BR112015009607A2 - letalidade sintética e o tratamento de câncer - Google Patents

letalidade sintética e o tratamento de câncer

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Publication number
BR112015009607A2
BR112015009607A2 BR112015009607A BR112015009607A BR112015009607A2 BR 112015009607 A2 BR112015009607 A2 BR 112015009607A2 BR 112015009607 A BR112015009607 A BR 112015009607A BR 112015009607 A BR112015009607 A BR 112015009607A BR 112015009607 A2 BR112015009607 A2 BR 112015009607A2
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BR
Brazil
Prior art keywords
cancer
synthetic lethality
cancer treatment
treatment
subject
Prior art date
Application number
BR112015009607A
Other languages
English (en)
Other versions
BR112015009607B1 (pt
Inventor
Yap Chuiyee
Maneka Anne Perinpanayagam Conganige
Beauchamp Erwan
G Berthiaume Luc
Original Assignee
Pacylex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pacylex Pharmaceuticals Inc filed Critical Pacylex Pharmaceuticals Inc
Publication of BR112015009607A2 publication Critical patent/BR112015009607A2/pt
Publication of BR112015009607B1 publication Critical patent/BR112015009607B1/pt

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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
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Abstract

resumo da patente de invenção para: “letalidade sintética e o tratamento de câncer”. são aqui descritos compostos, composições e métodos para o tratamento de câncer. também são descritos métodos e usos para a identificação de um indivíduo com câncer que são adequados para o tratamento com os compostos, composição e métodos aqui descritos. em um aspecto da presente invenção, é proporcionado um método de tratamento de um indivíduo tendo um câncer deficiente em nmt2, que compreende: a administração ao referido indivíduo de um inibidor nmt
BR112015009607-7A 2012-10-30 2013-10-30 Método e kit para identificar um sujeito adequado para o tratamento com um inibidor de nmt1 ou nmt, e seus usos BR112015009607B1 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261720218P 2012-10-30 2012-10-30
US61/720,218 2012-10-30
US201361870435P 2013-08-27 2013-08-27
US201361870418P 2013-08-27 2013-08-27
US61/870,435 2013-08-27
US61/870,418 2013-08-27
PCT/CA2013/050821 WO2014067002A1 (en) 2012-10-30 2013-10-30 Synthetic lethality and the treatment of cancer

Publications (2)

Publication Number Publication Date
BR112015009607A2 true BR112015009607A2 (pt) 2017-07-04
BR112015009607B1 BR112015009607B1 (pt) 2023-07-04

Family

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Also Published As

Publication number Publication date
AU2018203395A1 (en) 2018-05-31
US20150275309A1 (en) 2015-10-01
SG10201703505VA (en) 2017-06-29
MX2015005441A (es) 2015-07-21
IL238481A0 (en) 2015-06-30
US20230374603A1 (en) 2023-11-23
CA2890113A1 (en) 2014-05-08
JP2016506362A (ja) 2016-03-03
RU2676697C2 (ru) 2019-01-10
RU2015118294A (ru) 2016-12-20
EP2914261B1 (en) 2020-12-16
SG11201503187UA (en) 2015-05-28
JP6463685B2 (ja) 2019-02-06
CN110974967B (zh) 2023-11-07
CN110974967A (zh) 2020-04-10
US20190010555A1 (en) 2019-01-10
EP2914261A4 (en) 2016-07-27
AU2018203395B2 (en) 2020-05-21
MX369609B (es) 2019-11-13
CA2890113C (en) 2023-01-17
DK2914261T3 (da) 2021-03-22
CN104768550A (zh) 2015-07-08
NZ707090A (en) 2019-03-29
AU2013337569A1 (en) 2015-05-07
IL238481B (en) 2018-11-29
ZA201502280B (en) 2019-06-26
KR20150079949A (ko) 2015-07-08
ES2856701T3 (es) 2021-09-28
KR102496892B1 (ko) 2023-02-06
EP3858350A1 (en) 2021-08-04
KR20220040509A (ko) 2022-03-30
EP2914261A1 (en) 2015-09-09
WO2014067002A1 (en) 2014-05-08
PL2914261T3 (pl) 2021-06-28

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06I Publication of requirement cancelled [chapter 6.9 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2462 DE 13/03/2018 POR TER SIDO INDEVIDA.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B25G Requested change of headquarter approved

Owner name: PACYLEX PHARMACEUTICALS INC. (CA)

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 30/10/2013, OBSERVADAS AS CONDICOES LEGAIS