BR112015010704B8 - Partícula compósita, e, processo para preparar uma partícula compósita - Google Patents

Partícula compósita, e, processo para preparar uma partícula compósita

Info

Publication number
BR112015010704B8
BR112015010704B8 BR112015010704A BR112015010704A BR112015010704B8 BR 112015010704 B8 BR112015010704 B8 BR 112015010704B8 BR 112015010704 A BR112015010704 A BR 112015010704A BR 112015010704 A BR112015010704 A BR 112015010704A BR 112015010704 B8 BR112015010704 B8 BR 112015010704B8
Authority
BR
Brazil
Prior art keywords
composite particle
particles
ingestible
nanoparticles
composite
Prior art date
Application number
BR112015010704A
Other languages
English (en)
Portuguese (pt)
Other versions
BR112015010704B1 (pt
BR112015010704A2 (pt
Inventor
Catharina Knieke
Daniel To
A Bilgili Ecevit
A Azad Mohammed
Rajesh Dave
Original Assignee
New Jersey Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by New Jersey Inst Technology filed Critical New Jersey Inst Technology
Publication of BR112015010704A2 publication Critical patent/BR112015010704A2/pt
Publication of BR112015010704B1 publication Critical patent/BR112015010704B1/pt
Publication of BR112015010704B8 publication Critical patent/BR112015010704B8/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1611Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1617Organic compounds, e.g. phospholipids, fats
    • A61K9/1623Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1652Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682Processes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682Processes
    • A61K9/1694Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/501Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089Processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B05SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05DPROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D1/00Processes for applying liquids or other fluent materials
    • B05D1/18Processes for applying liquids or other fluent materials performed by dipping
    • B05D1/22Processes for applying liquids or other fluent materials performed by dipping using fluidised-bed technique

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
BR112015010704A 2012-11-12 2013-11-08 Partícula compósita, e, processo para preparar uma partícula compósita BR112015010704B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261725301P 2012-11-12 2012-11-12
US61/725,301 2012-11-12
PCT/US2013/069128 WO2014074808A1 (en) 2012-11-12 2013-11-08 Pharmaceutical core-shell composite powder and processes for making the same

Publications (3)

Publication Number Publication Date
BR112015010704A2 BR112015010704A2 (pt) 2017-07-11
BR112015010704B1 BR112015010704B1 (pt) 2022-05-31
BR112015010704B8 true BR112015010704B8 (pt) 2022-06-14

Family

ID=50685172

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015010704A BR112015010704B8 (pt) 2012-11-12 2013-11-08 Partícula compósita, e, processo para preparar uma partícula compósita

Country Status (9)

Country Link
US (1) US9801820B2 (https=)
EP (1) EP2916824B1 (https=)
JP (1) JP6460562B2 (https=)
CN (1) CN104968332B (https=)
AR (1) AR093449A1 (https=)
BR (1) BR112015010704B8 (https=)
DK (1) DK2916824T3 (https=)
ES (1) ES2745759T3 (https=)
WO (1) WO2014074808A1 (https=)

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US10149826B2 (en) * 2015-01-20 2018-12-11 Hyalo Technologies, LLC Method of preparing microspheres
JPWO2017047650A1 (ja) * 2015-09-14 2018-06-28 大和製罐株式会社 粉末吸入剤、吸入器、及び粉末吸入剤の製造方法
EP3352723B1 (en) * 2015-09-24 2019-03-06 Unilever NV Oral care composition
US9675609B2 (en) * 2015-11-11 2017-06-13 Cao Pharmaceuticals Inc. Nano- and micro-sized particles of 20-camptothecin or derivative thereof and pharmaceutical compositions containing same, and treatment of cancers therewith
JP6067154B1 (ja) * 2016-01-25 2017-01-25 株式会社樋口商会 コーティング粒子の製造方法
KR101809139B1 (ko) 2016-11-15 2017-12-15 주식회사 이코블록 무기물 코어에 유기물을 코팅하는 방법 및 그에 따른 용사코팅장치
JP6935501B2 (ja) * 2017-08-25 2021-09-15 福田金属箔粉工業株式会社 積層造形用粉末の評価方法
DE102017215328A1 (de) * 2017-09-01 2019-03-07 Henkel Ag & Co. Kgaa Treibmittelhaltige kosmetische Zusammensetzungen mit Pigment-haltigen Stärkepartikeln und anionischem Polymer
CN107649063B (zh) * 2017-11-02 2023-08-29 黑龙江省科学院自动化研究所 一种纳米材料超声共振乳化混配装置
CN115715766A (zh) * 2018-09-03 2023-02-28 正大天晴药业集团股份有限公司 包含1,3,5-三嗪衍生物或其盐的固体药物组合物
CN109046187B (zh) * 2018-10-09 2023-05-23 天津西敦津洋环保科技有限公司 一种高充气率的气固流化床反应器、实现在流化床中高充气率的方法及其应用
JP7147523B2 (ja) * 2018-12-06 2022-10-05 三生医薬株式会社 造粒方法
US11549381B2 (en) * 2019-09-05 2023-01-10 Raytheon Technologies Corporation Coating fabrication method for producing engineered microstructure of silicate-resistant barrier coating
WO2021110545A1 (en) * 2019-12-02 2021-06-10 Merck Patent Gmbh Deposition of nanosuspensions of active pharmaceutical ingredients on carriers
WO2021126548A1 (en) * 2019-12-16 2021-06-24 Cooper Tire & Rubber Company Silica coated starch
AU2021221987B2 (en) * 2020-02-19 2026-02-12 Nano Pharmasolutions, Inc. Therapeutic agent nanoparticles and methods of preparation
CN112522863B (zh) * 2020-11-26 2021-12-07 内蒙古工业大学 气流铺覆纤维装置
EP4507510A4 (en) * 2022-04-10 2026-03-25 Incredo Ltd COATED SWEETENER PARTICLES
CN115386208B (zh) * 2022-08-11 2025-06-24 长兴电子(苏州)有限公司 可降解微珠及其制备方法与应用
TWI859571B (zh) * 2022-08-29 2024-10-21 長興材料工業股份有限公司 可降解微珠及其製備方法與應用
TWI842445B (zh) * 2023-03-21 2024-05-11 國立臺灣海洋大學 含有褐藻萃取物的多層顆粒結構及其製造方法
CN119555851B (zh) * 2025-02-06 2025-06-03 上海新黄河制药有限公司 一种吸入用混悬液的体外溶出曲线测定方法

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GB9515182D0 (en) 1995-07-24 1995-09-20 Co Ordinated Drug Dev Improvements in and relating to powders for use in dry powder inhalers
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JP4547888B2 (ja) * 2003-10-10 2010-09-22 小野薬品工業株式会社 胃内浮遊性固形製剤
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BRPI0711606A2 (pt) * 2006-05-22 2012-02-14 Teva Pharma formulações de hidrocloreto de duloxetina de liberação retardada
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BRPI0717721A2 (pt) * 2006-11-28 2013-10-29 Marinus Pharmaceuticals "partículas complexadas de drogas, composição farmacêutica, uso de uma composição farmacêutica, partículas complexadas de droga estabilizadas no tamanho, método para a preparação de partículas estabilizadas da droga, composição farmacêutica sólida, comprimido oral ingerível e composição líquida em nanopartículas estabilizadas no tamanho"
US8993041B2 (en) 2012-10-15 2015-03-31 New Jersey Institute Of Technology Taste masked active pharmaceutical powder compositions and processes for making them

Also Published As

Publication number Publication date
BR112015010704B1 (pt) 2022-05-31
EP2916824A4 (en) 2016-08-17
BR112015010704A2 (pt) 2017-07-11
WO2014074808A1 (en) 2014-05-15
CN104968332B (zh) 2020-10-20
JP6460562B2 (ja) 2019-01-30
JP2016503411A (ja) 2016-02-04
CN104968332A (zh) 2015-10-07
EP2916824A1 (en) 2015-09-16
AR093449A1 (es) 2015-06-10
EP2916824B1 (en) 2019-06-19
ES2745759T3 (es) 2020-03-03
DK2916824T3 (da) 2019-09-30
US20150297521A1 (en) 2015-10-22
US9801820B2 (en) 2017-10-31

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
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