BR0315746A - Redução estereospecìfica de sapogen-3-onas - Google Patents
Redução estereospecìfica de sapogen-3-onasInfo
- Publication number
- BR0315746A BR0315746A BR0315746-6A BR0315746A BR0315746A BR 0315746 A BR0315746 A BR 0315746A BR 0315746 A BR0315746 A BR 0315746A BR 0315746 A BR0315746 A BR 0315746A
- Authority
- BR
- Brazil
- Prior art keywords
- derivative
- steroidal
- steroidal sapogenin
- sapogenin
- reducing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Catalysts (AREA)
Abstract
"REDUçãO ESTEREOSPECìFICA DE SAPOGEN-3-ONAS". A presente invenção refere-se a um método para preparar estereospecificamente uma sapogenina esteroidal ou um derivado desta, mediante redução de uma 3-ceto,5<225>-H sapogenina esteroidal com um organoborano bloqueado ou um hidreto de organoalumínio. Uma 3<225>-hidróxi,5<225>-H sapogenina esteroidal ou derivado desta poderá ser preparada mediante redução da 3-ceto,5<225>-H sapogenina esteroidal usando como agente redutor um reagente de organoborano relativamente altamente bloqueado, ou por meio de inversão S~ N~2 de uma 3<244>-hidróxi,5<225>-H sapogenina esteroidal ou derivado desta. O hidreto de organoalumínio poderá ser usado para preparar uma 3a,5<225>-H sapogenina esteroidal ou derivado desta. A invenção proporciona uma rota conveniente para sapogeninas esteroidais úteis tais como sarsassapogenina, epissarsassapogenina, esmilagenina, epiesmilagenina e ésteres destas, a partir de materiais de partida prontamente disponíveis ou facilmente preparáveis (por exemplo, diosgenona, preparável a partir de diosgenina).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0225106A GB0225106D0 (en) | 2002-10-28 | 2002-10-28 | Synthesis of 3 hydroxy-5 -steroids |
| GB0301505A GB0301505D0 (en) | 2003-01-22 | 2003-01-22 | Stereospecific synthesis of sapogenins |
| PCT/GB2003/001780 WO2004037845A1 (en) | 2002-10-28 | 2003-04-28 | Stereospecific reduction of sapogen-3-ones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0315746A true BR0315746A (pt) | 2005-09-06 |
Family
ID=32178884
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0315746-6A BR0315746A (pt) | 2002-10-28 | 2003-04-28 | Redução estereospecìfica de sapogen-3-onas |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7718792B2 (pt) |
| EP (1) | EP1558627B1 (pt) |
| JP (1) | JP4607758B2 (pt) |
| KR (1) | KR101092150B1 (pt) |
| AT (1) | ATE459636T1 (pt) |
| AU (1) | AU2003224308A1 (pt) |
| BR (1) | BR0315746A (pt) |
| CA (1) | CA2503899C (pt) |
| DE (1) | DE60331572D1 (pt) |
| ES (1) | ES2342274T3 (pt) |
| MX (1) | MXPA05004494A (pt) |
| PL (1) | PL210114B1 (pt) |
| PT (1) | PT1558627E (pt) |
| RU (1) | RU2326890C2 (pt) |
| SG (1) | SG148860A1 (pt) |
| TW (1) | TWI334781B (pt) |
| WO (1) | WO2004037845A1 (pt) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0000228D0 (en) * | 2000-01-06 | 2000-03-01 | Phytopharm Plc | Fluoro substituted sapogenins and their use |
| CN102727501A (zh) * | 2002-03-27 | 2012-10-17 | 菲特法姆股份有限公司 | 皂角苷配基及其衍生物的用途 |
| GB0409567D0 (en) | 2004-04-28 | 2004-06-02 | Phytopharm Plc | Chemical compounds |
| EP2274317A4 (en) * | 2008-04-30 | 2012-10-24 | Inst Radiation Med Amms Pla | SYNTHESIS OF TIMOSAPONINE BII |
