BR112013023812A2 - agente de contraste de mri para linfografia com base em nanopartículas de óxido de ferro e método para imagem do nódulo linfático usando o mesmo - Google Patents

agente de contraste de mri para linfografia com base em nanopartículas de óxido de ferro e método para imagem do nódulo linfático usando o mesmo

Info

Publication number
BR112013023812A2
BR112013023812A2 BR112013023812A BR112013023812A BR112013023812A2 BR 112013023812 A2 BR112013023812 A2 BR 112013023812A2 BR 112013023812 A BR112013023812 A BR 112013023812A BR 112013023812 A BR112013023812 A BR 112013023812A BR 112013023812 A2 BR112013023812 A2 BR 112013023812A2
Authority
BR
Brazil
Prior art keywords
lymphography
imaging
iron oxide
same
contrast agent
Prior art date
Application number
BR112013023812A
Other languages
English (en)
Inventor
Bong Sik Jeon
Daishun Ling
Eun Byul Kwon
Eung Gyu Kim
Ju Young Park
Taeghwan Hyeon
Wan Jae Myeong
Original Assignee
Hanwha Chemical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hanwha Chemical Corp filed Critical Hanwha Chemical Corp
Publication of BR112013023812A2 publication Critical patent/BR112013023812A2/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/124—Macromolecular compounds dendrimers, dendrons, hyperbranched compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
    • A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
    • A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
    • A61K49/1851—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule
    • A61K49/1857—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule the organic macromolecular compound being obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. PLGA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
    • A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
    • A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
    • A61K49/1851—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule
    • A61K49/1857—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule the organic macromolecular compound being obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. PLGA
    • A61K49/186—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule the organic macromolecular compound being obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. PLGA the organic macromolecular compound being polyethyleneglycol [PEG]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Nanotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
BR112013023812A 2011-06-22 2012-06-20 agente de contraste de mri para linfografia com base em nanopartículas de óxido de ferro e método para imagem do nódulo linfático usando o mesmo BR112013023812A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020110060438A KR101721570B1 (ko) 2011-06-22 2011-06-22 산화철 나노입자 기반 림프절 이미징용 ｍｒｉ 조영제 및 이를 이용하여 림프절을 조영하는 방법
PCT/KR2012/004861 WO2012177039A2 (en) 2011-06-22 2012-06-20 Mri contrast agent for lymphography based on iron oxide nanoparticles and method for imaging lymph node using the same

Publications (1)

Publication Number Publication Date
BR112013023812A2 true BR112013023812A2 (pt) 2016-12-13

Family

ID=47423073

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013023812A BR112013023812A2 (pt) 2011-06-22 2012-06-20 agente de contraste de mri para linfografia com base em nanopartículas de óxido de ferro e método para imagem do nódulo linfático usando o mesmo

Country Status (10)

Country Link
US (1) US8906346B2 (pt)
EP (1) EP2723392B1 (pt)
JP (1) JP5799161B2 (pt)
KR (1) KR101721570B1 (pt)
CN (1) CN103458932B (pt)
AU (1) AU2012274234A1 (pt)
BR (1) BR112013023812A2 (pt)
CA (1) CA2827752C (pt)
MX (1) MX2013009212A (pt)
WO (1) WO2012177039A2 (pt)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101685646B1 (ko) * 2010-12-29 2016-12-13 한화케미칼 주식회사 홍합 접착단백질 모방을 통한 나노입자를 수계 매질에 분산시키는 생체적합성 분산 안정화제
CN106068128B (zh) * 2014-01-07 2020-04-10 卡罗比亚意大利（共同）股份公司 用儿茶酚功能化的磁性纳米颗粒、其制备和用途
KR101510835B1 (ko) * 2014-01-09 2015-04-10 원광대학교산학협력단 홍합 접착 단백질 유래 키토산올리고당 리간드 및 이를 포함하는 조영제
KR101508600B1 (ko) * 2014-01-09 2015-04-07 원광대학교산학협력단 생체유래 키토올리고당 리간드 및 이를 포함하는 조영제
CN104258421B (zh) * 2014-09-12 2016-09-21 温州大学 一种贵金属/顺磁金属复合纳米粒子及其应用
KR101720046B1 (ko) * 2014-09-26 2017-03-29 서울대학교산학협력단 광역학 치료용 자기조립형 약학 조성물
KR101765335B1 (ko) * 2014-09-26 2017-08-22 서울대학교산학협력단 암 세포 조영용 ｍｒｉ 조영제 조성물
KR101722503B1 (ko) * 2015-03-13 2017-04-04 포항공과대학교 산학협력단 홍합 접착 단백질을 이용한 약물전달용 pH-반응성 나노입자 및 이의 제조방법
CN105400517B (zh) * 2015-10-30 2018-03-13 玉林师范学院 检测镉离子的双功能磁性荧光探针制备方法及其应用
CN110496231B (zh) * 2018-05-16 2020-09-18 浙江大学 一种含有聚多巴氨基酸螯合三价铁离子的两亲性聚合物纳米胶束及应用
WO2020072840A1 (en) * 2018-10-03 2020-04-09 Prescient Pharma Llc Compositions and methods for isolating circulating cells
WO2023040037A1 (zh) * 2021-09-18 2023-03-23 中国科学院大学附属肿瘤医院 氧化铁纳米粒子在制备甲状旁腺和/或淋巴结显影剂中的应用

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JPS6323670A (ja) * 1986-04-25 1988-01-30 バイオ−ポリマ−ズ　インコ−ポレ−テツド 接着・被覆組成物とその使用方法
US4908404A (en) * 1988-08-22 1990-03-13 Biopolymers, Inc. Synthetic amino acid-and/or peptide-containing graft copolymers
JPH10120597A (ja) * 1996-10-22 1998-05-12 Eiken Chem Co Ltd リンパ節高集積性コロイド粒子
US20020012698A1 (en) * 1999-09-01 2002-01-31 Edmund Bauerlein Magnetosomes, method for making and using
EP1778298A4 (en) * 2004-04-01 2010-03-31 Univ Pennsylvania LIPOPROTEIN-NANO PLATFORMS
US20090280063A1 (en) 2008-05-09 2009-11-12 General Electric Company Novel pei-peg graft copolymer coating of iron oxide nanoparticles for inflammation imaging
EP2289553A1 (en) * 2009-09-01 2011-03-02 ETH Zurich Dispersant stabilization of inorganic non-metallic particles
JP2011079781A (ja) * 2009-10-08 2011-04-21 Keio Gijuku センチネルリンパ節の造影剤ないし同定剤、温熱療法剤
KR101685646B1 (ko) * 2010-12-29 2016-12-13 한화케미칼 주식회사 홍합 접착단백질 모방을 통한 나노입자를 수계 매질에 분산시키는 생체적합성 분산 안정화제

Also Published As

Publication number Publication date
WO2012177039A3 (en) 2013-04-04
KR101721570B1 (ko) 2017-03-30
JP5799161B2 (ja) 2015-10-21
US20140023594A1 (en) 2014-01-23
JP2014514301A (ja) 2014-06-19
AU2012274234A1 (en) 2013-08-22
US8906346B2 (en) 2014-12-09
CN103458932A (zh) 2013-12-18
CA2827752C (en) 2016-05-17
CA2827752A1 (en) 2012-12-27
WO2012177039A2 (en) 2012-12-27
MX2013009212A (es) 2013-08-29
CN103458932B (zh) 2015-12-09
EP2723392A2 (en) 2014-04-30
EP2723392B1 (en) 2016-09-28
KR20130008095A (ko) 2013-01-22
EP2723392A4 (en) 2014-12-17

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]