BR112013011693A2 - derivados de ácido hidroxâmico e seu uso no tratamento de infecções por bactérias - Google Patents
derivados de ácido hidroxâmico e seu uso no tratamento de infecções por bactériasInfo
- Publication number
- BR112013011693A2 BR112013011693A2 BR112013011693A BR112013011693A BR112013011693A2 BR 112013011693 A2 BR112013011693 A2 BR 112013011693A2 BR 112013011693 A BR112013011693 A BR 112013011693A BR 112013011693 A BR112013011693 A BR 112013011693A BR 112013011693 A2 BR112013011693 A2 BR 112013011693A2
- Authority
- BR
- Brazil
- Prior art keywords
- treatment
- acid derivatives
- bacterial infections
- hydroxamic acid
- hydroxamic
- Prior art date
Links
- NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical compound C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 title 1
- 208000035143 Bacterial infection Diseases 0.000 title 1
- 239000002253 acid Substances 0.000 title 1
- 208000022362 bacterial infectious disease Diseases 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41231110P | 2010-11-10 | 2010-11-10 | |
| PCT/US2011/059280 WO2012154204A1 (en) | 2010-11-10 | 2011-11-04 | Hydroxamic acid derivatives and their use in the treatment of bacterial infections |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112013011693A2 true BR112013011693A2 (pt) | 2016-08-09 |
Family
ID=46317476
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112013011693A BR112013011693A2 (pt) | 2010-11-10 | 2011-11-04 | derivados de ácido hidroxâmico e seu uso no tratamento de infecções por bactérias |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP2638006A1 (https=) |
| JP (1) | JP2014501716A (https=) |
| KR (1) | KR20140023869A (https=) |
| CN (1) | CN103298780A (https=) |
| AR (1) | AR083760A1 (https=) |
| AU (1) | AU2011367819A1 (https=) |
| BR (1) | BR112013011693A2 (https=) |
| CA (1) | CA2817211A1 (https=) |
| EA (1) | EA201390626A1 (https=) |
| IL (1) | IL226270A0 (https=) |
| MX (1) | MX2013005200A (https=) |
| SG (1) | SG190243A1 (https=) |
| TW (1) | TW201249786A (https=) |
| WO (1) | WO2012154204A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5539864B2 (ja) | 2007-06-12 | 2014-07-02 | アカオゲン，インコーポレーテッド | 抗菌剤 |
| EP2847162A1 (en) * | 2012-05-09 | 2015-03-18 | Achaogen, Inc. | Antibacterial agents |
| WO2013170165A1 (en) | 2012-05-10 | 2013-11-14 | Achaogen, Inc. | Antibacterial agents |
| AR097617A1 (es) | 2013-09-13 | 2016-04-06 | Actelion Pharmaceuticals Ltd | Derivados antibacterianos del 2h-indazol |
| AU2014368619B2 (en) | 2013-12-19 | 2018-11-22 | Idorsia Pharmaceuticals Ltd | Antibacterial 1H-indazole and 1H-indole derivatives |
| AR099612A1 (es) | 2014-03-04 | 2016-08-03 | Actelion Pharmaceuticals Ltd | Derivados antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona |
| US9539305B1 (en) | 2014-03-14 | 2017-01-10 | Fleurir Abx Llc | Pristinamycin compositions, LpxC compositions, their improvements, and combinations thereof |
| ES2687040T3 (es) | 2014-05-16 | 2018-10-23 | Idorsia Pharmaceuticals Ltd | Derivados antibacterianos de quinazolin4(3H)ona |
| SG11201703992YA (en) | 2014-11-19 | 2017-06-29 | Actelion Pharmaceuticals Ltd | Antibacterial benzothiazole derivatives |
| HRP20192009T1 (hr) | 2014-12-16 | 2020-02-07 | Novartis Ag | Spojevi izoksazol hidroksamske kiseline kao inhibitori lpxc-a |
| EP3448375B1 (en) | 2016-04-25 | 2023-09-27 | Duke University | Benzoylglycine derivatives and methods of making and using same |
| SG11201810656WA (en) | 2016-06-14 | 2018-12-28 | Novartis Ag | Crystalline form of (r)-4-(5-(cyclopropylethynyl)isoxazol-3-yl)-n-hydroxy-2-methyl-2-(methylsulfonyl)butanamide as an antibacterial agent |
| TW201803847A (zh) | 2016-06-23 | 2018-02-01 | 美商爾察禎有限公司 | 抗菌劑 |
| WO2019154412A1 (zh) * | 2018-02-10 | 2019-08-15 | 山东亨利医药科技有限责任公司 | 作为抗菌素的化合物 |
| CN110563611B (zh) * | 2019-09-19 | 2021-02-02 | 中国医学科学院医药生物技术研究所 | 一种异羟肟酸类衍生物及其制备方法和应用 |
| CN113957098A (zh) * | 2021-09-13 | 2022-01-21 | 湖南工业大学 | 普罗威登斯属细菌菌株在制备二价锰氧化剂中的应用 |
| CN116730870B (zh) | 2023-08-08 | 2023-10-13 | 中国医学科学院医药生物技术研究所 | 异羟肟酸类化合物或其可药用盐、及其用途和制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5925659A (en) | 1996-05-07 | 1999-07-20 | Merck & Co., Inc. | Antibacterial agents |
| US6541276B2 (en) | 1996-10-28 | 2003-04-01 | Versicor, Inc. | Methods for solid-phase synthesis of hydroxylamine compounds and derivatives and combinatorial libraries thereof |
| EP1169031A1 (en) | 1999-04-09 | 2002-01-09 | British Biotech Pharmaceuticals Limited | Antimicrobial agents |
| CA2851462A1 (en) * | 2003-01-08 | 2004-07-29 | University Of Washington | Antibacterial agents |
| DE102006032709A1 (de) | 2006-07-14 | 2008-01-17 | BSH Bosch und Siemens Hausgeräte GmbH | Luftschallgedämmte Lebensmittelmühle |
| CN101209974A (zh) * | 2006-12-31 | 2008-07-02 | 天津药物研究院 | 异羟肟酸类衍生物及其用途 |
| JP5539864B2 (ja) * | 2007-06-12 | 2014-07-02 | アカオゲン，インコーポレーテッド | 抗菌剤 |
| WO2011005355A1 (en) * | 2009-05-07 | 2011-01-13 | Achaogen, Inc. | Combinations comprising a lpxc inhibitor and an antibiotic for use in the treatment of infections caused by gram-negative bacteria |
| CA2796750C (en) * | 2010-04-20 | 2017-09-19 | Taisho Pharmaceutical Co., Ltd. | Novel hydroxamic acid derivative |
-
2011
- 2011-11-04 EA EA201390626A patent/EA201390626A1/ru unknown
- 2011-11-04 TW TW100140449A patent/TW201249786A/zh unknown
- 2011-11-04 EP EP11849908.6A patent/EP2638006A1/en not_active Withdrawn
- 2011-11-04 CA CA2817211A patent/CA2817211A1/en not_active Abandoned
- 2011-11-04 WO PCT/US2011/059280 patent/WO2012154204A1/en not_active Ceased
- 2011-11-04 MX MX2013005200A patent/MX2013005200A/es not_active Application Discontinuation
- 2011-11-04 BR BR112013011693A patent/BR112013011693A2/pt not_active IP Right Cessation
- 2011-11-04 AR ARP110104117A patent/AR083760A1/es not_active Application Discontinuation
- 2011-11-04 JP JP2013538794A patent/JP2014501716A/ja active Pending
- 2011-11-04 CN CN2011800639128A patent/CN103298780A/zh active Pending
- 2011-11-04 KR KR1020137012799A patent/KR20140023869A/ko not_active Withdrawn
- 2011-11-04 AU AU2011367819A patent/AU2011367819A1/en not_active Abandoned
- 2011-11-04 SG SG2013036272A patent/SG190243A1/en unknown
-
2013
- 2013-05-09 IL IL226270A patent/IL226270A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN103298780A (zh) | 2013-09-11 |
| TW201249786A (en) | 2012-12-16 |
| MX2013005200A (es) | 2013-06-28 |
| AU2011367819A1 (en) | 2013-05-02 |
| CA2817211A1 (en) | 2012-11-15 |
| SG190243A1 (en) | 2013-06-28 |
| KR20140023869A (ko) | 2014-02-27 |
| IL226270A0 (en) | 2013-07-31 |
| EA201390626A1 (ru) | 2013-12-30 |
| EP2638006A1 (en) | 2013-09-18 |
| WO2012154204A1 (en) | 2012-11-15 |
| JP2014501716A (ja) | 2014-01-23 |
| AR083760A1 (es) | 2013-03-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2385 DE 20-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |