BR112012027447A2 - polímero indigerível: revestimentos de filme à base de acetato de amido para veiculação de fármaco para o cólon - Google Patents

polímero indigerível: revestimentos de filme à base de acetato de amido para veiculação de fármaco para o cólon

Info

Publication number
BR112012027447A2
BR112012027447A2 BR112012027447A BR112012027447A BR112012027447A2 BR 112012027447 A2 BR112012027447 A2 BR 112012027447A2 BR 112012027447 A BR112012027447 A BR 112012027447A BR 112012027447 A BR112012027447 A BR 112012027447A BR 112012027447 A2 BR112012027447 A2 BR 112012027447A2
Authority
BR
Brazil
Prior art keywords
starch acetate
film coatings
acetate film
indigestible
colon drug
Prior art date
Application number
BR112012027447A
Other languages
English (en)
Other versions
BR112012027447B1 (pt
Inventor
Daniel Wils
Juergen Siepmann
Jérôme Klaeyle
Laëtitia Guerin-Deremaux
Youness Karrout
Original Assignee
Roquette Freres
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roquette Freres filed Critical Roquette Freres
Publication of BR112012027447A2 publication Critical patent/BR112012027447A2/pt
Publication of BR112012027447B1 publication Critical patent/BR112012027447B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

polímero indigerível: revestimentos de filme à base de acetato de amido para veiculação de fármaco para o cólon. a presente invenção proporciona uma forma de dosagem de entrega veiculada para o cólon para liberação controlada de um ingrediente ativo que compreende um ingrediente ativo revestido em uma mistura polimérica de : uma composição de polímero insolúvel em água que contém pelo menos um acetato de amido, e uma composição de polissacarídeo indigerível. a presente invenção também se refere ao uso e método para fabricação do mesmo.
BR112012027447-3A 2010-04-28 2011-04-28 Forma de dosagem de entrega veiculada para o cólon para liberação controlada de um ingrediente ativo e método para a preparação da mesma BR112012027447B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10305452A EP2386297A1 (en) 2010-04-28 2010-04-28 Indigestible polymer: starch acetate -based film coatings for colon targeting
EP10305452.4 2010-04-28
PCT/EP2011/056794 WO2011135055A1 (en) 2010-04-28 2011-04-28 Indigestible polymer: starch acetate -based film coatings for colon targeting

Publications (2)

Publication Number Publication Date
BR112012027447A2 true BR112012027447A2 (pt) 2016-07-19
BR112012027447B1 BR112012027447B1 (pt) 2021-06-01

Family

ID=43063550

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012027447-3A BR112012027447B1 (pt) 2010-04-28 2011-04-28 Forma de dosagem de entrega veiculada para o cólon para liberação controlada de um ingrediente ativo e método para a preparação da mesma

Country Status (10)

Country Link
US (1) US20130078289A1 (pt)
EP (2) EP2386297A1 (pt)
JP (1) JP5875196B2 (pt)
KR (1) KR20130072203A (pt)
CN (1) CN102883714B (pt)
BR (1) BR112012027447B1 (pt)
CA (1) CA2796955A1 (pt)
MX (1) MX336462B (pt)
RU (1) RU2012150803A (pt)
WO (1) WO2011135055A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2425762T3 (es) * 2008-10-27 2013-10-17 Roquette Freres Polímero insoluble en agua: revestimientos de película a base de derivados de almidón modificado para la liberación dirigida al colon
FR2951177B1 (fr) * 2009-10-09 2012-12-21 Roquette Freres Procede de preparation de derives acetyles de matiere amylacee
CN107847454B (zh) * 2015-08-06 2023-09-12 罗盖特公司 基于淀粉材料的成膜组合物及由其获得的制品

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3795670A (en) 1973-03-05 1974-03-05 Us Agriculture Process for making starch triacetates
GB8926639D0 (en) * 1989-11-24 1990-01-17 Agricultural & Food Res Delayed release formulations
US5236719A (en) * 1991-09-27 1993-08-17 Wm. Wrigley Jr. Company Chewing gum and other comestibles containing purified indigestible dextrin
US5545450A (en) * 1992-08-11 1996-08-13 E. Khashoggi Industries Molded articles having an inorganically filled organic polymer matrix
US5321132A (en) 1992-12-23 1994-06-14 National Starch And Chemical Investment Holding Corporation Method of preparing intermediate DS starch esters in aqueous solution
FI942686A0 (fi) 1994-06-07 1994-06-07 Alko Ab Oy Komposition innehaollande staerkelseacetat med varierande egenskaper, foerfarande foer dess framstaellning och anvaendning
US5656292A (en) * 1994-06-07 1997-08-12 Alko Group Ltd. Composition for pH dependent controlled release of active ingredients and methods for producing it
JPH11514391A (ja) 1995-07-12 1999-12-07 ヴァルティオン・テクニッリネン・トゥトキムスケスクス 熱可塑性スターチ成分およびその製造方法
FI107930B (fi) 1996-12-31 2001-10-31 Valtion Teknillinen Hydroksialkyloitu tärkkelysesteri, sen valmistus ja käyttö
FI107386B (fi) 1996-12-31 2001-07-31 Valtion Teknillinen Menetelmä tärkkelysesterien valmistamiseksi
FR2786775B1 (fr) 1998-12-04 2001-02-16 Roquette Freres Maltodextrines branchees et leur procede de preparation
IT1318597B1 (it) * 2000-06-23 2003-08-27 A C R Applied Coating Res S A Uso di un amido ad alto contenuto di amilosio acetilato epregelatinizzato.
US6607748B1 (en) * 2000-06-29 2003-08-19 Vincent Lenaerts Cross-linked high amylose starch for use in controlled-release pharmaceutical formulations and processes for its manufacture
FI113874B (fi) * 2002-09-27 2004-06-30 Valtion Teknillinen Polymeeriliuokset ja -dispersiot ja menetelmä niiden valmistamiseksi
US8168228B2 (en) * 2003-10-17 2012-05-01 Sandoz Ag Antibiotic clarithromycin micropellet compositions
FR2862654B1 (fr) * 2003-11-20 2006-02-10 Roquette Freres Composition amylacee filmogene
US9149439B2 (en) * 2005-03-21 2015-10-06 Sandoz Ag Multi-particulate, modified-release composition
FR2884422B1 (fr) * 2005-04-18 2008-04-11 Roquette Freres Composition anti-inflammatoire de l'intestin comprenant des maltodextrines branchees
US9198871B2 (en) * 2005-08-15 2015-12-01 Abbott Products Gmbh Delayed release pancreatin compositions
CN100518830C (zh) * 2006-07-12 2009-07-29 华南理工大学 变性淀粉口服结肠靶向控释薄膜包衣材料及其制备方法和制备包衣材料的应用
WO2008028193A2 (en) * 2006-09-01 2008-03-06 Pharmion Corporation Colon-targeted oral formulations of cytidine analogs
US8853386B2 (en) 2006-12-18 2014-10-07 Celanese Acetate Llc Starch esters, methods of making same, and articles made therefrom
ES2425762T3 (es) * 2008-10-27 2013-10-17 Roquette Freres Polímero insoluble en agua: revestimientos de película a base de derivados de almidón modificado para la liberación dirigida al colon

Also Published As

Publication number Publication date
JP2013525410A (ja) 2013-06-20
CA2796955A1 (en) 2011-11-03
CN102883714B (zh) 2016-04-13
MX336462B (es) 2016-01-20
US20130078289A1 (en) 2013-03-28
MX2012012557A (es) 2012-11-23
WO2011135055A1 (en) 2011-11-03
CN102883714A (zh) 2013-01-16
EP2563342A1 (en) 2013-03-06
EP2386297A1 (en) 2011-11-16
RU2012150803A (ru) 2014-06-10
KR20130072203A (ko) 2013-07-01
EP2563342B1 (en) 2016-04-20
BR112012027447B1 (pt) 2021-06-01
JP5875196B2 (ja) 2016-03-02

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06T Formal requirements before examination [chapter 6.20 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 28/04/2011, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF