BR0214821A - Métodos de tratamento da psicose e esquizofrenia com base nos polimorfismos no gene cntf - Google Patents

Métodos de tratamento da psicose e esquizofrenia com base nos polimorfismos no gene cntf

Info

Publication number
BR0214821A
BR0214821A BR0214821-8A BR0214821A BR0214821A BR 0214821 A BR0214821 A BR 0214821A BR 0214821 A BR0214821 A BR 0214821A BR 0214821 A BR0214821 A BR 0214821A
Authority
BR
Brazil
Prior art keywords
methods
gene polymorphisms
cntf gene
treating psychosis
schizophrenia based
Prior art date
Application number
BR0214821-8A
Other languages
English (en)
Other versions
BRPI0214821B1 (pt
BRPI0214821B8 (pt
Inventor
Sridhar Kudaravalli
Mihael Hristos Polymeropoulos
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BR0214821A publication Critical patent/BR0214821A/pt
Publication of BRPI0214821B1 publication Critical patent/BRPI0214821B1/pt
Publication of BRPI0214821B8 publication Critical patent/BRPI0214821B8/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/30—Psychoses; Psychiatry
    • G01N2800/302—Schizophrenia

Abstract

"MéTODOS DE TRATAMENTO DA PSICOSE E ESQUIZOFRENIA COM BASE NOS POLIMORFISMOS NO GENE CNTF". A presente invenção refere-se ao uso da associação entre o polimorfismo 103 G>A no gene do CNTF para determinar estratégias de tratamento antipsicótico em pacientes com distúrbios psicóticos.
BRPI0214821A 2001-12-10 2002-12-09 método para determinar a responsividade de indivíduo com distúrbio psicótico ao tratamento com loperidona BRPI0214821B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33983501P 2001-12-10 2001-12-10
PCT/EP2002/013937 WO2003054226A2 (en) 2001-12-10 2002-12-09 Methods of treating psychosis and schizophrenia based on a polymorphism in the ctf gene

Publications (3)

Publication Number Publication Date
BR0214821A true BR0214821A (pt) 2004-11-03
BRPI0214821B1 BRPI0214821B1 (pt) 2015-07-07
BRPI0214821B8 BRPI0214821B8 (pt) 2021-07-27

Family

ID=23330814

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0214821A BRPI0214821B8 (pt) 2001-12-10 2002-12-09 método para determinar a responsividade de indivíduo com distúrbio psicótico ao tratamento com loperidona

Country Status (16)

Country Link
US (3) US20050059006A1 (pt)
EP (1) EP1458888B1 (pt)
JP (2) JP2005512576A (pt)
CN (1) CN1612941B (pt)
AT (1) ATE503845T1 (pt)
AU (1) AU2002358110A1 (pt)
BR (1) BRPI0214821B8 (pt)
CA (1) CA2468972A1 (pt)
CY (1) CY1111594T1 (pt)
DE (1) DE60239634D1 (pt)
DK (1) DK1458888T3 (pt)
ES (1) ES2364037T3 (pt)
HK (1) HK1069413A1 (pt)
PT (1) PT1458888E (pt)
SI (1) SI1458888T1 (pt)
WO (1) WO2003054226A2 (pt)

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US11214827B2 (en) * 2018-08-30 2022-01-04 Vanda Pharmaceuticals Inc. Genetic markers for enhancing efficacy of antipsychotic treatment with iloperidone
EP3959340A1 (en) * 2019-04-24 2022-03-02 Institut National de la Santé et de la Recherche Médicale (INSERM) Method for predicting the response of antipsychotic drugs
CN110184345B (zh) * 2019-07-11 2020-05-05 南京先声医学检验有限公司 用于检测精神及神经类疾病用药相关snp位点的引物组、应用、产品及方法
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Also Published As

Publication number Publication date
US8460867B2 (en) 2013-06-11
US20080027106A1 (en) 2008-01-31
AU2002358110A8 (en) 2003-07-09
BRPI0214821B1 (pt) 2015-07-07
AU2002358110A1 (en) 2003-07-09
DE60239634D1 (de) 2011-05-12
PT1458888E (pt) 2011-06-01
CY1111594T1 (el) 2015-10-07
CA2468972A1 (en) 2003-07-03
ES2364037T3 (es) 2011-08-23
BRPI0214821B8 (pt) 2021-07-27
WO2003054226A3 (en) 2004-04-01
EP1458888B1 (en) 2011-03-30
US20050059006A1 (en) 2005-03-17
JP2011006422A (ja) 2011-01-13
CN1612941A (zh) 2005-05-04
CN1612941B (zh) 2011-11-16
US20090239908A1 (en) 2009-09-24
EP1458888A2 (en) 2004-09-22
SI1458888T1 (sl) 2011-07-29
JP2005512576A (ja) 2005-05-12
HK1069413A1 (en) 2005-05-20
JP5785697B2 (ja) 2015-09-30
WO2003054226A2 (en) 2003-07-03
ATE503845T1 (de) 2011-04-15
DK1458888T3 (da) 2011-06-20

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