BR112013009029B1 - Métodos e composições para inibição de polimerase - Google Patents

Métodos e composições para inibição de polimerase Download PDF

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Publication number
BR112013009029B1
BR112013009029B1 BR112013009029-4A BR112013009029A BR112013009029B1 BR 112013009029 B1 BR112013009029 B1 BR 112013009029B1 BR 112013009029 A BR112013009029 A BR 112013009029A BR 112013009029 B1 BR112013009029 B1 BR 112013009029B1
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Prior art keywords
virus
influenza
viral
compound
use according
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BR112013009029-4A
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English (en)
Portuguese (pt)
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BR112013009029A2 (pt
Inventor
Shanta Bantia
Pravin L. Kotian
Yarlagadda S. Babu
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Biocryst Pharmaceuticals, Inc.
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Publication of BR112013009029A2 publication Critical patent/BR112013009029A2/pt
Publication of BR112013009029B1 publication Critical patent/BR112013009029B1/pt

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/06Heterocyclic radicals
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Emergency Medicine (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
BR112013009029-4A 2010-10-15 2011-10-14 Métodos e composições para inibição de polimerase BR112013009029B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US39352210P 2010-10-15 2010-10-15
US61/393,522 2010-10-15
US201161492054P 2011-06-01 2011-06-01
US61/492,054 2011-06-01
PCT/US2011/056421 WO2012051570A1 (en) 2010-10-15 2011-10-14 Methods and compositions for inhibition of polymerase

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BR112013009029A2 BR112013009029A2 (pt) 2018-06-19
BR112013009029B1 true BR112013009029B1 (pt) 2021-06-29

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US (5) US20130331404A1 (enExample)
EP (3) EP2627334B1 (enExample)
JP (2) JP5902698B2 (enExample)
KR (1) KR101850925B1 (enExample)
CN (1) CN103429245B (enExample)
AU (2) AU2011315902B2 (enExample)
BR (1) BR112013009029B1 (enExample)
CA (1) CA2813783C (enExample)
CY (1) CY1119880T1 (enExample)
DK (2) DK2627334T3 (enExample)
ES (2) ES2536831T3 (enExample)
HR (2) HRP20150487T1 (enExample)
HU (1) HUE036387T2 (enExample)
IL (1) IL225672B (enExample)
LT (1) LT2898885T (enExample)
MX (1) MX348759B (enExample)
PL (2) PL2898885T3 (enExample)
PT (2) PT2627334E (enExample)
RS (2) RS54072B1 (enExample)
RU (3) RU2718690C2 (enExample)
SI (2) SI2898885T1 (enExample)
SM (2) SMT201800064T1 (enExample)
WO (1) WO2012051570A1 (enExample)

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KR102871928B1 (ko) * 2021-06-25 2025-10-20 전남대학교 산학협력단 지방분해효소 억제제를 포함하는 rna 바이러스 감염증 예방 또는 치료용 약제학적 조성물
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JP2013544788A (ja) 2013-12-19
RU2718690C2 (ru) 2020-04-13
US9492452B2 (en) 2016-11-15
RU2016134401A3 (enExample) 2020-01-24
US20150051230A1 (en) 2015-02-19
SI2627334T1 (sl) 2015-08-31
MX2013003938A (es) 2013-07-05
CN103429245B (zh) 2016-10-05
DK2898885T3 (en) 2018-02-05
HRP20150487T1 (hr) 2015-08-28
EP3345605B1 (en) 2019-11-20
EP3345605A1 (en) 2018-07-11
IL225672A0 (en) 2013-06-27
HK1257363A1 (en) 2019-10-18
ES2657687T3 (es) 2018-03-06
EP2898885B1 (en) 2017-11-22
AU2017200471B2 (en) 2018-04-12
SMT201800064T1 (it) 2018-03-08
US10022375B2 (en) 2018-07-17
PT2627334E (pt) 2015-07-07
PT2898885T (pt) 2018-02-05
EP2627334B1 (en) 2015-04-29
RS56870B1 (sr) 2018-04-30
SI2898885T1 (en) 2018-03-30
WO2012051570A1 (en) 2012-04-19
RU2599013C2 (ru) 2016-10-10
CN103429245A (zh) 2013-12-04
RU2020111042A (ru) 2021-09-17
US11173159B2 (en) 2021-11-16
CA2813783A1 (en) 2012-04-19
IL225672B (en) 2019-02-28
HK1212914A1 (en) 2016-06-24
CA2813783C (en) 2019-01-22
RS54072B1 (sr) 2015-10-30
RU2016134401A (ru) 2018-12-10
AU2011315902B2 (en) 2016-11-17
US20180360836A1 (en) 2018-12-20
DK2627334T3 (en) 2015-05-18
JP2016135790A (ja) 2016-07-28
PL2627334T3 (pl) 2015-08-31
PL2898885T3 (pl) 2018-04-30
MX348759B (es) 2017-06-28
US20130331404A1 (en) 2013-12-12
US20170042901A1 (en) 2017-02-16
US10420769B2 (en) 2019-09-24
KR101850925B1 (ko) 2018-04-20
EP2627334A4 (en) 2014-04-16
US20220040190A1 (en) 2022-02-10
KR20140040676A (ko) 2014-04-03
LT2898885T (lt) 2018-02-26
AU2011315902A1 (en) 2013-05-30
HUE036387T2 (hu) 2018-07-30
EP2898885A1 (en) 2015-07-29
SMT201500148B (it) 2015-09-07
RU2013121794A (ru) 2014-11-20
CY1119880T1 (el) 2018-06-27
ES2536831T3 (es) 2015-05-29
AU2017200471A1 (en) 2017-02-23
BR112013009029A2 (pt) 2018-06-19
US20190374544A1 (en) 2019-12-12
HRP20180220T1 (hr) 2018-03-09
JP5902698B2 (ja) 2016-04-13
EP2627334A1 (en) 2013-08-21

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

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