院 青蒿素衍生物在制备预防和治疗2型糖尿病及其并发症药物中的应用及药物组合物
CN108403686A (zh) * 2018-02-12 2018-08-17 深圳市中医院 青蒿素衍生物在制备预防和治疗2型糖尿病及其并发症药物中的应用及药物组合物
CN108354927A (zh) * 2018-03-29 2018-08-03 上海壹志医药科技有限公司 蒿乙醚的新药物用途
CN109331012A (zh) * 2018-11-02 2019-02-15 广州中医药大学(广州中医药研究院) 青蒿素衍生物在制备抗癫痫药物中的应用
CN110200980B (zh) * 2019-05-13 2022-07-12 华南师范大学 一种荷载青蒿素的柑橘果胶的口服纳米粒子
CN110938080A (zh) * 2019-08-15 2020-03-31 恩施硒禾生物科技有限公司 一种青蒿琥酯的制备方法
KR102524408B1 (ko) * 2020-08-19 2023-04-21 주식회사 노브메타파마 아모디아퀸 및 아르테수네이트계 약물을 유효성분으로 함유하는 제2형 당뇨병 예방 또는 치료용 약학적 조성물
WO2022159581A2 (en) * 2021-01-20 2022-07-28 Cornell University Artemisinin-proteasome inhibitor conjugates and their use in the treatment of disease
CN114807015B (zh) * 2022-05-20 2022-11-22 呈诺再生医学科技(北京)有限公司 一种促进胰岛α细胞转化为β细胞的诱导方法及其应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2054975T3 (es) * 1988-10-07 1994-08-16 Hoechst Ag Composiciones antimalaricas que emplean quinidina, artemisinina y sus derivados.
EP1978028A1 (en) 2007-04-05 2008-10-08 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Use of gene variants of the human MEIS1, BTBD9, MAP2K5, LBXCOR1, PTPRD or A2BP1 gene for diagnostic and therapeutic approaches to restless legs syndrome (RLS)
US20100151056A1 (en) * 2008-12-16 2010-06-17 Hanan Polansky Dietary supplements for decreasing the latent foreign dna load
CN101879158B (zh) * 2010-07-01 2012-02-29 中国科学院广州生物医药与健康研究院 青蒿素衍生物的新应用
KR101277710B1 (ko) * 2010-09-07 2013-06-24 연세대학교 산학협력단 신규한 아테미시닌 또는 디옥소아테미시닌-당지질 복합유도체 및 그의 혈관신생억제 용도
WO2014007853A1 (en) * 2012-07-03 2014-01-09 The Regents Of The University Of California Dihydromyricetin for the treatment of diseases and disorders of the glutamatergic system
WO2014048788A1 (en) * 2012-09-27 2014-04-03 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for producing a population of pancreatic beta-cells

Also Published As

Publication number Publication date
KR20160136452A (ko) 2016-11-29
WO2015155303A2 (en) 2015-10-15
CY1122185T1 (el) 2020-11-25
AU2015245523A1 (en) 2016-11-03
US9999621B2 (en) 2018-06-19
PL3129019T3 (pl) 2020-01-31
RU2016144173A3 (pt) 2018-12-03
CN106459079B (zh) 2019-09-24
HUE046397T2 (hu) 2020-03-30
RS59476B1 (sr) 2019-12-31
HRP20191795T1 (hr) 2019-12-27
EP3129019A2 (en) 2017-02-15
US20170027929A1 (en) 2017-02-02
JP6680759B2 (ja) 2020-04-15
ES2749074T3 (es) 2020-03-19
DK3129019T3 (da) 2019-10-07
SI3129019T1 (sl) 2019-11-29
RU2016144173A (ru) 2018-05-11
CA2945046A1 (en) 2015-10-15
MX2016013323A (es) 2017-04-27
EP3129019B1 (en) 2019-07-17
CN106459079A (zh) 2017-02-22
IL248259A0 (en) 2016-11-30
LT3129019T (lt) 2019-11-11
PT3129019T (pt) 2019-10-28
WO2015155303A3 (en) 2016-02-04
EP2929881A1 (en) 2015-10-14
JP2017513936A (ja) 2017-06-01

Similar Documents

Publication Publication Date Title
BR112016023607A2 (pt) uso médico de compostos de artemisinina e agonistas de gefirina
CL2018000685A1 (es) Nuevos compuestos bicíclicos como inhibidores duales de atx/ca
CL2018000596A1 (es) Nuevos compuestos bicíclicos como inhibidores de la atx
UY36445A (es) Compuestos moduladores de fxr (nr1h4 que contiene grupos hidroxi)
CR20140161A (es) Benzilindazoles sustituidos para uso como inhibidores de la quinasa bub1 en el tratamiento de enfermedades hiperproliferativas
CL2016001911A1 (es) Compuesto heterocíclico fusionado
CL2016002679A1 (es) Métodos para mejorar o acelerar la recuperación física después la cirugía por fractura de cadera.
UY35500A (es) Indazoles sustituidos con heteroarilo
UY36452A (es) Novedosos compuestos moduladores de fxr (nr1h4)
CL2016001737A1 (es) Derivados heterocíclicos bicíclicos como inhibidores de bromodominio
BR112017010481A2 (pt) agonista parcial de receptor de insulina, composição, dímeros de análogo de insulina e de insulina, método para tratar diabetes, usos de um agonista parcial de receptor de insulina e de um composto, e, composto.
CL2015001442A1 (es) Metodo para tratar enfermedades pulmonares que comprende el uso de compuestos derivados del acido obeticolico.
CL2016000373A1 (es) Beneficio de supervivencia en pacientes con tumores sólidos con niveles elevados de proteína c reactiva
CL2012003588S1 (es) Utensilio de proteccion para utilizar como traje quirurgico o de laboratorio
UY36175A (es) 3-amino-1,5,6,7-tetrahidro-4h-indol-4-onas
BR112015031475A2 (pt) composto, composição farmacêutica, método para tratamento de uma doença ou condição, kit, e, uso de composto.
CL2017000792A1 (es) Derivados del ácido borónico
CL2008001682A1 (es) Metodos para el mejoramiento de plantas mediante el uso de informacion directa de secuencias de acidos nucleicos.
AR095075A1 (es) Acoplamiento electroquímico de anilinas
MX2016006356A (es) Metodos de tratamiento de una tauopatia.
NI201700054A (es) Síntesis de copanlisib y su sal diclorhidrato
UY34097A (es) Alineación de anticoagulante de cebado para extracción de sangre.
BR112015032526A2 (pt) composições anticaspa e métodos de uso das mesmas
EA201591399A1 (ru) РАППγ АГОНИСТЫ ДЛЯ ЛЕЧЕНИЯ РАССЕЯННОГО СКЛЕРОЗА
BR112017014416A2 (pt) sal de mangiferina-6-o-berberina e método de preparação e uso do mesmo

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements