PL2914261T3 - Śmiertelność syntetyczna i leczenie nowotworu - Google Patents

Śmiertelność syntetyczna i leczenie nowotworu

Info

Publication number
PL2914261T3
PL2914261T3 PL13852049T PL13852049T PL2914261T3 PL 2914261 T3 PL2914261 T3 PL 2914261T3 PL 13852049 T PL13852049 T PL 13852049T PL 13852049 T PL13852049 T PL 13852049T PL 2914261 T3 PL2914261 T3 PL 2914261T3
Authority
PL
Poland
Prior art keywords
cancer
treatment
mortality
synthetic
synthetic mortality
Prior art date
Application number
PL13852049T
Other languages
English (en)
Inventor
Luc G. Berthiaume
Conganige Maneka Anne Perinpanayagam
Chuiyee YAP
Erwan BEAUCHAMP
Original Assignee
Pacylex Pharmaceuticals Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pacylex Pharmaceuticals Inc. filed Critical Pacylex Pharmaceuticals Inc.
Publication of PL2914261T3 publication Critical patent/PL2914261T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/28Compounds containing heavy metals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/20Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/7105Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/713Double-stranded nucleic acids or oligonucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G01N33/575
    • G01N33/57505
    • G01N33/5758
    • G01N33/57585
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/112Disease subtyping, staging or classification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/91Transferases (2.)
    • G01N2333/91045Acyltransferases (2.3)
    • G01N2333/91051Acyltransferases other than aminoacyltransferases (general) (2.3.1)
    • G01N2333/91057Acyltransferases other than aminoacyltransferases (general) (2.3.1) with definite EC number (2.3.1.-)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Mycology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • General Physics & Mathematics (AREA)
PL13852049T 2012-10-30 2013-10-30 Śmiertelność syntetyczna i leczenie nowotworu PL2914261T3 (pl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261720218P 2012-10-30 2012-10-30
US201361870435P 2013-08-27 2013-08-27
US201361870418P 2013-08-27 2013-08-27
EP13852049.9A EP2914261B1 (en) 2012-10-30 2013-10-30 Synthetic lethality and the treatment of cancer
PCT/CA2013/050821 WO2014067002A1 (en) 2012-10-30 2013-10-30 Synthetic lethality and the treatment of cancer

Publications (1)

Publication Number Publication Date
PL2914261T3 true PL2914261T3 (pl) 2021-06-28

Family

ID=50626256

Family Applications (1)

Application Number Title Priority Date Filing Date
PL13852049T PL2914261T3 (pl) 2012-10-30 2013-10-30 Śmiertelność syntetyczna i leczenie nowotworu

Country Status (17)

Country Link
US (4) US20150275309A1 (pl)
EP (2) EP2914261B1 (pl)
JP (1) JP6463685B2 (pl)
KR (2) KR20220040509A (pl)
CN (2) CN104768550A (pl)
AU (2) AU2013337569A1 (pl)
CA (1) CA2890113C (pl)
DK (1) DK2914261T3 (pl)
ES (1) ES2856701T3 (pl)
IL (1) IL238481B (pl)
MX (1) MX369609B (pl)
NZ (1) NZ707090A (pl)
PL (1) PL2914261T3 (pl)
RU (1) RU2676697C2 (pl)
SG (2) SG10201703505VA (pl)
WO (1) WO2014067002A1 (pl)
ZA (1) ZA201502280B (pl)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103826623A (zh) 2011-07-22 2014-05-28 厄尔莱克斯制药公司 合成致死与癌症的治疗
WO2017011907A1 (en) 2015-07-17 2017-01-26 Pacylex Pharmaceuticals Inc. Epigenetic silencing of nmt2
JP6963164B2 (ja) * 2017-04-24 2021-11-05 チンワー ユニバーシティー アポトーシス誘導及び抗感染治療における自己誘導物質関連経路の応用
CN107893119B (zh) * 2017-12-27 2020-09-22 青岛泱深生物医药有限公司 Zcchc12在骨肉瘤中的应用
GB201820660D0 (en) * 2018-12-19 2019-01-30 Imperial Innovations Ltd Cancer treatments
CN111621576B (zh) * 2020-06-18 2022-11-08 深圳市计量质量检测研究院(国家高新技术计量站、国家数字电子产品质量监督检验中心) 用于检测油鱼的rpa引物和探针及检测方法
WO2022082306A1 (en) * 2020-10-20 2022-04-28 Pacylex Pharmaceuticals Inc. Use of n-myristoyl transferase (nmt) inhibitors in the treatment of cancer, autoimmune disorders, and inflammatory disorders
CA3191934A1 (en) * 2021-05-20 2022-11-20 12987490 Canada Inc. Predicting prognosis and treatment response of breast cancer patients using expression and cellular localization of n-myristoyltransferase
US11885808B2 (en) 2021-05-20 2024-01-30 Oneodrek Inc. Predicting prognosis and treatment response of breast cancer patients using expression and cellular localization of N-myristoyltransferase
IL314984A (en) * 2022-03-03 2024-10-01 Pacylex Pharmaceuticals Inc Oral PCLX-001 for the treatment of human cancer
WO2024145711A1 (en) * 2023-01-06 2024-07-11 Pacylex Pharmaceuticals Inc. Crystalline form of an n-heteroarylsulphonamide, compositions and methods thereof
WO2025050208A1 (en) * 2023-09-05 2025-03-13 Pacylex Pharmaceuticals Inc. Oral pclx-001 in the treatment of human cancer
WO2025208214A1 (en) * 2024-04-03 2025-10-09 Pacylex Pharmaceuticals Inc. Myristoylation inhibitor sensitivity signature miss-54, identifies new cancer indications for nmt inhibitor pclx-001

