BR112012033590A2 - composição farmacêutica tópica que contém flurbiprofeno. - Google Patents
composição farmacêutica tópica que contém flurbiprofeno.Info
- Publication number
- BR112012033590A2 BR112012033590A2 BR112012033590A BR112012033590A BR112012033590A2 BR 112012033590 A2 BR112012033590 A2 BR 112012033590A2 BR 112012033590 A BR112012033590 A BR 112012033590A BR 112012033590 A BR112012033590 A BR 112012033590A BR 112012033590 A2 BR112012033590 A2 BR 112012033590A2
- Authority
- BR
- Brazil
- Prior art keywords
- topical pharmaceutical
- composition containing
- pharmaceutical composition
- containing flurbiprofen
- flurbiprofen
- Prior art date
Links
- SYTBZMRGLBWNTM-UHFFFAOYSA-N flurbiprofen Chemical compound FC1=CC(C(C(O)=O)C)=CC=C1C1=CC=CC=C1 SYTBZMRGLBWNTM-UHFFFAOYSA-N 0.000 title abstract 3
- 229960002390 flurbiprofen Drugs 0.000 title abstract 3
- 239000012049 topical pharmaceutical composition Substances 0.000 title abstract 3
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 206010052904 Musculoskeletal stiffness Diseases 0.000 abstract 1
- 208000001294 Nociceptive Pain Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 abstract 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 abstract 1
- -1 glycol ester Chemical class 0.000 abstract 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 210000005067 joint tissue Anatomy 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 210000004872 soft tissue Anatomy 0.000 abstract 1
- 230000007928 solubilization Effects 0.000 abstract 1
- 238000005063 solubilization Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
- A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Anesthesiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
composição farmacêutica tópica que contém flurbiprofeno. a invenção propõe composições farmacêuticas tópicas que contém flurbiprofeno, ou um derivado farmacêutico aceitável deste, junto com um sistema de solubilização que compreende ao menos um glicol-éter a ao menos um glicol-éster. essas composições são adequadas para o tratamento de qualquer condição associada a dores, inflamação ou rigidez, por exemplo, dores subdérmicas nas articulações ou no tecido mole.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1010954.4A GB201010954D0 (en) | 2010-06-29 | 2010-06-29 | Compositions |
PCT/GB2011/051220 WO2012001403A1 (en) | 2010-06-29 | 2011-06-28 | Topical pharmaceutical composition comprising flurbiprofen |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112012033590A2 true BR112012033590A2 (pt) | 2016-11-29 |
Family
ID=42583177
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112012033590A BR112012033590A2 (pt) | 2010-06-29 | 2011-06-28 | composição farmacêutica tópica que contém flurbiprofeno. |
Country Status (11)
Country | Link |
---|---|
US (1) | US20130143831A1 (pt) |
EP (1) | EP2588100A1 (pt) |
KR (1) | KR20130139842A (pt) |
CN (1) | CN103079552A (pt) |
AR (1) | AR082030A1 (pt) |
BR (1) | BR112012033590A2 (pt) |
EA (1) | EA201370006A1 (pt) |
GB (1) | GB201010954D0 (pt) |
MX (1) | MX2013000256A (pt) |
SG (1) | SG186866A1 (pt) |
WO (1) | WO2012001403A1 (pt) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI433674B (zh) | 2006-12-28 | 2014-04-11 | Infinity Discovery Inc | 環杷明(cyclopamine)類似物類 |
ES2567134T3 (es) | 2009-08-05 | 2016-04-20 | Infinity Pharmaceuticals, Inc. | Transaminación enzimática de análogos de ciclopamina |
US9394313B2 (en) | 2010-09-14 | 2016-07-19 | Infinity Pharmaceuticals, Inc. | Transfer hydrogenation of cyclopamine analogs |
EP2833721B1 (en) * | 2012-03-14 | 2021-02-17 | Novan Inc. | Nitric oxide releasing pharmaceutical compositions |
WO2015021382A2 (en) | 2013-08-08 | 2015-02-12 | Novan, Inc. | Topical compositions and methods of using the same |
US10206947B2 (en) | 2013-08-08 | 2019-02-19 | Novan, Inc. | Topical compositions and methods of using the same |
CA2926874C (en) * | 2013-10-11 | 2018-12-11 | Yinxiang Wang | Icotinib-containing topical skin pharmaceutical compositions and uses thereof |
CN106456556A (zh) * | 2014-06-18 | 2017-02-22 | 豪夫迈·罗氏有限公司 | 包含非离子性表面活性剂的新型药物组合物 |
TWI717323B (zh) * | 2014-10-07 | 2021-02-01 | 日商大正製藥股份有限公司 | 含有s-氟白普洛芬之外用劑組成物 |
JP6796638B2 (ja) | 2015-06-04 | 2020-12-09 | ペレファーム, インク.Pellepharm, Inc. | ヘッジホッグ阻害性化合物の送達のための局所的製剤及びその使用 |
EP3423100A4 (en) | 2016-03-02 | 2019-10-16 | Novan, Inc. | COMPOSITIONS FOR THE TREATMENT OF INFLAMMATION AND METHOD FOR THE TREATMENT THEREOF |
JP2019521993A (ja) * | 2016-06-13 | 2019-08-08 | ビオーム セラピューティクス リミテッド | 相乗的な抗真菌組成物及びその方法 |
AU2017283276B2 (en) * | 2016-06-20 | 2023-02-16 | Capretto Ehf. | Thermostable formulation of biologically active substances |
CN112165935A (zh) | 2018-03-01 | 2021-01-01 | 诺万公司 | 一氧化氮释放性栓剂及其使用方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS52156913A (en) | 1976-06-21 | 1977-12-27 | Toko Yakuhin Kogyo Kk | Production of injectionable medicine |
JPS56154413A (en) | 1980-04-30 | 1981-11-30 | Riide Chem Kk | Anti-inflammatory analgesic for external use |
GB2075837B (en) | 1980-05-14 | 1984-03-14 | Hisamitsu Pharmaceutical Co | Topical pharmaceutical gel containing anti-inflammatory analgesic agents |
JPS5829706A (ja) * | 1981-08-14 | 1983-02-22 | Toko Yakuhin Kogyo Kk | 消炎鎮痛外用剤 |
JPS59222409A (ja) | 1983-06-01 | 1984-12-14 | Nippon Redarii Kk | 消炎鎮痛ゲル軟膏剤 |
EP0695179A1 (en) * | 1993-04-22 | 1996-02-07 | Minnesota Mining And Manufacturing Company | Transdermal antiinflammatory composition |
US5807568A (en) | 1994-12-27 | 1998-09-15 | Mcneil-Ppc, Inc. | Enhanced delivery of topical compositions containing flurbiprofen |
US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
US20030143165A1 (en) * | 2002-01-25 | 2003-07-31 | Allan Evans | NSAID-containing topical formulations that demonstrate chemopreventive activity |
TR200703092A1 (tr) * | 2007-05-08 | 2008-12-22 | SANOVEL �LA� SAN. VE TiC. A.�. | Flurbiprofen ve kas gevşetici kombinasyonları |
-
2010
- 2010-06-29 GB GBGB1010954.4A patent/GB201010954D0/en not_active Ceased
-
2011
- 2011-06-28 CN CN2011800411747A patent/CN103079552A/zh active Pending
- 2011-06-28 MX MX2013000256A patent/MX2013000256A/es not_active Application Discontinuation
- 2011-06-28 US US13/807,324 patent/US20130143831A1/en not_active Abandoned
- 2011-06-28 EP EP11729666.5A patent/EP2588100A1/en not_active Withdrawn
- 2011-06-28 KR KR1020137002225A patent/KR20130139842A/ko not_active Application Discontinuation
- 2011-06-28 SG SG2012096335A patent/SG186866A1/en unknown
- 2011-06-28 WO PCT/GB2011/051220 patent/WO2012001403A1/en active Application Filing
- 2011-06-28 EA EA201370006A patent/EA201370006A1/ru unknown
- 2011-06-28 BR BR112012033590A patent/BR112012033590A2/pt not_active IP Right Cessation
- 2011-06-29 AR ARP110102297A patent/AR082030A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
KR20130139842A (ko) | 2013-12-23 |
EA201370006A1 (ru) | 2013-05-30 |
AR082030A1 (es) | 2012-11-07 |
WO2012001403A1 (en) | 2012-01-05 |
GB201010954D0 (en) | 2010-08-11 |
MX2013000256A (es) | 2013-05-30 |
US20130143831A1 (en) | 2013-06-06 |
EP2588100A1 (en) | 2013-05-08 |
SG186866A1 (en) | 2013-02-28 |
CN103079552A (zh) | 2013-05-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |