BR112012018961A2 - método e dispositivo para a produção de ^ 99m^tc - Google Patents
método e dispositivo para a produção de ^ 99m^tcInfo
- Publication number
- BR112012018961A2 BR112012018961A2 BR112012018961A BR112012018961A BR112012018961A2 BR 112012018961 A2 BR112012018961 A2 BR 112012018961A2 BR 112012018961 A BR112012018961 A BR 112012018961A BR 112012018961 A BR112012018961 A BR 112012018961A BR 112012018961 A2 BR112012018961 A2 BR 112012018961A2
- Authority
- BR
- Brazil
- Prior art keywords
- solution
- nuclear reaction
- molybdate ions
- production
- induction
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/04—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators
- G21G1/10—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators by bombardment with electrically charged particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/025—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus inorganic Tc complexes or compounds
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
- C01G99/00—Subject matter not provided for in other groups of this subclass
- C01G99/003—Preparation involving a liquid-liquid extraction, an adsorption or an ion-exchange
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/001—Recovery of specific isotopes from irradiated targets
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/001—Recovery of specific isotopes from irradiated targets
- G21G2001/0042—Technetium
Landscapes
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
- High Energy & Nuclear Physics (AREA)
- General Engineering & Computer Science (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Optics & Photonics (AREA)
- Extraction Or Liquid Replacement (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
Abstract
método e dispositivo para a produção de ^ 99m^tc. a presente invenção refere-se a um método para a produção de ^ 99^tc que consiste nas seguintes etapas ; uma solução (11, 21, 31) que compreende íons de molibdato ^ 100^mo é usada; um feixe de próton (15) que possui uma energia a qual é adequada para a indução de uma reação nuclear de ^ 100^mo (p, 2n) ^ 99m^tc- quando exposta aos íons de molibdato ^ 100^mo é usado; a solução é exposta aos feixes de próton (15) e uma reação nuclear de ^ 100^mo (p, 2n) ^ 99m^tc é induzida; um método de extração para a extração de ^ 99m^tc da solução é usado. a presente invenção também refere-se a um dispositivo para a produção de ^ 99m^tc que compreende uma solução (11, 21, 31) com íons de molibdato ^ 100^mo; um acelerador para o fornecimento de um feixe de próton com energia a qual é adequada para a indução da reação nuclear de ^ 100^mo (p, 2n) ^ 99m^tc durante a exposição aos íons de molibdato ^ 100^mo; para a exposição da solução e para a indução da reação nuclear de ^ 100^mo (p,2n) ^ 99m^tc; uma etapa de extração (19) para a extração de ^ 99m^tc da solução.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102010006435A DE102010006435B3 (de) | 2010-02-01 | 2010-02-01 | Verfahren und Vorrichtung zur Produktion von 99mTc |
| PCT/EP2011/050728 WO2011092102A1 (de) | 2010-02-01 | 2011-01-20 | VERFAHREN UND VORRICHTUNG ZUR PRODUKTION VON 99mTc |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112012018961A2 true BR112012018961A2 (pt) | 2017-10-10 |
| BR112012018961A8 BR112012018961A8 (pt) | 2017-12-26 |
Family
ID=43735753
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012018961A BR112012018961A8 (pt) | 2010-02-01 | 2011-01-20 | método e dispositivo para a produção de 99mtc |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9576692B2 (pt) |
| EP (1) | EP2531449B1 (pt) |
| JP (2) | JP2013518265A (pt) |
| CN (1) | CN102741169B (pt) |
| BR (1) | BR112012018961A8 (pt) |
| CA (1) | CA2788546C (pt) |
| DE (1) | DE102010006435B3 (pt) |
| RU (1) | RU2548168C2 (pt) |
| WO (1) | WO2011092102A1 (pt) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102010006435B3 (de) | 2010-02-01 | 2011-07-21 | Siemens Aktiengesellschaft, 80333 | Verfahren und Vorrichtung zur Produktion von 99mTc |
| JP5817977B2 (ja) * | 2011-08-08 | 2015-11-18 | 国立研究開発法人日本原子力研究開発機構 | 高濃度かつ高放射能をもつテクネチウム−９９ｍ溶液の製造方法 |
| WO2014057900A1 (ja) * | 2012-10-10 | 2014-04-17 | 国立大学法人大阪大学 | Ｒｉの単離装置 |
| JP6377497B2 (ja) * | 2014-11-12 | 2018-08-22 | 住友重機械工業株式会社 | 放射性同位元素の分離装置及び放射性同位元素の分離方法 |
| WO2019054539A1 (ko) * | 2017-09-18 | 2019-03-21 | 한국수력원자력 주식회사 | 핵공명형광을 이용한 tc-99m의 제조방법 |
| RU2701552C1 (ru) * | 2019-01-25 | 2019-09-30 | Федеральное государственное унитарное предприятие "Производственное объединение "Маяк" | Способ получения технеция-99m |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3382152A (en) * | 1964-09-28 | 1968-05-07 | Union Carbide Corp | Production of high purity radioactive isotopes |
| US3920545A (en) * | 1973-11-02 | 1975-11-18 | Marathon Oil Co | Ion exchange of metals from aqueous solutions |
| US3957946A (en) * | 1974-12-23 | 1976-05-18 | Amax Inc. | Molybdenum oxide purification process |
| US4158700A (en) * | 1976-03-08 | 1979-06-19 | Karageozian Hampar L | Method of producing radioactive technetium-99M |
| US4046852A (en) * | 1976-05-19 | 1977-09-06 | Amax Inc. | Purification process for technical grade molybdenum oxide |
| US4107044A (en) * | 1976-08-25 | 1978-08-15 | Epicor, Inc. | Method of and apparatus for purifying fluids with radioactive impurities |
| CA1113257A (en) | 1978-03-14 | 1981-12-01 | Hampar L. Karageozian | Method of producing radioactive technetium-99m |
| US4276267A (en) * | 1979-10-17 | 1981-06-30 | The United States Of America As Represented By The United States Department Of Energy | Hot cell purification of strontium-82, 85 and other isotopes from proton irradiated molybdenum |
| US5049256A (en) * | 1990-02-06 | 1991-09-17 | Chevron Research And Technology Company | Recovery of hydrocarbons from acid sludge |
| US5116470A (en) * | 1990-08-10 | 1992-05-26 | The United States Of America As Represented By The United States Department Of Energy | Preparation of high specific activity technetium-96 |
| US6490330B1 (en) * | 1994-04-12 | 2002-12-03 | The Regents Of The University Of California | Production of high specific activity copper -67 |
| WO1996006519A1 (en) * | 1994-08-19 | 1996-02-29 | Amersham International Plc | Superconducting cyclotron and target for use in the production of heavy isotopes |
| RU2118858C1 (ru) * | 1994-10-14 | 1998-09-10 | Научно-исследовательский институт ядерной физики при Томском политехническом университете | Способ экстракционного получения технеция-99м и устройство для его осуществления |
| US5784423A (en) * | 1995-09-08 | 1998-07-21 | Massachusetts Institute Of Technology | Method of producing molybdenum-99 |
| US5802439A (en) * | 1997-02-19 | 1998-09-01 | Lockheed Martin Idaho Technologies Company | Method for the production of 99m Tc compositions from 99 Mo-containing materials |
| JP4317269B2 (ja) * | 1997-06-19 | 2009-08-19 | ヨーロピアン・オーガニゼーション・フォア・ニュークリア・リサーチ | 中性子束による被爆方法、有用な同位元素を生成する方法及び長寿命同位元素を変換する方法 |
| US5910971A (en) * | 1998-02-23 | 1999-06-08 | Tci Incorporated | Method and apparatus for the production and extraction of molybdenum-99 |
| US20030058980A1 (en) * | 2000-10-31 | 2003-03-27 | El-Sharaway El-Badawy A. | Method and apparatus for the transmutation of nuclear waste with tandem production of tritium |
| WO2004033613A2 (en) | 2002-10-11 | 2004-04-22 | Scantech Holdings, Llc | Standing-wave electron linear accelerator |
| EP1429345A1 (fr) * | 2002-12-10 | 2004-06-16 | Ion Beam Applications S.A. | Dispositif et procédé de production de radio-isotopes |
| DE10341727A1 (de) * | 2003-09-10 | 2005-04-28 | Starck H C Gmbh | Reinigung von Ammoniummetallat-Lösungen |
| DE10353534A1 (de) * | 2003-11-14 | 2005-06-16 | Bayer Chemicals Ag | Chelataustauscher |
| US7968503B2 (en) * | 2004-06-07 | 2011-06-28 | Ppg Industries Ohio, Inc. | Molybdenum comprising nanomaterials and related nanotechnology |
| US20060023829A1 (en) * | 2004-08-02 | 2006-02-02 | Battelle Memorial Institute | Medical radioisotopes and methods for producing the same |
| WO2006039787A1 (en) * | 2004-10-12 | 2006-04-20 | Mcmaster University | GENERATOR AND METHOD FOR PRODUCTION OF TECHNETIUM-99m |
| US20070160176A1 (en) * | 2006-01-06 | 2007-07-12 | Ryoichi Wada | Isotope generator |
| JP4618732B2 (ja) | 2006-10-20 | 2011-01-26 | 独立行政法人 日本原子力研究開発機構 | 放射性モリブデンの製造方法と装置 |
| KR101591688B1 (ko) | 2007-12-28 | 2016-02-04 | 피닉스 뉴클리어 랩스 엘엘씨 | 고에너지 양성자 및 또는 중성자 소스 |
| US20100215137A1 (en) * | 2009-02-24 | 2010-08-26 | Yasuki Nagai | Method and apparatus for producing radioisotope |
| US8699651B2 (en) * | 2009-04-15 | 2014-04-15 | Ge-Hitachi Nuclear Energy Americas Llc | Method and system for simultaneous irradiation and elution capsule |
| PT104656A (pt) * | 2009-07-01 | 2011-01-03 | Ray Johnson Richard | Processo de produção de tecnécio-99 metaestável em ciclotrões de baixa energia e alvo de molibdnénio-100 utilizado no processo |
| US8557119B1 (en) * | 2009-09-11 | 2013-10-15 | Stc.Unm | High water recovery from desalination systems using ion exchange technology |
| DE102010006435B3 (de) | 2010-02-01 | 2011-07-21 | Siemens Aktiengesellschaft, 80333 | Verfahren und Vorrichtung zur Produktion von 99mTc |
| US9336916B2 (en) * | 2010-05-14 | 2016-05-10 | Tcnet, Llc | Tc-99m produced by proton irradiation of a fluid target system |
-
2010
- 2010-02-01 DE DE102010006435A patent/DE102010006435B3/de not_active Expired - Fee Related
-
2011
- 2011-01-20 JP JP2012550395A patent/JP2013518265A/ja active Pending
- 2011-01-20 BR BR112012018961A patent/BR112012018961A8/pt active Search and Examination
- 2011-01-20 CA CA2788546A patent/CA2788546C/en not_active Expired - Fee Related
- 2011-01-20 US US13/576,475 patent/US9576692B2/en not_active Expired - Fee Related
- 2011-01-20 CN CN201180007948.4A patent/CN102741169B/zh not_active Expired - Fee Related
- 2011-01-20 EP EP11700448.1A patent/EP2531449B1/de not_active Not-in-force
- 2011-01-20 RU RU2012137210/07A patent/RU2548168C2/ru not_active IP Right Cessation
- 2011-01-20 WO PCT/EP2011/050728 patent/WO2011092102A1/de active Application Filing
-
2014
- 2014-10-31 JP JP2014222952A patent/JP6001035B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| BR112012018961A8 (pt) | 2017-12-26 |
| RU2012137210A (ru) | 2014-03-10 |
| WO2011092102A1 (de) | 2011-08-04 |
| JP2013518265A (ja) | 2013-05-20 |
| DE102010006435B3 (de) | 2011-07-21 |
| JP2015038508A (ja) | 2015-02-26 |
| CA2788546A1 (en) | 2011-08-04 |
| CA2788546C (en) | 2018-11-13 |
| CN102741169B (zh) | 2015-07-15 |
| EP2531449B1 (de) | 2015-10-28 |
| JP6001035B2 (ja) | 2016-10-05 |
| CN102741169A (zh) | 2012-10-17 |
| EP2531449A1 (de) | 2012-12-12 |
| RU2548168C2 (ru) | 2015-04-20 |
| US20120314828A1 (en) | 2012-12-13 |
| US9576692B2 (en) | 2017-02-21 |
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Legal Events
| Date | Code | Title | Description |
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| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07G | Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette] |
Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO POR NAO SE ENQUADRAR NO ART. 229-C DA LPI. |
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| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B11D | Dismissal acc. art. 38, par 2 of ipl - failure to pay fee after grant in time |