BR112013030241A2 - método para o diagnóstico de artrite reumatoide - Google Patents

método para o diagnóstico de artrite reumatoide

Info

Publication number
BR112013030241A2
BR112013030241A2 BR112013030241A BR112013030241A BR112013030241A2 BR 112013030241 A2 BR112013030241 A2 BR 112013030241A2 BR 112013030241 A BR112013030241 A BR 112013030241A BR 112013030241 A BR112013030241 A BR 112013030241A BR 112013030241 A2 BR112013030241 A2 BR 112013030241A2
Authority
BR
Brazil
Prior art keywords
diagnosis
rheumatoid arthritis
relates
present
sera
Prior art date
Application number
BR112013030241A
Other languages
English (en)
Inventor
Anna Maria Papini
Federico Pratesi
Francesco Lolli
Ilaria Paolini
Maria Claudia Alcaro
Mario Chelli
Paola Migliorini
Paolo Rovero
Original Assignee
Toscana Biomarkers S R L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toscana Biomarkers S R L filed Critical Toscana Biomarkers S R L
Publication of BR112013030241A2 publication Critical patent/BR112013030241A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
    • G01N2800/102—Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Rheumatology (AREA)
  • Rehabilitation Therapy (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

resumo método para o diagnóstico de artrite reumatoide a presente invenção pertence ao campo da farmácia e química e refere-se ao uso de peptídeos sintéticos citrulinados para o diagnóstico de artrite reumatoide (ra). em particular, a invenção refere-se ao uso de sequências peptídidcas que reagem especificamente com autoanticorpos presentes nos soros de pacientes de ra.
BR112013030241A 2011-05-25 2012-05-24 método para o diagnóstico de artrite reumatoide BR112013030241A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11167420A EP2527841A1 (en) 2011-05-25 2011-05-25 Methods for the diagnosis of rheumatoid arthritis
PCT/EP2012/059680 WO2012160127A1 (en) 2011-05-25 2012-05-24 Method for the diagnosis of rheumatoid arthritis

Publications (1)

Publication Number Publication Date
BR112013030241A2 true BR112013030241A2 (pt) 2016-12-06

Family

ID=44993251

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013030241A BR112013030241A2 (pt) 2011-05-25 2012-05-24 método para o diagnóstico de artrite reumatoide

Country Status (10)

Country Link
US (1) US20140106381A1 (pt)
EP (2) EP2527841A1 (pt)
CN (1) CN103748468A (pt)
AU (1) AU2012260906A1 (pt)
BR (1) BR112013030241A2 (pt)
CA (1) CA2835517A1 (pt)
EA (1) EA201391772A1 (pt)
IL (1) IL229375A0 (pt)
WO (1) WO2012160127A1 (pt)
ZA (1) ZA201309665B (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9387246B2 (en) 2013-09-03 2016-07-12 L. Douglas Graham Treatment methods for rheumatoid arthritis
CN104262489B (zh) * 2014-09-30 2017-01-11 陈仁奋 一种环状瓜氨酸嵌合肽抗原及其应用
CN108196073B (zh) * 2018-03-13 2019-09-13 江苏浩欧博生物医药股份有限公司 一种测定抗环瓜氨酸肽抗体的试剂盒及其应用
CN110862450A (zh) * 2018-08-28 2020-03-06 东莞光极生物科技有限公司 基于cii的环状多肽及其应用

