BR112014032677A2 - ensaios rápido para ativação de célula t por medições de rna usando citometria de fluxo - Google Patents
ensaios rápido para ativação de célula t por medições de rna usando citometria de fluxoInfo
- Publication number
- BR112014032677A2 BR112014032677A2 BR112014032677A BR112014032677A BR112014032677A2 BR 112014032677 A2 BR112014032677 A2 BR 112014032677A2 BR 112014032677 A BR112014032677 A BR 112014032677A BR 112014032677 A BR112014032677 A BR 112014032677A BR 112014032677 A2 BR112014032677 A2 BR 112014032677A2
- Authority
- BR
- Brazil
- Prior art keywords
- flow cytometry
- cell activation
- rapid assays
- rna measurements
- rna
- Prior art date
Links
- 238000000684 flow cytometry Methods 0.000 title abstract 2
- 230000006044 T cell activation Effects 0.000 title 1
- 238000003556 assay Methods 0.000 title 1
- 238000005259 measurement Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6841—In situ hybridisation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1404—Handling flow, e.g. hydrodynamic focusing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- G01N33/6866—Interferon
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- G01N33/6869—Interleukin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/107—Nucleic acid detection characterized by the use of physical, structural and functional properties fluorescence
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261665231P | 2012-06-27 | 2012-06-27 | |
| US201361784802P | 2013-03-14 | 2013-03-14 | |
| PCT/US2013/047774 WO2014004609A2 (en) | 2012-06-27 | 2013-06-26 | Rapid assays for t-cell activation by rna measurements using flow cytometry |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112014032677A2 true BR112014032677A2 (pt) | 2019-01-15 |
Family
ID=49784002
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112014032677A BR112014032677A2 (pt) | 2012-06-27 | 2013-06-26 | ensaios rápido para ativação de célula t por medições de rna usando citometria de fluxo |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US10900072B2 (enExample) |
| EP (2) | EP2867374B1 (enExample) |
| JP (1) | JP6464081B2 (enExample) |
| KR (1) | KR20150036186A (enExample) |
| CN (2) | CN104662170A (enExample) |
| AU (2) | AU2013280416B2 (enExample) |
| BR (1) | BR112014032677A2 (enExample) |
| CA (1) | CA2877933A1 (enExample) |
| IN (1) | IN2015KN00073A (enExample) |
| RU (1) | RU2671707C2 (enExample) |
| WO (1) | WO2014004609A2 (enExample) |
| ZA (1) | ZA201500239B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112014019168B1 (pt) | 2012-02-03 | 2021-10-05 | California Institute Of Technology | Método capaz de detectar de forma não degenerada presença ou ausência de analitos em um único volume de amostra e método de detecção da presença ou ausência de cada analito dentre uma pluralidade de analitos |
| CN104662172B (zh) | 2012-08-03 | 2018-07-06 | 加州理工学院 | Pcr中具有减少的硬件和要求的多重化和定量 |
| CN106198358B (zh) * | 2016-06-24 | 2019-02-15 | 北京大学 | 基于"石英杯中激发型"流式细胞分选仪的染色体分选方法 |
| CN112424377A (zh) | 2018-04-17 | 2021-02-26 | 克罗玛科德公司 | 用于多重分析的方法和系统 |
| CN108732082A (zh) * | 2018-06-07 | 2018-11-02 | 北京唯公医疗技术有限公司 | 细胞分群方法 |
| US12203129B2 (en) * | 2018-07-03 | 2025-01-21 | ChromaCode, Inc. | Formulations and signal encoding and decoding methods for massively multiplexed biochemical assays |
| JP7457572B2 (ja) * | 2019-05-27 | 2024-03-28 | 住友化学株式会社 | 光学フィルムの反りの測定方法、及び、測定装置 |
