BR0304837A - Processo para a preparação de n-[3-(3-ciano-pirazol[1,5-a]pirimidin-7-il)fenil]-n-etilace tamida) (zaleplon) - Google Patents

Processo para a preparação de n-[3-(3-ciano-pirazol[1,5-a]pirimidin-7-il)fenil]-n-etilace tamida) (zaleplon)

Info

Publication number
BR0304837A
BR0304837A BR0304837-3A BR0304837A BR0304837A BR 0304837 A BR0304837 A BR 0304837A BR 0304837 A BR0304837 A BR 0304837A BR 0304837 A BR0304837 A BR 0304837A
Authority
BR
Brazil
Prior art keywords
zaleplon
pyrimidin
phenyl
preparation
ethylacidamide
Prior art date
Application number
BR0304837-3A
Other languages
English (en)
Inventor
Monika Korycinska
Tomasz Stawinski
Maciej Wieczorek
Original Assignee
Adamed Sp Zoo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adamed Sp Zoo filed Critical Adamed Sp Zoo
Publication of BR0304837A publication Critical patent/BR0304837A/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"PROCESSO PARA A PREPARAçãO DE N-[3-(3-CIANOPIRAZOL[1,5-a]PIRIMIDIN-7-IL)FENIL]-N-ETILACE TAMIDA) (ZALEPLON)". A invenção refere-se a um processo para a preparação de "zaleplon" (N-[3(3-cianopirazol]1,5-apirimidin-7-il)fenil]-N-etil-acetamida) na reação de 3-dimetilamino-1-(3-N-etil-N-acetilaminofenil)-2-propen-1-ona com 3-aminopirazoL-4-carbonitrilo, que compreende realizar a referida reação em uma solução aquosa de ácido fórmico, sob concentrações de ácido fórmico na faixa de 20-80% (p/p). O zaleplon é de utilidade como um ansiolítico, um sedativo e um relaxante muscular esqueletal.
BR0304837-3A 2002-05-14 2003-05-12 Processo para a preparação de n-[3-(3-ciano-pirazol[1,5-a]pirimidin-7-il)fenil]-n-etilace tamida) (zaleplon) BR0304837A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PL353870A PL207322B1 (pl) 2002-05-14 2002-05-14 Sposób wytwarzania zaleplonu
PCT/PL2003/000043 WO2003095456A1 (en) 2002-05-14 2003-05-12 A process for the preparation of zaleplon

Publications (1)

Publication Number Publication Date
BR0304837A true BR0304837A (pt) 2004-08-17

Family

ID=29417606

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0304837-3A BR0304837A (pt) 2002-05-14 2003-05-12 Processo para a preparação de n-[3-(3-ciano-pirazol[1,5-a]pirimidin-7-il)fenil]-n-etilace tamida) (zaleplon)

Country Status (13)

Country Link
US (1) US7057041B2 (pt)
EP (1) EP1506199B1 (pt)
AT (1) ATE342903T1 (pt)
AU (1) AU2003243061A1 (pt)
BR (1) BR0304837A (pt)
CA (1) CA2482545A1 (pt)
DE (1) DE60309159D1 (pt)
ES (1) ES2275110T3 (pt)
NO (1) NO20040029L (pt)
PL (1) PL207322B1 (pt)
RU (1) RU2004136843A (pt)
UA (1) UA77292C2 (pt)
WO (1) WO2003095456A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2450384A1 (en) * 2001-06-12 2002-12-19 Biogal Gyogyszergyar Rt. Process for the production of zaleplon
CZ200471A3 (cs) 2001-08-01 2004-11-10 Biogal Gyogyszergyar Rt Způsob purifikace N-[3-(3-kyanopyrazol[1,5-a]pyrimidin-7-yl)fenyl]-N-ethylacetamidu (zaleplon) a krystalické formy zaleplonu připravitelné tímto způsobem
HUP0400325A3 (en) * 2004-02-02 2005-11-28 Richter Gedeon Vegyeszet Pure n-[3-(-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-n-ethyl-acetamide, process for its preparation and intermediates
US9618162B2 (en) 2014-04-25 2017-04-11 Cree, Inc. LED lamp

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4626538A (en) * 1983-06-23 1986-12-02 American Cyanamid Company [7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines
US5714607A (en) * 1995-12-01 1998-02-03 American Cyanamid Company Process improvement in the synthesis of N- 3-(3-cyano-pyrazolo 1,5-a!pyrimidin-7-yl)phenyl!-N-ethylacetamide
CA2450384A1 (en) * 2001-06-12 2002-12-19 Biogal Gyogyszergyar Rt. Process for the production of zaleplon

Also Published As

Publication number Publication date
UA77292C2 (uk) 2006-11-15
PL207322B1 (pl) 2010-11-30
AU2003243061A1 (en) 2003-11-11
ES2275110T3 (es) 2007-06-01
RU2004136843A (ru) 2005-07-20
EP1506199B1 (en) 2006-10-18
US20050234237A1 (en) 2005-10-20
ATE342903T1 (de) 2006-11-15
NO20040029L (no) 2004-01-05
DE60309159D1 (de) 2006-11-30
CA2482545A1 (en) 2003-11-20
US7057041B2 (en) 2006-06-06
EP1506199A1 (en) 2005-02-16
PL353870A1 (en) 2003-11-17
WO2003095456A1 (en) 2003-11-20

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Legal Events

Date Code Title Description
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]