BR112014013108B1 - compostos, composição farmacêutica, uso do composto e método - Google Patents

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Publication number

BR112014013108B1

BR112014013108B1 BR112014013108-2A BR112014013108A BR112014013108B1 BR 112014013108 B1 BR112014013108 B1 BR 112014013108B1 BR 112014013108 A BR112014013108 A BR 112014013108A BR 112014013108 B1 BR112014013108 B1 BR 112014013108B1

Authority

BR

Brazil

Prior art keywords

heterocyclyl

heteroaryl

alkyl

cycloalkyl

aryl

Prior art date

2011-12-31

Links

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• 102000009929 raf Kinases Human genes 0.000 claims abstract description 13
• 108010077182 raf Kinases Proteins 0.000 claims abstract description 13
• 125000001072 heteroaryl group Chemical group 0.000 claims description 101
• 125000000623 heterocyclic group Chemical group 0.000 claims description 96
• 125000003118 aryl group Chemical group 0.000 claims description 84
• 125000000217 alkyl group Chemical group 0.000 claims description 80
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 68
• 125000003342 alkenyl group Chemical group 0.000 claims description 55
• 125000000304 alkynyl group Chemical group 0.000 claims description 52
• 125000001188 haloalkyl group Chemical group 0.000 claims description 52
• 229910052717 sulfur Inorganic materials 0.000 claims description 37
• 239000001257 hydrogen Substances 0.000 claims description 36
• 229910052739 hydrogen Inorganic materials 0.000 claims description 36
• 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 36
• 229910052736 halogen Inorganic materials 0.000 claims description 35
• 150000002367 halogens Chemical class 0.000 claims description 35
• 206010028980 Neoplasm Diseases 0.000 claims description 32
• 229910052760 oxygen Inorganic materials 0.000 claims description 32
• 229910052799 carbon Inorganic materials 0.000 claims description 28
• 201000011510 cancer Diseases 0.000 claims description 27
• 125000005842 heteroatom Chemical group 0.000 claims description 26
• 125000004429 atom Chemical group 0.000 claims description 25
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 20
• 125000004432 carbon atom Chemical group C* 0.000 claims description 17
• 239000003814 drug Substances 0.000 claims description 17
• 229910052757 nitrogen Inorganic materials 0.000 claims description 16
• 125000006413 ring segment Chemical group 0.000 claims description 15
• 238000011282 treatment Methods 0.000 claims description 15
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 14
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 14
• 125000001424 substituent group Chemical group 0.000 claims description 13
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• 125000002950 monocyclic group Chemical group 0.000 claims description 8
• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 4
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 4
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• HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 8
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