BR112013017154A8 - Uso de fitocanabinóide canabidiol (cbd) em combinação com um fármaco antiepiléptico padrão (saed) no tratamento de epilepsia - Google Patents
Uso de fitocanabinóide canabidiol (cbd) em combinação com um fármaco antiepiléptico padrão (saed) no tratamento de epilepsiaInfo
- Publication number
- BR112013017154A8 BR112013017154A8 BR112013017154A BR112013017154A BR112013017154A8 BR 112013017154 A8 BR112013017154 A8 BR 112013017154A8 BR 112013017154 A BR112013017154 A BR 112013017154A BR 112013017154 A BR112013017154 A BR 112013017154A BR 112013017154 A8 BR112013017154 A8 BR 112013017154A8
- Authority
- BR
- Brazil
- Prior art keywords
- saed
- cannabidiol
- cbd
- epilepsy
- treatment
- Prior art date
Links
- QHMBSVQNZZTUGM-UHFFFAOYSA-N Trans-Cannabidiol Natural products OC1=CC(CCCCC)=CC(O)=C1C1C(C(C)=C)CCC(C)=C1 QHMBSVQNZZTUGM-UHFFFAOYSA-N 0.000 title abstract 6
- QHMBSVQNZZTUGM-ZWKOTPCHSA-N cannabidiol Chemical compound OC1=CC(CCCCC)=CC(O)=C1[C@H]1[C@H](C(C)=C)CCC(C)=C1 QHMBSVQNZZTUGM-ZWKOTPCHSA-N 0.000 title abstract 6
- 229950011318 cannabidiol Drugs 0.000 title abstract 6
- ZTGXAWYVTLUPDT-UHFFFAOYSA-N cannabidiol Natural products OC1=CC(CCCCC)=CC(O)=C1C1C(C(C)=C)CC=C(C)C1 ZTGXAWYVTLUPDT-UHFFFAOYSA-N 0.000 title abstract 6
- PCXRACLQFPRCBB-ZWKOTPCHSA-N dihydrocannabidiol Natural products OC1=CC(CCCCC)=CC(O)=C1[C@H]1[C@H](C(C)C)CCC(C)=C1 PCXRACLQFPRCBB-ZWKOTPCHSA-N 0.000 title abstract 6
- 239000001961 anticonvulsive agent Substances 0.000 title abstract 3
- 229960003965 antiepileptics Drugs 0.000 title abstract 3
- 206010015037 epilepsy Diseases 0.000 title abstract 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 2
- 239000011734 sodium Substances 0.000 abstract 2
- 229910052708 sodium Inorganic materials 0.000 abstract 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- 108090000312 Calcium Channels Proteins 0.000 abstract 1
- 102000003922 Calcium Channels Human genes 0.000 abstract 1
- 108010052164 Sodium Channels Proteins 0.000 abstract 1
- 102000018674 Sodium Channels Human genes 0.000 abstract 1
- 230000036982 action potential Effects 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229960002767 ethosuximide Drugs 0.000 abstract 1
- HAPOVYFOVVWLRS-UHFFFAOYSA-N ethosuximide Chemical compound CCC1(C)CC(=O)NC1=O HAPOVYFOVVWLRS-UHFFFAOYSA-N 0.000 abstract 1
- 229960003692 gamma aminobutyric acid Drugs 0.000 abstract 1
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 abstract 1
- 230000001537 neural effect Effects 0.000 abstract 1
- 230000008062 neuronal firing Effects 0.000 abstract 1
- AEQFSUDEHCCHBT-UHFFFAOYSA-M sodium valproate Chemical compound [Na+].CCCC(C([O-])=O)CCC AEQFSUDEHCCHBT-UHFFFAOYSA-M 0.000 abstract 1
- 230000001052 transient effect Effects 0.000 abstract 1
- 238000000101 transmission high energy electron diffraction Methods 0.000 abstract 1
- 229940102566 valproate Drugs 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
- A61K31/515—Barbituric acids; Derivatives thereof, e.g. sodium pentobarbital
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
USO DE FITOCANABINÓIDE CANABIDIOL (CBD) EM COMBINAÇÃO COM UM FÁRMACO ANTIEPILÉPTICO PADRÃO (SAED) NO TRATAMENTO DE EPILEPSIA A invenção relaciona-se com a utilização de canabidiol (CBD), a uma dose maior do que 300mg/dia, em combinação com um fármaco antiepiléptico padrão (SAED) , que atua através de canais de sódio ou cálcio, para utilização no tratamento de epilepsia. O SAED, de preferência, modifica as correntes de cálcio neuronais de baixo limiar ou transitórias, ou ?reduz disparo neuronal de alta frequência e potenciais de ação dependentes de sódio e aumenta os efeitos do GABA. SAEDs preferidos são etossuximida e valproato.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1100043.7A GB2487712B (en) | 2011-01-04 | 2011-01-04 | Use of the phytocannabinoid cannabidiol (CBD) in combination with a standard anti-epileptic drug (SAED) in the treatment of epilepsy |
| PCT/GB2012/050002 WO2012093255A1 (en) | 2011-01-04 | 2012-01-03 | Use of the phytocannabinoid cannabidiol (cbd) in combination with a standard anti-epileptic drug (saed) in the treatment of epilepsy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112013017154A2 BR112013017154A2 (pt) | 2016-09-20 |
| BR112013017154A8 true BR112013017154A8 (pt) | 2018-04-03 |
Family
ID=43639013
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112013017154A BR112013017154A8 (pt) | 2011-01-04 | 2012-01-03 | Uso de fitocanabinóide canabidiol (cbd) em combinação com um fármaco antiepiléptico padrão (saed) no tratamento de epilepsia |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US20140155456A9 (pt) |
| EP (2) | EP2661263B1 (pt) |
| JP (1) | JP6076259B2 (pt) |
| KR (1) | KR101853634B1 (pt) |
| CN (2) | CN103391775A (pt) |
| AR (1) | AR084559A1 (pt) |
| AU (1) | AU2012204800C1 (pt) |
| BR (1) | BR112013017154A8 (pt) |
| CA (1) | CA2822907C (pt) |
| CO (1) | CO6731122A2 (pt) |
| DK (1) | DK2661263T3 (pt) |
| ES (1) | ES2877502T3 (pt) |
| GB (1) | GB2487712B (pt) |
| IL (1) | IL227298A (pt) |
| MX (1) | MX349027B (pt) |
| RU (1) | RU2013136378A (pt) |
| SG (1) | SG191835A1 (pt) |
| TW (1) | TWI532479B (pt) |
| WO (1) | WO2012093255A1 (pt) |
| ZA (1) | ZA201305508B (pt) |
Families Citing this family (53)
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| EP1811983B1 (en) * | 2004-11-16 | 2020-10-07 | GW Pharma Limited | New use for cannabinoid |
| GB0425248D0 (en) | 2004-11-16 | 2004-12-15 | Gw Pharma Ltd | New use for cannabinoid |
| GB2471523A (en) | 2009-07-03 | 2011-01-05 | Gw Pharma Ltd | Use of tetrahydrocannibivarin (THCV) and optionally cannabidiol (CBD) in the treatment of epilepsy |
| TWI583374B (zh) | 2010-03-30 | 2017-05-21 | Ｇｗ伐瑪有限公司 | 使用植物大麻素次大麻二酚（ｃｂｄｖ）來治療癲癇之用途 |
| GB2514054A (en) * | 2011-09-29 | 2014-11-12 | Gw Pharma Ltd | A pharmaceutical composition comprising the phytocannabinoids cannabidivarin (CBDV) and cannabidiol (CBD) |
| US9549909B2 (en) | 2013-05-03 | 2017-01-24 | The Katholieke Universiteit Leuven | Method for the treatment of dravet syndrome |
| US9820988B2 (en) * | 2014-03-24 | 2017-11-21 | Boehringer Ingelheim Vetmedica Gmbh | Treatment of epileptic disorders in feline animals |
| US11911361B2 (en) | 2014-05-29 | 2024-02-27 | Radius Pharmaceuticals, Inc. | Stable cannabinoid formulations |
| GB2530001B (en) | 2014-06-17 | 2019-01-16 | Gw Pharma Ltd | Use of cannabidiol in the reduction of convulsive seizure frequency in treatment-resistant epilepsy |
| GB2527599A (en) * | 2014-06-27 | 2015-12-30 | Gw Pharma Ltd | Use of 7-OH-Cannabidiol (7-OH-CBD) and/or 7-OH-Cannabidivarin (7-OH-CBDV) in the treatment of epilepsy |
| EP3193862B1 (en) | 2014-09-16 | 2023-10-18 | Igc Pharma Ip, Llc | Topical cannabinoid composition for treating arthritic pain |
| GB2531282A (en) | 2014-10-14 | 2016-04-20 | Gw Pharma Ltd | Use of cannabinoids in the treatment of epilepsy |
| GB2531281A (en) | 2014-10-14 | 2016-04-20 | Gw Pharma Ltd | Use of cannabidiol in the treatment of intractable epilepsy |
| GB2531278A (en) | 2014-10-14 | 2016-04-20 | Gw Pharma Ltd | Use of cannabidiol in the treatment of intractable epilepsy |
| CA2974895A1 (en) | 2015-01-25 | 2016-07-28 | India Globalization Capital, Inc. | Composition and method for treating seizure disorders |
| GB2539472A (en) * | 2015-06-17 | 2016-12-21 | Gw Res Ltd | Use of cannabinoids in the treatment of epilepsy |
| GB2541191A (en) * | 2015-08-10 | 2017-02-15 | Gw Pharma Ltd | Use of cannabinoids in the treatment of epilepsy |
| US10596159B2 (en) | 2015-08-12 | 2020-03-24 | India Globalization Capital, Inc. | Method and composition for treating cachexia and eating disorders |
| EP3393470B1 (en) | 2015-12-22 | 2021-01-20 | Zogenix International Limited | Metabolism resistant fenfluramine analogs and methods of using the same |
| ES2861774T3 (es) | 2015-12-22 | 2021-10-06 | Zogenix International Ltd | Composiciones de fenfluramina y procedimientos para prepararlas |
| GB2548873B (en) * | 2016-03-31 | 2020-12-02 | Gw Res Ltd | Use of Cannabidiol in the Treatment of SturgeWeber Syndrome |
| CA3027862A1 (en) | 2016-06-15 | 2017-12-21 | India Globalization Capital, Inc. | Method and composition for treating seizure disorders |
| JP2019524655A (ja) | 2016-06-29 | 2019-09-05 | キャンサイエンス イノベーションズ インコーポレーテッドＣａｎｎｓｃｉｅｎｃｅ Ｉｎｎｏｖａｔｉｏｎｓ Ｉｎｃ． | 脱炭酸大麻樹脂、その使用、及びそれを製造する方法 |
| GB2551986A (en) | 2016-07-01 | 2018-01-10 | Gw Res Ltd | Parenteral formulations |
| GB2551987A (en) | 2016-07-01 | 2018-01-10 | Gw Res Ltd | Oral cannabinoid formulations |
| EP3518975A1 (en) | 2016-08-24 | 2019-08-07 | Zogenix International Limited | Formulation for inhibiting formation of 5-ht 2b agonists and methods of using same |
| GB2553139A (en) | 2016-08-25 | 2018-02-28 | Gw Res Ltd | Use of cannabinoids in the treatment of multiple myeloma |
| GB2557921A (en) | 2016-12-16 | 2018-07-04 | Gw Res Ltd | Use of cannabinoids in the treatment of angelman syndrome |
| CN108236608B (zh) * | 2016-12-27 | 2020-05-08 | 汉义生物科技（北京）有限公司 | 大麻二酚与氨己烯酸的药物组合物及其用途 |
| CN108245517B (zh) * | 2016-12-29 | 2020-05-08 | 汉义生物科技（北京）有限公司 | 大麻二酚与拉莫三嗪的药物组合物及其用途 |
| CN108245510B (zh) * | 2016-12-29 | 2020-11-20 | 汉义生物科技（北京）有限公司 | 大麻二酚与乙丙酰脲类抗癫痫药物的组合物及其用途 |
| CN108245499B (zh) * | 2016-12-29 | 2020-11-20 | 汉义生物科技（北京）有限公司 | 大麻二酚与双链脂肪酸类抗癫痫药物的组合物及其用途 |
| GB2559774B (en) | 2017-02-17 | 2021-09-29 | Gw Res Ltd | Oral cannabinoid formulations |
| US10682317B2 (en) | 2017-09-26 | 2020-06-16 | Zogenix International Limited | Ketogenic diet compatible fenfluramine formulation |
| GB201715919D0 (en) * | 2017-09-29 | 2017-11-15 | Gw Res Ltd | use of cannabinoids in the treatment of epilepsy |
| GB2569961B (en) | 2018-01-03 | 2021-12-22 | Gw Res Ltd | Pharmaceutical |
| GB2572737A (en) * | 2018-01-24 | 2019-10-16 | Gw Res Ltd | Use of cannabinoids in the treatment of epilepsy |
| GB201806953D0 (en) | 2018-04-27 | 2018-06-13 | Gw Res Ltd | Cannabidiol Preparations |
| CA3097335A1 (en) | 2018-05-11 | 2019-11-14 | Zogenix International Limited | Compositions and methods for treating seizure-induced sudden death |
| EP3806835A1 (en) | 2018-06-14 | 2021-04-21 | Zogenix International Limited | Compositions and methods for treating respiratory depression with fenfluramine |
| GB2580881A (en) | 2018-11-30 | 2020-08-05 | Gw Res Ltd | Use of cannabinoids in the treatment of epilepsy |
| GB2581517A (en) | 2019-02-22 | 2020-08-26 | Gw Res Ltd | Use of cannabinoids in the treatment of epilepsy |
| GB2583526A (en) | 2019-05-03 | 2020-11-04 | Gw Res Ltd | Use of cannabidiol in the treatment of tuberous sclerosis complex |
| CN110101804A (zh) * | 2019-05-30 | 2019-08-09 | 厦门梓素生物科技有限公司 | 一种含大麻二酚提取物的癫痫药物组合及其制备方法 |
| EP4031120A4 (en) * | 2019-09-17 | 2023-08-02 | Zynerba Pharmaceuticals, Inc. | TREATMENT OF SYNGAP1 ENCEPHALOPATHY |
| GB2588460A (en) * | 2019-10-25 | 2021-04-28 | Gw Res Ltd | Use of cannabidiol preparations in the treatment of temporal lobe epilepsy |
| GB202002754D0 (en) | 2020-02-27 | 2020-04-15 | Gw Res Ltd | Methods of treating tuberous sclerosis complex with cannabidiol and everolimus |
| CN113521050B (zh) * | 2020-04-20 | 2023-05-09 | 铸鼎(北京)医学技术发展有限公司 | 含有大麻二酚的组合物及其在治疗全身炎症反应综合征中的用途 |
| EP3912485A1 (en) | 2020-05-18 | 2021-11-24 | Del-Vis Sp. z o.o. | Cigarette product and a method for manufacturing the product |
| US11612574B2 (en) | 2020-07-17 | 2023-03-28 | Zogenix International Limited | Method of treating patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) |
| GB2597296A (en) * | 2020-07-20 | 2022-01-26 | Gw Res Ltd | Use of cannabidiol in the treatment of seizures associated with rare epilepsy syndromes related to brain injury |
| US11160757B1 (en) | 2020-10-12 | 2021-11-02 | GW Research Limited | pH dependent release coated microparticle cannabinoid formulations |
| GB2604132A (en) | 2021-02-25 | 2022-08-31 | Gw Res Ltd | Use of cannabidiol and clobazam in the treatment of childhood-onset epilepsy syndromes |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1140635B (de) | 1959-10-24 | 1962-12-06 | Ellenberger & Poensgen | Mehrpoliger Motorschutzschalter |
| SE9802331L (sv) * | 1998-06-29 | 1999-12-30 | Ericsson Telefon Ab L M | Metod och arrangemang avseende service vid ett intelligent nät |
| DE10051427C1 (de) * | 2000-10-17 | 2002-06-13 | Adam Mueller | Verfahren zur Herstellung eines Tetrahydrocannabinol- und Cannabidiol-haltigen Extraktes aus Cannabis-Pflanzenmaterial sowie Cannabis-Extrakte |
| WO2002064109A2 (en) | 2001-02-14 | 2002-08-22 | Gw Pharma Limited | Mucoadhesive pharmaceutical formulations |
| US7025992B2 (en) * | 2001-02-14 | 2006-04-11 | Gw Pharma Limited | Pharmaceutical formulations |
| GB2381450B (en) * | 2001-10-31 | 2006-05-31 | Gw Pharma Ltd | Compositions for administration of natural or synthetic cannabinoids by vaporisation |
| EP1811983B1 (en) | 2004-11-16 | 2020-10-07 | GW Pharma Limited | New use for cannabinoid |
| GB2450753B (en) | 2007-07-06 | 2012-07-18 | Gw Pharma Ltd | New Pharmaceutical formulation |
| GB2471523A (en) * | 2009-07-03 | 2011-01-05 | Gw Pharma Ltd | Use of tetrahydrocannibivarin (THCV) and optionally cannabidiol (CBD) in the treatment of epilepsy |
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2011
- 2011-01-04 GB GB1100043.7A patent/GB2487712B/en active Active
- 2011-12-08 TW TW100145265A patent/TWI532479B/zh active
- 2011-12-22 AR ARP110104907A patent/AR084559A1/es unknown
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2012
- 2012-01-03 CN CN2012800045726A patent/CN103391775A/zh active Pending
- 2012-01-03 EP EP12700294.7A patent/EP2661263B1/en active Active
- 2012-01-03 ES ES12700294T patent/ES2877502T3/es active Active
- 2012-01-03 CA CA2822907A patent/CA2822907C/en active Active
- 2012-01-03 WO PCT/GB2012/050002 patent/WO2012093255A1/en active Application Filing
- 2012-01-03 KR KR1020137020543A patent/KR101853634B1/ko active IP Right Grant
- 2012-01-03 EP EP20193228.2A patent/EP3791868A1/en active Pending
- 2012-01-03 CN CN201710873483.XA patent/CN107510846A/zh active Pending
- 2012-01-03 BR BR112013017154A patent/BR112013017154A8/pt not_active Application Discontinuation
- 2012-01-03 SG SG2013051487A patent/SG191835A1/en unknown
- 2012-01-03 RU RU2013136378/15A patent/RU2013136378A/ru not_active Application Discontinuation
- 2012-01-03 DK DK12700294.7T patent/DK2661263T3/da active
- 2012-01-03 MX MX2013007609A patent/MX349027B/es active IP Right Grant
- 2012-01-03 JP JP2013546766A patent/JP6076259B2/ja active Active
- 2012-01-03 US US13/977,766 patent/US20140155456A9/en not_active Abandoned
- 2012-01-03 AU AU2012204800A patent/AU2012204800C1/en active Active
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2013
- 2013-07-02 IL IL227298A patent/IL227298A/en active IP Right Grant
- 2013-07-19 ZA ZA2013/05508A patent/ZA201305508B/en unknown
- 2013-07-23 CO CO13173886A patent/CO6731122A2/es unknown
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2022
- 2022-01-26 US US17/585,415 patent/US20220395470A1/en active Pending
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