BR112014007042A8 - Métodos e composições para reduzir níveis séricos de triacilglicerídeos em seres humanos que utilizam uma lipase fúngica - Google Patents
Métodos e composições para reduzir níveis séricos de triacilglicerídeos em seres humanos que utilizam uma lipase fúngicaInfo
- Publication number
- BR112014007042A8 BR112014007042A8 BR112014007042A BR112014007042A BR112014007042A8 BR 112014007042 A8 BR112014007042 A8 BR 112014007042A8 BR 112014007042 A BR112014007042 A BR 112014007042A BR 112014007042 A BR112014007042 A BR 112014007042A BR 112014007042 A8 BR112014007042 A8 BR 112014007042A8
- Authority
- BR
- Brazil
- Prior art keywords
- compositions
- methods
- triacylglycerides
- human subjects
- reducing serum
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
MÉTODOS E COMPOSIÇÕES PARA REDUZIR NÍVEIS SÉRICOS DE TRIACILGLICERÍDEOS EM SERES HUMANOS QUE UTILIZAM UMA LIPASE FÚNGICA. A presente invenção refere-se a métodos e composições para reduzir os níveis séricos de triacilglicerídeos em seres humanos. Em particular, a invenção refere-se à administração oral de uma quantidade eficaz de uma formulação de lipase fúngica, para um ser humano com níveis séricos elevados ou limítrofes elevados de triacilglicerídeos, por um período de tempo suficiente para reduzir os níveis de triacilglicerídeo séricos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/244,131 US8268305B1 (en) | 2011-09-23 | 2011-09-23 | Method and compositions to reduce serum levels of triacylglycerides in human beings using a fungal lipase |
PCT/US2012/055899 WO2013043587A1 (en) | 2011-09-23 | 2012-09-18 | Methods and compositions to reduce serum levels of triacylglycerides in human beings using a fungal lipase |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112014007042A2 BR112014007042A2 (pt) | 2017-04-11 |
BR112014007042A8 true BR112014007042A8 (pt) | 2018-04-03 |
Family
ID=46800675
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014007042A BR112014007042A8 (pt) | 2011-09-23 | 2012-09-18 | Métodos e composições para reduzir níveis séricos de triacilglicerídeos em seres humanos que utilizam uma lipase fúngica |
Country Status (8)
Country | Link |
---|---|
US (2) | US8268305B1 (pt) |
EP (1) | EP2758070B1 (pt) |
JP (1) | JP6170051B2 (pt) |
AU (1) | AU2012312661B2 (pt) |
BR (1) | BR112014007042A8 (pt) |
CA (1) | CA2849250C (pt) |
MX (1) | MX368742B (pt) |
WO (1) | WO2013043587A1 (pt) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201501081D0 (en) | 2015-01-22 | 2015-03-11 | Cilian Ag | Use of enzymes with a wide pH activity range as medicaments for promoting digestion |
Family Cites Families (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US496A (en) | 1837-12-01 | Mode of com-stbuctiire sawmills fob sawing timber | ||
US6699A (en) | 1849-09-04 | Improvement in street-sweeping machines | ||
GB1084431A (en) | 1964-05-06 | 1967-09-20 | Analyses Et De Rech S Biolog M | Improvements in and relating to lipases |
DE1964909A1 (de) | 1969-12-24 | 1971-07-08 | Jungheinrich & Co Maschf | Kehrsaugmaschine und Kehrwalze fuer eine Kehrsaugmaschine |
GB1503653A (en) | 1974-03-07 | 1978-03-15 | Unilever Ltd | Yeast containing food emulsions |
US3898130A (en) | 1974-03-18 | 1975-08-05 | American Hospital Supply Corp | Rapid enzymatic hydrolysis of triglycerides |
US4056442A (en) | 1976-06-01 | 1977-11-01 | The Dow Chemical Company | Lipase composition for glycerol ester determination |
