BR112015008477A2 - método para a síntese de 5-(clorometil)-2-furaldeído (cmf) de sacarídeos - Google Patents

método para a síntese de 5-(clorometil)-2-furaldeído (cmf) de sacarídeos

Info

Publication number
BR112015008477A2
BR112015008477A2 BR112015008477A BR112015008477A BR112015008477A2 BR 112015008477 A2 BR112015008477 A2 BR 112015008477A2 BR 112015008477 A BR112015008477 A BR 112015008477A BR 112015008477 A BR112015008477 A BR 112015008477A BR 112015008477 A2 BR112015008477 A2 BR 112015008477A2
Authority
BR
Brazil
Prior art keywords
furaldehyde
cmf
chloromethyl
synthesis
saccharide
Prior art date
Application number
BR112015008477A
Other languages
English (en)
Other versions
BR112015008477B1 (pt
Inventor
Cahana Aviad
Nikitin Edward
Standiford Jeremy
Ellis Kyle
Mikochik Peter
George Timothy
Luzheng Zhang
Original Assignee
Xf Tech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xf Tech Inc filed Critical Xf Tech Inc
Publication of BR112015008477A2 publication Critical patent/BR112015008477A2/pt
Publication of BR112015008477B1 publication Critical patent/BR112015008477B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/46—Doubly bound oxygen atoms, or two oxygen atoms singly bound to the same carbon atom
    • C07D307/48—Furfural
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/46—Doubly bound oxygen atoms, or two oxygen atoms singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/46—Doubly bound oxygen atoms, or two oxygen atoms singly bound to the same carbon atom
    • C07D307/48—Furfural
    • C07D307/50—Preparation from natural products

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

resumo método para a síntese de 5-(clorometil)-2- furaldeído (cmf) de sacarídeos a presente invenção descreve métodos e aparelhos para a síntese de 5-(clorometil)-2-furaldeído (cmf) de monossacarídeos, sendo que o método compreende: (a) colocar em contato monossacarídeos, ácido clorídrico e o solvente orgânico, por meio de uma montagem de reator de fluxo bifásico contínuo a uma temperatura de cerca de 60 °c a cerca de 200 °c e pressões de cerca de 0,1 mpa a 1 mpa (1 atm a 10 atm), de modo que seja produzido cmf; (b) separar 5-(clorometil)-2-furaldeído por meio de separação de fase líquida/líquida e sólida/líquida; (c) produzir pelo menos cinco quilogramas por dia com pelo menos 50% de rendimento. 1/1
BR112015008477-0A 2012-10-16 2013-09-03 método para a síntese de 5-(clorometil)-2-furaldeído (cmf) de sacarídeos BR112015008477B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261714225P 2012-10-16 2012-10-16
US61/714,225 2012-10-16
US201361818418P 2013-05-01 2013-05-01
US61/818,418 2013-05-01
PCT/US2013/057795 WO2014062303A2 (en) 2012-10-16 2013-09-03 Efficient, high-yield conversion of monosaccharides to 5-(chloromethyl)-2-furaldehyde

Publications (2)

Publication Number Publication Date
BR112015008477A2 true BR112015008477A2 (pt) 2017-07-04
BR112015008477B1 BR112015008477B1 (pt) 2020-12-08

Family

ID=50488863

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015008477-0A BR112015008477B1 (pt) 2012-10-16 2013-09-03 método para a síntese de 5-(clorometil)-2-furaldeído (cmf) de sacarídeos

Country Status (10)

Country Link
US (1) US9102644B2 (pt)
EP (1) EP2909187A4 (pt)
CN (1) CN105102440A (pt)
BR (1) BR112015008477B1 (pt)
CA (1) CA2888298C (pt)
IN (1) IN2015DN03835A (pt)
MX (1) MX363821B (pt)
PH (1) PH12015500818A1 (pt)
SG (1) SG11201502939WA (pt)
WO (1) WO2014062303A2 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY184015A (en) 2011-06-09 2021-03-17 Micromidas Inc Utilizing a multiphase reactor for the conversion of biomass to produce substituted furans
TW201431844A (zh) 2012-10-26 2014-08-16 Micromidas Inc 用以製造５－（鹵甲基）糠醛之方法
MX2015012878A (es) 2013-03-14 2016-02-03 Micromidas Inc Metodos para purificar 5-(halometil)furfural.
BR112015023218A2 (pt) 2013-03-14 2017-07-18 Micromidas Inc formas sólidas de 5- (halometil)furfural e métodos para preparar as mesmas
ES2932619T3 (es) 2013-09-20 2023-01-23 Origin Mat Operating Inc Métodos para producir 5-(halometil)furfural
EP3498699A1 (en) 2017-12-13 2019-06-19 Basf Se Chromatography method for the purification of furfural derivatives
JP2021511412A (ja) 2018-01-19 2021-05-06 キューマックス プロダクツ グループ， インク．Ｑｍａｘｘ Ｐｒｏｄｕｃｔｓ Ｇｒｏｕｐ， Ｉｎｃ． フロ酸エステルを含む金属洗浄組成物及びその使用
CN111936477B (zh) * 2018-01-31 2023-10-10 福兰尼克斯科技公司 用于转化固体木质纤维素材料的工艺
CN111936478B (zh) * 2018-01-31 2023-10-10 福兰尼克斯科技公司 用于转化固体木质纤维素材料的工艺
WO2020039386A1 (en) 2018-08-23 2020-02-27 Novartis Ag New pharmaceutical use for the treatment of heart failure
WO2020039394A1 (en) 2018-08-24 2020-02-27 Novartis Ag New drug combinations

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4154744A (en) * 1976-10-12 1979-05-15 Sumitomo Chemical Company, Limited Process for producing a furan derivative
US4335049A (en) * 1980-07-16 1982-06-15 Sumitomo Chemical Company, Limited Process for producing 5-methylfurfural
DE3842825A1 (de) * 1988-01-08 1989-07-20 Krupp Gmbh Verfahren und vorrichtung zur herstellung von furfural
US7829732B2 (en) * 2008-03-17 2010-11-09 Regents Of The University Of California High-yield conversion of cellulosic biomass into furanic biofuels and value-added products
KR20140012045A (ko) * 2011-02-28 2014-01-29 미도리 리뉴어블즈 인코퍼레이티드 중합체 산 촉매 및 그의 사용

Also Published As

Publication number Publication date
CA2888298A1 (en) 2014-04-24
BR112015008477B1 (pt) 2020-12-08
MX2015004716A (es) 2016-08-17
MX363821B (es) 2019-04-04
CN105102440A (zh) 2015-11-25
PH12015500818A1 (en) 2015-06-08
SG11201502939WA (en) 2015-05-28
US9102644B2 (en) 2015-08-11
WO2014062303A2 (en) 2014-04-24
CA2888298C (en) 2022-05-31
EP2909187A4 (en) 2016-05-11
IN2015DN03835A (pt) 2015-10-02
US20140187802A1 (en) 2014-07-03
WO2014062303A3 (en) 2015-07-16
EP2909187A2 (en) 2015-08-26

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Legal Events

Date Code Title Description
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 03/09/2013, OBSERVADAS AS CONDICOES LEGAIS.