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2657259A1 (fr) * 1990-01-25 1991-07-26 Adir Utilisation de la n-myristoyl-(s)-phenylalanine pour l'obtention de medicaments destines au traitement des maladies faisant intervenir la myristoylation.
DK1771474T3 (da) * 2004-07-20 2010-05-31 Genentech Inc Inhibitorer af angiopoitin-like 4 protein, kombinationer og anvendelser deraf
WO2006086043A2 (en) 2004-11-23 2006-08-17 Science & Technology Corporation @ Unm Molecular technologies for improved risk classification and therapy for acute lymphoblastic leukemia in children and adults
CA2670837C (en) * 2006-12-18 2016-03-29 Jack Arbiser Novel palladium complexes inhibit n-myristoyltransferase activity in vitro and cancer growth in vivo
GB0815947D0 (en) * 2008-09-02 2008-10-08 Univ Dundee Compounds
CN103826623A (zh) * 2011-07-22 2014-05-28 厄尔莱克斯制药公司 合成致死与癌症的治疗

Also Published As

Publication number Publication date
EP3858350A1 (en) 2021-08-04
KR20150079949A (ko) 2015-07-08
US20250179589A1 (en) 2025-06-05
EP2914261A1 (en) 2015-09-09
DK2914261T3 (da) 2021-03-22
NZ707090A (en) 2019-03-29
SG10201703505VA (en) 2017-06-29
US20230374603A1 (en) 2023-11-23
IL238481A0 (en) 2015-06-30
EP2914261A4 (en) 2016-07-27
RU2015118294A (ru) 2016-12-20
EP2914261B1 (en) 2020-12-16
AU2013337569A1 (en) 2015-05-07
MX369609B (es) 2019-11-13
MX2015005441A (es) 2015-07-21
KR20220040509A (ko) 2022-03-30
AU2018203395A1 (en) 2018-05-31
IL238481B (en) 2018-11-29
US20150275309A1 (en) 2015-10-01
WO2014067002A1 (en) 2014-05-08
KR102496892B1 (ko) 2023-02-06
US20190010555A1 (en) 2019-01-10
JP2016506362A (ja) 2016-03-03
ES2856701T3 (es) 2021-09-28
CA2890113C (en) 2023-01-17
CN104768550A (zh) 2015-07-08
JP6463685B2 (ja) 2019-02-06
CA2890113A1 (en) 2014-05-08
RU2676697C2 (ru) 2019-01-10
SG11201503187UA (en) 2015-05-28
AU2018203395B2 (en) 2020-05-21
ZA201502280B (en) 2019-06-26
BR112015009607A2 (pt) 2017-07-04
CN110974967A (zh) 2020-04-10
CN110974967B (zh) 2023-11-07

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