US5164410A
(en)
|
1988-01-09 |
1992-11-17 |
Takeda Chemical Industries, Ltd. |
Fumagillol derivatives and pharmaceutical compositions thereof
|
PH26256A
(en)
|
1988-08-12 |
1992-04-01 |
Fujisawa Pharmaceutical Co |
Oxaspiro [2,5] octane derivative
|
EP0359036B1
(en)
|
1988-09-01 |
1997-03-26 |
Takeda Chemical Industries, Ltd. |
Fumagillol derivatives
|
US5180738A
(en)
|
1988-09-01 |
1993-01-19 |
Takeda Chemical Industries |
Fumagillol derivatives and pharmaceutical compositions thereof
|
US5166172A
(en)
|
1988-09-01 |
1992-11-24 |
Takeda Chemical Industries, Ltd. |
Fumagillol derivatives and pharmaceutical compositions thereof
|
DE69001187T2
(de)
|
1989-03-06 |
1993-07-08 |
Takeda Chemical Industries Ltd |
6-epifumagillole, ihre herstellung und ihre verwendung.
|
US5288722A
(en)
|
1989-03-06 |
1994-02-22 |
Takeda Chemical Industries, Ltd. |
6-amino-6-desoxyfumagillols, production and use thereof
|
US6017954A
(en)
|
1989-08-10 |
2000-01-25 |
Children's Medical Center Corp. |
Method of treating tumors using O-substituted fumagillol derivatives
|
US5290807A
(en)
|
1989-08-10 |
1994-03-01 |
Children's Medical Center Corporation |
Method for regressing angiogenesis using o-substituted fumagillol derivatives
|
EP0415294A3
(en)
|
1989-08-31 |
1991-06-12 |
Takeda Chemical Industries, Ltd. |
Cyclohexanol derivatives, production and use thereof
|
TW282399B
(US07794700-20100914-C00152.png)
|
1990-05-25 |
1996-08-01 |
Takeda Pharm Industry Co Ltd |
|
US5238950A
(en)
|
1991-12-17 |
1993-08-24 |
Schering Corporation |
Inhibitors of platelet-derived growth factor
|
ATE205092T1
(de)
|
1992-01-30 |
2001-09-15 |
Takeda Chemical Industries Ltd |
Verfahren zur herstellung hoch-wasserlöslicher zyklodextrinkomplexe
|
DE69311278T2
(de)
|
1992-12-16 |
1997-10-30 |
Takeda Chemical Industries Ltd |
Stabile pharmazeutische Zubereitung mit Fumagillolderivaten
|
EA000150B1
(ru)
|
1995-03-27 |
1998-10-29 |
Санофи |
Применение фумагиллола и его производных для приготовления лекарств, предназначенных для борьбы с кишечными инфекциями, и фармацевтическая композиция на их основе
|
CA2234401A1
(en)
|
1995-10-11 |
1997-04-17 |
Fujisawa Pharmaceutical Co., Ltd. |
Vascular permeation inhibitor
|
EP0799616A1
(en)
|
1996-04-01 |
1997-10-08 |
Takeda Chemical Industries, Ltd. |
Oral composition comprising a fumagillol derivative
|
WO1998005293A2
(en)
|
1996-08-02 |
1998-02-12 |
The Children's Medical Center Corporation |
Method of regulating the female reproductive system through angiogenesis inhibitors
|
US6281245B1
(en)
|
1996-10-28 |
2001-08-28 |
Versicor, Inc. |
Methods for solid-phase synthesis of hydroxylamine compounds and derivatives, and combinatorial libraries thereof
|
US7115632B1
(en)
|
1999-05-12 |
2006-10-03 |
G. D. Searle & Co. |
Sulfonyl aryl or heteroaryl hydroxamic acid compounds
|
EP0983257A4
(en)
|
1997-03-04 |
2001-05-02 |
Monsanto Co |
AROMATIC SULPHONYL-ALPHA-CYCLOAMINO-HYDROXAMIC ACID COMPOUNDS
|
US6207704B1
(en)
|
1997-06-09 |
2001-03-27 |
Massachusetts Institute Of Technology |
Type 2 methionine aminopeptidase [MetAP2] inhibitors and uses thereof
|
JP2002502814A
(ja)
|
1997-10-31 |
2002-01-29 |
チルドレンズ・メディカル・センター・コーポレイション |
血管化した正常組織の大きさおよび増殖の調節のための方法
|
JP2001526255A
(ja)
|
1997-12-23 |
2001-12-18 |
ワーナー−ランバート・カンパニー |
炎症性疾患およびアテローム性動脈硬化症を治療または予防するチオ尿素およびベンズアミド化合物、組成物並びに方法
|
US6242494B1
(en)
|
1998-05-01 |
2001-06-05 |
Abbott Laboratories |
Substituted β-amino acid inhibitors of methionine aminopeptidase-2
|
KR100357541B1
(ko)
|
1998-05-15 |
2002-10-18 |
주식회사종근당 |
5-데메톡시 푸마질롤 유도체 및 그 제조방법
|
KR100357542B1
(ko)
|
1998-05-15 |
2002-10-18 |
주식회사종근당 |
푸마질롤 유도체 및 그 제조방법
|
JP2000116337A
(ja)
|
1998-10-09 |
2000-04-25 |
Nippon Shokuhin Kako Co Ltd |
ペットフード
|
US6383471B1
(en)
|
1999-04-06 |
2002-05-07 |
Lipocine, Inc. |
Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents
|
SK15522001A3
(sk)
|
1999-04-28 |
2002-06-04 |
Aventis Pharma Deutschland Gmbh |
Deriváty kyselín s tromi arylovými zvyškami ako ligandy receptorov PPAR a farmaceutické kompozície, ktoré ich obsahujú
|
US6593480B2
(en)
*
|
1999-09-01 |
2003-07-15 |
Abbott Laboratories |
Glucocorticoid receptor antagonists for treatment of diabetes
|
EP1223932A4
(en)
|
1999-10-01 |
2003-01-15 |
Smithkline Beecham Corp |
COMPOUNDS AND METHODS
|
US20020002152A1
(en)
|
2000-04-14 |
2002-01-03 |
Craig Richard A. |
Hydrazide and alkoxyamide angiogenesis inhibitors
|
US6323228B1
(en)
|
2000-09-15 |
2001-11-27 |
Abbott Laboratories |
3-substituted indole angiogenesis inhibitors
|
PE20020376A1
(es)
|
2000-09-29 |
2002-05-13 |
Abbott Lab |
Polipeptidos antiangiogenicos y metodos para inhibir la angiogenesis
|
US6548477B1
(en)
|
2000-11-01 |
2003-04-15 |
Praecis Pharmaceuticals Inc. |
Therapeutic agents and methods of use thereof for the modulation of angiogenesis
|
PL366216A1
(en)
|
2000-11-01 |
2005-01-24 |
Praecis Pharmaceuticals Inc. |
Therapeutic agents and methods of use thereof for the modulation of angiogenesis
|
DE60139511D1
(de)
|
2000-12-20 |
2009-09-17 |
Bristol Myers Squibb Co |
Substituierte pyrrolochinoline und pyridochinoline als serotonin- agonisten und- antagonisten
|
WO2002078699A1
(en)
|
2001-03-29 |
2002-10-10 |
Smithkline Beecham Corporation |
Compounds and methods
|
US20020183242A1
(en)
|
2001-04-11 |
2002-12-05 |
Jack Henkin |
Peptide antiangiogenic drugs
|
EP1436286B1
(en)
|
2001-09-27 |
2009-08-19 |
Equispharm Co., Ltd. |
Fumagillol derivatives and preparing method thereof
|
US6803382B2
(en)
|
2001-11-09 |
2004-10-12 |
Galderma Research & Development, S.N.C. |
Angiogenesis inhibitors and pharmaceutical and cosmetic use thereof
|
US7119120B2
(en)
|
2001-12-26 |
2006-10-10 |
Genzyme Corporation |
Phosphate transport inhibitors
|
KR100451485B1
(ko)
|
2002-03-28 |
2004-10-06 |
주식회사종근당 |
푸마질롤 유도체 또는 그 염의 포접 화합물, 및 이를포함하는 약제학적 조성물
|
US6989392B2
(en)
|
2002-06-18 |
2006-01-24 |
Abbott Laboratories |
2-Aminoquinolines as melanin concentrating hormone receptor antagonists
|
US7030262B2
(en)
|
2002-08-06 |
2006-04-18 |
Abbott Laboratories |
3-Amino-2-hydroxyalkanoic acids and their prodrugs
|
US20040067266A1
(en)
|
2002-10-07 |
2004-04-08 |
Toppo Frank R. |
Weight loss compound
|
US20040157836A1
(en)
*
|
2002-10-08 |
2004-08-12 |
Comess Kenneth M. |
Sulfonamides having antiangiogenic and anticancer activity
|
US20040068012A1
(en)
|
2002-10-08 |
2004-04-08 |
Comess Kenneth M. |
Sulfonamides having antiangiogenic and anticancer activity
|
US7491718B2
(en)
|
2002-10-08 |
2009-02-17 |
Abbott Laboratories |
Sulfonamides having antiangiogenic and anticancer activity
|
US20040204472A1
(en)
|
2003-03-04 |
2004-10-14 |
Pharmacia Corporation |
Treatment and prevention of obesity with COX-2 inhibitors alone or in combination with weight-loss agents
|
DK1651622T3
(da)
|
2003-08-08 |
2007-05-07 |
Janssen Pharmaceutica Nv |
Fremgangsmåde til fremstilling af 2-(quinoxalin-5-ylsulfonylamino)-benzamidforbindelser
|
AR046330A1
(es)
|
2003-09-09 |
2005-12-07 |
Japan Tobacco Inc |
Inhibidor de dipeptidilpeptidasa iv
|
DE602004010299T2
(de)
|
2003-12-22 |
2008-09-18 |
Memory Pharmaceuticals Corp. |
Indole, 1h-indazole, 1,2-benzisoxazole und 1,2-benzisothiazole und deren herstellung und anwendungen
|
EP1699812A2
(en)
|
2003-12-29 |
2006-09-13 |
Praecis Pharmaceuticals Inc. |
Inhibitors of methionine aminopeptidase-2 and uses thereof
|
KR100552043B1
(ko)
|
2004-02-28 |
2006-02-20 |
주식회사종근당 |
푸마질롤 유도체를 포함하는 비만치료용 조성물
|
EP1748989A2
(en)
|
2004-05-12 |
2007-02-07 |
ChemoCentryx Inc |
Aryl sulfonamides
|
RU2007103178A
(ru)
|
2004-06-30 |
2008-08-10 |
Комбинаторкс, Инкорпорейтед (Us) |
Способы и реагенты для лечения метаболических нарушений
|
US20060045865A1
(en)
|
2004-08-27 |
2006-03-02 |
Spherics, Inc. |
Controlled regional oral delivery
|
KR20070057252A
(ko)
|
2004-09-24 |
2007-06-04 |
얀센 파마슈티카 엔.브이. |
설폰아미드 화합물
|
US20100056623A1
(en)
|
2005-01-26 |
2010-03-04 |
Chong Kun Dang Pharmaceutical Corp. |
Fumagillol derivatives or method for preparation of fumagillol derivatives, and pharmaceutical compositions comprising the same
|
FR2886855B1
(fr)
|
2005-06-08 |
2009-07-17 |
Agronomique Inst Nat Rech |
Utilisation de la fumagilline et de ses derives pour augmenter la biodisponibilite des lactones macrocyliques
|
US20070078172A1
(en)
|
2005-06-16 |
2007-04-05 |
Jenrin Discovery |
Mao-b inhibitors useful for treating obesity
|
CN101389324A
(zh)
|
2005-12-23 |
2009-03-18 |
史密丝克莱恩比彻姆公司 |
Aurora激酶的氮杂吲哚抑制剂
|
WO2008008374A2
(en)
|
2006-07-14 |
2008-01-17 |
Chemocentryx, Inc. |
Ccr2 inhibitors and methods of use thereof
|
DE102007020492A1
(de)
|
2007-04-30 |
2008-11-06 |
Grünenthal GmbH |
Substituierte Sulfonamid-Derivate
|
JP2010531896A
(ja)
|
2007-06-26 |
2010-09-30 |
チルドレンズ メディカル センター コーポレーション |
治療的投与のためのMetAP−2阻害剤ポリマーソーム
|
US20090011994A1
(en)
|
2007-07-06 |
2009-01-08 |
Bristol-Myers Squibb Company |
Non-basic melanin concentrating hormone receptor-1 antagonists and methods
|
US8399512B2
(en)
|
2007-11-28 |
2013-03-19 |
Mersana Therapeutics, Inc. |
Biocompatible biodegradable fumagillin analog conjugates
|
JP5450435B2
(ja)
|
2007-11-30 |
2014-03-26 |
バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング |
ヘテロアリールで置換されたピペリジン類
|
WO2010009374A1
(en)
|
2008-07-18 |
2010-01-21 |
Zafgen, Inc. |
Methods of treating an overweight or obese subject
|
WO2010042163A2
(en)
|
2008-10-06 |
2010-04-15 |
The Johns Hopkins University |
Quinoline compounds as inhibitors of angiogenesis, human methionine aminopeptidase, and sirt1, and methods of treating disorders
|
CA2741683C
(en)
|
2008-10-24 |
2016-03-22 |
Wake Forest University |
Platinum acridine anti-cancer compounds and methods thereof
|
US20120004162A1
(en)
|
2008-12-04 |
2012-01-05 |
Vath James E |
Methods of Treating an Overweight or Obese Subject
|
US8642650B2
(en)
*
|
2008-12-04 |
2014-02-04 |
Zafgen, Inc. |
Methods of treating an overweight or obese subject
|
WO2010065881A2
(en)
|
2008-12-04 |
2010-06-10 |
Zafgen Corporation |
Methods of treating an overweight or obese subject
|
US20120010290A1
(en)
|
2008-12-04 |
2012-01-12 |
Vath James E |
Methods of Treating an Overweight or Obese Subject
|
CA2777108A1
(en)
|
2009-10-09 |
2011-04-14 |
Zafgen Corporation |
Sulphone compounds and methods of making and using same
|
US8815309B2
(en)
|
2010-01-08 |
2014-08-26 |
Zafgen, Inc. |
Methods of treating a subject with benign prostate hyperplasia
|
WO2011088055A2
(en)
|
2010-01-12 |
2011-07-21 |
Zafgen Corporation |
Methods and compositions for treating cardiovascular disorders
|
WO2011127304A2
(en)
|
2010-04-07 |
2011-10-13 |
Zafgen Corporation |
Methods of treating an overweight subject
|
US20130210821A1
(en)
|
2010-05-27 |
2013-08-15 |
James E. Vath |
Methods for Treating Obesity
|
EP2595988B1
(en)
*
|
2010-07-22 |
2014-12-17 |
Zafgen, Inc. |
Tricyclic compounds and methds of making and using same
|
AU2011316550A1
(en)
|
2010-10-12 |
2013-05-02 |
Zafgen, Inc |
Sulphonamide compounds and methods of making and using same
|
NZ610569A
(en)
|
2010-11-09 |
2015-06-26 |
Zafgen Inc |
Crystalline solids of a metap-2 inhibitor and methods of making and using same
|
WO2012064928A1
(en)
|
2010-11-10 |
2012-05-18 |
Zafgen Corporation |
Methods and compositions for treating thyroid hormone related disorders
|
US20140011870A1
(en)
|
2010-11-29 |
2014-01-09 |
Zafgen, Inc. |
Methods of Treating Obesity Using an Effective Dose of a METAP-2 Inhibitor
|
CA2819251A1
(en)
|
2010-11-29 |
2012-06-07 |
Zafgen Corporation |
Treatment of obesity using non-daily administration of 6 - 0 - (4 - dimethylaminoethoxy) cinnamoyl fumagillol
|
US20130316994A1
(en)
|
2010-11-29 |
2013-11-28 |
Zafgen, Inc. |
Methods of Reducing Risk of Hepatobiliary Dysfunction During Rapid Weight Loss with METAP-2 Inhibitors
|
CA2825408A1
(en)
|
2011-01-26 |
2012-08-02 |
Zafgen, Inc. |
Tetrazole compounds and methods of making and using same
|
EP2705035B1
(en)
|
2011-05-06 |
2016-12-14 |
Zafgen, Inc. |
Tricyclic pyrazole sulfonamide compounds and methods of making and using same
|
JP5941981B2
(ja)
|
2011-05-06 |
2016-06-29 |
ザフゲン,インコーポレイテッド |
三環式スルホンアミド化合物ならびにその製造および使用方法
|
WO2012154676A1
(en)
|
2011-05-06 |
2012-11-15 |
Zafgen Corporation |
Partially saturated tricyclic compounds and methods of making and using same
|
WO2013033430A1
(en)
|
2011-09-02 |
2013-03-07 |
Wake Forest School Of Medicine |
Targeted delivery and prodrug designs for platinum-acridine anti-cancer compounds and methods thereof
|
US9440943B2
(en)
|
2012-01-18 |
2016-09-13 |
Zafgen, Inc. |
Tricyclic sulfone compounds and methods of making and using same
|
WO2013109739A1
(en)
|
2012-01-18 |
2013-07-25 |
Zafgen, Inc. |
Tricyclic sulfonamide compounds and methods of making and using same
|