BR112014017645A2 - molécula imunológica; polinucleotídeo; vetor; célula recombinante que compreende o vetor; método para produzir molécula imunológica; anticorpo ou fragmento de ligação de antígeno do mesmo; composição farmacêutica; uso da molécula imunológica, do anticorpo, do fragmento de ligação de anticorpo ou da composição farmacêutica; método diagnóstico para diagnosticar uma doença em um indivíduo, em que a doença é selecionada do grupo que consiste em câncer, uma doença autoimune ou uma doença infecciosa; ensaio para diagnosticar uma doença em uma amostra de tecido tomada de um indivíduo; uso de um anticorpo ou um fragmento que se liga especificamente à seq id no: 10; e método diagnóstico para determinar se realiza o uso ou administra a composição - Google Patents
molécula imunológica; polinucleotídeo; vetor; célula recombinante que compreende o vetor; método para produzir molécula imunológica; anticorpo ou fragmento de ligação de antígeno do mesmo; composição farmacêutica; uso da molécula imunológica, do anticorpo, do fragmento de ligação de anticorpo ou da composição farmacêutica; método diagnóstico para diagnosticar uma doença em um indivíduo, em que a doença é selecionada do grupo que consiste em câncer, uma doença autoimune ou uma doença infecciosa; ensaio para diagnosticar uma doença em uma amostra de tecido tomada de um indivíduo; uso de um anticorpo ou um fragmento que se liga especificamente à seq id no: 10; e método diagnóstico para determinar se realiza o uso ou administra a composiçãoInfo
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- BR112014017645A2 BR112014017645A2 BR112014017645A BR112014017645A BR112014017645A2 BR 112014017645 A2 BR112014017645 A2 BR 112014017645A2 BR 112014017645 A BR112014017645 A BR 112014017645A BR 112014017645 A BR112014017645 A BR 112014017645A BR 112014017645 A2 BR112014017645 A2 BR 112014017645A2
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- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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PCT/IL2013/050527 WO2013190555A1 (en) | 2012-06-21 | 2013-06-19 | Lsr antibodies, and uses thereof for treatment of cancer |
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BR112014017645A BR112014017645A2 (pt) | 2012-06-21 | 2013-06-19 | molécula imunológica; polinucleotídeo; vetor; célula recombinante que compreende o vetor; método para produzir molécula imunológica; anticorpo ou fragmento de ligação de antígeno do mesmo; composição farmacêutica; uso da molécula imunológica, do anticorpo, do fragmento de ligação de anticorpo ou da composição farmacêutica; método diagnóstico para diagnosticar uma doença em um indivíduo, em que a doença é selecionada do grupo que consiste em câncer, uma doença autoimune ou uma doença infecciosa; ensaio para diagnosticar uma doença em uma amostra de tecido tomada de um indivíduo; uso de um anticorpo ou um fragmento que se liga especificamente à seq id no: 10; e método diagnóstico para determinar se realiza o uso ou administra a composição |
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Families Citing this family (75)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2632630C (en) | 2005-12-13 | 2016-12-06 | President And Fellows Of Harvard College | Scaffolds for cell transplantation |
US11202759B2 (en) | 2010-10-06 | 2021-12-21 | President And Fellows Of Harvard College | Injectable, pore-forming hydrogels for materials-based cell therapies |
CN104244929B (zh) | 2012-04-16 | 2017-04-05 | 哈佛学院董事会 | 用于调节免疫反应的介孔二氧化硅组合物 |
US9890215B2 (en) * | 2012-06-22 | 2018-02-13 | King's College London | Vista modulators for diagnosis and treatment of cancer |
HK1216647A1 (zh) | 2012-12-12 | 2016-11-25 | Vasculox Inc. | 治疗性cd47抗体 |
US9221908B2 (en) | 2012-12-12 | 2015-12-29 | Vasculox, Inc. | Therapeutic CD47 antibodies |
US9433689B2 (en) * | 2013-03-12 | 2016-09-06 | The Board Of Trustees Of The Leland Stanford Junio | Probes and methods of imaging non-Hodgkins lymphoma |
EP3041500B1 (en) * | 2013-09-06 | 2021-05-19 | New York University | Method for inducing antitumor immunity using sindbis viral vectors and tumor associated antigens |
PE20160685A1 (es) | 2013-10-04 | 2016-07-23 | Infinity Pharmaceuticals Inc | Compuestos heterociclicos y usos de los mismos |
AU2014360318B2 (en) | 2013-12-05 | 2019-10-31 | Rfemb Holdings, Llc | Cancer immunotherapy by radiofrequency electrical membrane breakdown (RF-EMB) |
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US9394365B1 (en) | 2014-03-12 | 2016-07-19 | Yeda Research And Development Co., Ltd | Reducing systemic regulatory T cell levels or activity for treatment of alzheimer's disease |
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EP3116542B1 (en) | 2014-03-12 | 2025-07-30 | Yeda Research and Development Co., Ltd. | Reducing systemic regulatory t cell levels or activity for treatment of disease and injury of the cns |
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WO2015153820A1 (en) * | 2014-04-02 | 2015-10-08 | Felder Mitchell S | Ctla-4 blockade with metronomic chemotherapy for the treatment of cancer |
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US10092645B2 (en) | 2014-06-17 | 2018-10-09 | Medimmune Limited | Methods of treatment with antagonists against PD-1 and PD-L1 in combination with radiation therapy |
US9212225B1 (en) | 2014-07-01 | 2015-12-15 | Amphivena Therapeutics, Inc. | Bispecific CD33 and CD3 binding proteins |
US11186640B2 (en) * | 2014-07-31 | 2021-11-30 | The University Of Western Australia | Method for the identification of immunotherapy-drug combinations using a network approach |
JP6245622B2 (ja) * | 2014-08-07 | 2017-12-13 | 学校法人兵庫医科大学 | Il−18と分子標的抗体とを併用する癌治療薬 |
CA2958771A1 (en) * | 2014-09-08 | 2016-03-17 | Dana-Farber Cancer Institute, Inc. | Methods of treating cancer |
US9708348B2 (en) | 2014-10-03 | 2017-07-18 | Infinity Pharmaceuticals, Inc. | Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof |
CN113694193A (zh) | 2014-11-13 | 2021-11-26 | 约翰·霍普金斯大学 | 检查点阻断和微卫星不稳定性 |
HK1247861A1 (zh) | 2015-01-30 | 2018-10-05 | President And Fellows Of Harvard College | 用於癌症治疗的肿瘤周围和肿瘤内部材料 |
US11596652B2 (en) | 2015-02-18 | 2023-03-07 | Enlivex Therapeutics R&D Ltd | Early apoptotic cells for use in treating sepsis |
KR20170117450A (ko) | 2015-02-18 | 2017-10-23 | 엔리벡스 테라퓨틱스 리미티드 | 암 치료를 위한 면역 요법 및 사이토카인 조절 요법의 조합 |
US11497767B2 (en) | 2015-02-18 | 2022-11-15 | Enlivex Therapeutics R&D Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
US11318163B2 (en) | 2015-02-18 | 2022-05-03 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
US11304976B2 (en) | 2015-02-18 | 2022-04-19 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
US11000548B2 (en) | 2015-02-18 | 2021-05-11 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
HK1249452A1 (zh) | 2015-04-10 | 2018-11-02 | President And Fellows Of Harvard College | 免疫细胞捕获装置及其制备和使用方法 |
CN120381515A (zh) * | 2015-04-17 | 2025-07-29 | 百时美施贵宝公司 | 包含抗pd-1抗体和另外的抗体的组合的组合物 |
AU2016250570B2 (en) | 2015-04-21 | 2021-07-01 | Enlivex Therapeutics Rdo Ltd | Therapeutic pooled blood apoptotic cell preparations and uses thereof |
CN115109158A (zh) | 2015-05-07 | 2022-09-27 | 阿吉纳斯公司 | 抗ox40抗体及其使用方法 |
CN114652827A (zh) | 2015-05-29 | 2022-06-24 | 安普希韦纳治疗公司 | 双特异性cd33和cd3结合蛋白质的使用方法 |
CN114146056A (zh) * | 2015-07-29 | 2022-03-08 | 纳米提克斯有限责任公司 | 用于清除可溶性生物分子的模块化组合物及其相关方法 |
LU92821B1 (en) * | 2015-09-09 | 2017-03-20 | Mologen Ag | Combination comprising immunostimulatory oligonucleotides |
MX390633B (es) | 2015-09-14 | 2025-03-04 | Infinity Pharmaceuticals Inc | Formas solidas de derivados de isoquinolinona, proceso de fabricacion, composiciones que las contienen y metodos de uso de las mismas. |
UA126146C2 (uk) | 2015-09-18 | 2022-08-25 | Арч Онколоджі, Інк. | Терапевтичне антитіло до cd47 |
MX2018005551A (es) * | 2015-11-03 | 2018-11-09 | Janssen Biotech Inc | Anticuerpos que se unen especificamente a pd-1, y sus usos. |
TWI717432B (zh) | 2015-12-02 | 2021-02-01 | 美商艾吉納斯公司 | 抗體和使用彼之方法 |
US11752238B2 (en) | 2016-02-06 | 2023-09-12 | President And Fellows Of Harvard College | Recapitulating the hematopoietic niche to reconstitute immunity |
US11730761B2 (en) | 2016-02-18 | 2023-08-22 | Enlivex Therapeutics Rdo Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
US20190307820A1 (en) * | 2016-02-19 | 2019-10-10 | Virogin Biotech Canada Ltd | Compositions and methods of using stat1/3 inhibitors with oncolytic herpes virus |
US20200002422A1 (en) * | 2016-03-14 | 2020-01-02 | Millennium Pharmaceuticals, Inc. | Method of preventing graft versus host disease |
US10759806B2 (en) | 2016-03-17 | 2020-09-01 | Infinity Pharmaceuticals, Inc. | Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as PI3K kinase inhibitors |
TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Hdac抑制劑與pd-l1抑制劑之組合治療 |
TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
EP3464349A4 (en) | 2016-05-23 | 2020-08-26 | New York University | COMPOSITIONS AND METHODS ASSOCIATED WITH ANTIBODIES TARGETING STAPHYLOCCAL LEUCOTOXINS |
EP3463434B1 (en) * | 2016-06-06 | 2024-12-25 | Excoso a.s. | Immunotherapy for cancer |
US10919914B2 (en) | 2016-06-08 | 2021-02-16 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
CN109789092A (zh) | 2016-07-13 | 2019-05-21 | 哈佛学院院长等 | 抗原呈递细胞模拟支架及其制备和使用方法 |
AU2017305345B2 (en) | 2016-08-02 | 2024-09-05 | President And Fellows Of Harvard College | Biomaterials for modulating immune responses |
WO2018075960A1 (en) | 2016-10-21 | 2018-04-26 | Tioma Therapeutics, Inc. | Therapeutic cd47 antibodies |
WO2018089628A1 (en) | 2016-11-09 | 2018-05-17 | Agenus Inc. | Anti-ox40 antibodies, anti-gitr antibodies, and methods of use thereof |
CN111148535A (zh) * | 2017-03-22 | 2020-05-12 | 安驰肿瘤公司 | 治疗实体癌和血液癌的组合疗法 |
CN110636855B (zh) * | 2017-03-28 | 2024-08-09 | 俄亥俄州创新基金会 | 人pd1肽疫苗及其用途 |
CN107082812B (zh) * | 2017-03-29 | 2018-11-13 | 上海科医联创生物科技有限公司 | 一种恢复衰竭性免疫细胞功能的融合蛋白及其应用 |
CN111148518A (zh) * | 2017-03-30 | 2020-05-12 | 丹娜法伯癌症研究院 | 使用cdk4/6抑制剂调控调节性t细胞和免疫应答的方法 |
JOP20190222A1 (ar) * | 2017-04-11 | 2019-09-24 | Zymeworks Inc | الأجسام المضادة ثنائية النوعية المضادة لـ pd-l1 والمضادة لـ tim-3 |
CA3066007A1 (en) * | 2017-06-09 | 2018-12-13 | Glaxosmithkline Intellectual Property Development Limited | Combination therapy with icos agonist and ox40 agonist to treat cancer |
CA3066048A1 (en) * | 2017-06-09 | 2018-12-13 | Glaxosmithkline Intellectual Property Development Limited | Combination therapy |
US12398209B2 (en) | 2018-01-22 | 2025-08-26 | Janssen Biotech, Inc. | Methods of treating cancers with antagonistic anti-PD-1 antibodies |
WO2020061129A1 (en) | 2018-09-19 | 2020-03-26 | President And Fellows Of Harvard College | Compositions and methods for labeling and modulation of cells in vitro and in vivo |
CN109886170B (zh) * | 2019-02-01 | 2019-12-17 | 河海大学 | 一种钉螺智能检测识别与统计系统 |
CN109884319B (zh) * | 2019-03-21 | 2022-05-10 | 福建师范大学 | 一种卵巢癌肿瘤标记物的双模式免疫分析方法 |
EP3725370A1 (en) | 2019-04-19 | 2020-10-21 | ImmunoBrain Checkpoint, Inc. | Modified anti-pd-l1 antibodies and methods and uses for treating a neurodegenerative disease |
EP4232052A4 (en) * | 2020-10-22 | 2025-08-20 | Actinium Pharmaceuticals Inc | COMBINATION OF RADIOMUNOTHERAPY AND CD47 BLOCKADE IN THE TREATMENT OF CANCER |
WO2024101382A1 (ja) * | 2022-11-09 | 2024-05-16 | 学校法人 岩手医科大学 | 免疫チェックポイントの調節に用いるための組成物 |
CN117054649A (zh) * | 2023-08-04 | 2023-11-14 | 广州中医药大学第一附属医院 | 一种慢性萎缩性胃炎向胃癌转化标志物及其应用 |
CN120420412A (zh) * | 2025-07-04 | 2025-08-05 | 山东大学齐鲁医院 | Ildr3基因和/或ildr3蛋白在制备预防和/或治疗肿瘤的药物、诊断肿瘤的产品中的应用 |
CN120505318A (zh) * | 2025-07-22 | 2025-08-19 | 山东大学齐鲁医院 | LSR、LncRNA-LSR-AS1或靶向siRNA在预防和/或治疗高脂血症或其相关疾病中的应用 |
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FR2767135B1 (fr) * | 1997-08-06 | 2002-07-12 | Genset Sa | Recepteur complexe lsr, activite, clonage, et application au diagnostic, a la prevention et/ou au traitement de d'obesite et des risques ou complications associes |
AU4082100A (en) * | 1999-06-18 | 2001-01-09 | Immunex Corporation | Lsr, a cdna of the ig superfamily expressed in human leukocytes |
AU2010225456B2 (en) * | 2009-03-18 | 2016-03-17 | Carina Biotech Pty Ltd | Biomarkers and uses thereof |
CA2830923A1 (en) * | 2011-04-15 | 2012-10-18 | Compugen Ltd. | Polypeptides and polynucleotides, and uses thereof for treatment of immune related disorders and cancer |
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