BR112015011478A2 - - Google Patents
Info
- Publication number
- BR112015011478A2 BR112015011478A2 BR112015011478A BR112015011478A BR112015011478A2 BR 112015011478 A2 BR112015011478 A2 BR 112015011478A2 BR 112015011478 A BR112015011478 A BR 112015011478A BR 112015011478 A BR112015011478 A BR 112015011478A BR 112015011478 A2 BR112015011478 A2 BR 112015011478A2
- Authority
- BR
- Brazil
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2/00—Peptides of undefined number of amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Toxicology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261728649P | 2012-11-20 | 2012-11-20 | |
| US61/728,649 | 2012-11-20 | ||
| PCT/US2013/071077 WO2014081872A1 (en) | 2012-11-20 | 2013-11-20 | Improved peptide pharmaceuticals for insulin resistance |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112015011478A2 true BR112015011478A2 (pt) | 2017-08-15 |
| BR112015011478B1 BR112015011478B1 (pt) | 2022-10-25 |
Family
ID=50776533
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112015011478-4A BR112015011478B1 (pt) | 2012-11-20 | 2013-11-20 | Produtos de peptídeo, seus usos e composição farmacêutica |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US11065304B2 (pt) |
| EP (3) | EP3653649A1 (pt) |
| JP (1) | JP6525456B2 (pt) |
| KR (2) | KR102213907B1 (pt) |
| CN (2) | CN117903257A (pt) |
| AU (1) | AU2013347975B2 (pt) |
| BR (1) | BR112015011478B1 (pt) |
| CA (1) | CA2891931A1 (pt) |
| DK (1) | DK2922876T3 (pt) |
| MX (2) | MX360816B (pt) |
| WO (1) | WO2014081872A1 (pt) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2602801C2 (ru) * | 2011-05-18 | 2016-11-20 | МЕДЕРИС ДАЙАБИТИЗ, ЭлЭлСи | Пептидные лекарственные препараты с повышенной эффективностью против инсулинорезистентности |
| JP6148228B2 (ja) | 2011-05-18 | 2017-06-14 | ユーメデリス ファーマシューティカルズ，インク． | 改善されたペプチド製剤 |
| UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
| US11065304B2 (en) | 2012-11-20 | 2021-07-20 | Mederis Diabetes, Llc | Peptide pharmaceuticals for insulin resistance |
| EP4047023A1 (en) | 2012-11-20 | 2022-08-24 | Eumederis Pharmaceuticals, Inc. | Improved peptide pharmaceuticals |
| ES2653765T3 (es) | 2012-12-21 | 2018-02-08 | Sanofi | Agonistas duales de GLP1/GIP o trigonales de GLP1/GIP/glucagón |
| WO2015086729A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Dual glp-1/gip receptor agonists |
| TW201609795A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 作為雙重ｇｌｐ－１／ｇｉｐ受體促效劑的艾塞那肽－４（ｅｘｅｎｄｉｎ－４）胜肽類似物 |
| EP3080149A1 (en) | 2013-12-13 | 2016-10-19 | Sanofi | Dual glp-1/glucagon receptor agonists |
| TW201609796A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 非醯化之艾塞那肽－４（ｅｘｅｎｄｉｎ－４）胜肽類似物 |
| TW201625668A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物 |
| TW201625670A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑 |
| TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑 |
| MX371033B (es) | 2014-05-28 | 2020-01-13 | Mederis Diabetes Llc | Productos farmacéuticos mejorados de péptido para resistencia a la insulina. |
| US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
| PE20230304A1 (es) | 2014-12-30 | 2023-02-13 | Hanmi Pharm Ind Co Ltd | Derivados de glucagon como agentes hipoglucemicos y antiobesidad |
| AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
| WO2016198628A1 (en) | 2015-06-12 | 2016-12-15 | Sanofi | Non-acylated exendin-4 derivatives as dual glp-1/glucagon receptor agonists |
| WO2016198624A1 (en) | 2015-06-12 | 2016-12-15 | Sanofi | Exendin-4 derivatives as trigonal glp-1/glucagon/gip receptor agonists |
| AR105485A1 (es) | 2015-06-30 | 2017-10-11 | Hanmi Pharm Ind Co Ltd | Derivado de glucagón y una composición que comprende un conjugado de acción prolongada del mismo |
| AR105284A1 (es) * | 2015-07-10 | 2017-09-20 | Sanofi Sa | Derivados de exendina-4 como agonistas peptídicos duales específicos de los receptores de glp-1 / glucagón |
| CR20180380A (es) | 2015-12-31 | 2018-12-07 | Hanmi Pharm Ind Co Ltd | Agosnista triple de receptores de glucagón/glp-1/gip |
