BR112013023960A2 - método de análise de uma amostra de sangue de um indivíduo para a presença de um marcador de doença - Google Patents
método de análise de uma amostra de sangue de um indivíduo para a presença de um marcador de doençaInfo
- Publication number
- BR112013023960A2 BR112013023960A2 BR112013023960A BR112013023960A BR112013023960A2 BR 112013023960 A2 BR112013023960 A2 BR 112013023960A2 BR 112013023960 A BR112013023960 A BR 112013023960A BR 112013023960 A BR112013023960 A BR 112013023960A BR 112013023960 A2 BR112013023960 A2 BR 112013023960A2
- Authority
- BR
- Brazil
- Prior art keywords
- individual
- analyzing
- disease marker
- blood sample
- disease
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
método de análise de uma amostra de sangue de um indivíduo para a presença de um marcador de doença a presente invenção refere-se a um método de análise de uma amostra de sangue de um individuo para a presença de um marcador de doença, o referido método compreendendo as etapas de a) extração nucleicos de células de sangue anucleadas na referida amostra de sangue para fornecer uma fração de ácidos nucléicos extraídos de células de sangue anucleadas, e b) análise da referida fração de ácidos nucléicos extraídos de células de sangue anucleadas para a presença de um marcador de doença, em que o referido marcador de doença é uma mutação específica da doença em um gene de uma célula do referido indivíduo, ou em que o referido marcador de doença é perfil de expressão de doenças específicas de genes de uma célula do referido indivíduo.
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11158912.3 | 2011-03-18 | ||
| EP11158912 | 2011-03-18 | ||
| EP11167973 | 2011-05-27 | ||
| EP11167973.4 | 2011-05-27 | ||
| PCT/NL2011/050518 WO2012008839A2 (en) | 2010-07-16 | 2011-07-15 | A method of analysing a blood sample of a subject for the presence of a disease marker |
| NLPCT/NL2011/050518 | 2011-07-15 | ||
| PCT/NL2012/050025 WO2012128616A1 (en) | 2011-03-18 | 2012-01-16 | A method of analysing a blood sample of a subject for the presence of a disease marker |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112013023960A2 true BR112013023960A2 (pt) | 2016-12-13 |
| BR112013023960B1 BR112013023960B1 (pt) | 2020-12-01 |
Family
ID=45562414
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112013023960-3A BR112013023960B1 (pt) | 2011-03-18 | 2012-01-16 | método para analisar uma amostra de sangue de um indivíduo para a presença de um marcador de doença e métodos para determinar o estágio da doença ou a eficácia de um tratamento da doença em um indivíduo |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US10174365B2 (pt) |
| EP (2) | EP2686677B1 (pt) |
| JP (1) | JP5934726B2 (pt) |
| CN (1) | CN103547920B (pt) |
| AU (1) | AU2012231884B2 (pt) |
| BR (1) | BR112013023960B1 (pt) |
| CA (1) | CA2830461C (pt) |
| MX (1) | MX347555B (pt) |
| SG (1) | SG193539A1 (pt) |
| WO (1) | WO2012128616A1 (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2593787B1 (en) | 2010-07-16 | 2018-07-04 | Stichting VUmc | A method of analysing a blood sample of a subject for the presence of a disease marker |
| US10174365B2 (en) | 2011-03-18 | 2019-01-08 | Stichting Vu-Vumc | Method of analysing a blood sample of a subject for the presence of a disease marker |
