BR112015008477A2 - método para a síntese de 5-(clorometil)-2-furaldeído (cmf) de sacarídeos - Google Patents

método para a síntese de 5-(clorometil)-2-furaldeído (cmf) de sacarídeos

Info

Publication number
BR112015008477A2
BR112015008477A2 BR112015008477A BR112015008477A BR112015008477A2 BR 112015008477 A2 BR112015008477 A2 BR 112015008477A2 BR 112015008477 A BR112015008477 A BR 112015008477A BR 112015008477 A BR112015008477 A BR 112015008477A BR 112015008477 A2 BR112015008477 A2 BR 112015008477A2
Authority
BR
Brazil
Prior art keywords
furaldehyde
cmf
chloromethyl
synthesis
saccharide
Prior art date
Application number
BR112015008477A
Other languages
English (en)
Other versions
BR112015008477B1 (pt
Inventor
Cahana Aviad
Nikitin Edward
Standiford Jeremy
Ellis Kyle
Mikochik Peter
George Timothy
Luzheng Zhang
Original Assignee
Xf Tech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xf Tech Inc filed Critical Xf Tech Inc
Publication of BR112015008477A2 publication Critical patent/BR112015008477A2/pt
Publication of BR112015008477B1 publication Critical patent/BR112015008477B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/46—Doubly bound oxygen atoms, or two oxygen atoms singly bound to the same carbon atom
    • C07D307/48—Furfural
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/46—Doubly bound oxygen atoms, or two oxygen atoms singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/46—Doubly bound oxygen atoms, or two oxygen atoms singly bound to the same carbon atom
    • C07D307/48—Furfural
    • C07D307/50—Preparation from natural products

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

resumo método para a síntese de 5-(clorometil)-2- furaldeído (cmf) de sacarídeos a presente invenção descreve métodos e aparelhos para a síntese de 5-(clorometil)-2-furaldeído (cmf) de monossacarídeos, sendo que o método compreende: (a) colocar em contato monossacarídeos, ácido clorídrico e o solvente orgânico, por meio de uma montagem de reator de fluxo bifásico contínuo a uma temperatura de cerca de 60 °c a cerca de 200 °c e pressões de cerca de 0,1 mpa a 1 mpa (1 atm a 10 atm), de modo que seja produzido cmf; (b) separar 5-(clorometil)-2-furaldeído por meio de separação de fase líquida/líquida e sólida/líquida; (c) produzir pelo menos cinco quilogramas por dia com pelo menos 50% de rendimento. 1/1
BR112015008477-0A 2012-10-16 2013-09-03 método para a síntese de 5-(clorometil)-2-furaldeído (cmf) de sacarídeos BR112015008477B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261714225P 2012-10-16 2012-10-16
US61/714,225 2012-10-16
US201361818418P 2013-05-01 2013-05-01
US61/818,418 2013-05-01
PCT/US2013/057795 WO2014062303A2 (en) 2012-10-16 2013-09-03 Efficient, high-yield conversion of monosaccharides to 5-(chloromethyl)-2-furaldehyde

Publications (2)

Publication Number Publication Date
BR112015008477A2 true BR112015008477A2 (pt) 2017-07-04
BR112015008477B1 BR112015008477B1 (pt) 2020-12-08

Family

ID=50488863

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015008477-0A BR112015008477B1 (pt) 2012-10-16 2013-09-03 método para a síntese de 5-(clorometil)-2-furaldeído (cmf) de sacarídeos

Country Status (10)

Country Link
US (1) US9102644B2 (pt)
EP (1) EP2909187A4 (pt)
CN (1) CN105102440A (pt)
BR (1) BR112015008477B1 (pt)
CA (1) CA2888298C (pt)
IN (1) IN2015DN03835A (pt)
MX (1) MX363821B (pt)
PH (1) PH12015500818A1 (pt)
SG (1) SG11201502939WA (pt)
WO (1) WO2014062303A2 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112013031703B1 (pt) 2011-06-09 2019-04-02 Micromidas, Inc. Método para a produção de um furano substituído em um reator multifásico.
KR20150072453A (ko) 2012-10-26 2015-06-29 마이크로마이다스, 인코포레이티드 5-(할로메틸) 푸르푸랄 생산 방법
MY193787A (en) 2013-03-14 2022-10-27 Micromidas Inc Solid forms of 5-(halomethyl) furfural and methods for preparing thereof
MX2015012878A (es) 2013-03-14 2016-02-03 Micromidas Inc Metodos para purificar 5-(halometil)furfural.
EP4166546A1 (en) 2013-09-20 2023-04-19 Origin Materials Operating, Inc. Methods for producing 5-(halomethyl) furfural
EP3498699A1 (en) 2017-12-13 2019-06-19 Basf Se Chromatography method for the purification of furfural derivatives
AU2019210042A1 (en) 2018-01-19 2020-08-06 Qmaxx Products Group, Inc. Metal cleaning compositions comprising furoate esters and uses therefor
WO2019149853A1 (en) * 2018-01-31 2019-08-08 Avantium Knowledge Centre B.V. A process for the conversion of a solid lignocellulosic material
KR102660275B1 (ko) 2018-01-31 2024-04-23 퓨라닉스 테크놀러지스 비.브이. 고상 리그노셀룰로오스 물질의 전환 방법
EP3840746A1 (en) 2018-08-23 2021-06-30 Novartis AG New pharmaceutical use for the treatment of heart failure
WO2020039394A1 (en) 2018-08-24 2020-02-27 Novartis Ag New drug combinations

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4154744A (en) * 1976-10-12 1979-05-15 Sumitomo Chemical Company, Limited Process for producing a furan derivative
US4335049A (en) * 1980-07-16 1982-06-15 Sumitomo Chemical Company, Limited Process for producing 5-methylfurfural
DE3842825A1 (de) * 1988-01-08 1989-07-20 Krupp Gmbh Verfahren und vorrichtung zur herstellung von furfural
US7829732B2 (en) * 2008-03-17 2010-11-09 Regents Of The University Of California High-yield conversion of cellulosic biomass into furanic biofuels and value-added products
SG192958A1 (en) * 2011-02-28 2013-09-30 Midori Renewables Inc Polymeric acid catalysts and uses thereof

Also Published As

Publication number Publication date
CN105102440A (zh) 2015-11-25
US9102644B2 (en) 2015-08-11
PH12015500818A1 (en) 2015-06-08
EP2909187A4 (en) 2016-05-11
MX2015004716A (es) 2016-08-17
SG11201502939WA (en) 2015-05-28
WO2014062303A2 (en) 2014-04-24
BR112015008477B1 (pt) 2020-12-08
WO2014062303A3 (en) 2015-07-16
IN2015DN03835A (pt) 2015-10-02
CA2888298C (en) 2022-05-31
EP2909187A2 (en) 2015-08-26
CA2888298A1 (en) 2014-04-24
US20140187802A1 (en) 2014-07-03
MX363821B (es) 2019-04-04

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Legal Events

Date Code Title Description
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 03/09/2013, OBSERVADAS AS CONDICOES LEGAIS.