BR0311720A - Método para mapear e eliminar epitopos de células t - Google Patents
Método para mapear e eliminar epitopos de células tInfo
- Publication number
- BR0311720A BR0311720A BR0311720-0A BR0311720A BR0311720A BR 0311720 A BR0311720 A BR 0311720A BR 0311720 A BR0311720 A BR 0311720A BR 0311720 A BR0311720 A BR 0311720A
- Authority
- BR
- Brazil
- Prior art keywords
- epitopes
- identification
- mapping
- eliminating
- cell epitopes
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in eptitope analysis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
- G01N33/505—Cells of the immune system involving T-cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
"MéTODO PARA MAPEAR E ELIMINAR EPITOPOS DE CéLULAS T". A presente invenção refere-se a métodos de varredura para a identificação de determinantes e epitopos em moléculas proteicas capazes de incitar a uma resposta imune. Particularmente, a presente invenção está relacionada com a identificação de epitopos para células T em proteínas terapêuticas. A presente invenção também refere-se a uma abordagem combinada do uso de um mapeamento de epitopo com a identificação de ligantes de MHC classe II derivados do referido método de mapeamento de epitopo e o desenho do ánalogo de seq³ência apresentando um número reduzido de tais ligantes e epitopos, respectivamente.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02012919 | 2002-06-11 | ||
| PCT/EP2003/006110 WO2003104803A2 (en) | 2002-06-11 | 2003-06-11 | Method for mapping and eliminating t-cell epitopes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0311720A true BR0311720A (pt) | 2005-03-01 |
Family
ID=29724386
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0311720-0A BR0311720A (pt) | 2002-06-11 | 2003-06-11 | Método para mapear e eliminar epitopos de células t |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP1512004B1 (pt) |
| JP (1) | JP2005529170A (pt) |
| CN (1) | CN100401064C (pt) |
| AT (1) | ATE320603T1 (pt) |
| AU (1) | AU2003273679A1 (pt) |
| BR (1) | BR0311720A (pt) |
| CA (1) | CA2489180A1 (pt) |
| DE (1) | DE60304040T2 (pt) |
| DK (1) | DK1512004T3 (pt) |
| ES (1) | ES2257680T3 (pt) |
| MX (1) | MXPA04012209A (pt) |
| PL (1) | PL371675A1 (pt) |
| PT (1) | PT1512004E (pt) |
| RU (1) | RU2334235C2 (pt) |
| WO (1) | WO2003104803A2 (pt) |
| ZA (1) | ZA200500214B (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004074486A2 (en) * | 2003-02-18 | 2004-09-02 | Merck Patent Gmbh | Fusion proteins of interferon alpha muteins with improved properties |
| PT1737961E (pt) | 2004-03-19 | 2013-08-26 | Merck Patent Gmbh | Proteínas buganina modificadas, citotoxinas e métodos e utilizações das mesmas |
| FR2940451B1 (fr) | 2008-12-18 | 2014-09-12 | Proteus | Procede d'evaluation de l'immunogenicite des proteines |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6001349A (en) * | 1995-02-22 | 1999-12-14 | Therion Biologics Corporation | Generation of human cytotoxic T-cells specific for carcinoma self-associated antigens and uses thereof |
| US5945401A (en) * | 1995-06-23 | 1999-08-31 | Conlon; Paul J. | Peptide analogues of the 65KD isoform of human glutamic acid decarboxylase and uses thereof |
| US6165460A (en) * | 1995-07-10 | 2000-12-26 | Therion Biologics Corporation | Generation of immune responses to prostate-specific antigen (PSA) |
| ATE412175T1 (de) * | 1996-03-21 | 2008-11-15 | Circassia Ltd | Verwendung von kryptischen peptiden zur induktion von immunologischer toleranz |
| US5750356A (en) * | 1996-05-31 | 1998-05-12 | Anergen, Inc. | Method for monitoring T cell reactivity |
| EP0983303B1 (en) * | 1997-05-21 | 2006-03-08 | Biovation Limited | Method for the production of non-immunogenic proteins |
| WO2000034317A2 (en) * | 1998-12-08 | 2000-06-15 | Biovation Limited | Method for reducing immunogenicity of proteins |
| WO2002040997A2 (en) * | 2000-10-02 | 2002-05-23 | Genencor International, Inc. | Production and use of proteins producing an altered immunogenic response |
-
2003
- 2003-06-11 WO PCT/EP2003/006110 patent/WO2003104803A2/en active IP Right Grant
- 2003-06-11 PT PT03740219T patent/PT1512004E/pt unknown
- 2003-06-11 RU RU2005100758/15A patent/RU2334235C2/ru not_active IP Right Cessation
- 2003-06-11 AT AT03740219T patent/ATE320603T1/de not_active IP Right Cessation
- 2003-06-11 CA CA002489180A patent/CA2489180A1/en not_active Abandoned
- 2003-06-11 CN CNB038134519A patent/CN100401064C/zh not_active Expired - Fee Related
- 2003-06-11 DK DK03740219T patent/DK1512004T3/da active
- 2003-06-11 AU AU2003273679A patent/AU2003273679A1/en not_active Abandoned
- 2003-06-11 MX MXPA04012209A patent/MXPA04012209A/es unknown
- 2003-06-11 EP EP03740219A patent/EP1512004B1/en not_active Revoked
- 2003-06-11 PL PL03371675A patent/PL371675A1/xx unknown
- 2003-06-11 JP JP2004511824A patent/JP2005529170A/ja active Pending
- 2003-06-11 DE DE60304040T patent/DE60304040T2/de not_active Revoked
- 2003-06-11 ES ES03740219T patent/ES2257680T3/es not_active Expired - Lifetime
- 2003-06-11 BR BR0311720-0A patent/BR0311720A/pt not_active Application Discontinuation
-
2005
- 2005-01-10 ZA ZA200500214A patent/ZA200500214B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005529170A (ja) | 2005-09-29 |
| WO2003104803A3 (en) | 2004-04-15 |
| CA2489180A1 (en) | 2003-12-18 |
| ATE320603T1 (de) | 2006-04-15 |
| ES2257680T3 (es) | 2006-08-01 |
| WO2003104803A2 (en) | 2003-12-18 |
| RU2005100758A (ru) | 2006-01-20 |
| EP1512004B1 (en) | 2006-03-15 |
| DK1512004T3 (da) | 2006-06-06 |
| MXPA04012209A (es) | 2005-02-25 |
| EP1512004A2 (en) | 2005-03-09 |
| RU2334235C2 (ru) | 2008-09-20 |
| CN1659437A (zh) | 2005-08-24 |
| AU2003273679A1 (en) | 2003-12-22 |
| PT1512004E (pt) | 2006-08-31 |
| DE60304040T2 (de) | 2006-09-28 |
| PL371675A1 (en) | 2005-06-27 |
| CN100401064C (zh) | 2008-07-09 |
| DE60304040D1 (de) | 2006-05-11 |
| ZA200500214B (en) | 2006-02-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |