BR0314006A - Métodos de administração de dose tóxica de um composto de vitamina d a um mamìfero, sem desenvolvimento de hipercalcemia, e de tratemento da psorìase, de doença selecionada do grupo que consiste em leucemia, câncer de cólon, câncer da mama ou câncer de próstata, de doença auto-imune selecionada do grupo que consiste em esclerose múltipla, lúpus, doença inflamatória do intestino, diabete do tipo i, reação do hospedeiro contra enxerto e rejeição de transplante de órgão e composição farmacêutica - Google Patents

Métodos de administração de dose tóxica de um composto de vitamina d a um mamìfero, sem desenvolvimento de hipercalcemia, e de tratemento da psorìase, de doença selecionada do grupo que consiste em leucemia, câncer de cólon, câncer da mama ou câncer de próstata, de doença auto-imune selecionada do grupo que consiste em esclerose múltipla, lúpus, doença inflamatória do intestino, diabete do tipo i, reação do hospedeiro contra enxerto e rejeição de transplante de órgão e composição farmacêutica

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Publication number
BR0314006A
BR0314006A BR0314006-7A BR0314006A BR0314006A BR 0314006 A BR0314006 A BR 0314006A BR 0314006 A BR0314006 A BR 0314006A BR 0314006 A BR0314006 A BR 0314006A
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BR
Brazil
Prior art keywords
cancer
disease
group
disease selected
lupus
Prior art date
Application number
BR0314006-7A
Other languages
English (en)
Inventor
Hector F Deluca
J Wesley Pike
Lori A Plum
Nirupama K Shevde
Margaret Clagett-Dame
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Wisconsin Alumni Res Found
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=31977538&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0314006(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found
Publication of BR0314006A publication Critical patent/BR0314006A/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nutrition Science (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"MéTODOS DE ADMINISTRAçãO DE DOSE TóXICA DE UM COMPOSTO DE VITAMINA D A UM MAMìFERO, SEM DESENVOLVIMENTO DE HIPERCALCEMIA, E DE TRATAMENTO DA PSORìASE, DE DOENçA SELECIONADA DO GRUPO QUE CONSISTE EM LEUCEMIA, CâNCER DO CóLON, CâNCER DA MAMA OU CâNCER DA PRóSTATA, DE DOENçA AUTO-IMUNE SELECIONADA DO GRUPO QUE CONSISTE EM ESCLEROSE MúLTIPLA, LúPUS, DOENçA INFLAMATóRIA DO INTESTINO, DIABETE DO TIPO I, REAçãO DO HOSPEDEIRO CONTRA ENXERTO E REJEIçãO DE TRANSPLANTES DE óRGãO E COMPOSIçãO FARMACêUTICA". São administrados inibidores de reabsorção de cálcio do osso para permitir que sejam dadas elevadas dosagens de compostos de vitamina D ou miméticos com o intento de tratamento de doenças não relacionadas a cálcio tais como câncer, psoríase e doença auto-imune sem os perigos de calcificação do rim, coração e aorta. Os inibidores de reabsorção de cálcio do osso incluem os bifosfonatos, OPG ou o receptor RANK solúvel conhecido como sRANK, e funcionam de modo a bloquear a disponibilidade de cálcio a partir do osso, impedindo, desse modo, a hipercalcemia e a calcificação resultante de tecidos moles. Assim, podem ser utilizadas elevadas dosagens de 1<244>,25-dihidroxivitamina D~ 3~ (1,25-(OH)~ 2~D~ 3~), seus análogos, prodrogas ou miméticos com risco mínimo para o paciente. Especificamente, mostra-se que o alendronato bloqueia a atividade de mobilização do cálcio do osso de ambos os 1,25-(OH)~ 2~D~ 3~ e seu análogo muito potente, 2-metileno-19-nor-20 (S)-1<244>,25-dihidroxi-vitamina D~ 3~.
BR0314006-7A 2002-09-05 2003-06-26 Métodos de administração de dose tóxica de um composto de vitamina d a um mamìfero, sem desenvolvimento de hipercalcemia, e de tratemento da psorìase, de doença selecionada do grupo que consiste em leucemia, câncer de cólon, câncer da mama ou câncer de próstata, de doença auto-imune selecionada do grupo que consiste em esclerose múltipla, lúpus, doença inflamatória do intestino, diabete do tipo i, reação do hospedeiro contra enxerto e rejeição de transplante de órgão e composição farmacêutica BR0314006A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/235,244 US7259143B2 (en) 2002-09-05 2002-09-05 Method of extending the dose range of vitamin D compounds
PCT/US2003/020517 WO2004022068A1 (en) 2002-09-05 2003-06-26 A method of extending the dose range of vitamin d compounds

Publications (1)

Publication Number Publication Date
BR0314006A true BR0314006A (pt) 2005-08-09

Family

ID=31977538

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0314006-7A BR0314006A (pt) 2002-09-05 2003-06-26 Métodos de administração de dose tóxica de um composto de vitamina d a um mamìfero, sem desenvolvimento de hipercalcemia, e de tratemento da psorìase, de doença selecionada do grupo que consiste em leucemia, câncer de cólon, câncer da mama ou câncer de próstata, de doença auto-imune selecionada do grupo que consiste em esclerose múltipla, lúpus, doença inflamatória do intestino, diabete do tipo i, reação do hospedeiro contra enxerto e rejeição de transplante de órgão e composição farmacêutica

Country Status (13)

Country Link
US (1) US7259143B2 (pt)
EP (1) EP1545549A1 (pt)
JP (1) JP2006500388A (pt)
KR (1) KR100835456B1 (pt)
CN (1) CN1694711A (pt)
AU (2) AU2003245748A1 (pt)
BR (1) BR0314006A (pt)
CA (1) CA2497828A1 (pt)
MX (1) MXPA05002467A (pt)
NZ (1) NZ539129A (pt)
PL (1) PL375558A1 (pt)
WO (1) WO2004022068A1 (pt)
ZA (1) ZA200501843B (pt)

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WO2006086613A2 (en) * 2005-02-11 2006-08-17 Wisconsin Alumni Research Foundation 2-METHYLENE-19-NOR- (20S-24S) - 1α, 25-D IHYDROXYVITAMIN-D2
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Also Published As

Publication number Publication date
ZA200501843B (en) 2006-05-31
KR100835456B1 (ko) 2008-06-09
PL375558A1 (en) 2005-11-28
US20040053813A1 (en) 2004-03-18
AU2003245748A1 (en) 2004-03-29
JP2006500388A (ja) 2006-01-05
AU2009217403A1 (en) 2009-10-08
MXPA05002467A (es) 2005-05-27
CA2497828A1 (en) 2004-03-18
US7259143B2 (en) 2007-08-21
EP1545549A1 (en) 2005-06-29
CN1694711A (zh) 2005-11-09
WO2004022068A1 (en) 2004-03-18
NZ539129A (en) 2008-05-30
KR20050057180A (ko) 2005-06-16

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: PARA:INT.CI. A61K 31/59, A61P 35/00, A61P 17/00

Ipc: A61K 31/59 (2011.01), A61P 35/00 (2011.01), A61P 1

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]