| EP4025595A4 (en) * | 2019-09-03 | 2023-11-29 | The Regents Of The University Of California | METHOD FOR SEQUENCE OF MRNA IN PARALLEL SINGLE CELLS WITH QUANTIFICATION OF INTRACELLULAR PHENOTYPE |
| JP7784139B2 (ja) * | 2019-10-29 | 2025-12-11 | ウニベルジテート ハイデルベルク | 人工抗原提示分子とその利用 |
| CN111999235A (zh) * | 2020-07-03 | 2020-11-27 | 青岛农业大学 | 一种利用流式细胞术快速检测有活力的食用菌原生质体数量的方法 |
| RU2766781C1 (ru) * | 2021-03-03 | 2022-03-15 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр кардиологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ кардиологии" Минздрава России) | Способ выявления поражения сосудистого эндотелия |
| WO2022271272A1 (en) * | 2021-06-22 | 2022-12-29 | Nantcell, Inc. | Rapid test for patient cd8 t-cell activation, systems and methods |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4994369A (en) * | 1987-12-15 | 1991-02-19 | The Board Of Trustees Of The Leland Stanford Jr. Univ. | T-cell activation related gene |
| US5866331A (en) | 1995-10-20 | 1999-02-02 | University Of Massachusetts | Single molecule detection by in situ hybridization |
| EP0841396B2 (en) * | 1996-10-01 | 2012-04-11 | Geron Corporation | Human telomerase catalytic subunit |
| US6610839B1 (en) * | 1997-08-14 | 2003-08-26 | Geron Corporation | Promoter for telomerase reverse transcriptase |
| US7514232B2 (en) | 1996-12-06 | 2009-04-07 | Becton, Dickinson And Company | Method for detecting T cell response to specific antigens in whole blood |
| ATE377076T1 (de) | 1999-03-09 | 2007-11-15 | Zymogenetics Inc | Humanes cytokin als ligand des zalpha rezeptors und dessen verwendungen |
| RU2258710C2 (ru) * | 1999-03-09 | 2005-08-20 | Займодженетикс, Инк. | Новый цитокин zalpha11-лиганд |
| EP1502109A4 (en) * | 2002-04-19 | 2007-01-10 | Scripps Research Inst | COMPOSITIONS AND METHODS ASSOCIATED WITH SIGNALING OF ENDOTHELIAL CELLS USING THE PROTEASE-ACTIVATED RECEPTOR (PAR1) |
| EP2363710B1 (en) * | 2002-08-08 | 2015-07-01 | Baylor College Of Medicine | Isolation and identification of T cells |
| WO2005118788A2 (en) * | 2004-05-27 | 2005-12-15 | The Trustees Of The University Of Pennsylvania | Novel artificial antigen presenting cells and uses therefor |
| DE102005020754B3 (de) | 2005-05-02 | 2007-01-11 | Altana Pharma Ag | Zelluläres Assayverfahren zur Identifizierung von PKCtheta-Inhibitoren |
| US20090081688A1 (en) | 2005-06-20 | 2009-03-26 | Advanced Cell Diagnostics | Methods of detecting nucleic acids in individual cells and of identifying rare cells from large heterogeneous cell populations |
| US20080038725A1 (en) | 2005-06-20 | 2008-02-14 | Yuling Luo | Methods of detecting nucleic acids in individual cells and of identifying rare cells from large heterogeneous cell populations |
| EP1760089B1 (en) * | 2005-09-05 | 2009-08-19 | Immatics Biotechnologies GmbH | Tumor-associated peptides binding to human leukocyte antigen (HLA) class I or II molecules and related anti-cancer vaccine |
| US8114982B2 (en) * | 2006-12-06 | 2012-02-14 | Albert Einstein College Of Medicine Of Yeshiva University | Multi-microRNA methods and compositions |
| WO2009003493A2 (en) | 2007-07-03 | 2009-01-08 | Dako Denmark A/S | Mhc multimers, methods for their generation, labeling and use |
| JP2010004750A (ja) * | 2008-06-24 | 2010-01-14 | Institute For Rheumatic Diseases Co Ltd | 自己免疫疾患による組織傷害の発症または発症可能性の診断方法、およびその利用 |
| EP2186827A1 (en) * | 2008-11-14 | 2010-05-19 | HS LifeSciences Ltd. | Surrogate marker directed cDNA cloning of selectively induced mRNAs |
| ES2363545B2 (es) * | 2010-01-26 | 2012-04-18 | Universidade De Santiago De Compostela | Método para identificar y purificar células t reguladoras naturales humanas (ntreg). |
| DE102010037622B4 (de) * | 2010-09-17 | 2012-07-12 | Lophius Biosciences Gmbh | Verfahren zum Nachweis, Differenzieren und Quantifizieren von T-Zellpopulationen mittels der Reverse Transkription quantitativen Real-Time PCR (RT-qPCR) Technologie |
| WO2012092458A2 (en) * | 2010-12-30 | 2012-07-05 | Anthrogenesis Corporation | Compositions comprising placental stem cells and platelet rich plasma, and methods of use thereof |
| EP2714884B1 (en) * | 2011-05-27 | 2019-08-21 | The University Of British Columbia | Microfluidic cell trap and assay apparatus for high-throughput analysis |
| JP5344007B2 (ja) * | 2011-06-30 | 2013-11-20 | 株式会社デンソー | 近距離無線通信装置 |
-
2013
- 2013-06-26 WO PCT/US2013/047774 patent/WO2014004609A2/en not_active Ceased
- 2013-06-26 CN CN201380045036.5A patent/CN104662170A/zh active Pending
- 2013-06-26 US US14/411,224 patent/US10900072B2/en active Active
- 2013-06-26 EP EP13809753.0A patent/EP2867374B1/en active Active
- 2013-06-26 BR BR112014032677A patent/BR112014032677A2/pt not_active IP Right Cessation
- 2013-06-26 AU AU2013280416A patent/AU2013280416B2/en not_active Ceased
- 2013-06-26 RU RU2015102447A patent/RU2671707C2/ru not_active IP Right Cessation
- 2013-06-26 CN CN201810454480.7A patent/CN108624654A/zh active Pending
- 2013-06-26 KR KR20157001942A patent/KR20150036186A/ko not_active Ceased
- 2013-06-26 CA CA2877933A patent/CA2877933A1/en not_active Abandoned
- 2013-06-26 EP EP20203726.3A patent/EP3828278A1/en active Pending
- 2013-06-26 IN IN73KON2015 patent/IN2015KN00073A/en unknown
- 2013-06-26 JP JP2015520420A patent/JP6464081B2/ja not_active Expired - Fee Related
-
2015
- 2015-01-13 ZA ZA2015/00239A patent/ZA201500239B/en unknown
-
2017
- 2017-09-15 AU AU2017228677A patent/AU2017228677B2/en not_active Ceased
-
2021
- 2021-01-08 US US17/144,793 patent/US11767551B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2867374A2 (en) | 2015-05-06 |
| AU2013280416B2 (en) | 2017-06-15 |
| AU2017228677A1 (en) | 2017-10-05 |
| CN108624654A (zh) | 2018-10-09 |
| WO2014004609A2 (en) | 2014-01-03 |
| US20160201122A1 (en) | 2016-07-14 |
| EP3828278A1 (en) | 2021-06-02 |
| RU2015102447A (ru) | 2016-08-20 |
| EP2867374B1 (en) | 2020-10-28 |
| AU2013280416A1 (en) | 2015-02-05 |
| JP6464081B2 (ja) | 2019-02-06 |
| WO2014004609A3 (en) | 2014-02-27 |
| US10900072B2 (en) | 2021-01-26 |
| IN2015KN00073A (enExample) | 2015-07-31 |
| EP2867374A4 (en) | 2016-05-11 |
| US11767551B2 (en) | 2023-09-26 |
| CN104662170A (zh) | 2015-05-27 |
| KR20150036186A (ko) | 2015-04-07 |
| RU2671707C2 (ru) | 2018-11-06 |
| CA2877933A1 (en) | 2014-01-03 |
| AU2017228677B2 (en) | 2019-02-14 |
| US20210139965A1 (en) | 2021-05-13 |
| ZA201500239B (en) | 2015-12-23 |
| JP2015522284A (ja) | 2015-08-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A ANUIDADE. |
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| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2625 DE 27-04-2021 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |
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| B350 | Update of information on the portal [chapter 15.35 patent gazette] |