BR112014011316A2 - derivado de 2,5-dioxoimidazolidin-1-il-3-feniluréia como moduladores do receptor de receptor do peptídeo como formil-1 (fprl-1) - Google Patents
derivado de 2,5-dioxoimidazolidin-1-il-3-feniluréia como moduladores do receptor de receptor do peptídeo como formil-1 (fprl-1)Info
- Publication number
- BR112014011316A2 BR112014011316A2 BR112014011316A BR112014011316A BR112014011316A2 BR 112014011316 A2 BR112014011316 A2 BR 112014011316A2 BR 112014011316 A BR112014011316 A BR 112014011316A BR 112014011316 A BR112014011316 A BR 112014011316A BR 112014011316 A2 BR112014011316 A2 BR 112014011316A2
- Authority
- BR
- Brazil
- Prior art keywords
- receptor
- fprl
- dioxoimidazolidin
- formyl
- modulators
- Prior art date
Links
- VEGWMKUYJXOJOT-UHFFFAOYSA-N 1-(2,5-dioxoimidazolidin-1-yl)-3-phenylurea Chemical class C=1C=CC=CC=1NC(=O)NN1C(=O)CNC1=O VEGWMKUYJXOJOT-UHFFFAOYSA-N 0.000 title abstract 3
- 102000014187 peptide receptors Human genes 0.000 title abstract 3
- 108010011903 peptide receptors Proteins 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/86—Oxygen and sulfur atoms, e.g. thiohydantoin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/80—Two oxygen atoms, e.g. hydantoin with hetero atoms or acyl radicals directly attached to ring nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
abstract of the disclosure the present invention relates to novel 2,5-dioxoimidazolidin-1-yl-3-phenylurea derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of the n-formyl peptide receptor like-1 (fprl-1) receptor. 18945 pct (ap) tradução do resumo resumo patente de invenção: "derivado de 2,5-dioxoimidazolidin-1-il-3-feniluréia como moduladores do receptor de receptor do peptídeo como formil-1 (fprl-1)". a presente invenção refere-se aos novos derivados de 2,5-dioxoimidazolidin-1-il-3-feniluréia, processos para a sua preparação, composições farmacêuticas contendo-os e seu uso como moduladores farmacêuticos do receptor de receptor do peptídeo como formil-1 (fprl-1).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161558080P | 2011-11-10 | 2011-11-10 | |
PCT/US2012/064571 WO2013071203A1 (en) | 2011-11-10 | 2012-11-10 | 2,5-dioxoimidazolidin-1-yl-3-phenylurea derivatives as formyl peptide receptor like-1 (fprl-1) receptor modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112014011316A2 true BR112014011316A2 (pt) | 2017-05-09 |
Family
ID=47222328
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014011316A BR112014011316A2 (pt) | 2011-11-10 | 2012-11-10 | derivado de 2,5-dioxoimidazolidin-1-il-3-feniluréia como moduladores do receptor de receptor do peptídeo como formil-1 (fprl-1) |
Country Status (13)
Country | Link |
---|---|
US (1) | US8492556B2 (pt) |
EP (2) | EP2776403B1 (pt) |
JP (2) | JP6078075B2 (pt) |
KR (1) | KR102271500B1 (pt) |
CN (1) | CN104114541A (pt) |
AU (2) | AU2012335039C1 (pt) |
BR (1) | BR112014011316A2 (pt) |
CA (1) | CA2855390C (pt) |
DK (1) | DK3103797T3 (pt) |
