BR0312429A - Pistão de deformidade mìnima e de volume eficiente para sistemas de distribuição de drogas por osmose - Google Patents

Pistão de deformidade mìnima e de volume eficiente para sistemas de distribuição de drogas por osmose

Info

Publication number
BR0312429A
BR0312429A BR0312429-0A BR0312429A BR0312429A BR 0312429 A BR0312429 A BR 0312429A BR 0312429 A BR0312429 A BR 0312429A BR 0312429 A BR0312429 A BR 0312429A
Authority
BR
Brazil
Prior art keywords
piston
capsule
agent
deformity
minimal
Prior art date
Application number
BR0312429-0A
Other languages
English (en)
Portuguese (pt)
Inventor
Scott D Lautenbach
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of BR0312429A publication Critical patent/BR0312429A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M2005/14513—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons with secondary fluid driving or regulating the infusion

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BR0312429-0A 2002-06-26 2003-06-25 Pistão de deformidade mìnima e de volume eficiente para sistemas de distribuição de drogas por osmose BR0312429A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39200402P 2002-06-26 2002-06-26
PCT/US2003/020130 WO2004002565A1 (en) 2002-06-26 2003-06-25 Minimally compliant, volume efficient piston for osmotic drug delivery systems

Publications (1)

Publication Number Publication Date
BR0312429A true BR0312429A (pt) 2005-04-19

Family

ID=30000792

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0312429-0A BR0312429A (pt) 2002-06-26 2003-06-25 Pistão de deformidade mìnima e de volume eficiente para sistemas de distribuição de drogas por osmose

Country Status (19)

Country Link
US (3) US6939556B2 (enExample)
EP (1) EP1551493B1 (enExample)
JP (1) JP4485945B2 (enExample)
KR (1) KR101046903B1 (enExample)
CN (1) CN100453130C (enExample)
AT (1) ATE376854T1 (enExample)
AU (1) AU2003256308B2 (enExample)
BR (1) BR0312429A (enExample)
CA (1) CA2490544C (enExample)
DE (1) DE60317225T2 (enExample)
EC (1) ECSP055578A (enExample)
ES (1) ES2295642T3 (enExample)
IL (1) IL165975A (enExample)
MX (1) MXPA05000224A (enExample)
NO (1) NO20050368L (enExample)
NZ (1) NZ537628A (enExample)
TW (1) TW200531709A (enExample)
WO (1) WO2004002565A1 (enExample)
ZA (1) ZA200500744B (enExample)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY125870A (en) * 1997-07-25 2006-08-30 Alza Corp Osmotic delivery system flow modulator apparatus and method
US7919109B2 (en) 1999-02-08 2011-04-05 Intarcia Therapeutics, Inc. Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles
US7258869B1 (en) 1999-02-08 2007-08-21 Alza Corporation Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicle
US7731947B2 (en) 2003-11-17 2010-06-08 Intarcia Therapeutics, Inc. Composition and dosage form comprising an interferon particle formulation and suspending vehicle
RU2342118C2 (ru) * 2002-12-19 2008-12-27 Алза Корпорейшн Стабильные неводные однофазные гели и композиции на их основе для доставки из имплантируемого устройства
CA2520766A1 (en) * 2003-03-31 2004-10-21 Alza Corporation Osmotic delivery system and method for decreasing start-up times for osmotic delivery systems
EP1613389B8 (en) * 2003-03-31 2008-05-07 Intarcia Therapeutics, Inc. Osmotic pump with means for dissipating internal pressure
KR20060121890A (ko) * 2003-11-06 2006-11-29 알자 코포레이션 이식형 삼투 펌프와 함께 사용하기 위한 모듈식 흡수율감소기
US20050266087A1 (en) * 2004-05-25 2005-12-01 Gunjan Junnarkar Formulations having increased stability during transition from hydrophobic vehicle to hydrophilic medium
BRPI0518483A2 (pt) 2004-11-23 2008-11-18 Neuromolecular Pharmaceuticals Inc composiÇço compreendendo uma matriz ou revestimento de liberaÇço controlada e um antagonista de receptor de nmda, mÉtodo para administraÇço de tal antagonista de nmda a um paciente
US7619007B2 (en) 2004-11-23 2009-11-17 Adamas Pharmaceuticals, Inc. Method and composition for administering an NMDA receptor antagonist to a subject
CA2588296A1 (en) 2004-11-24 2006-06-01 Neuromolecular Pharmaceuticals, Inc. Composition comprising an nmda receptor antagonist and levodopa and use thereof for treating neurological disease
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
EP1877077A2 (en) * 2005-02-03 2008-01-16 Intarcia Therapeutics, Inc. An implantable interferon-containing device
WO2006083761A2 (en) 2005-02-03 2006-08-10 Alza Corporation Solvent/polymer solutions as suspension vehicles
US7959938B2 (en) * 2005-03-15 2011-06-14 Intarcia Therapeutics, Inc. Polyoxaester suspending vehicles for use with implantable delivery systems
BRPI0607017B8 (pt) 2005-04-06 2021-05-25 Adamas Pharmaceuticals Inc composição farmacêutica compreendendo memantina e donezepil, e seu uso para o tratamento de condições relacionadas ao snc
EP1948183B1 (en) * 2005-10-13 2013-12-18 Duke University Compositions for the treatment and prevention of heart disease and methods of using same
MX2008014870A (es) 2006-05-30 2009-02-12 Intarcia Therapeutics Inc Modulador de flujo para sistema de suministro osmotico con canal interno de dos piezas.
MX2009001114A (es) 2006-08-09 2009-02-10 Intarcia Therapeutics Inc Sistemas de suministro osmotico y ensambles de piston.
CN104000779A (zh) 2007-04-23 2014-08-27 精达制药公司 促胰岛素释放肽的混悬制剂及其应用
US8105261B2 (en) * 2007-07-02 2012-01-31 Cardiac Pacemakers, Inc. Osmotic devices and methods for diuretic therapy
US8394644B2 (en) * 2007-11-08 2013-03-12 Honeywell International Inc. Microfluidic osmotic pump
CA2726861C (en) 2008-02-13 2014-05-27 Intarcia Therapeutics, Inc. Devices, formulations, and methods for delivery of multiple beneficial agents
US20100092566A1 (en) * 2008-10-15 2010-04-15 Alessi Thomas R Highly concentrated drug particles, formulations, suspensions and uses thereof
US8343516B2 (en) * 2009-06-26 2013-01-01 Taris Biomedical, Inc. Solid drug tablets for implantable drug delivery devices
DK2462246T3 (da) 2009-09-28 2017-11-06 Intarcia Therapeutics Inc Hurtig etablering og/eller afslutning af væsentlig steady-state-lægemiddelafgivelse
EP2482677A1 (en) 2009-09-30 2012-08-08 The Regents of The University of California Cofactors and methods for use for individuals
CN106389381A (zh) 2009-12-02 2017-02-15 阿达玛斯医药公司 金刚烷胺组合物及其使用方法
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
EP3466418A1 (en) 2011-07-15 2019-04-10 NuSirt Sciences, Inc. Compositions and methods for modulating metabolic pathways
US9198454B2 (en) 2012-03-08 2015-12-01 Nusirt Sciences, Inc. Compositions, methods, and kits for regulating energy metabolism
KR101723319B1 (ko) * 2012-10-12 2017-04-04 일라이 릴리 앤드 캄파니 화학 엔진, 및 특히 고점성 유체의 주사에서의 그의 사용을 위한 방법
CN108452311A (zh) 2012-11-13 2018-08-28 纽斯尔特科学公司 用于增强能量代谢的组合物和方法
WO2014113404A1 (en) 2013-01-15 2014-07-24 Nusirt Sciences, Inc. Treating pulmonary conditions
JP2016508842A (ja) * 2013-03-05 2016-03-24 タリス バイオメディカル エルエルシー 装置の開口部を通じて制御された薬物放出のための薬物送達装置及び方法
WO2014152016A1 (en) 2013-03-15 2014-09-25 Nusirt Sciences, Inc. Leucine and nicotinic acid reduces lipid levels
US10154971B2 (en) 2013-06-17 2018-12-18 Adamas Pharma, Llc Methods of administering amantadine
MX2016011063A (es) 2014-02-27 2016-11-30 Nusirt Sciences Inc Composiciones y metodos para la reduccion o prevencion de esteatosis hepatica.
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
US10925639B2 (en) 2015-06-03 2021-02-23 Intarcia Therapeutics, Inc. Implant placement and removal systems
AU2016349381B2 (en) 2015-11-05 2023-02-23 The General Hospital Corporation Intrathecal delivery of nucleic acid sequences encoding ABCD1 for treatment of adrenomyeloneuropathy
JP6902033B2 (ja) 2015-12-30 2021-07-14 アダマス ファーマシューティカルズ， インコーポレイテッド 発作−関連障害の処置のための方法および組成物
MA53353A (fr) 2016-05-16 2021-06-09 Intarcia Therapeutics Inc Polypeptides sélectifs pour le récepteur du glucagon et méthodes pour leur utilisation
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
US10406336B2 (en) 2016-08-03 2019-09-10 Neil S. Davey Adjustable rate drug delivery implantable device
SG11201903462UA (en) 2016-10-20 2019-05-30 Peptron Inc Methods of delivering a neuroprotective polypeptide to the central nervous system
KR20190104039A (ko) 2017-01-03 2019-09-05 인타르시아 세라퓨틱스 인코포레이티드 Glp-1 수용체 효능제의 연속적인 투여 및 약물의 동시-투여를 포함하는 방법
WO2018152018A1 (en) 2017-02-17 2018-08-23 Eli Lilly And Company Processes and devices for delivery of fluid by chemical reaction
US20200188479A1 (en) 2017-03-08 2020-06-18 Intarcia Therapeutics, Inc. Apparatus and methods for administration of a nauseogenic compound from a drug delivery device
WO2018200885A1 (en) 2017-04-26 2018-11-01 Neurocentria, Inc. Magnesium compositions and methods of use
CA3074810C (en) 2017-09-08 2022-07-12 Eli Lilly And Company System for controlling gas generation within a drug delivery device
USD933219S1 (en) 2018-07-13 2021-10-12 Intarcia Therapeutics, Inc. Implant removal tool and assembly
US12128201B2 (en) 2018-08-23 2024-10-29 Baywind Bioventures Capsule device for delivery of active agent to gastrointestinal tract
BR112021006823A2 (pt) 2018-10-11 2021-07-27 Intarcia Therapeutics, Inc. polipeptídeos análogos de amilina humana e métodos de uso
AU2019402055B2 (en) 2018-12-19 2022-09-29 Eli Lilly And Company Devices for delivery of therapeutic fluids
CN113164681B (zh) 2018-12-19 2024-12-06 伊莱利利公司 用于递送治疗性流体的装置和过程
WO2025160155A1 (en) 2024-01-22 2025-07-31 The Broad Institute, Inc. Epigenetic targeting of prion diseases

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4753651A (en) 1982-08-30 1988-06-28 Alza Corporation Self-driven pump
US4765989A (en) 1983-05-11 1988-08-23 Alza Corporation Osmotic device for administering certain drugs
US4558888A (en) * 1983-09-19 1985-12-17 Minnesota Mining And Manufacturing Company Strip of binding tape
US4874388A (en) 1987-06-25 1989-10-17 Alza Corporation Multi-layer delivery system
US5728088A (en) 1988-12-13 1998-03-17 Alza Corporation Osmotic system for delivery of fluid-sensitive somatotropins to bovine animals
US5034229A (en) 1988-12-13 1991-07-23 Alza Corporation Dispenser for increasing feed conversion of hog
US4969884A (en) 1988-12-28 1990-11-13 Alza Corporation Osmotically driven syringe
US5234424A (en) 1988-12-28 1993-08-10 Alza Corporation Osmotically driven syringe
US5133974A (en) 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
US5030216A (en) 1989-12-15 1991-07-09 Alza Corporation Osmotically driven syringe
US5324280A (en) 1990-04-02 1994-06-28 Alza Corporation Osmotic dosage system for delivering a formulation comprising liquid carrier and drug
US5234692A (en) 1990-07-11 1993-08-10 Alza Corporation Delivery device with a protective sleeve
US5180591A (en) 1990-07-11 1993-01-19 Alza Corporation Delivery device with a protective sleeve
US5443459A (en) 1991-01-30 1995-08-22 Alza Corporation Osmotic device for delayed delivery of agent
US5861166A (en) 1991-03-12 1999-01-19 Alza Corporation Delivery device providing beneficial agent stability
CN2085662U (zh) * 1991-03-29 1991-10-02 毕勇 药物″渗透泵″的生产装置
US5137727A (en) 1991-06-12 1992-08-11 Alza Corporation Delivery device providing beneficial agent stability
DE69229881T2 (de) 1991-10-04 1999-12-09 Yoshitomi Pharmaceutical Industries, Ltd. Tablette mit verzögerter freisetzung
EP0607321A1 (en) 1991-10-10 1994-07-27 Alza Corporation Osmotic drug delivery devices with hydrophobic wall materials
US5580578A (en) 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
US5308348A (en) 1992-02-18 1994-05-03 Alza Corporation Delivery devices with pulsatile effect
US5456679A (en) 1992-02-18 1995-10-10 Alza Corporation Delivery devices with pulsatile effect
US5209746A (en) 1992-02-18 1993-05-11 Alza Corporation Osmotically driven delivery devices with pulsatile effect
US5221278A (en) 1992-03-12 1993-06-22 Alza Corporation Osmotically driven delivery device with expandable orifice for pulsatile delivery effect
US5260069A (en) 1992-11-27 1993-11-09 Anda Sr Pharmaceuticals Inc. Pulsatile particles drug delivery system
US5540665A (en) 1994-01-31 1996-07-30 Alza Corporation Gas driven dispensing device and gas generating engine therefor
US5458888A (en) 1994-03-02 1995-10-17 Andrx Pharmaceuticals, Inc. Controlled release tablet formulation
US5690952A (en) 1995-06-07 1997-11-25 Judy A. Magruder et al. Implantable system for delivery of fluid-sensitive agents to animals
US6261584B1 (en) 1996-02-02 2001-07-17 Alza Corporation Sustained delivery of an active agent using an implantable system
US6156331A (en) 1996-02-02 2000-12-05 Alza Corporation Sustained delivery of an active agent using an implantable system
PL189289B1 (pl) * 1996-02-02 2005-07-29 Alza Corp Sposób przygotowania implantowanego układu do dostarczania substancji aktywnej
US6395292B2 (en) 1996-02-02 2002-05-28 Alza Corporation Sustained delivery of an active agent using an implantable system
US6132420A (en) 1996-02-02 2000-10-17 Alza Corporation Osmotic delivery system and method for enhancing start-up and performance of osmotic delivery systems
ZA981610B (en) 1997-03-24 1999-08-26 Alza Corp Self adjustable exit port.
MY125870A (en) * 1997-07-25 2006-08-30 Alza Corp Osmotic delivery system flow modulator apparatus and method
MY125849A (en) * 1997-07-25 2006-08-30 Alza Corp Osmotic delivery system, osmotic delivery system semipermeable body assembly, and method for controlling delivery rate of beneficial agents from osmotic delivery systems
WO1999033446A1 (en) 1997-12-29 1999-07-08 Alza Corporation Osmotic delivery system with membrane plug retention mechanism
AU765909C (en) 1998-12-17 2004-09-23 Alza Corporation Conversion of liquid filled gelatin capsules into controlled release systems by multiple coatings
AU2587002A (en) * 2000-11-03 2002-05-15 Biomedicines Inc Method for short-term and long-term drug dosimetry

Also Published As

Publication number Publication date
JP2005530588A (ja) 2005-10-13
ES2295642T3 (es) 2008-04-16
US20060111693A1 (en) 2006-05-25
US7112335B2 (en) 2006-09-26
US20070088337A1 (en) 2007-04-19
WO2004002565A1 (en) 2004-01-08
EP1551493A1 (en) 2005-07-13
ZA200500744B (en) 2006-03-29
TW200531709A (en) 2005-10-01
AU2003256308A1 (en) 2004-01-19
DE60317225T2 (de) 2008-05-29
ECSP055578A (es) 2005-04-18
IL165975A (en) 2009-07-20
CN100453130C (zh) 2009-01-21
CA2490544C (en) 2011-04-19
AU2003256308B2 (en) 2008-07-03
NO20050368L (no) 2005-01-24
US20040019345A1 (en) 2004-01-29
KR101046903B1 (ko) 2011-07-06
DE60317225D1 (de) 2007-12-13
IL165975A0 (en) 2006-01-15
ATE376854T1 (de) 2007-11-15
CA2490544A1 (en) 2004-01-08
NZ537628A (en) 2005-12-23
JP4485945B2 (ja) 2010-06-23
CN1671439A (zh) 2005-09-21
KR20050026416A (ko) 2005-03-15
HK1080402A1 (en) 2006-04-28
US6939556B2 (en) 2005-09-06
MXPA05000224A (es) 2005-06-03
EP1551493B1 (en) 2007-10-31

Similar Documents

Publication Publication Date Title
BR0312429A (pt) Pistão de deformidade mìnima e de volume eficiente para sistemas de distribuição de drogas por osmose
WO2000040218A3 (en) Osmotic delivery system having space efficient piston
AR033418A1 (es) Preparado farmaceutico mucoadhesivo desintegrable para la administracion de sustancia activa en medicina veterinaria y humana
BRPI0412975A (pt) espuma penetrante para uso farmacêutico
CO4810236A1 (es) Bomba y sistema de irrigacion medico
AU2003282683A1 (en) Photokinetic delivery of biologically active substances using pulsed incoherent light
UY27940A1 (es) Formulacion de anticuerpos humanos para el tratamiento de trastornos asociados con tnf-a
DK1328256T3 (da) Ventil til osmotiske indretninger
WO2003024508A3 (en) Gas pressure actuated microneedle arrays, and systems and methods relating to same
CO4970812A1 (es) Sistemas de suministro osmotico, ensamble del cuerpo del sistema de suministro osmotico y sistema para controlar la tasa de suministro de agentes beneficos del sistema de suministro osmotico.
AR055256A1 (es) Capsula descartable para bebidas y metodo de apertura de dicha capsula
WO2002085428A3 (en) Implantable osmotic pump
CO4700491A1 (es) Sistema transcorneal de liberacion de medicamentos
WO2002068013A3 (en) Multiple canopy
BRPI0910341A2 (pt) dispositivo para conservação, preparação espontanea e administração de um principio ativo
WO2007024800A3 (en) Device and method for making discrete volumes of a first fluid in contact with a second fluid, which are immiscible with each other
BRPI0508442A (pt) dispositivo mecánico para misturar uma amostra fluida com uma solução de tratamento
CL2004000899A1 (es) Composicion farmaceutica que contiene la sal sodica de telmisartan y un agente diuretico y procedimiento de preparacion.
PL1716224T3 (pl) Od rzadkiego po gęsty układ wieloskładnikowy
CA2468788A1 (en) Reverse-micellar delivery system for controlled transportation and enhanced absorption of agents
MX2008001043A (es) Contenedor.
TW200509999A (en) Osmotic delivery system and method for decreasing start-up times for osmotic delivery systems
BR0111095A (pt) Recipiente de múltiplos compartimentos para soluções médicas estéreis, solução médica estéril, e, método de estabilização e uso de uma solução médica estéril contendo carboidrato
US20050215850A1 (en) Syringe pump
AR033182A1 (es) Composicion

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE 7A. E 8A. ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: NAO APRESENTADA A GUIA DE CUMPRIMENTO DE EXIGENCIA. REFERENTE AS 7A E 8A ANUIDADES.