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030144473A1 (en) 1992-09-16 2003-07-31 Michael Zeppezauer Peptides for the production of preparations for the diagnosis and therapy of autoimmun diseases
FR2752842B1 (fr) 1996-08-30 1998-11-06 Biomerieux Sa Antigenes derives des filaggrines et leur utilisation pour le diagnostic de la polyarthrite rhumatoide
NL1004539C2 (nl) 1996-11-15 1998-05-20 Stichting Tech Wetenschapp Peptide afgeleid van een door auto-antilichamen van patiënten met reumatoïde artritis herkend antigeen, antilichaam daartegen en werkwijze voor het detecteren van auto-immuunantilichamen.
WO1999028344A2 (en) 1997-11-28 1999-06-10 Innogenetics N.V. Synthetic peptides containing citrulline recognized by rheumatoid arthritis sera as tools for diagnosis and treatment
DE19860460C2 (de) 1998-12-28 2001-03-29 Bosch Gmbh Robert Integrierter rekuperativer Brenner
FR2795735B1 (fr) 1999-07-01 2001-09-07 Univ Toulouse Derives citrullines de la fibrine et leur utilisation pour le diagnostic ou le traitement de la polyarthrite rhumatoide
EP1240180A2 (en) 1999-12-21 2002-09-18 Innogenetics N.V. Peptides designed for the diagnosis and treatment of rheumatoid arthritis
NL1019540C2 (nl) 2001-12-11 2003-07-01 Stichting Tech Wetenschapp Werkwijze voor het detecteren van auto-antilichamen van patienten die lijden aan reumatoïde artritis, peptide en assaykit.
ITTO20030246A1 (it) 2003-03-31 2004-10-01 Univ Pisa Nuovi peptidi sintetici citrullinati e loro usi.
JP5060300B2 (ja) 2004-11-04 2012-10-31 ビオメリュー リウマチ性関節炎特異的自己抗体により認識されるフィブリン由来シトルリンペプチド、及びその使用
FI20050814A0 (fi) 2005-08-11 2005-08-11 Procollagen Oy Menetelmä nivelreumassa muodostuvien kollageeniautovasta-aineiden havaitsemiseksi
US20070148704A1 (en) 2005-10-06 2007-06-28 Ursula Klause Anti-CCPand antinuclear antibodies in diagnosis of rheumatoid arthritis
GB0609119D0 (en) 2006-05-09 2006-06-21 Univ Birmingham Histones
ES2307421B1 (es) 2007-04-30 2009-09-28 Consejo Superiorde Investigaciones Cientificas (Csic) Polipeptido quimerico fibrina-filagrina citruinado capaz de detectar los anticuerpos generados en la artritis reumatoide.
WO2009007846A2 (en) 2007-06-15 2009-01-15 Universitetet If Oslo Methods for modifying, isolating, detecting, visualizing, and quantifying citrullinated and/or homocitrullinated peptides, polypeptides and proteins
US8323656B2 (en) 2007-06-25 2012-12-04 Yijun Xu Antigen determinant of rheumatoid arthritis-specific autoantibody and use thereof
JP5663723B2 (ja) 2008-05-14 2015-02-04 アンセルム（アンスチチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル） 関節リウマチの診断のための方法およびキット
DK2294086T3 (en) * 2008-06-04 2018-01-02 Modiquest B V ANTI-INFLAMMATORY AGENTS
NZ595310A (en) 2009-03-30 2013-05-31 Nestec Sa Citrullinated peptides for diagnosing and prognosing rheumatoid arthritis; vimentin fragments
EP2414836B1 (en) 2009-03-30 2014-05-07 INSERM (Institut National de la Santé et de la Recherche Médicale) Biomarkers, methods and kits for the diagnosis of rheumatoid arthritis
EP2325195A1 (en) 2009-11-23 2011-05-25 Toscana Biomarkers S.r.l. Viral citrullinated peptides and uses thereof

Also Published As

Publication number Publication date
ZA201309665B (en) 2014-08-27
EP2527841A1 (en) 2012-11-28
US20140106381A1 (en) 2014-04-17
AU2012260906A1 (en) 2013-12-12
WO2012160127A1 (en) 2012-11-29
EA201391772A1 (ru) 2014-04-30
IL229375A0 (en) 2014-01-30
EP2715362A1 (en) 2014-04-09
CA2835517A1 (en) 2012-11-29
CN103748468A (zh) 2014-04-23

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]