BR112014015033A2 - isotiazolpiridina-2-carboxamidas e seu uso como fármacos - Google Patents
isotiazolpiridina-2-carboxamidas e seu uso como fármacosInfo
- Publication number
- BR112014015033A2 BR112014015033A2 BR112014015033A BR112014015033A BR112014015033A2 BR 112014015033 A2 BR112014015033 A2 BR 112014015033A2 BR 112014015033 A BR112014015033 A BR 112014015033A BR 112014015033 A BR112014015033 A BR 112014015033A BR 112014015033 A2 BR112014015033 A2 BR 112014015033A2
- Authority
- BR
- Brazil
- Prior art keywords
- carboxamides
- formula
- isothiazolpyridine
- pharmaceuticals
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
- C07H13/06—Fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Psychology (AREA)
- Genetics & Genomics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biotechnology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Saccharide Compounds (AREA)
Abstract
resumo patente de invenção: "isotiazolpiridina-2-carboxamidas e seu uso como fármacos". a presente invenção refere-se a isotiazolo[5,4-b]piridina-2-carboxamidas substituídas da fórmula i, em que r1, r2, r3, r10, r11 e x são como definidos nas reivindicações. os compostos da fórmula i são inibidores de transglutaminases, em particular transglutaminase 2 (tgm2), e são adequados para o tratamento de várias doenças, por exemplo doenças articulares degenerativas, tais como osteoartrite. a invenção refere-se ainda a processos para a preparação dos compostos da fórmula i, seu uso como fármacos, e composições farmacêuticas compreendendo os mesmos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11306711 | 2011-12-20 | ||
PCT/EP2012/075932 WO2013092574A1 (en) | 2011-12-20 | 2012-12-18 | Isothiazolopyridine-2-carboxamides and their use as pharmaceuticals |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112014015033A2 true BR112014015033A2 (pt) | 2017-06-13 |
Family
ID=47429823
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014015033A BR112014015033A2 (pt) | 2011-12-20 | 2012-12-18 | isotiazolpiridina-2-carboxamidas e seu uso como fármacos |
Country Status (24)
Country | Link |
---|---|
US (1) | US9260454B2 (pt) |
EP (1) | EP2794618B1 (pt) |
JP (1) | JP6099669B2 (pt) |
KR (1) | KR20140103150A (pt) |
CN (1) | CN104136443B (pt) |
AR (1) | AR089329A1 (pt) |
AU (1) | AU2012357864B2 (pt) |
BR (1) | BR112014015033A2 (pt) |
CA (1) | CA2856964A1 (pt) |
CY (1) | CY1118854T1 (pt) |
DK (1) | DK2794618T3 (pt) |
ES (1) | ES2613826T3 (pt) |
HK (1) | HK1198587A1 (pt) |
HR (1) | HRP20170159T1 (pt) |
HU (1) | HUE033049T2 (pt) |
IL (1) | IL232809A (pt) |
LT (1) | LT2794618T (pt) |
MX (1) | MX2014007465A (pt) |
PL (1) | PL2794618T3 (pt) |
PT (1) | PT2794618T (pt) |
RU (1) | RU2014129903A (pt) |
SG (1) | SG11201402623RA (pt) |
SI (1) | SI2794618T1 (pt) |
WO (1) | WO2013092574A1 (pt) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3189046B1 (en) * | 2014-09-05 | 2020-08-26 | Genentech, Inc. | Therapeutic compounds and uses thereof |
US10011611B2 (en) * | 2015-08-14 | 2018-07-03 | Reaction Biology Corp. | Histone deacetylase inhibitors and methods for use thereof |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3892745A (en) * | 1972-11-20 | 1975-07-01 | Sankyo Co | Isoxazolone derivatives and process for preparing the same |
US3965107A (en) | 1974-07-08 | 1976-06-22 | Rohm And Haas Company | Isothiazolopyridinones |
LU84091A1 (fr) * | 1982-04-16 | 1984-03-02 | Oreal | Derives n-carbamoyl d'isothiazolo-(5,4b)pyridine one-3,leur procede de preparation et leurs utilisations comme agents bactericides et fongicides |
US4968713A (en) | 1989-07-31 | 1990-11-06 | Merck & Co., Inc. | Certain imidazole compounds as transglutaminase inhibitors |
DE10054687A1 (de) | 2000-11-03 | 2002-05-16 | N Zyme Biotec Gmbh | Inhibitoren von Transglutaminasen |
EP1613608A1 (en) * | 2003-04-01 | 2006-01-11 | Eli Lilly And Company | Phospholipase inhibitors |
WO2004094394A1 (en) * | 2003-04-01 | 2004-11-04 | Eli Lilly And Company | Benzisothiazol-3-one-carboxylic acid amides as phospholipase inhibitors |
GB0314262D0 (en) | 2003-06-19 | 2003-07-23 | Univ Nottingham Trent | Novel compounds and methods of using the same |
CA2559105A1 (en) * | 2004-03-16 | 2005-09-29 | Janssen Pharmaceutica N.V. | Benzisoxazoles |
DE102006014688A1 (de) | 2006-03-28 | 2007-10-04 | Sanofi-Aventis | Azolopyridin-3-on-derivate als Inhibitoren von Lipasen und Phospholipasen |
DE102006052755A1 (de) | 2006-11-08 | 2008-05-15 | N-Zyme Biotec Gmbh | Michaelsysteme als Transglutaminaseinhibitoren |
WO2011060321A1 (en) | 2009-11-16 | 2011-05-19 | Chdi, Inc. | Transglutaminase tg2 inhibitors, pharmaceutical compositions, and methods of use thereof |
EP2582709B1 (de) * | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
-
2012
- 2012-12-18 JP JP2014547921A patent/JP6099669B2/ja not_active Expired - Fee Related
- 2012-12-18 PT PT128060431T patent/PT2794618T/pt unknown
- 2012-12-18 CN CN201280070206.0A patent/CN104136443B/zh not_active Expired - Fee Related
- 2012-12-18 LT LTEP12806043.1T patent/LT2794618T/lt unknown
- 2012-12-18 ES ES12806043.1T patent/ES2613826T3/es active Active
- 2012-12-18 RU RU2014129903A patent/RU2014129903A/ru not_active Application Discontinuation
- 2012-12-18 WO PCT/EP2012/075932 patent/WO2013092574A1/en active Application Filing
- 2012-12-18 EP EP12806043.1A patent/EP2794618B1/en active Active
- 2012-12-18 AU AU2012357864A patent/AU2012357864B2/en not_active Ceased
- 2012-12-18 KR KR1020147019341A patent/KR20140103150A/ko not_active Application Discontinuation
- 2012-12-18 HU HUE12806043A patent/HUE033049T2/hu unknown
- 2012-12-18 MX MX2014007465A patent/MX2014007465A/es unknown
- 2012-12-18 SG SG11201402623RA patent/SG11201402623RA/en unknown
- 2012-12-18 PL PL12806043T patent/PL2794618T3/pl unknown
- 2012-12-18 CA CA2856964A patent/CA2856964A1/en not_active Abandoned
- 2012-12-18 BR BR112014015033A patent/BR112014015033A2/pt not_active IP Right Cessation
- 2012-12-18 SI SI201230855A patent/SI2794618T1/sl unknown
- 2012-12-18 DK DK12806043.1T patent/DK2794618T3/en active
- 2012-12-19 AR ARP120104822A patent/AR089329A1/es unknown
-
2014
- 2014-05-26 IL IL232809A patent/IL232809A/en not_active IP Right Cessation
- 2014-06-18 US US14/307,961 patent/US9260454B2/en active Active
- 2014-12-01 HK HK14112083A patent/HK1198587A1/xx not_active IP Right Cessation
-
2017
- 2017-02-01 HR HRP20170159TT patent/HRP20170159T1/hr unknown
- 2017-02-15 CY CY20171100208T patent/CY1118854T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
AU2012357864A1 (en) | 2014-07-03 |
MX2014007465A (es) | 2014-07-30 |
WO2013092574A1 (en) | 2013-06-27 |
CY1118854T1 (el) | 2018-01-10 |
PT2794618T (pt) | 2017-01-17 |
ES2613826T3 (es) | 2017-05-26 |
KR20140103150A (ko) | 2014-08-25 |
CN104136443B (zh) | 2017-01-18 |
EP2794618B1 (en) | 2016-11-16 |
AU2012357864B2 (en) | 2017-03-02 |
HUE033049T2 (hu) | 2017-11-28 |
HRP20170159T1 (hr) | 2017-03-24 |
IL232809A0 (en) | 2014-08-03 |
PL2794618T3 (pl) | 2017-05-31 |
JP2015500855A (ja) | 2015-01-08 |
CN104136443A (zh) | 2014-11-05 |
JP6099669B2 (ja) | 2017-03-22 |
RU2014129903A (ru) | 2016-02-10 |
DK2794618T3 (en) | 2017-02-20 |
EP2794618A1 (en) | 2014-10-29 |
HK1198587A1 (en) | 2015-04-30 |
US9260454B2 (en) | 2016-02-16 |
SI2794618T1 (sl) | 2017-03-31 |
US20140296169A1 (en) | 2014-10-02 |
AR089329A1 (es) | 2014-08-13 |
CA2856964A1 (en) | 2013-06-27 |
IL232809A (en) | 2017-05-29 |
SG11201402623RA (en) | 2014-09-26 |
LT2794618T (lt) | 2017-02-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112013026834A2 (pt) | composto, composição farmacêutica, produto farmacêutico de combinação, uso de um composto, e, método para tratar doenças ou condições e para inibir um bromodomínio | |
BR112012017269A2 (pt) | compostos heterocíclicos tricíclicos, composições e métodos de uso dos mesmos | |
BR112013019714A2 (pt) | azaindolilfenil sulfonamidas como inibidores de serina/treonina quinase | |
BR112013000107A2 (pt) | aminopirazoloquinazolinas | |
BR112014010576B8 (pt) | compostos inibidores de neprilisina (nep), seus usos, processo de preparação dos compostos e composição farmacêutica compreendendo os compostos | |
BR112012027034A2 (pt) | inibidores da arginase e suas aplicações terapêuticas | |
BR112014027181A2 (pt) | derivados de benzamida para a inibição da atividade de abl1, abl2 e bcr-abl1 | |
BR112015014372A8 (pt) | inibidores de autotaxina, seus usos, e composição e combinação farmacêuticas". | |
BR112013020996A8 (pt) | derivados aminobutíricos substituídos como inibidores de neprilisina | |
BR112014018990A8 (pt) | Derivados de ácido benzotiazol-6-il acético e seu uso para tratamento de uma infecção | |
BR112013018515A2 (pt) | derivados de pirrol tricíclico, processo para preparação e seu uso como inibidores da quinase | |
BR112013016595A2 (pt) | inibidores de neprilisina | |
BR112013002484A2 (pt) | composto, composição farmacêutica, métodos para tratar esclerose múltipla e artrite reumatoide, e, uso de um composto. | |
BR112014026383A2 (pt) | derivados de benzamida para inibir a atividade de abl1, abl2 e bcr-abl1 | |
BR112013023876A2 (pt) | derivados de pirroltriazinona como inibidores de pi3k | |
UA109010C2 (en) | MORPHOLINOPYRIMIDINES AND THEIR APPLICATIONS IN THERAPY | |
BR112014018702A8 (pt) | Composto, cristal, inibidor, medicamento, composição farmacêutica, e, uso de um composto ou sal | |
BRPI0610850A2 (pt) | derivados de Ácido aril alquila, composiÇço farmacÊutica, medicamento, bem como uso dos referidos derivados | |
BR112014002245A2 (pt) | derivados de piridin-2(1h)-ona como inibidores de jak | |
BR112012018253A2 (pt) | Derivados de ácido 3-heteroaroilamino-propiônico oxigênio-substituídos e seu uso como fármacos | |
BR112012010186B8 (pt) | derivados de heteroarila contendo n como inibidores de quinase jak3 e composição farmacêutica compreendendo os mesmos | |
BRPI0915064B8 (pt) | derivados de quinoxalinadiona, seus usos, e medicamentos | |
BR112015024971A2 (pt) | derivados de n-(2,3-di-hidro-1h-pirrolo[2,3-b]piridin-5-il)-4-quinazolinamina e n-(2,3-di-hidro-1h-indol-5-il)-4-quinazolinamina como inibidores de perk | |
BR112013005622A2 (pt) | heteroaril metil amidas | |
BR112014018795A2 (pt) | derivados de 1h-pirrolo[2,3-b]piridina e seu uso como inibidores de cinase |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A ANUIDADE. |
|
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2545 DE 15-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |
|
B350 | Update of information on the portal [chapter 15.35 patent gazette] |