| BR112018077457A2 (pt) | 2016-06-29 | 2019-04-02 | Hanmi Pharm. Co., Ltd. | composição farmacêutica para evitar ou tratar hiperinsulinismo congênito e seu método, hipoglicemia e seu método, síndrome metabólica e seu método e peptídeo isolado |
| KR20190124704A (ko) | 2017-01-24 | 2019-11-05 | 마크레젠, 인크. | 아포지질단백질 모방체를 이용하는, 나이 관련 황반 변성 및 기타 안질환의 치료 |
| WO2018161035A1 (en) | 2017-03-03 | 2018-09-07 | Macregen, Inc. | Treatment of age-related macular degeneration and other eye diseases with one or more therapeutic agents |
| KR20200106173A (ko) * | 2018-01-03 | 2020-09-11 | 메더리스 다이어비티즈, 엘엘씨 | Nash 및 다른 질병의 치료를 위한 개선된 펩티드 약제 |
| EP4106796A4 (en) * | 2020-02-21 | 2024-04-17 | Spitfire Pharma LLC | GLP-1R AND GCGR AGONISTS, FORMULATIONS AND METHODS OF USE |
| CN113461747B (zh) * | 2021-07-12 | 2023-02-03 | 吉林化工学院 | 刺玫果中2个具有降血糖活性的化合物 |
| WO2024026012A1 (en) * | 2022-07-29 | 2024-02-01 | The Regents Of The University Of California | Compositions and methods for treating metabolic disorders |
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| JP6148228B2 (ja) | 2011-05-18 | 2017-06-14 | ユーメデリス ファーマシューティカルズ，インク． | 改善されたペプチド製剤 |
| RU2602801C2 (ru) | 2011-05-18 | 2016-11-20 | МЕДЕРИС ДАЙАБИТИЗ, ЭлЭлСи | Пептидные лекарственные препараты с повышенной эффективностью против инсулинорезистентности |
| JP2014011554A (ja) | 2012-06-28 | 2014-01-20 | Seiichi Onoda | 光線路監視方法、および光線路監視システム |
| EP4047023A1 (en) | 2012-11-20 | 2022-08-24 | Eumederis Pharmaceuticals, Inc. | Improved peptide pharmaceuticals |
| US11065304B2 (en) | 2012-11-20 | 2021-07-20 | Mederis Diabetes, Llc | Peptide pharmaceuticals for insulin resistance |
| MX371033B (es) | 2014-05-28 | 2020-01-13 | Mederis Diabetes Llc | Productos farmacéuticos mejorados de péptido para resistencia a la insulina. |
| KR20200106173A (ko) * | 2018-01-03 | 2020-09-11 | 메더리스 다이어비티즈, 엘엘씨 | Nash 및 다른 질병의 치료를 위한 개선된 펩티드 약제 |
| EP4106796A4 (en) * | 2020-02-21 | 2024-04-17 | Spitfire Pharma LLC | GLP-1R AND GCGR AGONISTS, FORMULATIONS AND METHODS OF USE |
-
2013
- 2013-11-20 US US14/646,264 patent/US11065304B2/en active Active
- 2013-11-20 MX MX2015006336A patent/MX360816B/es active IP Right Grant
- 2013-11-20 DK DK13856357.2T patent/DK2922876T3/en active
- 2013-11-20 JP JP2015543145A patent/JP6525456B2/ja active Active
- 2013-11-20 EP EP19188938.5A patent/EP3653649A1/en active Pending
- 2013-11-20 AU AU2013347975A patent/AU2013347975B2/en active Active
- 2013-11-20 WO PCT/US2013/071077 patent/WO2014081872A1/en active Application Filing
- 2013-11-20 CN CN202311534812.XA patent/CN117903257A/zh active Pending
- 2013-11-20 EP EP13856357.2A patent/EP2922876B1/en active Active
- 2013-11-20 EP EP18193667.5A patent/EP3434696A1/en not_active Withdrawn
- 2013-11-20 CN CN201380069707.1A patent/CN104918961A/zh active Pending
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- 2013-11-20 KR KR1020217003371A patent/KR102365582B1/ko active IP Right Grant
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| CN104918961A (zh) | 2015-09-16 |
| KR102365582B1 (ko) | 2022-02-18 |
| MX2018013981A (es) | 2021-11-16 |
| US20220362345A1 (en) | 2022-11-17 |
| US11911447B2 (en) | 2024-02-27 |
| KR20150088294A (ko) | 2015-07-31 |
| EP2922876B1 (en) | 2018-10-10 |
| EP2922876A4 (en) | 2016-06-01 |
| WO2014081872A1 (en) | 2014-05-30 |
| BR112015011478B1 (pt) | 2022-10-25 |
| DK2922876T3 (en) | 2019-02-04 |
| EP3434696A1 (en) | 2019-01-30 |
| MX2015006336A (es) | 2016-02-05 |
| KR102213907B1 (ko) | 2021-02-09 |
| JP6525456B2 (ja) | 2019-06-05 |
| US20150290334A1 (en) | 2015-10-15 |
| JP2016501204A (ja) | 2016-01-18 |
| AU2013347975A1 (en) | 2015-06-11 |
| AU2013347975B2 (en) | 2018-07-26 |
| CA2891931A1 (en) | 2014-05-30 |
| CN117903257A (zh) | 2024-04-19 |
| MX360816B (es) | 2018-11-15 |
| KR20210016083A (ko) | 2021-02-10 |
| US11065304B2 (en) | 2021-07-20 |
| EP3653649A1 (en) | 2020-05-20 |
| EP2922876A1 (en) | 2015-09-30 |
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