BR0308164A - Método e aparelho melhorados para a separação contìnua de fluidos biológicos em componentes - Google Patents

Método e aparelho melhorados para a separação contìnua de fluidos biológicos em componentes

Info

Publication number
BR0308164A
BR0308164A BR0308164-8A BR0308164A BR0308164A BR 0308164 A BR0308164 A BR 0308164A BR 0308164 A BR0308164 A BR 0308164A BR 0308164 A BR0308164 A BR 0308164A
Authority
BR
Brazil
Prior art keywords
components
basket
lumen
improved method
biological fluids
Prior art date
Application number
BR0308164-8A
Other languages
English (en)
Other versions
BR0308164B1 (pt
Inventor
Dennis A Briggs
Michael Hutchinson
Original Assignee
Therakos Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Therakos Inc filed Critical Therakos Inc
Publication of BR0308164A publication Critical patent/BR0308164A/pt
Publication of BR0308164B1 publication Critical patent/BR0308164B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3681—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation
    • A61M1/3683—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation using photoactive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A61M1/3696—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3681—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/05—General characteristics of the apparatus combined with other kinds of therapy
    • A61M2205/051—General characteristics of the apparatus combined with other kinds of therapy with radiation therapy
    • A61M2205/053—General characteristics of the apparatus combined with other kinds of therapy with radiation therapy ultraviolet
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B04B2005/0464—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation with hollow or massive core in centrifuge bowl
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B04B2005/0492—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation with fluid conveying umbilicus between stationary and rotary centrifuge parts

Abstract

"MéTODO E APARELHO MELHORADOS PARA A SEPARAçãO CONTìNUA DE FLUIDOS BIOLóGICOS EM COMPONENTES". A presente invenção refere-se a sistemas, métodos e aparelhos para a melhoria da produção para a separação de componentes de fluidos, por exemplo, fluidos biológicos ou sensíveis, tal como sangue, e a melhoria da produção de componente, por exemplo, a partir de sangue total doado pela separação de seus componentes por densidade em um cesto de centrífuga com um lúmen multiaxial. O aparelho, o sistema e o método eliminam a necessidade de uma separação tipo de batelada do sangue e podem reduzir o tempo necessário para o tratamento de pacientes que sofram de doenças ou condições mediadas por células T ou leucócitos para menos de 70 minutos. Em um aspecto, a invenção é um cesto de centrífuga (10) que compreende um alojamento externo (100); um núcleo (200); uma placa inferior (300); um lúmen (400); um primeiro canal de cesto (420) no referido lúmen (400) para o fluxo de entrada do referido fluido (800); um segundo canal de cesto (410) para a remoção do primeiro componente de fluido separado (810); e um terceiro canal de cesto (740) para a remoção de um segundo componente de fluido separado (820).
BRPI0308164-8A 2002-03-04 2003-02-28 aparelho e método para separar componentes de um fluido. BR0308164B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US36128702P 2002-03-04 2002-03-04
US60/361,287 2002-03-04
US10/375,629 2003-02-27
US10/375,629 US7186230B2 (en) 2002-03-04 2003-02-27 Method and apparatus for the continuous separation of biological fluids into components
PCT/US2003/006032 WO2003075983A2 (en) 2002-03-04 2003-02-28 Method and apparatus for the continuous fractionation of biological fluids

Publications (2)

Publication Number Publication Date
BR0308164A true BR0308164A (pt) 2005-01-04
BR0308164B1 BR0308164B1 (pt) 2012-12-11

Family

ID=28045234

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0308164-8A BR0308164B1 (pt) 2002-03-04 2003-02-28 aparelho e método para separar componentes de um fluido.

Country Status (10)

Country Link
US (1) US7186230B2 (pt)
EP (1) EP1483000B1 (pt)
JP (1) JP4519467B2 (pt)
AU (1) AU2003219935B2 (pt)
BR (1) BR0308164B1 (pt)
CA (1) CA2478187C (pt)
ES (1) ES2483169T3 (pt)
MX (1) MXPA04008548A (pt)
NZ (3) NZ544491A (pt)
WO (1) WO2003075983A2 (pt)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6524231B1 (en) 1999-09-03 2003-02-25 Baxter International Inc. Blood separation chamber with constricted interior channel and recessed passage
ITMI20010899A1 (it) * 2001-04-30 2002-10-30 Dideco Spa Sistema di controllo della fase di lavaggio in cella per la centrifugazione del sangue
US7479123B2 (en) * 2002-03-04 2009-01-20 Therakos, Inc. Method for collecting a desired blood component and performing a photopheresis treatment
US7211037B2 (en) * 2002-03-04 2007-05-01 Therakos, Inc. Apparatus for the continuous separation of biological fluids into components and method of using same
US7297272B2 (en) 2002-10-24 2007-11-20 Fenwal, Inc. Separation apparatus and method
TWM269966U (en) * 2005-01-21 2005-07-11 Tian-Ju Ruan Plasmapheresis centrifuge bowl
EP1683579A1 (fr) * 2005-01-25 2006-07-26 Jean-Denis Rochat Dispositif jetable pour la séparation en continu par centrifugation d'un liquide physiologique
US8506825B2 (en) 2006-11-27 2013-08-13 Sorin Group Italia S.R.L. Method and apparatus for controlling the flow rate of washing solution during the washing step in a blood centrifugation bowl
US20080200859A1 (en) * 2007-02-15 2008-08-21 Mehdi Hatamian Apheresis systems & methods
US8685258B2 (en) 2008-02-27 2014-04-01 Fenwal, Inc. Systems and methods for conveying multiple blood components to a recipient
US8075468B2 (en) 2008-02-27 2011-12-13 Fenwal, Inc. Systems and methods for mid-processing calculation of blood composition
EP2138237B1 (en) 2008-06-10 2011-01-19 Sorin Group Italia S.r.l. A securing mechanism, particularly for blood separation centrifuges and the like
US9078964B2 (en) * 2008-08-21 2015-07-14 Sur-Real Industries, Inc. Pump device, tube device and method for movement and collection of fluid
US20100210989A1 (en) 2008-12-23 2010-08-19 Janet Lesley Macpherson Processing blood
US8469871B2 (en) * 2010-11-19 2013-06-25 Kensey Nash Corporation Centrifuge
US9308314B2 (en) 2011-04-08 2016-04-12 Sorin Group Italia S.R.L. Disposable device for centrifugal blood separation
CA2890542C (en) * 2012-11-05 2020-10-27 Haemonetics Corporation Continuous flow separation chamber
USD809909S1 (en) 2013-03-15 2018-02-13 Cook Medical Technologies Llc Tubing clips
US10039876B2 (en) 2014-04-30 2018-08-07 Sorin Group Italia S.R.L. System for removing undesirable elements from blood using a first wash step and a second wash step
CN106267426A (zh) * 2016-08-15 2017-01-04 董稳 一种离心分离法血浆采集装置
US11465160B2 (en) 2016-09-16 2022-10-11 Fenwal, Inc. Blood separation systems and methods employing centrifugal and spinning membrane separation techniques
US11065376B2 (en) 2018-03-26 2021-07-20 Haemonetics Corporation Plasmapheresis centrifuge bowl
US11311823B2 (en) 2019-03-05 2022-04-26 Fenwal, Inc. Collection of mononuclear cells and peripheral blood stem cells
US10683478B1 (en) * 2019-05-16 2020-06-16 Shenzhen Eureka biotechnology Co. Ltd Device and system for processing a liquid sample containing cells
US11484891B2 (en) 2019-05-23 2022-11-01 Fenwal, Inc. Adjustment of target interface location between separated fluid components in a centrifuge
US11890399B2 (en) 2019-05-23 2024-02-06 Fenwal, Inc. Centrifugal separation and collection of red blood cells, plasma, or both red blood cells and plasma
CN110801649B (zh) * 2019-11-14 2021-08-24 安徽理工大学 一种实验室用的矿浆离心浓缩分离装置
WO2022240568A1 (en) * 2021-05-11 2022-11-17 Kaloud, Inc. Assembly and device for a sealed interim chamber within a hookah
US20230285654A1 (en) * 2022-03-10 2023-09-14 Terumo Bct, Inc. Blood component collection bladder
CN115125102A (zh) * 2022-08-25 2022-09-30 深圳赛桥生物创新技术有限公司 细胞分离装置及方法

Family Cites Families (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2880722A (en) * 1953-10-19 1959-04-07 Becton Dickinson Co Coupling
US3145713A (en) 1963-09-12 1964-08-25 Protein Foundation Inc Method and apparatus for processing blood
US4059108A (en) 1974-08-15 1977-11-22 Haemonetics Corporation Process for pheresis procedure and disposable pheresis bowl therefor
US4204537A (en) 1974-08-15 1980-05-27 Haemonetics Corporation Process for pheresis procedure and disposable plasma
US3982691A (en) * 1974-10-09 1976-09-28 Schlutz Charles A Centrifuge separation and washing device and method
US3986442A (en) 1975-10-09 1976-10-19 Baxter Laboratories, Inc. Drive system for a centrifugal liquid processing system
US4086924A (en) 1976-10-06 1978-05-02 Haemonetics Corporation Plasmapheresis apparatus
US4109854A (en) 1977-06-13 1978-08-29 Baxter Travenol Laboratories, Inc. Centrifugal apparatus with outer enclosure
US4120449A (en) 1977-06-13 1978-10-17 Baxter Travenol Laboratories, Inc. Centrifugal processing apparatus using tube drive
US4111356A (en) 1977-07-13 1978-09-05 Baxter Travenol Laboratories, Inc. Centrifugal apparatus with flexible sheath
US4114802A (en) 1977-08-29 1978-09-19 Baxter Travenol Laboratories, Inc. Centrifugal apparatus with biaxial connector
US4108353A (en) 1977-08-31 1978-08-22 Baxter Travenol Laboratories, Inc. Centrifugal apparatus with oppositely positioned rotational support means
US4109852A (en) 1977-10-21 1978-08-29 Baxter Travenol Laboratories, Inc. Centrifugal strain relief sheath for processing apparatus
US4109855A (en) 1977-10-25 1978-08-29 Baxter Travenol Laboratories, Inc. Drive system for centrifugal processing apparatus
US4201525A (en) 1978-07-05 1980-05-06 Baxter Travenol Laboratories, Inc. Peristaltic pump
US4285464A (en) 1979-01-22 1981-08-25 Haemonetics Corporation Apparatus for separation of blood into components thereof
US4303193A (en) 1979-01-22 1981-12-01 Haemonetics Corporation Apparatus for separating blood into components thereof
US4300717A (en) 1979-04-02 1981-11-17 Haemonetics Corporation Rotary centrifuge seal
US4398906A (en) 1979-12-11 1983-08-16 Frederic A. Bourke, Jr. Method for externally treating the blood
US4321919A (en) 1979-12-11 1982-03-30 Leukocyte Research, Inc. Method and system for externally treating human blood
US4428744A (en) * 1979-12-11 1984-01-31 Frederic A. Bourke, Jr. Method and system for externally treating the blood
US4374731A (en) 1980-03-06 1983-02-22 Baxter Travenol Laboratories, Inc. Method and apparatus for obtaining a desired rate of plasma collection from a membrane plasmapheresis filter
US4305659A (en) 1980-03-06 1981-12-15 Baxter Travenol Laboratories, Inc. Photometric apparatus and method
US4333016A (en) 1980-03-06 1982-06-01 Baxter Travenol Laboratories, Inc. Liquid presence detector
US4309993A (en) 1980-03-06 1982-01-12 Baxter Travenol Laboratories, Inc. Liquid flow sensing apparatus
US4425116A (en) 1980-04-14 1984-01-10 Baxter Travenol Laboratories, Inc. Control system for fluid flow apparatus
US4389206A (en) 1980-10-09 1983-06-21 Baxter Travenol Laboratories, Inc. Centrifugal processing apparatus and rotatable processing bowl apparatus
US4464166A (en) 1981-06-12 1984-08-07 Frederic A. Bourke, Jr. Method for externally treating the blood
US4421503A (en) 1981-07-09 1983-12-20 Haemonetics Corporation Fluid processing centrifuge and apparatus thereof
US4417884A (en) 1981-07-09 1983-11-29 Haemonetics Corporation Centrifuge timer clamp
US4680025A (en) 1982-08-24 1987-07-14 Baxter Travenol Laboratories, Inc. Blood component collection systems and methods
US4479761A (en) 1982-12-28 1984-10-30 Baxter Travenol Laboratories, Inc. Actuator apparatus for a prepackaged fluid processing module having pump and valve elements operable in response to externally applied pressures
US4479762A (en) 1982-12-28 1984-10-30 Baxter Travenol Laboratories, Inc. Prepackaged fluid processing module having pump and valve elements operable in response to applied pressures
US4479760A (en) 1982-12-28 1984-10-30 Baxter Travenol Laboratories, Inc. Actuator apparatus for a prepackaged fluid processing module having pump and valve elements operable in response to applied pressures
US4605503A (en) 1983-05-26 1986-08-12 Baxter Travenol Laboratories, Inc. Single needle blood fractionation system having adjustable recirculation through filter
US4530691A (en) 1983-12-13 1985-07-23 Baxter Travenol Laboratories, Inc. Centrifuge with movable mandrel
US4724317A (en) 1985-12-05 1988-02-09 Baxter Travenol Laboratories, Inc. Optical data collection apparatus and method used with moving members
US5656163A (en) 1987-01-30 1997-08-12 Baxter International Inc. Chamber for use in a rotating field to separate blood components
US4940543A (en) 1987-01-30 1990-07-10 Baxter International Inc. Plasma collection set
US5076911A (en) 1987-01-30 1991-12-31 Baxter International Inc. Centrifugation chamber having an interface detection surface
US5628915A (en) 1987-01-30 1997-05-13 Baxter International Inc. Enhanced yield blood processing systems and methods establishing controlled vortex flow conditions
US5573678A (en) 1987-01-30 1996-11-12 Baxter International Inc. Blood processing systems and methods for collecting mono nuclear cells
US5104526A (en) 1987-01-30 1992-04-14 Baxter International Inc. Centrifugation system having an interface detection system
US5792372A (en) 1987-01-30 1998-08-11 Baxter International, Inc. Enhanced yield collection systems and methods for obtaining concentrated platelets from platelet-rich plasma
US4834890A (en) 1987-01-30 1989-05-30 Baxter International Inc. Centrifugation pheresis system
US5632893A (en) 1987-01-30 1997-05-27 Baxter Internatinoal Inc. Enhanced yield blood processing systems with angled interface control surface
US5370802A (en) 1987-01-30 1994-12-06 Baxter International Inc. Enhanced yield platelet collection systems and methods
US5641414A (en) 1987-01-30 1997-06-24 Baxter International Inc. Blood processing systems and methods which restrict in flow of whole blood to increase platelet yields
US4806252A (en) 1987-01-30 1989-02-21 Baxter International Inc. Plasma collection set and method
IT1203462B (it) * 1987-04-08 1989-02-15 Dideco Spa Cella per la centrifugazione in continuo del sangue
DE3817664A1 (de) * 1988-05-25 1989-11-30 Josef Dr Theissen Verfahren und vorrichtung zum waschen von blutzellen
US5316667A (en) 1989-05-26 1994-05-31 Baxter International Inc. Time based interface detection systems for blood processing apparatus
US5676841A (en) 1991-12-23 1997-10-14 Baxter International Inc. Blood processing systems and methods which monitor citrate return to the donor
CA2103911C (en) 1991-12-23 1999-08-24 Warren P. Williamson, Iv Centrifuge with separable bowl and spool elements providing access to the separation chamber
US5639382A (en) 1991-12-23 1997-06-17 Baxter International Inc. Systems and methods for deriving recommended storage parameters for collected blood components
US5681273A (en) 1991-12-23 1997-10-28 Baxter International Inc. Systems and methods for predicting blood processing parameters
US5730883A (en) 1991-12-23 1998-03-24 Baxter International Inc. Blood processing systems and methods using apparent hematocrit as a process control parameter
US5833866A (en) 1991-12-23 1998-11-10 Baxter International Inc. Blood collection systems and methods which derive instantaneous blood component yield information during blood processing
US6007725A (en) 1991-12-23 1999-12-28 Baxter International Inc. Systems and methods for on line collection of cellular blood components that assure donor comfort
US5690835A (en) 1991-12-23 1997-11-25 Baxter International Inc. Systems and methods for on line collection of cellular blood components that assure donor comfort
US5549834A (en) 1991-12-23 1996-08-27 Baxter International Inc. Systems and methods for reducing the number of leukocytes in cellular products like platelets harvested for therapeutic purposes
US5527467A (en) 1992-01-10 1996-06-18 Baxter International Inc. Rectifying dialyzer, bioreactor and membrane
US5240614A (en) 1992-01-10 1993-08-31 Baxter International Inc. Process for removing unwanted materials from fluids and for producing biological products
US6204058B1 (en) 1992-02-07 2001-03-20 Vasogen Ireland Limited Treatment of autoimmune diseases
JP2776988B2 (ja) 1993-04-27 1998-07-16 ヘモネティクス・コーポレイション アフェレーシス装置
US5427695A (en) 1993-07-26 1995-06-27 Baxter International Inc. Systems and methods for on line collecting and resuspending cellular-rich blood products like platelet concentrate
US5525218A (en) 1993-10-29 1996-06-11 Baxter International Inc. Centrifuge with separable bowl and spool elements providing access to the separation chamber
US5462416A (en) 1993-12-22 1995-10-31 Baxter International Inc. Peristaltic pump tube cassette for blood processing systems
US5551942A (en) 1993-12-22 1996-09-03 Baxter International Inc. Centrifuge with pivot-out, easy-load processing chamber
US5427509A (en) 1993-12-22 1995-06-27 Baxter International Inc. Peristaltic pump tube cassette with angle pump tube connectors
US5514069A (en) 1993-12-22 1996-05-07 Baxter International Inc. Stress-bearing umbilicus for a compact centrifuge
JPH07266351A (ja) * 1994-03-30 1995-10-17 Sumitomo Chem Co Ltd 導電性樹脂複合体の製造方法
US5538405A (en) 1994-07-01 1996-07-23 Baxter International Inc. Peristaltic pulse pumping systems and methods
US5759413A (en) 1995-06-07 1998-06-02 Baxter International Inc. Systems and method for estimating platelet counts using a spleen mobilization function
US5961842A (en) 1995-06-07 1999-10-05 Baxter International Inc. Systems and methods for collecting mononuclear cells employing control of packed red blood cell hematocrit
US6312607B1 (en) 1995-06-07 2001-11-06 Baxter International Inc. Blood processing systems and methods which optically monitor incremental platelet volumes in a plasma constituent
US5958250A (en) 1995-06-07 1999-09-28 Baxter International Inc. Blood processing systems and methods which optically derive the volume of platelets contained in a plasma constituent
EP0786324A1 (de) * 1996-01-24 1997-07-30 B. Braun Melsungen Ag Verfahren zum Verbinden eines medizinischen Schlauchs an einem Adapter aus Kunststoff
JP2000510003A (ja) 1996-03-29 2000-08-08 セラコス・インコーポレーテツド 慢性ｈｃｖ感染のフォトフェレーシス処置
BR9708468A (pt) * 1996-03-29 2000-01-04 Therakos Inc Tratamento de fotoferese de leucocitos.
US5846203A (en) * 1997-03-27 1998-12-08 Siemens Medical Systems, Inc. Method and apparatus for noise suppression in a doppler ultrasound system.
WO1998043720A1 (en) 1997-04-03 1998-10-08 Baxter International Inc. Interface detection and control systems and methods
US5980760A (en) 1997-07-01 1999-11-09 Baxter International Inc. System and methods for harvesting mononuclear cells by recirculation of packed red blood cells
US6027657A (en) 1997-07-01 2000-02-22 Baxter International Inc. Systems and methods for collecting diluted mononuclear cells
US5945291A (en) 1997-11-10 1999-08-31 Coulter International Corp. Method for distinguishing viable, early apoptotic, late apoptotic, and necrotic cells
EP1043071A1 (fr) * 1999-04-09 2000-10-11 Jean-Denis Rochat Appareil de cetrifugation de liquide et utillisation de cet appareil
US6219584B1 (en) * 1999-07-09 2001-04-17 Therakos, Inc. Method and system for determining an effective amount of light energy to delivery to fluids having targets for the light energy
US7041076B1 (en) * 1999-09-03 2006-05-09 Baxter International Inc. Blood separation systems and methods using a multiple function pump station to perform different on-line processing tasks
US6322488B1 (en) 1999-09-03 2001-11-27 Baxter International Inc. Blood separation chamber with preformed blood flow passages and centralized connection to external tubing
US6296450B1 (en) 1999-09-03 2001-10-02 Baxter International Inc. Systems and methods for control of pumps employing gravimetric sensing
US6495366B1 (en) 1999-09-03 2002-12-17 Therakos, Inc. Uninterrupted flow pump apparatus and method
US6261065B1 (en) 1999-09-03 2001-07-17 Baxter International Inc. System and methods for control of pumps employing electrical field sensing

Also Published As

Publication number Publication date
AU2003219935A1 (en) 2003-09-22
NZ544491A (en) 2007-06-29
WO2003075983A3 (en) 2004-02-05
CA2478187A1 (en) 2003-09-18
ES2483169T3 (es) 2014-08-05
MXPA04008548A (es) 2005-08-19
US20030181305A1 (en) 2003-09-25
NZ552287A (en) 2008-08-29
CA2478187C (en) 2011-07-19
NZ534867A (en) 2006-09-29
US7186230B2 (en) 2007-03-06
JP2006513019A (ja) 2006-04-20
EP1483000B1 (en) 2014-04-23
EP1483000A2 (en) 2004-12-08
WO2003075983A2 (en) 2003-09-18
AU2003219935B2 (en) 2009-04-23
BR0308164B1 (pt) 2012-12-11
JP4519467B2 (ja) 2010-08-04

Similar Documents

Publication Publication Date Title
BR0308164A (pt) Método e aparelho melhorados para a separação contìnua de fluidos biológicos em componentes
Powers et al. Mechanical ventilation results in progressive contractile dysfunction in the diaphragm
Zhang et al. The HMGB1‑RAGE/TLR‑TNF‑α signaling pathway may contribute to kidney injury induced by hypoxia
WO2003103533A3 (en) QUALITY CONTROL OF LAST CHANCE AND / OR AIR / PYROGEN FILTER FOR TRANSFUSION SYSTEMS
UY29557A1 (es) Metodo y sistema de verificación para tratamiento medico
NO20062908L (no) Handteringssystemer for medisinsk materiell
JP6995916B2 (ja) 体液から物質を濾過する為の接線流フィルターシステム
ATE531405T1 (de) Vorrichtung zur extrakorporalen blutbehandlung
MA29640B1 (fr) Dispositif de separation du sang sterilisable a la vapeur
DK0567514T3 (da) System til forøget in vivo udskillelse af diagnostiske og/eller terapeutiske midler ved ekstrakorporal depletering af midle
Chen et al. Ferrostatin-1 obviates seizures and associated cognitive deficits in ferric chloride-induced posttraumatic epilepsy via suppressing ferroptosis
NO20062363L (no) Fremgangsmater og reagenser for behandling av inflammatoriske forstyrrelser
CN104815360A (zh) 循环肿瘤细胞过滤治疗仪
JP2007516043A (ja) 血液を収集および加工するための方法および装置
WO2009027845A3 (es) Cubetas microperforadas
WO2002094199A3 (en) METHOD OF INCREASING ANTI-NeuGc ANTIBODY LEVELS IN BLOOD
CN104941019A (zh) 血液净化装置
CN205360105U (zh) 血浆吸附系统及其用管路
CN105126787B (zh) 一种提高吸附剂抗凝血性的方法
Su et al. Study on the efficacy and safety of ambroxol combined with methylprednisolone in patients with acute lung injury
US20100316727A1 (en) Treatment of inflammatory disorders with ozone
CN112057474A (zh) 间充质干细胞用于调控病毒性感染患者单核细胞的应用
JP3125643U (ja) 給水装置
Piechota Hepatic encephalopathy in the course of alcoholic liver disease—treatment options in the intensive care unit
Ali et al. Biochemical effects of Trichomonas Gallinae on pigeons reared on irrigation channels water and water treated with anti-protozoal agents

Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 28/02/2003, OBSERVADAS AS DEMAIS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 20A ANUIDADE.

B21H Decision of lapse of a patent or of a certificate of addition of invention cancelled [chapter 21.8 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 21.6 NA RPI NO 2711 DE 20/12/2022 POR TER SIDO INDEVIDA.