PT2941434T - Agentes de contraste para ressonância magnética à base de manganês - Google Patents

Agentes de contraste para ressonância magnética à base de manganês

Info

Publication number
PT2941434T
PT2941434T PT147351662T PT14735166T PT2941434T PT 2941434 T PT2941434 T PT 2941434T PT 147351662 T PT147351662 T PT 147351662T PT 14735166 T PT14735166 T PT 14735166T PT 2941434 T PT2941434 T PT 2941434T
Authority
PT
Portugal
Prior art keywords
manganese
magnetic resonance
contrast agents
based magnetic
resonance contrast
Prior art date
Application number
PT147351662T
Other languages
English (en)
Original Assignee
Massachusetts Gen Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Gen Hospital filed Critical Massachusetts Gen Hospital
Publication of PT2941434T publication Critical patent/PT2941434T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0033—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
    • A61B5/0035—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for acquisition of images from more than one imaging mode, e.g. combining MRI and optical tomography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A61K49/16—Antibodies; Immunoglobulins; Fragments thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Immunology (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Soft Magnetic Materials (AREA)
PT147351662T 2013-01-07 2014-01-07 Agentes de contraste para ressonância magnética à base de manganês PT2941434T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361749614P 2013-01-07 2013-01-07

Publications (1)

Publication Number Publication Date
PT2941434T true PT2941434T (pt) 2021-05-28

Family

ID=51062506

Family Applications (1)

Application Number Title Priority Date Filing Date
PT147351662T PT2941434T (pt) 2013-01-07 2014-01-07 Agentes de contraste para ressonância magnética à base de manganês

Country Status (15)

Country Link
US (2) US9944668B2 (pt)
EP (1) EP2941434B1 (pt)
CN (1) CN105492449B (pt)
CY (1) CY1124501T1 (pt)
DK (1) DK2941434T3 (pt)
ES (1) ES2871852T3 (pt)
HK (1) HK1223622A1 (pt)
HR (1) HRP20210723T1 (pt)
HU (1) HUE054111T2 (pt)
LT (1) LT2941434T (pt)
PL (1) PL2941434T3 (pt)
PT (1) PT2941434T (pt)
RS (1) RS61869B1 (pt)
SI (1) SI2941434T1 (pt)
WO (1) WO2014107722A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2941434B1 (en) 2013-01-07 2021-03-24 The General Hospital Corporation Manganese-based magnetic resonance contrast agents
US10233205B2 (en) 2015-08-07 2019-03-19 Auburn University Magnetic resonance imaging contrast agent capable of detecting hydrogen peroxide and reducing reactive oxygen species
JP7523883B2 (ja) * 2015-08-13 2024-07-29 ザ ジェネラル ホスピタル コーポレイション 分子ｍｒイメージング用マンガン系キレートコンジュゲート
CN105424938A (zh) * 2015-11-09 2016-03-23 南昌大学 一种基于KMnF4纳米探针的NMR病毒快速检测方法
US11353533B2 (en) 2016-02-24 2022-06-07 Ohio State Innovation Foundation Methods and devices for contrast agent magnetic resonance imaging
CN106187800B (zh) * 2016-07-05 2018-04-24 川北医学院 一种含有邻二酚羟基的类edta配体和非钆磁共振造影剂及其制备方法
CN113372384B (zh) * 2020-02-25 2022-10-11 广州平澜医疗科技有限公司 磁共振造影剂及其制备方法和应用
CN111973572A (zh) * 2020-06-11 2020-11-24 浙江大学 一种基于锰基的树枝状大分子复合纳米材料、制备方法及应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4622420A (en) 1980-03-18 1986-11-11 The Regents Of The University Of California Chelating agents and method
US4647447A (en) * 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
NO884225L (no) 1987-09-25 1989-03-28 Salutar Inc Nmr-bildedannelse mn(ii)- koordinasjonsforbindelser.
US4889931A (en) * 1988-09-27 1989-12-26 Salutar, Inc. Manganese (II) chelate manufacture
CN1687181A (zh) * 2005-04-18 2005-10-26 南京大学 含二亚乙基三胺五乙酸的可生物降解聚酯大分子配体及其制法和用途
GB0700999D0 (en) * 2007-01-18 2007-02-28 Ntnu Technology Transfer As Magnetic resonance imaging
EP2941434B1 (en) 2013-01-07 2021-03-24 The General Hospital Corporation Manganese-based magnetic resonance contrast agents

Also Published As

Publication number Publication date
EP2941434B1 (en) 2021-03-24
ES2871852T3 (es) 2021-11-02
HUE054111T2 (hu) 2021-08-30
EP2941434A1 (en) 2015-11-11
HRP20210723T1 (hr) 2021-06-11
RS61869B1 (sr) 2021-06-30
HK1223622A1 (zh) 2017-08-04
US20150336997A1 (en) 2015-11-26
EP2941434A4 (en) 2016-08-24
US9944668B2 (en) 2018-04-17
PL2941434T3 (pl) 2021-09-06
CN105492449A (zh) 2016-04-13
DK2941434T3 (da) 2021-05-25
CY1124501T1 (el) 2022-07-22
SI2941434T1 (sl) 2021-08-31
LT2941434T (lt) 2021-06-10
CN105492449B (zh) 2018-02-27
US20150336996A1 (en) 2015-11-26
WO2014107722A1 (en) 2014-07-10

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