BR112013032398A2 - método para a produção de alergênicos hidrolisados - Google Patents

método para a produção de alergênicos hidrolisados

Info

Publication number
BR112013032398A2
BR112013032398A2 BR112013032398A BR112013032398A BR112013032398A2 BR 112013032398 A2 BR112013032398 A2 BR 112013032398A2 BR 112013032398 A BR112013032398 A BR 112013032398A BR 112013032398 A BR112013032398 A BR 112013032398A BR 112013032398 A2 BR112013032398 A2 BR 112013032398A2
Authority
BR
Brazil
Prior art keywords
extract
denatured
allergens
denaturing
production
Prior art date
Application number
BR112013032398A
Other languages
English (en)
Inventor
Gael Placier
Laetitia Frisch
Marie-Ange Benoit
Thierry Legon
Original Assignee
Biotech Tools Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotech Tools Sa filed Critical Biotech Tools Sa
Publication of BR112013032398A2 publication Critical patent/BR112013032398A2/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/35—Allergens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43531—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from mites
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Wood Science & Technology (AREA)
  • Insects & Arthropods (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

resumo de patente de invenção para: “método para a produção de alergênicos hidrolisados”. um método para a produção de alergênicos hidrolisados a partir de alergênicos compreendendo as etapas de: a) extrair uma fonte alergênica compreendendo proteínas alergênicas para formar um extrato, b) purificar o extrato para remover os componentes não-proteicos, de modo a formar um extrato purificado, c) desnaturar o extrato purificado, com um primeiro agente desnaturante para formar um extrato desnaturado purificado, d) refinar o extrato desnaturado purificado para remover as impurezas, de modo a formar um extrato desnaturado refinado, e) desnaturar o extrato desnaturado refinado com um segundo agente desnaturante para formar uma mistura alergênica desnaturada, e f) hidrolisar a mistura alergênica desnaturada para formar os alergênicos hidrolisados
BR112013032398A 2011-06-15 2012-06-15 método para a produção de alergênicos hidrolisados BR112013032398A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11170031 2011-06-15
PCT/EP2012/061404 WO2012172037A1 (en) 2011-06-15 2012-06-15 A method for the production of hydrolyzed allergens

Publications (1)

Publication Number Publication Date
BR112013032398A2 true BR112013032398A2 (pt) 2016-09-20

Family

ID=44881614

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013032398A BR112013032398A2 (pt) 2011-06-15 2012-06-15 método para a produção de alergênicos hidrolisados

Country Status (11)

Country Link
US (2) US10195276B2 (pt)
EP (2) EP2721051B1 (pt)
JP (2) JP2014518065A (pt)
CN (2) CN110041419A (pt)
AU (1) AU2012269031B2 (pt)
BR (1) BR112013032398A2 (pt)
CA (1) CA2838888A1 (pt)
DK (1) DK2721051T3 (pt)
ES (1) ES2659186T3 (pt)
PL (1) PL2721051T3 (pt)
WO (1) WO2012172037A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014147131A1 (en) * 2013-03-19 2014-09-25 Biotech Tools S.A. Allergen preparation
DK3129001T3 (da) * 2014-04-10 2020-01-20 Asit Biotech S A Hsp-fri fremstilling af allergen
CN104447943A (zh) * 2014-11-21 2015-03-25 浙江我武生物科技股份有限公司 一种提取狗毛皮屑变应原的方法
BR112019006844A2 (pt) 2016-10-05 2019-06-25 Asit Biotech S A prevenção de alergia
CN108129558B (zh) * 2017-12-21 2021-10-12 中国医学科学院北京协和医院 一种桦树花粉主要致敏蛋白Bet v 8的提取和分离纯化方法及应用
WO2019166544A1 (en) 2018-02-28 2019-09-06 Asit Biotech Sa Detection of blocking antibodies
AU2019264459A1 (en) * 2018-04-30 2020-11-19 Asit Biotech Sa Evaluation of hydrolyzed allergen preparations
CN110713520B (zh) * 2019-11-06 2021-01-01 中国石油天然气股份有限公司 油酰基氨基酸-γ-L-谷氨酰-L-半胱氨酰-甘氨酸多肽及其制备与应用
CN113831400A (zh) * 2021-07-29 2021-12-24 沈阳医学院 一种尘螨致敏蛋白Der p 1的分离纯化方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0321603A1 (fr) 1987-12-23 1989-06-28 Societe Des Produits Nestle S.A. Procédé de préparation d'un hydrolysat de protéines de lactosérum et d'un aliment hypoallergéniques
DE10044360A1 (de) * 2000-09-08 2002-03-21 Merck Patent Gmbh Verfahren zur Aufreinigung von rekombinanten als unlösliche Aggregate exprimierte Proteinen
JP2002249442A (ja) * 2001-02-21 2002-09-06 Fumakilla Ltd アレルギー減感作治療薬
EP1872792A1 (en) * 2006-06-29 2008-01-02 Biotech Tools S.A. A method for the production of hydrolyzed allergen
SI2190473T1 (sl) * 2007-08-15 2013-05-31 Circassia Limited Peptid z zmanjšano tvorbo dimerov
US20100278880A1 (en) * 2008-01-02 2010-11-04 Biotech Tools S.A. Pharmaceutical formulation for allergen preparation
JP2009195158A (ja) * 2008-02-21 2009-09-03 Unitika Ltd モノガラクツロン酸の製造方法
JP5488885B2 (ja) * 2009-10-28 2014-05-14 国立大学法人 東京大学 感染症の疾患マーカー

Also Published As

Publication number Publication date
ES2659186T3 (es) 2018-03-14
JP2018039822A (ja) 2018-03-15
US10195276B2 (en) 2019-02-05
CN103748105A (zh) 2014-04-23
EP3299379A1 (en) 2018-03-28
US20140220044A1 (en) 2014-08-07
AU2012269031A1 (en) 2013-12-12
CA2838888A1 (en) 2012-12-20
EP2721051B1 (en) 2017-11-29
US20190134199A1 (en) 2019-05-09
DK2721051T3 (en) 2018-03-05
JP2014518065A (ja) 2014-07-28
CN110041419A (zh) 2019-07-23
WO2012172037A1 (en) 2012-12-20
EP2721051A1 (en) 2014-04-23
JP6581636B2 (ja) 2019-09-25
PL2721051T3 (pl) 2018-05-30
AU2012269031B2 (en) 2016-10-06

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06T Formal requirements before examination [chapter 6.20 patent gazette]
B06G Technical and formal requirements: other requirements [chapter 6.7 patent gazette]
B06I Publication of requirement cancelled [chapter 6.9 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 6.7 NA RPI NO 2579 DE 09/06/2020 POR TER SIDO INDEVIDA.

B350 Update of information on the portal [chapter 15.35 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL