BR0311659A - Derivado de azuleno e sal do mesmo - Google Patents
Derivado de azuleno e sal do mesmoInfo
- Publication number
- BR0311659A BR0311659A BR0311659-0A BR0311659A BR0311659A BR 0311659 A BR0311659 A BR 0311659A BR 0311659 A BR0311659 A BR 0311659A BR 0311659 A BR0311659 A BR 0311659A
- Authority
- BR
- Brazil
- Prior art keywords
- diabetes
- salt
- azulene
- insulin
- type
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrane Compounds (AREA)
Abstract
"DERIVADO DE AZULENO E SAL DO MESMO". A presente invenção refere-se a um derivado de azuleno e um sal do mesmo, em que um anel azuleno é ligado a um anel benzênico diretamente ou via um alquileno inferior que poderá ser substituído por um átomo de halogênio e o anel benzênico que é diretamente ligado ao resíduo glicose, e são utilizáveis como inibidor de co-transportador de Na^ +^-glicose, especialmente para um agente terapêutico e/ou agente preventivo para diabetes, tais como diabetes dependente de insulina (diabetes tipo 1) e diabetes independente de insulina (diabetes tipo 2), bem como doenças relacionadas com diabetes, tais como doenças resistentes a insulina e obesidade.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002226869 | 2002-08-05 | ||
JP2003130991 | 2003-05-09 | ||
PCT/JP2003/009868 WO2004013118A1 (ja) | 2002-08-05 | 2003-08-04 | アズレン誘導体及びその塩 |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0311659A true BR0311659A (pt) | 2005-03-15 |
Family
ID=31497629
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0311659-0A BR0311659A (pt) | 2002-08-05 | 2003-08-04 | Derivado de azuleno e sal do mesmo |
Country Status (17)
Country | Link |
---|---|
US (1) | US7169761B2 (pt) |
EP (1) | EP1553094A4 (pt) |
JP (1) | JP3989934B2 (pt) |
KR (1) | KR20050088041A (pt) |
CN (1) | CN1288143C (pt) |
AR (1) | AR040780A1 (pt) |
AU (1) | AU2003252370C1 (pt) |
BR (1) | BR0311659A (pt) |
CA (1) | CA2494177C (pt) |
IL (1) | IL165177A (pt) |
MX (1) | MXPA05000718A (pt) |
NO (1) | NO20051161L (pt) |
NZ (1) | NZ536681A (pt) |
PL (1) | PL375297A1 (pt) |
RU (1) | RU2295522C2 (pt) |
TW (1) | TWI254635B (pt) |
WO (1) | WO2004013118A1 (pt) |
Families Citing this family (83)
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US8785403B2 (en) | 2003-08-01 | 2014-07-22 | Mitsubishi Tanabe Pharma Corporation | Glucopyranoside compound |
SI1651658T2 (sl) | 2003-08-01 | 2020-12-31 | Mitsubishi Tanabe Pharma Corporation | Nove spojine, ki imajo inhibitorno aktivnost proti transporterju, ki je odvisen od natrija |
WO2005085265A1 (ja) * | 2004-03-04 | 2005-09-15 | Kissei Pharmaceutical Co., Ltd. | 縮合ヘテロ環誘導体、それを含有する医薬組成物およびその医薬用途 |
SG151271A1 (en) | 2004-03-16 | 2009-04-30 | Boehringer Ingelheim Int | Glucopyranosyl-substituted benzol derivatives, drugs containing said compounds, the use thereof and method for the production thereof |
TW200602335A (en) * | 2004-03-31 | 2006-01-16 | Kissei Pharmaceutical | Naphthalene derivative, medicinal composition containing the same, and medicinal use thereof |
JPWO2005095372A1 (ja) * | 2004-03-31 | 2008-02-21 | キッセイ薬品工業株式会社 | ナフタレン誘導体、それを含有する医薬組成物及びその医薬用途 |
US7393836B2 (en) | 2004-07-06 | 2008-07-01 | Boehringer Ingelheim International Gmbh | D-xylopyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture |
CN1984898A (zh) * | 2004-07-08 | 2007-06-20 | 安斯泰来制药有限公司 | 生产薁衍生物的方法和合成该薁衍生物的中间体 |
TW200606129A (en) | 2004-07-26 | 2006-02-16 | Chugai Pharmaceutical Co Ltd | Novel cyclohexane derivative, its prodrug, its salt and diabetic therapeutic agent containing the same |
CA2574451A1 (en) | 2004-07-27 | 2006-02-02 | Boehringer Ingelheim International Gmbh | D-glucopyranosyl phenyl-substituted cyclene, medicaments containing these compounds, their use, and method for the production thereof |
WO2006018150A1 (de) * | 2004-08-11 | 2006-02-23 | Boehringer Ingelheim International Gmbh | D-xylopyranosyl-phenyl-substituierte cyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
DE102004048388A1 (de) * | 2004-10-01 | 2006-04-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | D-Pyranosyl-substituierte Phenyle, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
EP1828216B1 (en) | 2004-12-16 | 2008-09-10 | Boehringer Ingelheim International GmbH | Glucopyranosyl-substituted benzene derivatives, medicaments containing such compounds, their use and process for their manufacture |
TW200637839A (en) * | 2005-01-07 | 2006-11-01 | Taisho Pharmaceutical Co Ltd | 1-thio-d-glucitol derivatives |
TW200637869A (en) | 2005-01-28 | 2006-11-01 | Chugai Pharmaceutical Co Ltd | The spiroketal derivatives and the use as therapeutical agent for diabetes of the same |
MY147375A (en) | 2005-01-31 | 2012-11-30 | Mitsubishi Tanabe Pharma Corp | Indole derivatives |
JP5264183B2 (ja) | 2005-02-23 | 2013-08-14 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | グルコピラノシル置換((ヘテロ)アリールエチニル−ベンジル)−ベンゼン誘導体及びナトリウム依存性グルコース共輸送体2(sglt2)インヒビターとしてのそれらの使用 |
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US7723309B2 (en) | 2005-05-03 | 2010-05-25 | Boehringer Ingelheim International Gmbh | Crystalline forms of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((R)-tetrahydrofuran-3-yloxy)-benzyl]-benzene, a method for its preparation and the use thereof for preparing medicaments |
UA91546C2 (uk) | 2005-05-03 | 2010-08-10 | Бьорінгер Інгельхайм Інтернаціональ Гмбх | КРИСТАЛІЧНА ФОРМА 1-ХЛОР-4-(β-D-ГЛЮКОПІРАНОЗ-1-ИЛ)-2-[4-((S)-ТЕТРАГІДРОФУРАН-3-ІЛОКСИ)-БЕНЗИЛ]-БЕНЗОЛУ, СПОСІБ ЇЇ ОДЕРЖАННЯ ТА ЇЇ ЗАСТОСУВАННЯ ПРИ ПРИГОТУВАННІ ЛІКАРСЬКИХ ЗАСОБІВ |
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JP5128474B2 (ja) | 2005-07-27 | 2013-01-23 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | グルコピラノシル−置換((ヘテロ)シクロアルキルエチニル−ベンジル)−ベンゼン誘導体、該化合物を含有する薬剤、それらの使用及びそれらの製造方法 |
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AU6024998A (en) * | 1997-01-15 | 1998-08-07 | Glycomed Incorporated | Aryl c-glycoside compounds and sulfated esters thereof |
PH12000002657B1 (en) * | 1999-10-12 | 2006-02-21 | Bristol Myers Squibb Co | C-aryl glucoside SGLT2 inhibitors |
US6515117B2 (en) | 1999-10-12 | 2003-02-04 | Bristol-Myers Squibb Company | C-aryl glucoside SGLT2 inhibitors and method |
US6627611B2 (en) * | 2000-02-02 | 2003-09-30 | Kotobuki Pharmaceutical Co Ltd | C-glycosides and preparation of thereof as antidiabetic agents |
EP1385856B1 (en) * | 2001-04-11 | 2006-02-22 | Bristol-Myers Squibb Company | Amino acid complexes of c-aryl glucosides for treatment of diabetes and method |
-
2003
- 2003-08-01 TW TW092121191A patent/TWI254635B/zh not_active IP Right Cessation
- 2003-08-04 US US10/491,618 patent/US7169761B2/en not_active Expired - Fee Related
- 2003-08-04 BR BR0311659-0A patent/BR0311659A/pt not_active IP Right Cessation
- 2003-08-04 AR AR20030102793A patent/AR040780A1/es unknown
- 2003-08-04 KR KR1020047018879A patent/KR20050088041A/ko not_active Application Discontinuation
- 2003-08-04 JP JP2004525831A patent/JP3989934B2/ja not_active Expired - Fee Related
- 2003-08-04 WO PCT/JP2003/009868 patent/WO2004013118A1/ja active Application Filing
- 2003-08-04 CN CNB038175142A patent/CN1288143C/zh not_active Expired - Fee Related
- 2003-08-04 NZ NZ536681A patent/NZ536681A/en unknown
- 2003-08-04 PL PL03375297A patent/PL375297A1/xx not_active Application Discontinuation
- 2003-08-04 AU AU2003252370A patent/AU2003252370C1/en not_active Ceased
- 2003-08-04 MX MXPA05000718A patent/MXPA05000718A/es active IP Right Grant
- 2003-08-04 EP EP03766722A patent/EP1553094A4/en not_active Withdrawn
- 2003-08-04 CA CA002494177A patent/CA2494177C/en not_active Expired - Fee Related
- 2003-08-04 RU RU2005100053/04A patent/RU2295522C2/ru not_active IP Right Cessation
-
2004
- 2004-11-11 IL IL165177A patent/IL165177A/en not_active IP Right Cessation
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2005
- 2005-03-04 NO NO20051161A patent/NO20051161L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
RU2295522C2 (ru) | 2007-03-20 |
TWI254635B (en) | 2006-05-11 |
EP1553094A4 (en) | 2006-10-11 |
IL165177A0 (en) | 2005-12-18 |
RU2005100053A (ru) | 2005-07-20 |
JP3989934B2 (ja) | 2007-10-10 |
TW200406193A (en) | 2004-05-01 |
JPWO2004013118A1 (ja) | 2006-10-19 |
NZ536681A (en) | 2006-08-31 |
AU2003252370B2 (en) | 2008-11-06 |
CN1671682A (zh) | 2005-09-21 |
KR20050088041A (ko) | 2005-09-01 |
PL375297A1 (en) | 2005-11-28 |
CA2494177C (en) | 2008-10-14 |
NO20051161L (no) | 2005-03-04 |
US7169761B2 (en) | 2007-01-30 |
WO2004013118A1 (ja) | 2004-02-12 |
CN1288143C (zh) | 2006-12-06 |
EP1553094A1 (en) | 2005-07-13 |
MXPA05000718A (es) | 2005-04-08 |
CA2494177A1 (en) | 2004-02-12 |
AU2003252370C1 (en) | 2009-05-21 |
IL165177A (en) | 2009-06-15 |
US20050124555A1 (en) | 2005-06-09 |
AU2003252370A1 (en) | 2004-02-23 |
AR040780A1 (es) | 2005-04-20 |
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