FR2362863A1 (fr) | 1976-08-24 | 1978-03-24 | Degussa | Preparations de lipases a action amelioree et preparations medicales ameliorees contenant des lipases d'origine non animale |
US4245041A (en) | 1977-12-07 | 1981-01-13 | American Monitor Corporation | Triglycerides assay and reagents therefor |
US4264589A (en) | 1978-12-20 | 1981-04-28 | Felts James M | Separation of active α1 -acid glycoprotein and utilization in the lipoprotein lipase enzyme system |
JPS5584397A (en) | 1978-12-20 | 1980-06-25 | Ajinomoto Kk | Fat and oil ester exchange using lipase |
US4394445A (en) | 1979-02-22 | 1983-07-19 | Nix Paul T | Enzymatic glyceride hydrolysis |
US4259440A (en) | 1979-05-21 | 1981-03-31 | Miles Laboratories, Inc. | Hydrolysis and assay of triglycerides |
US4251519A (en) | 1979-07-30 | 1981-02-17 | Anheuser-Busch, Incorporated | Process for the prevention and reduction of elevated blood cholesterol and triglycerides levels |
DK0387945T3 (da) | 1989-03-08 | 1993-12-20 | Simon Lodewijk Scharpe | Middel til behandling af eksokrin pancresinsufficiens og midlets anvendelse til fremstilling af et lægemiddel til behandlingen |
US5108916A (en) | 1989-06-05 | 1992-04-28 | Rhone-Poulenc Rorer, S.A. | Process for stereoselectively hydrolyzing, transesterifying or esterifying with immobilized isozyme of lipase from candida rugosa |
DK95490D0 (da) | 1990-04-18 | 1990-04-18 | Novo Nordisk As | Fremgangsmaade til fremstilling af triglycerid og triglyceridsammensaetning |
DK173590D0 (da) | 1990-06-06 | 1990-07-19 | Novo Nordisk As | Rekombinante terapeutiske lipaser |
US5262172A (en) | 1992-06-19 | 1993-11-16 | Digestive Care Inc. | Compositions of gastric acid-resistant microspheres containing buffered bile acids |
US5578304A (en) | 1992-06-22 | 1996-11-26 | Digestive Care Inc. | Compositions of digestive enzymes and salts of bile acids and process for preparation thereof |
US5234697A (en) | 1992-06-22 | 1993-08-10 | Digestive Care Inc. | Compositions of gastric acid-resistant microspheres containing salts of bile acids |
US5260074A (en) | 1992-06-22 | 1993-11-09 | Digestive Care Inc. | Compositions of digestive enzymes and salts of bile acids and process for preparation thereof |
RU2040932C1 (ru) | 1993-12-17 | 1995-08-09 | Крестьянское хозяйство "Агрофирма Дижа" | Препарат, влияющий на тканевой обмен и применение штамма гриба fusarium sambucinum fuckel var ossicolum (berk.et curf) bilai для его получения |
WO1996038170A1 (en) | 1995-05-31 | 1996-12-05 | Medzyme N.V. | Composition to improve digestibility and utilisation of nutrients |
DE19649097A1 (de) | 1996-11-27 | 1998-05-28 | Beiersdorf Ag | Antiadhäsive Lipasen |
KR100516561B1 (ko) | 1996-12-06 | 2005-09-22 | 아벤티스 파마슈티칼스 인크. | 사람 리파제-유사 유전자에 의해 암호화된 폴리펩타이드, 조성물 및 방법 |
EP1067945B1 (en) | 1998-04-01 | 2006-01-04 | Ganeden Biotech, Inc. | Methods for reducing cholesterol using bacillus coagulans spores, systems and compositions |
JP2000226335A (ja) * | 1998-12-04 | 2000-08-15 | Amano Pharmaceut Co Ltd | 経口用酵素製剤、酵素含有食材及び酵素製剤の服用方法 |
NZ514826A (en) | 1999-03-17 | 2003-08-29 | Solvay Pharm Gmbh | Medicinal product for the treatment of diabetes |
DE60040548D1 (de) | 1999-07-21 | 2008-11-27 | Yakult Honsha Kk | Mittel zur senkung von cholesterin, mittel zur hemmung der produktion von sekundären gallensäuren, nahrungsmittel und getränke |
US20010046493A1 (en) | 2000-02-24 | 2001-11-29 | Alex Margolin | Lipase-containing composition and methods of use thereof |
WO2003016518A1 (en) | 2001-08-13 | 2003-02-27 | Bayer Healthcare Ag | Regulation of human triacylglycerol lipase |
ATE492166T1 (de) | 2002-04-05 | 2011-01-15 | Nestle Sa | Zusammensetzungen und verfahren zur verbesserung von lipidassimilation in haustieren |
US6660508B1 (en) | 2002-06-28 | 2003-12-09 | Ultra Biotech Limited | Dietary supplements for treating hyperlipemia |
CA2515583C (en) | 2003-03-07 | 2015-07-14 | Diversa Corporation | Hydrolases, nucleic acids encoding them and methods for making and using them |
US7067124B2 (en) | 2003-03-28 | 2006-06-27 | National Enzyme Company | Protease composition and method for treating a digestive disorder |
US7223401B2 (en) | 2003-06-11 | 2007-05-29 | Ultra Biotech Limited | Method to prepare compositions comprising yeast treated with electromagnetic energy |
AU2005227090B2 (en) | 2004-03-22 | 2010-12-09 | Abbott Laboratories Gmbh | Oral pharmaceutical compositions of lipase-containing products, in particular of pancreatin, containing surfactants |
DE602005022187D1 (de) | 2004-05-24 | 2010-08-19 | Novozymes As | Enzyme für pharmazeutische anwendung |
PT2198880T (pt) | 2004-10-14 | 2017-01-04 | Lilly Co Eli | Composições contendo lipase, protease e amilase para o tratamento de insuficiência pancreática |
US20060084153A1 (en) | 2004-10-15 | 2006-04-20 | Wuli Bao | Method of producing diacylglycerides |
EP1910530A2 (en) | 2005-05-31 | 2008-04-16 | Diversa Corporation | Hydrolases, nucleic acids encoding them and methods for making and using them |
NZ563777A (en) | 2005-06-24 | 2010-08-27 | Novozymes As | Serine protease derived from Bacillus licheniformis optionally in combination with lipases and amylases for pharmaceutical use |
US8017351B2 (en) | 2005-06-24 | 2011-09-13 | Novozymes A/S | Amylases for pharmaceutical use |
KR20080017025A (ko) | 2005-06-24 | 2008-02-25 | 노보자임스 에이/에스 | 약학적 용도의 리파제 |
WO2007053619A2 (en) | 2005-11-01 | 2007-05-10 | Bio-Cat, Inc. | A composition with a fungal (yeast) lipase and method for treating lipid malabsorption in cystic fibrous as well as people suffering from pancreatic lipase insufficiency |
EP2216403A3 (en) | 2006-02-02 | 2010-11-24 | Verenium Corporation | Esterases and related nucleic acids and methods |
EP2061483A1 (en) | 2006-09-07 | 2009-05-27 | McGill University | Oral polymeric membrane feruloyl esterase producing bacteria formulation |
MX2009006597A (es) | 2006-12-21 | 2009-07-02 | Novozymes As | Variantes de lipasa para uso farmaceutico. |
US20080199448A1 (en) | 2007-02-16 | 2008-08-21 | Ross Mairi R | Enzyme composition for improving food digestion |
AU2008239737A1 (en) | 2007-04-13 | 2008-10-23 | Beth Israel Deaconess Medical Center, Inc. | Novel nutritional food products for improved digestion and intestinal absorption |
FR2927254B1 (fr) | 2008-02-12 | 2010-03-26 | Lesaffre & Cie | Utilisation de substances actives naturelles dans des compositions cosmetiques ou therapeutiques |
US20090317371A1 (en) | 2008-06-08 | 2009-12-24 | Saccharides Science & Technology Ltd. | Method, Composition, and Device, for the Treatment of Amylase Malfunctions / Inactivity in Association with Saccharides (Mainly Polysaccharides) Based Diseases |
WO2010020693A2 (en) | 2008-08-21 | 2010-02-25 | Novozymes A/S | Enzymes for the treatment of obesity |
WO2010025126A1 (en) | 2008-08-26 | 2010-03-04 | Cystic Fibrosis Foundation Therapeutics, Inc. | Rapidly disintegrating tablets comprising lipase, amylase, and protease |
EP2328566A1 (en) | 2008-09-30 | 2011-06-08 | DSM IP Assets B.V. | Enzyme composition and application thereof in the treatment of pancreatic insufficiency |
EP2786761A1 (de) | 2009-01-29 | 2014-10-08 | Nordmark Arzneimittel GmbH & Co.KG | Pharmazeutisches Präparat |
US20100269989A1 (en) | 2009-04-28 | 2010-10-28 | Enzymatic Deinking Technologies, L.L.C. | Use of 1,3-selective lipases for pitch control in pulp and paper processes |
BRPI1009920A2 (pt) | 2009-05-01 | 2016-03-15 | Micropharma Ltd | composições bacterianas para profilaxina e tratamento de doença degenerativa. |
FR2966734B1 (fr) | 2010-10-29 | 2014-07-18 | Max Rombi | Composition comprenant au moins une enzyme proteolytique pour son utilisation pour empecher la synthese des triglycerides |
-
2011
- 2011-09-23 US US13/244,131 patent/US8268305B1/en active Active
-
2012
- 2012-09-18 JP JP2014531906A patent/JP6170051B2/ja active Active
- 2012-09-18 MX MX2014003478A patent/MX368742B/es active IP Right Grant
- 2012-09-18 EP EP12834418.1A patent/EP2758070B1/en active Active
- 2012-09-18 AU AU2012312661A patent/AU2012312661B2/en active Active
- 2012-09-18 BR BR112014007042A patent/BR112014007042A8/pt not_active Application Discontinuation
- 2012-09-18 US US14/346,942 patent/US9555083B2/en active Active
- 2012-09-18 CA CA2849250A patent/CA2849250C/en active Active
- 2012-09-18 WO PCT/US2012/055899 patent/WO2013043587A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
EP2758070B1 (en) | 2019-11-06 |
US8268305B1 (en) | 2012-09-18 |
CA2849250A1 (en) | 2013-03-28 |
AU2012312661A1 (en) | 2014-03-20 |
US9555083B2 (en) | 2017-01-31 |
US20140294802A1 (en) | 2014-10-02 |
BR112014007042A2 (pt) | 2017-04-11 |
WO2013043587A1 (en) | 2013-03-28 |
JP6170051B2 (ja) | 2017-07-26 |
EP2758070A4 (en) | 2015-03-25 |
AU2012312661B2 (en) | 2017-02-09 |
EP2758070A1 (en) | 2014-07-30 |
MX368742B (es) | 2019-10-14 |
MX2014003478A (es) | 2015-04-16 |
CA2849250C (en) | 2021-03-23 |
JP2014526553A (ja) | 2014-10-06 |
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Legal Events
Date | Code | Title | Description |
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B25C | Requirement related to requested transfer of rights |
Owner name: BIO-CAT, INC. (US) , KENNETH GREGORY MOORE (US) |
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B25L | Entry of change of name and/or headquarter and transfer of application, patent and certificate of addition of invention: publication cancelled |
Owner name: BIO-CAT, INC. (US) , KENNETH GREGORY MOORE (US) |
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B25A | Requested transfer of rights approved |
Owner name: BIO-CAT, INC. (US) |
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B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NAO 10196/2001, QUE MODIFICOU A LEI NAO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUAANCIA PRA VIA DA ANVISA. CONSIDERANDO A APROVAA AO DOS TERMOS DO PARECER NAO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NAO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDAANCIAS CABA-VEIS. |
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B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |