BR0211342A - Vìrus de raiva atenuado com mutação de nucleoproteìna no sìtio de fosforilação para vacinação contra raiva e terapia de gene na cns - Google Patents

Vìrus de raiva atenuado com mutação de nucleoproteìna no sìtio de fosforilação para vacinação contra raiva e terapia de gene na cns

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Publication number
BR0211342A
BR0211342A BR0211342-2A BR0211342A BR0211342A BR 0211342 A BR0211342 A BR 0211342A BR 0211342 A BR0211342 A BR 0211342A BR 0211342 A BR0211342 A BR 0211342A
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Prior art keywords
mutation
virus
mutant
rabies
viral
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BR0211342-2A
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English (en)
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Zhen Fang Fu
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Univ Georgia Res Found
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Publication of BR0211342A publication Critical patent/BR0211342A/pt

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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/205—Rhabdoviridae, e.g. rabies virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N2760/00011—Details
    • C12N2760/20011—Rhabdoviridae
    • C12N2760/20111—Lyssavirus, e.g. rabies virus
    • C12N2760/20161—Methods of inactivation or attenuation

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  • Health & Medical Sciences (AREA)
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Abstract

"VìRUS DE RAIVA ATENUADO COM MUTAçãO DE NUCLEOPROTEìNA NO SìTIO DE FOSFORILAçãO PARA VACINAçãO CONTRA RAIVA E TERAPIA DE GENE NA CNS". Um vírus mutante é provido o qual contem uma mutação em um sítio de fosforilação em uma ou mais das proteínas do vírus, cuja mutação faz com que o vírus seja atenuado, e por isso, uma composição de vacina aperfeiçoada pode ser produzida com o mesmo. A invenção também referese a composições de vacina que contêm os vírus mutantes, assim como a processos de indução de uma resposta imune, e de proteção de mamíferos de infecção por vírus da raiva. Também são incluídos na invenção processos de produção de vírus mutantes e proteínas virais, incluindo produção de vírus mutantes em uma célula hospedeira que produz ou mesmo super-produz uma contra-parte tipo selvagem da proteína viral mutante, que complementa as outras proteínas virais de modo que a produção da partícula viral mutante seja otimizada. A invenção também inclui aquelas células hospedeiras nas quais produção viral é otimizada, assim como composições de vacina incluindo as proteínas virais, tanto sozinhas como em combinação com os vírus intactos, e a processos de indução de uma resposta imune ou proteção de um mamífero contra infecção, usando as mesmas. Também são incluídos na invenção vetores apropriados para liberação de um gene para uma célula de um humano ou animal, assim como processo de liberação do mesmo.
BR0211342-2A 2001-07-20 2002-07-22 Vìrus de raiva atenuado com mutação de nucleoproteìna no sìtio de fosforilação para vacinação contra raiva e terapia de gene na cns BR0211342A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33135401P 2001-07-20 2001-07-20
PCT/US2002/023108 WO2003046506A2 (en) 2001-07-20 2002-07-22 Attenuated rabies virus with nucleoprotein mutation at the phosphorylation site for vaccination against rabies

Publications (1)

Publication Number Publication Date
BR0211342A true BR0211342A (pt) 2005-05-03

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ID=23293602

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BR0211342-2A BR0211342A (pt) 2001-07-20 2002-07-22 Vìrus de raiva atenuado com mutação de nucleoproteìna no sìtio de fosforilação para vacinação contra raiva e terapia de gene na cns

Country Status (17)

Country Link
US (3) US6706523B2 (pt)
EP (1) EP1434862A4 (pt)
JP (1) JP2005510249A (pt)
KR (1) KR20040029377A (pt)
CN (1) CN100346826C (pt)
AU (1) AU2002365029A1 (pt)
BR (1) BR0211342A (pt)
CA (1) CA2454397A1 (pt)
CO (1) CO5560623A2 (pt)
HR (1) HRP20040078A2 (pt)
HU (1) HUP0500722A2 (pt)
MX (1) MXPA04000589A (pt)
NZ (1) NZ531025A (pt)
PL (1) PL371967A1 (pt)
WO (1) WO2003046506A2 (pt)
YU (1) YU6304A (pt)
ZA (1) ZA200400340B (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6706523B2 (en) * 2001-07-20 2004-03-16 University Of Georgia Research Foundation, Inc. Attenuated rabies virus with nucleoprotein mutation at the phosphorylation site for vaccination against rabies and gene therapy in the CNS
MX343109B (es) * 2004-04-09 2016-10-25 Wyeth * Atenuacion sinergistica del virus de la estomatitis vesicular, vectores de los mismos y composiciones inmunogenicas de los mismos.
CA2576193A1 (en) 2004-08-03 2006-02-16 Biogen Idec Ma Inc. Taj in neuronal function
CN100341571C (zh) * 2005-09-16 2007-10-10 孙介光 一种治疗肿瘤的药物及该药物在制备治疗肿瘤药物中应用
WO2007047459A1 (en) * 2005-10-14 2007-04-26 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention Rabies virus vector systems and compositions and methods thereof
CN104059890A (zh) * 2005-12-14 2014-09-24 乔治亚大学研究基金公司 狂犬病疫苗
WO2008054544A2 (en) 2006-05-22 2008-05-08 Immune Disease Institute, Inc. Method for delivery across the blood brain barrier
CN102159240B (zh) * 2008-09-17 2014-12-24 美国政府健康及人类服务部，疾病控制和预防中心 基于狂犬病毒的重组免疫避孕组合物及其使用方法
US10849975B2 (en) 2011-02-03 2020-12-01 Thomas Jefferson University Multivalent vaccines for rabies virus and filoviruses
CN102205119B (zh) * 2011-04-12 2012-05-30 广州市华南农大生物药品有限公司 狂犬病灭活抗原及其制备方法
KR101479668B1 (ko) * 2012-07-31 2015-01-12 대한민국 광견병 바이러스 유전자를 발현하는 재조합 아데노바이러스 및 이를 포함하는 광견병의 예방 또는 치료용 백신 조성물
CN106929482A (zh) * 2015-12-31 2017-07-07 北京大学 定点突变的流感病毒、其活疫苗及其制备方法和应用
KR20170002590U (ko) 2016-01-08 2017-07-18 최문규 제조와 포장이 용이한 일회용 위생장갑
EP4104854A3 (en) 2016-04-04 2023-03-08 The United States of America as represented by the Secretary of the Department of Health and Human Services Multivalent vaccines for rabies virus and coronaviruses
WO2017200790A1 (en) * 2016-05-20 2017-11-23 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Real-time reverse transcriptase-polymerase chain reaction assay with modified probe for the diagnosis of rabies viruses and other lyssaviruses
GB201706945D0 (en) * 2017-05-02 2017-06-14 Medical Res Council Self-inactivating viral vector
US20230398201A1 (en) * 2020-11-03 2023-12-14 Thomas Jefferson University Gene shuffled lyssavirus vaccine
WO2022178307A1 (en) * 2021-02-19 2022-08-25 Beam Therapeutics Inc. Recombinant rabies viruses for gene therapy
CN114957408B (zh) * 2021-02-24 2024-04-23 东莞博盛生物科技有限公司 一种狂犬病毒的preG改性蛋白及其应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4342566A (en) 1980-02-22 1982-08-03 Scripps Clinic & Research Foundation Solid phase anti-C3 assay for detection of immune complexes
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
FR2693655B1 (fr) * 1992-07-20 1994-10-14 Virbac Vaccin antirabique avirulent.
US5583735A (en) 1994-01-18 1996-12-10 Hollingsead International, Inc. Aircraft video monitor deployment and retraction apparatus
PT702085E (pt) * 1994-07-18 2004-04-30 Karl Klaus Conzelmann Virus de arn de cadeia negativa nao segmentada infeccioso recombinante
UA78180C2 (uk) 1997-10-03 2007-03-15 Меріаль Кільцевий вірус свині типу ii, вакцини та діагностичні реагенти
US6719881B1 (en) 1998-09-22 2004-04-13 Charles R. Hunter Acid colloid in a microparticle system used in papermaking
EP1131414B1 (en) * 1998-11-27 2007-03-07 Intervet International BV Stable, attenuated rabies virus mutants and live vaccines thereof
US6706523B2 (en) * 2001-07-20 2004-03-16 University Of Georgia Research Foundation, Inc. Attenuated rabies virus with nucleoprotein mutation at the phosphorylation site for vaccination against rabies and gene therapy in the CNS

Also Published As

Publication number Publication date
NZ531025A (en) 2005-08-26
US7419816B2 (en) 2008-09-02
HUP0500722A2 (hu) 2005-11-28
MXPA04000589A (es) 2005-06-17
CA2454397A1 (en) 2003-06-05
EP1434862A4 (en) 2005-04-06
US20030099671A1 (en) 2003-05-29
US6706523B2 (en) 2004-03-16
HRP20040078A2 (en) 2004-08-31
CN1635905A (zh) 2005-07-06
CO5560623A2 (es) 2005-09-30
US20070178555A1 (en) 2007-08-02
CN100346826C (zh) 2007-11-07
ZA200400340B (en) 2004-08-18
JP2005510249A (ja) 2005-04-21
WO2003046506A3 (en) 2004-04-22
PL371967A1 (en) 2005-07-11
US20040208900A1 (en) 2004-10-21
KR20040029377A (ko) 2004-04-06
YU6304A (sh) 2006-08-17
WO2003046506A2 (en) 2003-06-05
US7544791B2 (en) 2009-06-09
AU2002365029A1 (en) 2003-06-10
EP1434862A2 (en) 2004-07-07

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