BR112012000320A2 - derivado de sulfeto de difenil, hidrato ou um sal farmaceuticamente aceitável do mesmo, medicamento baseado na ação antagônica-receptor da esfingosina-1-fosfato 3 (s1p3) e composição farmacêutica - Google Patents
derivado de sulfeto de difenil, hidrato ou um sal farmaceuticamente aceitável do mesmo, medicamento baseado na ação antagônica-receptor da esfingosina-1-fosfato 3 (s1p3) e composição farmacêuticaInfo
- Publication number
- BR112012000320A2 BR112012000320A2 BR112012000320A BR112012000320A BR112012000320A2 BR 112012000320 A2 BR112012000320 A2 BR 112012000320A2 BR 112012000320 A BR112012000320 A BR 112012000320A BR 112012000320 A BR112012000320 A BR 112012000320A BR 112012000320 A2 BR112012000320 A2 BR 112012000320A2
- Authority
- BR
- Brazil
- Prior art keywords
- sphingosine
- hydrate
- phosphate
- pharmaceutically acceptable
- pharmaceutical composition
- Prior art date
Links
- 230000003042 antagnostic effect Effects 0.000 title 1
- LTYMSROWYAPPGB-UHFFFAOYSA-N diphenyl sulfide Chemical class C=1C=CC=CC=1SC1=CC=CC=C1 LTYMSROWYAPPGB-UHFFFAOYSA-N 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- DUYSYHSSBDVJSM-KRWOKUGFSA-N sphingosine 1-phosphate Chemical compound CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)COP(O)(O)=O DUYSYHSSBDVJSM-KRWOKUGFSA-N 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4015—Esters of acyclic unsaturated acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Pulmonology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2009162289 | 2009-07-09 | ||
JP2010112138 | 2010-05-14 | ||
PCT/JP2010/004453 WO2011004604A1 (ja) | 2009-07-09 | 2010-07-08 | ジフェニルスルフィド誘導体及びそれらを有効成分とする医薬 |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112012000320A2 true BR112012000320A2 (pt) | 2016-03-22 |
Family
ID=43429031
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112012000320A BR112012000320A2 (pt) | 2009-07-09 | 2010-07-08 | derivado de sulfeto de difenil, hidrato ou um sal farmaceuticamente aceitável do mesmo, medicamento baseado na ação antagônica-receptor da esfingosina-1-fosfato 3 (s1p3) e composição farmacêutica |
Country Status (20)
Country | Link |
---|---|
US (1) | US8569270B2 (pt) |
EP (1) | EP2452944B1 (pt) |
JP (1) | JP5616342B2 (pt) |
KR (1) | KR20120089234A (pt) |
CN (1) | CN102471355B (pt) |
AU (1) | AU2010269668B2 (pt) |
BR (1) | BR112012000320A2 (pt) |
CA (1) | CA2764126A1 (pt) |
DK (1) | DK2452944T3 (pt) |
ES (1) | ES2514665T3 (pt) |
HK (1) | HK1171234A1 (pt) |
HR (1) | HRP20141065T1 (pt) |
MX (1) | MX2011013182A (pt) |
NZ (1) | NZ596605A (pt) |
PL (1) | PL2452944T3 (pt) |
PT (1) | PT2452944E (pt) |
SG (1) | SG176573A1 (pt) |
SI (1) | SI2452944T1 (pt) |
WO (1) | WO2011004604A1 (pt) |
ZA (1) | ZA201108459B (pt) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI519539B (zh) | 2010-12-21 | 2016-02-01 | Kyorin Seiyaku Kk | Diphenyl sulfide derivatives and pharmaceuticals as an active ingredient thereof |
CN102863345A (zh) * | 2011-07-06 | 2013-01-09 | 中国医学科学院药物研究所 | 胺基丙二醇类衍生物、其制备方法和其药物组合物与用途 |
WO2015194157A1 (ja) * | 2014-06-16 | 2015-12-23 | 杏林製薬株式会社 | ジフェニルスルフィド誘導体の製造方法及び製造中間体 |
CN110357773A (zh) * | 2019-07-08 | 2019-10-22 | 南通嘉禾化工有限公司 | 3-氯-4-羟基苯甲酸的合成 |
CN113754613B (zh) * | 2021-09-27 | 2023-06-30 | 北京工商大学 | 一种4-烯醇的苯硫基环醚化方法 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003020313A1 (fr) | 2001-09-04 | 2003-03-13 | Ono Pharmaceutical Co., Ltd. | Medicaments contre les maladies respiratoires renfermant un agent de regulation du recepteur de la sphingosine-1-phosphate |
DK1431284T3 (da) | 2001-09-27 | 2008-02-18 | Kyorin Seiyaku Kk | Diarylsulfidderivat, additionssalt deraf samt immunundertrykkende middel |
DE60235900D1 (de) | 2001-09-27 | 2010-05-20 | Kyorin Seiyaku Kk | Osuppressivum |
JP4571497B2 (ja) | 2002-09-19 | 2010-10-27 | 杏林製薬株式会社 | アミノアルコール誘導体とその付加塩及び免疫抑制剤 |
DK1602660T3 (da) | 2003-02-18 | 2011-05-23 | Kyorin Seiyaku Kk | Aminophosphonsyrederivater, additionssalte deraf og S1P-receptormodulatorer |
SA04250253B1 (ar) | 2003-08-21 | 2009-11-10 | استرازينيكا ايه بي | احماض فينوكسي اسيتيك مستبدلة باعتبارها مركبات صيدلانية لعلاج الامراض التنفسية مثل الربو ومرض الانسداد الرئوي المزمن |
WO2005044780A1 (ja) | 2003-11-10 | 2005-05-19 | Kyorin Pharmaceutical Co., Ltd. | アミノカルボン酸誘導体とその付加塩及びs1p受容体調節剤 |
JP2005247691A (ja) | 2004-03-01 | 2005-09-15 | Toa Eiyo Ltd | S1p3受容体拮抗薬 |
WO2006063033A2 (en) | 2004-12-06 | 2006-06-15 | University Of Virginia Patent Foundation | Aryl amide sphingosine 1-phosphate analogs |
US8546452B2 (en) | 2005-10-12 | 2013-10-01 | Toa Eiyo Ltd. | S1P3 receptor antagonist |
EP2099768A2 (en) * | 2006-08-04 | 2009-09-16 | Praecis Pharmaceuticals Incorporated | Agonists of the sphingosine-1-phosphate receptor |
KR101339976B1 (ko) | 2006-08-08 | 2013-12-10 | 교린 세이야꾸 가부시키 가이샤 | 아미노인산에스테르 유도체 및 그들을 유효성분으로 하는 s1p 수용체 조절제 |
JP2008239546A (ja) * | 2007-03-27 | 2008-10-09 | Kyorin Pharmaceut Co Ltd | アミノアルコール誘導体及びそれらを有効成分とする免疫抑制剤 |
JP2010013407A (ja) * | 2008-07-04 | 2010-01-21 | Kyorin Pharmaceut Co Ltd | アミノアルコール誘導体 |
JP2010077053A (ja) * | 2008-09-25 | 2010-04-08 | Kyorin Pharmaceut Co Ltd | フェノール誘導体及びそれらを有効成分とする医薬 |
-
2010
- 2010-07-08 AU AU2010269668A patent/AU2010269668B2/en not_active Ceased
- 2010-07-08 EP EP10796915.6A patent/EP2452944B1/en active Active
- 2010-07-08 US US13/382,011 patent/US8569270B2/en active Active
- 2010-07-08 JP JP2011521823A patent/JP5616342B2/ja not_active Expired - Fee Related
- 2010-07-08 PL PL10796915T patent/PL2452944T3/pl unknown
- 2010-07-08 BR BR112012000320A patent/BR112012000320A2/pt not_active IP Right Cessation
- 2010-07-08 KR KR1020127003551A patent/KR20120089234A/ko active IP Right Grant
- 2010-07-08 NZ NZ596605A patent/NZ596605A/xx not_active IP Right Cessation
- 2010-07-08 CN CN201080030630.3A patent/CN102471355B/zh not_active Expired - Fee Related
- 2010-07-08 PT PT107969156T patent/PT2452944E/pt unknown
- 2010-07-08 SG SG2011085511A patent/SG176573A1/en unknown
- 2010-07-08 WO PCT/JP2010/004453 patent/WO2011004604A1/ja active Application Filing
- 2010-07-08 SI SI201030811T patent/SI2452944T1/sl unknown
- 2010-07-08 MX MX2011013182A patent/MX2011013182A/es active IP Right Grant
- 2010-07-08 ES ES10796915.6T patent/ES2514665T3/es active Active
- 2010-07-08 CA CA2764126A patent/CA2764126A1/en not_active Abandoned
- 2010-07-08 DK DK10796915.6T patent/DK2452944T3/da active
-
2011
- 2011-11-17 ZA ZA2011/08459A patent/ZA201108459B/en unknown
-
2012
- 2012-11-21 HK HK12111884.2A patent/HK1171234A1/zh not_active IP Right Cessation
-
2014
- 2014-11-03 HR HRP20141065AT patent/HRP20141065T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
NZ596605A (en) | 2013-09-27 |
PL2452944T3 (pl) | 2015-03-31 |
AU2010269668B2 (en) | 2013-12-19 |
JPWO2011004604A1 (ja) | 2012-12-20 |
EP2452944A4 (en) | 2013-04-03 |
MX2011013182A (es) | 2012-01-31 |
HK1171234A1 (zh) | 2013-03-22 |
EP2452944A1 (en) | 2012-05-16 |
SG176573A1 (en) | 2012-01-30 |
ZA201108459B (en) | 2012-07-25 |
ES2514665T3 (es) | 2014-10-28 |
HRP20141065T1 (hr) | 2015-02-13 |
CA2764126A1 (en) | 2011-01-13 |
EP2452944B1 (en) | 2014-09-10 |
SI2452944T1 (sl) | 2015-01-30 |
US20120101068A1 (en) | 2012-04-26 |
PT2452944E (pt) | 2014-10-13 |
CN102471355B (zh) | 2015-10-07 |
DK2452944T3 (da) | 2014-10-27 |
KR20120089234A (ko) | 2012-08-09 |
CN102471355A (zh) | 2012-05-23 |
US8569270B2 (en) | 2013-10-29 |
AU2010269668A1 (en) | 2011-12-15 |
JP5616342B2 (ja) | 2014-10-29 |
WO2011004604A1 (ja) | 2011-01-13 |
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