HK1223622A1 - 錳基磁共振造影劑 - Google Patents

錳基磁共振造影劑

Info

Publication number
HK1223622A1
HK1223622A1 HK16111714.4A HK16111714A HK1223622A1 HK 1223622 A1 HK1223622 A1 HK 1223622A1 HK 16111714 A HK16111714 A HK 16111714A HK 1223622 A1 HK1223622 A1 HK 1223622A1
Authority
HK
Hong Kong
Prior art keywords
manganese
magnetic resonance
contrast agents
based magnetic
resonance contrast
Prior art date
Application number
HK16111714.4A
Other languages
English (en)
Inventor
‧卡拉文
‧蓋爾
‧洛文
‧慕克吉
朱江
Original Assignee
Massachusetts Gen Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Gen Hospital filed Critical Massachusetts Gen Hospital
Publication of HK1223622A1 publication Critical patent/HK1223622A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0033—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
    • A61B5/0035—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for acquisition of images from more than one imaging mode, e.g. combining MRI and optical tomography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A61K49/16—Antibodies; Immunoglobulins; Fragments thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Soft Magnetic Materials (AREA)
HK16111714.4A 2013-01-07 2016-10-11 錳基磁共振造影劑 HK1223622A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361749614P 2013-01-07 2013-01-07
PCT/US2014/010486 WO2014107722A1 (en) 2013-01-07 2014-01-07 Manganese-based magnetic resonance contrast agents

Publications (1)

Publication Number Publication Date
HK1223622A1 true HK1223622A1 (zh) 2017-08-04

Family

ID=51062506

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16111714.4A HK1223622A1 (zh) 2013-01-07 2016-10-11 錳基磁共振造影劑

Country Status (15)

Country Link
US (2) US9944668B2 (zh)
EP (1) EP2941434B1 (zh)
CN (1) CN105492449B (zh)
CY (1) CY1124501T1 (zh)
DK (1) DK2941434T3 (zh)
ES (1) ES2871852T3 (zh)
HK (1) HK1223622A1 (zh)
HR (1) HRP20210723T1 (zh)
HU (1) HUE054111T2 (zh)
LT (1) LT2941434T (zh)
PL (1) PL2941434T3 (zh)
PT (1) PT2941434T (zh)
RS (1) RS61869B1 (zh)
SI (1) SI2941434T1 (zh)
WO (1) WO2014107722A1 (zh)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2941434B1 (en) 2013-01-07 2021-03-24 The General Hospital Corporation Manganese-based magnetic resonance contrast agents
US10233205B2 (en) 2015-08-07 2019-03-19 Auburn University Magnetic resonance imaging contrast agent capable of detecting hydrogen peroxide and reducing reactive oxygen species
JP2018523671A (ja) * 2015-08-13 2018-08-23 ザ ジェネラル ホスピタル コーポレイション 分子ｍｒイメージング用マンガン系キレートコンジュゲート
CN105424938A (zh) * 2015-11-09 2016-03-23 南昌大学 一种基于KMnF4纳米探针的NMR病毒快速检测方法
US11353533B2 (en) 2016-02-24 2022-06-07 Ohio State Innovation Foundation Methods and devices for contrast agent magnetic resonance imaging
CN106187800B (zh) * 2016-07-05 2018-04-24 川北医学院 一种含有邻二酚羟基的类edta配体和非钆磁共振造影剂及其制备方法
CN113372384B (zh) * 2020-02-25 2022-10-11 广州平澜医疗科技有限公司 磁共振造影剂及其制备方法和应用
CN111973572A (zh) * 2020-06-11 2020-11-24 浙江大学 一种基于锰基的树枝状大分子复合纳米材料、制备方法及应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4622420A (en) * 1980-03-18 1986-11-11 The Regents Of The University Of California Chelating agents and method
US4647447A (en) * 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
FI884376A (fi) 1987-09-25 1989-03-26 Salutar Inc Nya mn (ii)-koordinationskompositioner vid fotografering med nmr.
US4889931A (en) * 1988-09-27 1989-12-26 Salutar, Inc. Manganese (II) chelate manufacture
CN1687181A (zh) 2005-04-18 2005-10-26 南京大学 含二亚乙基三胺五乙酸的可生物降解聚酯大分子配体及其制法和用途
GB0700999D0 (en) 2007-01-18 2007-02-28 Ntnu Technology Transfer As Magnetic resonance imaging
EP2941434B1 (en) 2013-01-07 2021-03-24 The General Hospital Corporation Manganese-based magnetic resonance contrast agents

Also Published As

Publication number Publication date
CY1124501T1 (el) 2022-07-22
SI2941434T1 (sl) 2021-08-31
CN105492449B (zh) 2018-02-27
HUE054111T2 (hu) 2021-08-30
RS61869B1 (sr) 2021-06-30
WO2014107722A1 (en) 2014-07-10
ES2871852T3 (es) 2021-11-02
PT2941434T (pt) 2021-05-28
EP2941434B1 (en) 2021-03-24
US20150336996A1 (en) 2015-11-26
US20150336997A1 (en) 2015-11-26
EP2941434A4 (en) 2016-08-24
CN105492449A (zh) 2016-04-13
PL2941434T3 (pl) 2021-09-06
EP2941434A1 (en) 2015-11-11
US9944668B2 (en) 2018-04-17
HRP20210723T1 (hr) 2021-06-11
DK2941434T3 (da) 2021-05-25
LT2941434T (lt) 2021-06-10

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