BR0314152A - Métodos para regular o nìvel de hematócrito em humanos, para preparar um produto de eritropoietina, e, para tratar anemia em pacientes em risco de lesão de tecido, produto de eritropoietina produzido pelo homem, e, composição farmacêutica - Google Patents
Métodos para regular o nìvel de hematócrito em humanos, para preparar um produto de eritropoietina, e, para tratar anemia em pacientes em risco de lesão de tecido, produto de eritropoietina produzido pelo homem, e, composição farmacêuticaInfo
- Publication number
- BR0314152A BR0314152A BR0314152-7A BR0314152A BR0314152A BR 0314152 A BR0314152 A BR 0314152A BR 0314152 A BR0314152 A BR 0314152A BR 0314152 A BR0314152 A BR 0314152A
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- erythropoietin product
- humans
- erythropoietin
- patients
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1816—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/10—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using coupling agents
Abstract
"MéTODOS PARA REGULAR O NìVEL DE HEMATóCRITO EM HUMANOS, PARA PREPARAR UM PRODUTO DE ERITROPOIETINA, E, PARA TRATAR ANEMIA EM PACIENTES EM RISCO DE LESãO DE TECIDO, PRODUTO DE ERITROPOIETINA PRODUZIDO PELO HOMEM, E, COMPOSIçãO FARMACêUTICA" Métodos para aumentar o hematócrito de um indivíduo, ao mesmo tempo em que são mantidas as atividades protetoras do tecido de endógena através da administração de um composto farmacêutico contendo eritropoietina de longa duração quimicamente modificada. São também expostas as novas eritropoietinas de longa duração quimicamente modificadas, métodos de produção de eritropoietinas de longa duração quimicamente modificadas, e composições compreendendo as eritropoietinas de longa duração quimicamente modificadas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40902002P | 2002-09-09 | 2002-09-09 | |
PCT/US2003/028073 WO2004022577A2 (en) | 2002-09-09 | 2003-09-09 | Long acting erythropoietins that maintain tissue protective activity of endogenous erythropoietin |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0314152A true BR0314152A (pt) | 2005-07-12 |
Family
ID=31978712
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0314152-7A BR0314152A (pt) | 2002-09-09 | 2003-09-09 | Métodos para regular o nìvel de hematócrito em humanos, para preparar um produto de eritropoietina, e, para tratar anemia em pacientes em risco de lesão de tecido, produto de eritropoietina produzido pelo homem, e, composição farmacêutica |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP1545586A4 (pt) |
JP (1) | JP2006511468A (pt) |
KR (1) | KR20050083682A (pt) |
CN (2) | CN1729015A (pt) |
AU (1) | AU2003273297A1 (pt) |
BR (1) | BR0314152A (pt) |
CA (1) | CA2497960A1 (pt) |
EA (1) | EA007812B1 (pt) |
IL (1) | IL174178A0 (pt) |
IS (1) | IS7731A (pt) |
MX (1) | MXPA05002617A (pt) |
NO (1) | NO20051714L (pt) |
PL (1) | PL375741A1 (pt) |
WO (1) | WO2004022577A2 (pt) |
ZA (1) | ZA200505423B (pt) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7718363B2 (en) | 2003-04-25 | 2010-05-18 | The Kenneth S. Warren Institute, Inc. | Tissue protective cytokine receptor complex and assays for identifying tissue protective compounds |
WO2006061853A2 (en) * | 2004-12-10 | 2006-06-15 | Serum Institute Of India Limited | Novel erythropoietic compounds and a process for producing erythropoietic compounds |
TWI376234B (en) | 2005-02-01 | 2012-11-11 | Msd Oss Bv | Conjugates of a polypeptide and an oligosaccharide |
ES2653790T3 (es) | 2005-08-05 | 2018-02-08 | Araim Pharmaceuticals, Inc. | Péptidos protectores de tejido y usos de los mismos |
KR101572286B1 (ko) | 2008-01-22 | 2015-11-27 | 아라임 파마슈티칼즈, 인크. | 조직 손상 관련 질환 및 장애를 예방 및 치료하기 위한 조직 보호 펩티드 및 펩티드 유사체 |
CN101671388B (zh) * | 2008-09-09 | 2013-01-02 | 曹国栋 | 血脑屏障穿透性促红细胞生成素及其应用 |
RU2475273C1 (ru) * | 2012-04-02 | 2013-02-20 | Юлия Николаевна Козлова | Способ получения полимерного цемента медицинского назначения |
CN102746405B (zh) * | 2012-07-24 | 2013-08-21 | 深圳赛保尔生物药业有限公司 | 重组人促红素的连续聚乙二醇化反应方法 |
RU2664588C2 (ru) * | 2015-11-05 | 2018-08-21 | Закрытое Акционерное Общество "Биокад" | Пролонгированный фактор эритропоэза человека и лекарственное средство на его основе |
CN109310741A (zh) | 2016-04-29 | 2019-02-05 | 阿拉伊姆药品公司 | 用于预防和治疗与组织损伤相关的疾病和障碍的组织保护肽 |
CN112741895A (zh) * | 2021-01-19 | 2021-05-04 | 中国人民解放军陆军军医大学 | Epo类似物在制备治疗脓毒症药物中的应用 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JO2291B1 (en) * | 1999-07-02 | 2005-09-12 | اف . هوفمان لاروش ايه جي | Erythropoietin derivatives |
MXPA02010333A (es) * | 2000-04-21 | 2003-04-25 | Amgen Inc | Metodos y composiciones para la prefencion y tratamiento de anemia. |
NZ522030A (en) * | 2000-05-15 | 2004-11-26 | F | Erythropoietin composition with a multiple charged inorganic anion i.e. a sulfate a citrate or a phosphate to stabilize the composition |
-
2003
- 2003-09-09 EA EA200500473A patent/EA007812B1/ru not_active IP Right Cessation
- 2003-09-09 WO PCT/US2003/028073 patent/WO2004022577A2/en active Application Filing
- 2003-09-09 PL PL03375741A patent/PL375741A1/xx not_active Application Discontinuation
- 2003-09-09 KR KR1020057004045A patent/KR20050083682A/ko not_active Application Discontinuation
- 2003-09-09 CN CNA038249154A patent/CN1729015A/zh active Pending
- 2003-09-09 BR BR0314152-7A patent/BR0314152A/pt not_active IP Right Cessation
- 2003-09-09 ZA ZA200505423A patent/ZA200505423B/xx unknown
- 2003-09-09 JP JP2004534745A patent/JP2006511468A/ja not_active Withdrawn
- 2003-09-09 CN CNA2008101490873A patent/CN101371920A/zh active Pending
- 2003-09-09 AU AU2003273297A patent/AU2003273297A1/en not_active Abandoned
- 2003-09-09 MX MXPA05002617A patent/MXPA05002617A/es unknown
- 2003-09-09 CA CA002497960A patent/CA2497960A1/en not_active Withdrawn
- 2003-09-09 EP EP03755796A patent/EP1545586A4/en not_active Withdrawn
-
2005
- 2005-03-08 IS IS7731A patent/IS7731A/is unknown
- 2005-04-06 NO NO20051714A patent/NO20051714L/no not_active Application Discontinuation
-
2006
- 2006-03-08 IL IL174178A patent/IL174178A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU2003273297A1 (en) | 2004-03-29 |
PL375741A1 (en) | 2005-12-12 |
NO20051714L (no) | 2005-06-06 |
EA200500473A1 (ru) | 2005-10-27 |
EA007812B1 (ru) | 2007-02-27 |
JP2006511468A (ja) | 2006-04-06 |
KR20050083682A (ko) | 2005-08-26 |
CN1729015A (zh) | 2006-02-01 |
AU2003273297A8 (en) | 2004-03-29 |
ZA200505423B (en) | 2008-08-27 |
CA2497960A1 (en) | 2004-03-18 |
WO2004022577A2 (en) | 2004-03-18 |
IL174178A0 (en) | 2006-08-01 |
EP1545586A4 (en) | 2007-09-26 |
IS7731A (is) | 2005-03-08 |
MXPA05002617A (es) | 2005-09-08 |
WO2004022577A3 (en) | 2004-09-16 |
CN101371920A (zh) | 2009-02-25 |
EP1545586A2 (en) | 2005-06-29 |
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B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A E 8AANUIDADE(S). |
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B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2129 DE 25/10/2011. |