ES (1) | ES2733826T3 (pt) |
RU (1) | RU2645673C2 (pt) |
TR (1) | TR201909663T4 (pt) |
WO (1) | WO2013071203A1 (pt) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT2770989T (pt) | 2011-10-26 | 2018-12-04 | Allergan Inc | Derivados de amida de aminoácidos substituídos por n-ureia como moduladores de recetor tipo-1 do recetor de péptidos formil (fprl-1) |
US8492556B2 (en) * | 2011-11-10 | 2013-07-23 | Allergan, Inc. | 2,5-Dioxoimidazolidin-1-yl-3-phenylurea derivatives as formyl peptide receptor like-1 (FPRL-1) receptor modulators |
CN105007909B (zh) * | 2013-03-06 | 2019-06-28 | 阿勒根公司 | 用于治疗眼部炎性疾病的甲酰基肽受体2激动剂的用途 |
CA3114477A1 (en) | 2013-03-06 | 2014-09-12 | Allergan, Inc. | Use of agonists of formyl peptide receptor 2 for treating dermatological diseases |
AR097279A1 (es) * | 2013-08-09 | 2016-03-02 | Actelion Pharmaceuticals Ltd | Derivados de benzimidazolil-metil urea como agonistas del receptor de alx |
CN105705484B (zh) | 2013-11-21 | 2018-09-14 | 阿勒根公司 | 作为甲酰肽受体调节剂的苯基氨基甲酸酯衍生物 |
ES2659156T3 (es) * | 2013-11-28 | 2018-03-14 | Kyorin Pharmaceutical Co., Ltd. | Derivados de urea o sales farmacológicamente aceptables de los mismos útiles como agonistas del receptor de péptido formilado 1 (FRPL-1) |
WO2015116566A1 (en) | 2014-01-29 | 2015-08-06 | Allergan, Inc. | 2,5-dioxoimidazolidin-1-yl-3-urea derivatives as formyl peptide modulators |
WO2015116574A1 (en) * | 2014-01-29 | 2015-08-06 | Allergan, Inc. | Urea hydantoin derivatives as formyl peptide modulators |
DK3145916T3 (da) * | 2014-05-21 | 2020-05-11 | Allergan Inc | Imidazolderivater som formylpeptidreceptormodulatorer |
SG11201704764PA (en) | 2014-12-11 | 2017-07-28 | Harvard College | Inhibitors of cellular necrosis and related methods |
ES2791340T3 (es) | 2015-05-27 | 2020-11-03 | Kyorin Seiyaku Kk | Derivado de urea o sal farmacológicamente aceptable del mismo |
PE20180234A1 (es) | 2015-05-27 | 2018-01-31 | Kyorin Seiyaku Kk | Derivado de urea o sal farmacologicamente aceptable del mismo |
JP2020015664A (ja) * | 2016-11-21 | 2020-01-30 | 宇部興産株式会社 | 含窒素多環式ヘテロ環誘導体 |
JP7094989B2 (ja) * | 2017-06-09 | 2022-07-04 | ブリストル-マイヤーズ スクイブ カンパニー | シクロプロピルウレアホルミルペプチド2受容体およびホルミルペプチド1受容体アゴニスト |
LT3762380T (lt) * | 2018-03-05 | 2022-02-25 | Bristol-Myers Squibb Company | Fenilpirolidinono formilpeptido 2 receptoriaus antagonistai |
KR102217512B1 (ko) * | 2020-07-07 | 2021-02-19 | 한화시스템 주식회사 | 배터리 관리 시스템을 통한 회수 요청 또는 자동 복귀를 수행하는 무인 잠수정 |
CN114805334B (zh) * | 2022-05-24 | 2023-06-09 | 深圳大学 | 一种QC和GSK-3β多靶向抑制剂及其制备方法与应用 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA02011858A (es) * | 2000-05-31 | 2004-07-30 | Tanabe Seiyaku Co | Inhibidores de adhesion de celula mediada por alfabeta2. |
SE0100903D0 (sv) * | 2001-03-15 | 2001-03-15 | Astrazeneca Ab | Compounds |
MXPA04000224A (es) * | 2001-07-10 | 2005-07-25 | 4Sc Ag | Novedosos compuestos como agentes antiinflamatorios, inmunomoduladores y antiproliferativos. |
