BR0313290A - Derivado de pirazol, composição medicinal contendo o mesmo, uso medicinal dele, e intermediário para a sua produção - Google Patents

Derivado de pirazol, composição medicinal contendo o mesmo, uso medicinal dele, e intermediário para a sua produção

Info

Publication number
BR0313290A
BR0313290A BR0313290-0A BR0313290A BR0313290A BR 0313290 A BR0313290 A BR 0313290A BR 0313290 A BR0313290 A BR 0313290A BR 0313290 A BR0313290 A BR 0313290A
Authority
BR
Brazil
Prior art keywords
optionally substituted
group etc
alkyl group
pyrazole
chem
Prior art date
Application number
BR0313290-0A
Other languages
English (en)
Other versions
BRPI0313290B1 (pt
Inventor
Hirotaka Teranishi
Nobuhiko Fushimi
Shigeru Yonekubo
Kazuo Shimizu
Toshihide Shibazaki
Masayuki Isaji
Original Assignee
Kissei Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kissei Pharmaceutical filed Critical Kissei Pharmaceutical
Publication of BR0313290A publication Critical patent/BR0313290A/pt
Publication of BRPI0313290B1 publication Critical patent/BRPI0313290B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Neurology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Neurosurgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"DERIVADO DE PIRAZOL, COMPOSIçãO MEDICINAL CONTENDO O MESMO, USO MEDICINAL DELE, E INTERMEDIáRIO PARA A SUA PRODUçãO". Um derivado de pirazol, representado pela fórmula geral (I) (em que R^ 1^ é H, alquila C~ 1-6~ opcionalmente substituído etc.; um de Q e T é o grupo da fórmula (II) ou da fórmula (III) e o outro é alquila C~ 1-6~ opcionalmente substituído etc.; R^ 2^ é H, halogênio, OH, alquila C~ 1-6~ opcionalmente substituído etc.; X é um ligação simples, O ou S; Y é urna ligação simples, alquileno C~ 1-6~ etc.; Z é CO OU SO~ 2~; cada um de R^ 4^ e R^ 5^ é H, alquila C~ 1-6~ opcionalmente substituído etc.; e cada um de R^ 3^, R^ 6^ e R^ 7^ é H, halogênio etc.), um sal farmaceuticamente aceitável do derivado ou um promedicamento de qualquer um dos dois. Eles têm uma atividade inibidora excelente de SGLT1 humano e são úteis como um agente preventivo ou terapêutico para doenças atribuíveis à hiperglicemia tais como diabetes, complicações de diabetes e obesidade.
BRPI0313290A 2002-08-08 2003-08-07 derivados de pirazol, promedicamento, composição farmacêutica, agentes terapêuticos e uso medicinal BRPI0313290B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2002232074 2002-08-08
JP2002321729 2002-11-05
PCT/JP2003/010048 WO2004014932A1 (ja) 2002-08-08 2003-08-07 ピラゾール誘導体、それを含有する医薬組成物、その医薬用途及びその製造中間体

Publications (2)

Publication Number Publication Date
BR0313290A true BR0313290A (pt) 2005-07-05
BRPI0313290B1 BRPI0313290B1 (pt) 2016-12-06

Family

ID=31719857

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0313290A BRPI0313290B1 (pt) 2002-08-08 2003-08-07 derivados de pirazol, promedicamento, composição farmacêutica, agentes terapêuticos e uso medicinal

Country Status (19)

Country Link
US (2) US7375087B2 (pt)
EP (1) EP1544208B1 (pt)
JP (1) JP4540475B2 (pt)
KR (1) KR100985502B1 (pt)
AT (1) ATE469161T1 (pt)
AU (1) AU2003254847B2 (pt)
BR (1) BRPI0313290B1 (pt)
CA (1) CA2494179C (pt)
DE (1) DE60332743D1 (pt)
ES (1) ES2345250T3 (pt)
HK (1) HK1082743A1 (pt)
IL (1) IL166748A0 (pt)
MX (1) MXPA05001549A (pt)
NO (1) NO330456B1 (pt)
NZ (1) NZ538117A (pt)
PL (1) PL213095B1 (pt)
RU (1) RU2356906C2 (pt)
TW (1) TW200413401A (pt)
WO (1) WO2004014932A1 (pt)

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Also Published As

Publication number Publication date
NZ538117A (en) 2007-01-26
NO330456B1 (no) 2011-04-18
US7375087B2 (en) 2008-05-20
EP1544208B1 (en) 2010-05-26
CA2494179C (en) 2012-04-24
HK1082743A1 (en) 2006-06-16
TW200413401A (en) 2004-08-01
JPWO2004014932A1 (ja) 2005-12-02
WO2004014932A1 (ja) 2004-02-19
EP1544208A1 (en) 2005-06-22
DE60332743D1 (de) 2010-07-08
EP1544208A4 (en) 2007-05-02
RU2005106259A (ru) 2005-08-27
MXPA05001549A (es) 2005-05-05
BRPI0313290B1 (pt) 2016-12-06
ATE469161T1 (de) 2010-06-15
KR20050059067A (ko) 2005-06-17
AU2003254847B2 (en) 2009-06-04
KR100985502B1 (ko) 2010-10-05
US20060166899A1 (en) 2006-07-27
ES2345250T3 (es) 2010-09-20
RU2356906C2 (ru) 2009-05-27
PL213095B1 (pl) 2013-01-31
NO20051209L (no) 2005-04-15
US7655632B2 (en) 2010-02-02
US20080312153A1 (en) 2008-12-18
CA2494179A1 (en) 2004-02-19
IL166748A0 (en) 2006-01-15
JP4540475B2 (ja) 2010-09-08
AU2003254847A1 (en) 2004-02-25
TWI341843B (pt) 2011-05-11
PL375473A1 (en) 2005-11-28

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