| CA2863190A1 (en) * | 2012-03-09 | 2013-09-12 | Basf Se | Means and methods for assessing hyperthyroidism |
| WO2017037539A2 (en) * | 2015-09-02 | 2017-03-09 | The Health Corporation Of The Galilee Medical Center | Modulation of the phospholipase a2-activating protein for treatment of myelin related diseases |
| US10233509B2 (en) | 2016-12-07 | 2019-03-19 | Credo Biomedical Pte Ltd. | Method for detection CPV 2a, 2b, and 2c and for discrimination wild type from vaccine type |
| DE102017125013B4 (de) * | 2017-10-25 | 2019-10-17 | Epiontis Gmbh | MCC als epigenetischer Marker zur Identifizierung von Immunzellen, insbesondere basophiler Granulozyten |
| CN112094907B (zh) * | 2019-06-18 | 2023-08-18 | 杭州太铭生物科技有限公司 | 外周血红细胞微核dna及其应用 |
| CN113430264A (zh) * | 2020-03-23 | 2021-09-24 | 南京梅傲红清生物科技有限公司 | 红细胞核酸在鉴定肿瘤的突变类型中的应用 |
| CN114324887A (zh) * | 2021-10-14 | 2022-04-12 | 深圳市华启生物科技有限公司 | 免疫球蛋白a肾病t细胞诊断标志物 |
| GB202203947D0 (en) * | 2022-03-21 | 2022-05-04 | Chancellor Masters And Scholars Of The Univ Of Oxford | Method |
| CN116087490A (zh) * | 2022-12-13 | 2023-05-09 | 安徽医科大学第一附属医院 | 多糖类物质的检测试剂在制备检测颅内感染试剂中的应用 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
| AU622426B2 (en) | 1987-12-11 | 1992-04-09 | Abbott Laboratories | Assay using template-dependent nucleic acid probe reorganization |
| US5192659A (en) | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
| US5185244A (en) | 1989-12-08 | 1993-02-09 | Emory University | Genetic test for hereditary neuromuscular disease |
| US5455166A (en) | 1991-01-31 | 1995-10-03 | Becton, Dickinson And Company | Strand displacement amplification |
| US5270184A (en) | 1991-11-19 | 1993-12-14 | Becton, Dickinson And Company | Nucleic acid target generation |
| US5719028A (en) | 1992-12-07 | 1998-02-17 | Third Wave Technologies Inc. | Cleavase fragment length polymorphism |
| SE9400522D0 (sv) | 1994-02-16 | 1994-02-16 | Ulf Landegren | Method and reagent for detecting specific nucleotide sequences |
| US5942391A (en) | 1994-06-22 | 1999-08-24 | Mount Sinai School Of Medicine | Nucleic acid amplification method: ramification-extension amplification method (RAM) |
| CA2359816C (en) * | 1999-01-06 | 2010-08-03 | Genenews Inc. | Method for the detection of gene transcripts in blood and uses thereof |
| JP2003521879A (ja) * | 1999-04-20 | 2003-07-22 | マイトコー | アルツハイマー病とともに分離するミトコンドリア遺伝子における一塩基多型 |
| EP1409725B1 (en) * | 2001-03-07 | 2014-05-07 | Andre Schuh | Diagnosis and treatment of blood disorders |
| GB2380194B (en) * | 2001-10-01 | 2005-06-22 | Roger Michael Marchbanks | A mitochondrial mutation associated with schizophrenia and increased oxidative stress |
| US6977162B2 (en) | 2002-03-01 | 2005-12-20 | Ravgen, Inc. | Rapid analysis of variations in a genome |
| CN1922304A (zh) | 2003-10-31 | 2007-02-28 | 维特克公司 | 用于检测循环肿瘤和内皮细胞的血液测试样机和方法 |
| CA2566411A1 (en) | 2004-05-11 | 2005-11-24 | Heptest Laboratories, Inc. | Compositions, kit and one-step method for monitoring compounds having anti-factor xa and/or anti factor iia activities |
| FR2877013A1 (fr) | 2004-10-27 | 2006-04-28 | Assist Publ Hopitaux De Paris | Indentification d'une mutation de jak2 impliquee dans la polyglobulie de vaquez |
| JP5159619B2 (ja) * | 2005-06-22 | 2013-03-06 | ザ・ジョンズ・ホプキンス・ユニバーシティ | 卵巣癌のバイオマーカー：ｃｔａｐ３関連タンパク質 |
| US20070059774A1 (en) | 2005-09-15 | 2007-03-15 | Michael Grisham | Kits for Prenatal Testing |
| EP1931800A4 (en) | 2005-09-15 | 2011-06-15 | Artemis Health Inc | SYSTEMS AND METHODS FOR ENRICHING ANALYTES |
| US20070059781A1 (en) | 2005-09-15 | 2007-03-15 | Ravi Kapur | System for size based separation and analysis |
| US20100297621A1 (en) * | 2007-06-20 | 2010-11-25 | University Of Utah Research Foundation | Use of pre-mrna splicing in platelet cells for the diagnosis of disease |
| CN101298630A (zh) * | 2008-06-11 | 2008-11-05 | 南京大学 | 一种Solexa技术鉴定结肠癌病人血清中微小核糖核酸的方法 |
| CN101363046A (zh) * | 2008-08-29 | 2009-02-11 | 芮屈生物技术（上海）有限公司 | 一种广谱性癌症原位杂交检测试剂盒及其检测方法和应用 |
| US11634747B2 (en) | 2009-01-21 | 2023-04-25 | Streck Llc | Preservation of fetal nucleic acids in maternal plasma |
| EP2336353A1 (en) * | 2009-12-17 | 2011-06-22 | febit holding GmbH | miRNA fingerprints in the diagnosis of diseases |
| EP2593787B1 (en) | 2010-07-16 | 2018-07-04 | Stichting VUmc | A method of analysing a blood sample of a subject for the presence of a disease marker |
| US10174365B2 (en) | 2011-03-18 | 2019-01-08 | Stichting Vu-Vumc | Method of analysing a blood sample of a subject for the presence of a disease marker |
| US20140256590A1 (en) | 2011-08-09 | 2014-09-11 | Vereniging Voor Christelijk Hoger Onderwijs | Method of analysing a blood sample of a subject for the presence of a foetal disease or condition marker |
-
2012
- 2012-01-16 US US14/006,089 patent/US10174365B2/en active Active
- 2012-01-16 MX MX2013010594A patent/MX347555B/es active IP Right Grant
- 2012-01-16 SG SG2013070487A patent/SG193539A1/en unknown
- 2012-01-16 BR BR112013023960-3A patent/BR112013023960B1/pt active IP Right Grant
- 2012-01-16 CN CN201280024044.7A patent/CN103547920B/zh active Active
- 2012-01-16 AU AU2012231884A patent/AU2012231884B2/en active Active
- 2012-01-16 WO PCT/NL2012/050025 patent/WO2012128616A1/en active Application Filing
- 2012-01-16 JP JP2013558804A patent/JP5934726B2/ja active Active
- 2012-01-16 EP EP12702324.0A patent/EP2686677B1/en active Active
- 2012-01-16 CA CA2830461A patent/CA2830461C/en active Active
- 2012-01-16 EP EP18198351.1A patent/EP3483607A1/en not_active Withdrawn
-
2018
- 2018-11-28 US US16/202,474 patent/US20190233886A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20140199693A1 (en) | 2014-07-17 |
| EP2686677B1 (en) | 2018-10-03 |
| AU2012231884A2 (en) | 2014-05-08 |
| AU2012231884A1 (en) | 2013-10-10 |
| JP2014512811A (ja) | 2014-05-29 |
| BR112013023960B1 (pt) | 2020-12-01 |
| MX2013010594A (es) | 2014-07-09 |
| CN103547920A (zh) | 2014-01-29 |
| US10174365B2 (en) | 2019-01-08 |
| WO2012128616A1 (en) | 2012-09-27 |
| CA2830461A1 (en) | 2012-09-27 |
| SG193539A1 (en) | 2013-10-30 |
| US20190233886A1 (en) | 2019-08-01 |
| JP5934726B2 (ja) | 2016-06-15 |
| CN103547920B (zh) | 2016-08-17 |
| EP2686677A1 (en) | 2014-01-22 |
| EP3483607A1 (en) | 2019-05-15 |
| AU2012231884B2 (en) | 2017-03-09 |
| MX347555B (es) | 2017-04-28 |
| CA2830461C (en) | 2021-06-29 |
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| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B25A | Requested transfer of rights approved |
Owner name: STICHTING VUMC (NL) |
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| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 16/01/2012, OBSERVADAS AS CONDICOES LEGAIS. |