| CN106810592A (zh) * | 2016-11-29 | 2017-06-09 | 杭州裕美生物科技有限公司 | 一种4‑烯‑3,6‑二酮甾体的合成工艺 |
| CN115595353B (zh) * | 2022-10-29 | 2024-08-23 | 西北农林科技大学 | 一种利用微生物转化制备薯蓣皂苷酮的方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB736818A (en) | 1951-12-28 | 1955-09-14 | Glidden Co | Improvements in or relating to preparation of 3-keto steroids having cis junction of rings a and b |
| GB763301A (en) | 1953-09-05 | 1956-12-12 | Farmaceutici Italia | Process for the reduction of í¸-3-keto-steroids to 5-ª -dihydro-steroids |
| DE2257132C3 (de) | 1972-11-18 | 1982-05-13 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur Reduktion von 3-Ketosteroiden |
| SK158394A3 (en) * | 1992-06-26 | 1995-05-10 | Pfizer | Steroidal glycosides |
| AU7948394A (en) | 1993-12-28 | 1995-07-17 | Pfizer Inc. | Hypocholesterolemic agents |
| JPH09511753A (ja) * | 1994-09-20 | 1997-11-25 | ファイザー・インコーポレーテッド | コレステロール吸収阻害薬とコレステロール合成阻害薬の併用 |
| WO1996038466A1 (en) * | 1995-05-29 | 1996-12-05 | Pfizer Inc. | Steroidal glycosides |
| JP3768100B2 (ja) | 1998-03-26 | 2006-04-19 | ファイトファーム・ピーエルシー | アルツハイマー病を治療するためのステロイドサポゲニンとその誘導体 |
| GB9923076D0 (en) | 1999-09-29 | 1999-12-01 | Phytopharm Plc | Sapogenin derivatives and their use |
| GB0000228D0 (en) | 2000-01-06 | 2000-03-01 | Phytopharm Plc | Fluoro substituted sapogenins and their use |
| GB0107822D0 (en) * | 2001-03-28 | 2001-05-23 | Phytopharm Plc | Sapogenin derivatives their synthesis and use methods based upon their use |
-
2003
- 2003-04-28 PT PT03720733T patent/PT1558627E/pt unknown
- 2003-04-28 ES ES03720733T patent/ES2342274T3/es not_active Expired - Lifetime
- 2003-04-28 KR KR1020057007429A patent/KR101092150B1/ko not_active IP Right Cessation
- 2003-04-28 AT AT03720733T patent/ATE459636T1/de active
- 2003-04-28 BR BR0315746-6A patent/BR0315746A/pt not_active IP Right Cessation
- 2003-04-28 EP EP03720733A patent/EP1558627B1/en not_active Expired - Lifetime
- 2003-04-28 SG SG200703083-6A patent/SG148860A1/en unknown
- 2003-04-28 DE DE60331572T patent/DE60331572D1/de not_active Expired - Lifetime
- 2003-04-28 RU RU2005111593/04A patent/RU2326890C2/ru not_active IP Right Cessation
- 2003-04-28 JP JP2005501542A patent/JP4607758B2/ja not_active Expired - Fee Related
- 2003-04-28 CA CA2503899A patent/CA2503899C/en not_active Expired - Fee Related
- 2003-04-28 AU AU2003224308A patent/AU2003224308A1/en not_active Abandoned
- 2003-04-28 WO PCT/GB2003/001780 patent/WO2004037845A1/en active Application Filing
- 2003-04-28 MX MXPA05004494A patent/MXPA05004494A/es active IP Right Grant
- 2003-04-28 TW TW092109883A patent/TWI334781B/zh not_active IP Right Cessation
- 2003-04-28 PL PL376791A patent/PL210114B1/pl not_active IP Right Cessation
- 2003-04-28 US US10/531,086 patent/US7718792B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1558627A1 (en) | 2005-08-03 |
| WO2004037845A1 (en) | 2004-05-06 |
| KR101092150B1 (ko) | 2011-12-12 |
| ES2342274T3 (es) | 2010-07-05 |
| PL210114B1 (pl) | 2011-12-30 |
| TW200406215A (en) | 2004-05-01 |
| ATE459636T1 (de) | 2010-03-15 |
| US7718792B2 (en) | 2010-05-18 |
| CA2503899A1 (en) | 2004-05-06 |
| TWI334781B (en) | 2010-12-21 |
| JP4607758B2 (ja) | 2011-01-05 |
| PT1558627E (pt) | 2010-05-06 |
| US20060041119A1 (en) | 2006-02-23 |
| DE60331572D1 (de) | 2010-04-15 |
| RU2326890C2 (ru) | 2008-06-20 |
| JP2006507360A (ja) | 2006-03-02 |
| PL376791A1 (pl) | 2006-01-09 |
| MXPA05004494A (es) | 2005-07-26 |
| SG148860A1 (en) | 2009-01-29 |
| KR20050090379A (ko) | 2005-09-13 |
| RU2005111593A (ru) | 2006-05-10 |
| AU2003224308A1 (en) | 2004-05-13 |
| EP1558627B1 (en) | 2010-03-03 |
| CA2503899C (en) | 2011-12-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69634039D1 (de) | Neuroaktive steroide der androstan- und pregnanreihe | |
| TW200603813A (en) | Cyclic progestin regimens and kits | |
| TW200605880A (en) | Progesterone receptor antagonist contraceptive regimens and kits | |
| Lipsett | Gas Chromatography of Steroids in Biological Fluids: Proceedings of theWorkshop on Gas-Liquid Chromatography of Steroids in Biological Fluids | |
| DE50308933D1 (de) | Zusammensetzung, enthaltend ein androgenes 11-b-halogensteroid und ein gestagen sowie m nnliches kontrazeptivum auf basis dieser zusammensetzung | |
| BR0315746A (pt) | Redução estereospecìfica de sapogen-3-onas | |
| KR890701612A (ko) | 개선된 9α-탈할로겐화 방법 | |
| Kirchhoff et al. | Differences in the steroid-binding site specificities of rat prostate androgen receptor and epididymal androgen-binding protein (ABP) | |
| WO2003082894A3 (en) | C-17 spirolactonization and 6,7 oxidation of steroids | |
| AU2953602A (en) | Process for the production of 16,17-((cyclohexylmethylen)bis(oxy))-11,21-dihydroxy-pregna- 1,4-dien-3,20-dion or its 21-isobutyrat by transketalisation | |
| ATE152119T1 (de) | Neue 16-methyl substituierte steroidderivate von pregna-1,4-dien-3,20-dion, ihre herstellung, ihre verwendung zur herstellung von 16-methylene- substituierte steroide und neue zwischenprodukten dafür | |
| IE37444B1 (en) | Novel steroids of the d-homo pregnane series | |
| YU22903A (sh) | 17alfa-fluoroalkil steroidi, postupak njihove proizvodnje i farmaceutski sastavi koji sadrže ova jedinjenja | |
| DE69126622D1 (de) | 2beta,19-methylenamin überbrückte steroide als aromatasehemmer | |
| DE60327946D1 (de) | Angiogen-wirkende trisulfat steroide und deren verwendung | |
| Le Pera et al. | A straightforward chemical synthesis of 17-ketosteroids by cleavage of the C-17-dihydroxy acetone side chain in corticosteroids | |
| ATE277071T1 (de) | Durch 11-beta-aryl-17,17-spirothiolan substituierte steroide | |
| NO20054636L (no) | Fremgangsmate for fremstilling av steroidale karbotiosyrederivater og -intermediater | |
| GB862621A (en) | Improvements in or relating to 4-organothiomethyl-3-oxo-delta-steroids | |
| TH67052A (th) | การสังเคราะห์ซาพอเจนินที่มีความจำเพาะทางสเตริโอเคมี | |
| Kirk et al. | The structure and nomenclature of steroids | |
| PL358032A1 (en) | New application of 22r-(11, 16)-16,17-[butylidene-bis-oxy)]-11,21-dihydroxypregna-1,4-diene-3,20-dione | |
| GB825210A (en) | Dehydro-compounds of the steroid series and process for their manufacture | |
| GB777996A (en) | Steriod compounds and their preparation | |
| GB834372A (en) | New compounds of the pregnene series and process for the preparation thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 11A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2259 DE 22/04/2014. |