FR2850652B1 (fr) * | 2003-01-31 | 2008-05-30 | Aventis Pharma Sa | Nouveaux derives d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases |
CN1894580A (zh) * | 2003-11-07 | 2007-01-10 | 阿卡蒂亚药品公司 | 脂氧素受体fprl1作为一种用于鉴定能有效治疗疼痛和炎症化合物的工具 |
WO2005087236A1 (en) * | 2004-03-11 | 2005-09-22 | Glaxo Group Limited | Novel m3 muscarinic acetylcholine receptor antagonists |
CN100506802C (zh) * | 2004-06-04 | 2009-07-01 | 中国科学院上海药物研究所 | 一类甲酰肽样受体-1调节剂、其制备方法和用途 |
US20080004282A1 (en) * | 2006-04-10 | 2008-01-03 | Painceptor Pharma Corporation | Compositions and methods for modulating gated ion channels |
EP2217242A1 (en) * | 2007-11-15 | 2010-08-18 | Eisai R&D Management Co., Ltd. | Methods of use |
US8541577B2 (en) * | 2011-11-10 | 2013-09-24 | Allergan, Inc. | Aryl urea derivatives as N-formyl peptide receptors like-1 (FPRL-1) receptor modulators |
US8492556B2 (en) * | 2011-11-10 | 2013-07-23 | Allergan, Inc. | 2,5-Dioxoimidazolidin-1-yl-3-phenylurea derivatives as formyl peptide receptor like-1 (FPRL-1) receptor modulators |
US8729096B2 (en) * | 2012-02-16 | 2014-05-20 | Allergan, Inc. | Imidazolidine-2,4-dione derivatives as N-formyl peptide receptor 2 modulators |
-
2012
- 2012-11-09 US US13/673,800 patent/US8492556B2/en active Active
- 2012-11-10 DK DK16177209.0T patent/DK3103797T3/da active
- 2012-11-10 RU RU2014122753A patent/RU2645673C2/ru active
- 2012-11-10 BR BR112014011316A patent/BR112014011316A2/pt not_active Application Discontinuation
- 2012-11-10 ES ES16177209T patent/ES2733826T3/es active Active
- 2012-11-10 AU AU2012335039A patent/AU2012335039C1/en active Active
- 2012-11-10 EP EP12791050.3A patent/EP2776403B1/en active Active
- 2012-11-10 JP JP2014541358A patent/JP6078075B2/ja active Active
- 2012-11-10 WO PCT/US2012/064571 patent/WO2013071203A1/en active Application Filing
- 2012-11-10 KR KR1020147015539A patent/KR102271500B1/ko active IP Right Grant
- 2012-11-10 CN CN201280060036.8A patent/CN104114541A/zh active Pending
- 2012-11-10 CA CA2855390A patent/CA2855390C/en active Active
- 2012-11-10 TR TR2019/09663T patent/TR201909663T4/tr unknown
- 2012-11-10 EP EP16177209.0A patent/EP3103797B1/en active Active
-
2017
- 2017-01-13 JP JP2017004062A patent/JP6392382B2/ja active Active
- 2017-11-16 AU AU2017261559A patent/AU2017261559C1/en active Active
Also Published As
Publication number | Publication date |
---|---|
AU2012335039A1 (en) | 2014-06-05 |
JP6078075B2 (ja) | 2017-02-08 |
EP3103797A1 (en) | 2016-12-14 |
JP2017066164A (ja) | 2017-04-06 |
CN104114541A (zh) | 2014-10-22 |
AU2017261559A1 (en) | 2017-12-07 |
US8492556B2 (en) | 2013-07-23 |
AU2012335039B2 (en) | 2017-08-17 |
CA2855390A1 (en) | 2013-05-16 |
AU2017261559B2 (en) | 2019-09-26 |
RU2645673C2 (ru) | 2018-02-27 |
KR102271500B1 (ko) | 2021-07-01 |
AU2012335039C1 (en) | 2018-03-01 |
RU2014122753A (ru) | 2015-12-20 |
EP3103797B1 (en) | 2019-04-10 |
AU2017261559C1 (en) | 2019-12-19 |
JP6392382B2 (ja) | 2018-09-19 |
DK3103797T3 (da) | 2019-07-15 |
EP2776403B1 (en) | 2016-09-14 |
CA2855390C (en) | 2020-08-25 |
WO2013071203A1 (en) | 2013-05-16 |
ES2733826T3 (es) | 2019-12-03 |
KR20140116379A (ko) | 2014-10-02 |
US20130123215A1 (en) | 2013-05-16 |
JP2014533282A (ja) | 2014-12-11 |
EP2776403A1 (en) | 2014-09-17 |
TR201909663T4 (tr) | 2019-07-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112014011316A2 (pt) | derivado de 2,5-dioxoimidazolidin-1-il-3-feniluréia como moduladores do receptor de receptor do peptídeo como formil-1 (fprl-1) | |
PH12019500171A1 (en) | Amide derivatives of n-urea substituted amino acids as formyl peptide receptor like-1 (fprl-1) receptor modulators | |
BR112015012555A2 (pt) | derivados de benzimidazol como antagonistas de ep4 | |
MX347280B (es) | Nuevos derivados de ciclohexilamina que tienen actividad como agonistas adrenergicos b2 y como antagonistas muscarinicos m3. | |
NZ700733A (en) | (2-ureidoacetamido)alkyl derivatives as formyl peptide receptor 2 modulators | |
BR112012012261A2 (pt) | compostos como moduladores de receptor com utilidade terapêutica | |
DOP2015000145A (es) | NUEVOS DERIVADOS CARBAMATO DE CICLOHEXILO Y QUINUCLIDINILO QUE TIENEN ACTIVIDAD COMO AGONISTAS ß2 ADRENÉRGICOS Y COMO ANTAGONISTAS MUSCARÍNICOS M3 | |
BR112014012459A2 (pt) | 2h-indazóis como antagonistas do receptor de ep2 | |
EA201391228A1 (ru) | (ПИРИДИН-4-ИЛ)БЕНЗИЛАМИДЫ КАК АЛЛОСТЕРИЧЕСКИЕ МОДУЛЯТОРЫ АЛЬФА 7 nAChR | |
EA201501163A1 (ru) | Модуляторы рецептора cxcr7 | |
GEP20186911B (en) | Substituted chroman compounds as calcium sensing receptor modulators | |
BR112016027133A8 (pt) | derivados de imidazol como moduladores do receptor de formil peptídeo, composição farmacêutica e uso | |
BR112013012715A2 (pt) | "ácidos fosfônicos como moduladores de receptores de s1p". | |
BR112012009670A2 (pt) | compostos de cumarina como moduladores de receptor com utilidade terapêutica | |
EA201391710A1 (ru) | Замещенные производные индола для лечения иммунологических расстройств | |
CO6680603A2 (es) | Antagonistas no competitivos de receptores nicotínicos | |
IN2015MN00421A (pt) | ||
BR112013012719A2 (pt) | "compostos como moduladores de receptor com utilidade terapêutica". | |
BR112014001951A2 (pt) | derivados de n-(imidazolidin-2-ilideno)-heterociclopenta[b]piridina como moduladores dos receptores adrenérgicos alfa 2 | |
ECSP13013080A (es) | Derivados de pirazol útiles como inhibidores de aldosterona sintasa | |
BR112013026507A2 (pt) | derivados de metil amina fenil bicíclicos como moduladores dos receptores de esfinfgosina-1 fosfato | |
BR112014001938A2 (pt) | derivados de n-(imidazolidin-2-ilideno) quinolina como moduladores dos receptores alfa 2 adrenérgicos | |
BR112013017405A2 (pt) | antagonistas não competitivos do receptor nicotínico | |
WO2013067105A3 (en) | Nicotinic receptor non-competitive modulators | |
ECSP12011641A (es) | Derivados de amidas espirocíclicas |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired | ||
B350 | Update of information on the portal [chapter 15.35 patent gazette] |