BR0210153A - Composto, uso do mesmo, métodos para a inibição de relaxamentos transitórios do esfìncter esofágico inferior, para o tratamento de doença do refluxo gastro-esofágico e de regurgitação em crianças, e para o tratamento de asma, hipercinesia, eructação, tosse, dor, vìcio de cocaìna, retirada de álcool, dependência de nicotina, soluços, ibs, dispepsia, êmese ou nocicepção, e, formulação farmacêutica - Google Patents
Composto, uso do mesmo, métodos para a inibição de relaxamentos transitórios do esfìncter esofágico inferior, para o tratamento de doença do refluxo gastro-esofágico e de regurgitação em crianças, e para o tratamento de asma, hipercinesia, eructação, tosse, dor, vìcio de cocaìna, retirada de álcool, dependência de nicotina, soluços, ibs, dispepsia, êmese ou nocicepção, e, formulação farmacêuticaInfo
- Publication number
- BR0210153A BR0210153A BR0210153-0A BR0210153A BR0210153A BR 0210153 A BR0210153 A BR 0210153A BR 0210153 A BR0210153 A BR 0210153A BR 0210153 A BR0210153 A BR 0210153A
- Authority
- BR
- Brazil
- Prior art keywords
- treatment
- addiction
- reflux disease
- nociception
- emesis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C313/02—Sulfinic acids; Derivatives thereof
- C07C313/04—Sulfinic acids; Esters thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C313/02—Sulfinic acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Addiction (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Nutrition Science (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
"COMPOSTO, USO DO MESMO, MéTODOS PARA A INIBIçãO DE RELAXAMENTOS TRANSITóRIOS DO ESFìNCTER ESOFáGICO INFERIOR, PARA O TRATAMENTO DE DOENçA DO REFLUXO GASTRO-ESOFáGICO E DE REGURGITAçãO EM CRIANçAS, E PARA O TRATAMENTO DE ASMA, HIPERCINESIA, ERUCTAçãO, TOSSE, DOR, VìCIO DE COCAìNA, RETIRADA DE áLCOOL, DEPENDêNCIA DE NICOTINA, SOLUçOS, IBS, DISPEPSIA, êMESE OU NOCICEPçãO, E, FORMULAçãO FARMACêUTICA". Novos compostos de fórmula (I): em que R~ 1~, representa hidrogênio; R~ 2~ representa hidróxi, fluoro ou um grupo oxo; R~ 3~ representa hidrogênio; R~ 4~ representa hidrogênio; e seus sais, solvatos e estereoisómeros farmaceuticamente aceitáveis, com exceção do racemato de ácido (3-amino-2-hidroxipropil)sulfínico. Os compostos são úteis em terapia, especialmente para o tratamento de doença de refluxo. A invenção é também relacionada com processos para sua preparação, intermediários de dito processo e composições farmacêuticas contendo ditos compostos terapeuticamente ativos e ao uso de ditos compostos ativos em terapia.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0102056A SE0102056D0 (sv) | 2001-06-08 | 2001-06-08 | New Compounds |
SE0104342A SE0104342D0 (sv) | 2001-12-20 | 2001-12-20 | New compounds |
PCT/SE2002/001085 WO2002100823A1 (en) | 2001-06-08 | 2002-06-04 | New compounds useful in reflux disease |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0210153A true BR0210153A (pt) | 2004-06-08 |
Family
ID=26655485
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0210153-0A BR0210153A (pt) | 2001-06-08 | 2002-06-04 | Composto, uso do mesmo, métodos para a inibição de relaxamentos transitórios do esfìncter esofágico inferior, para o tratamento de doença do refluxo gastro-esofágico e de regurgitação em crianças, e para o tratamento de asma, hipercinesia, eructação, tosse, dor, vìcio de cocaìna, retirada de álcool, dependência de nicotina, soluços, ibs, dispepsia, êmese ou nocicepção, e, formulação farmacêutica |
Country Status (14)
Country | Link |
---|---|
US (1) | US6919379B2 (pt) |
EP (1) | EP1399419A1 (pt) |
JP (1) | JP2004529982A (pt) |
KR (1) | KR20040007658A (pt) |
CN (1) | CN1514825A (pt) |
AR (1) | AR033779A1 (pt) |
AU (1) | AU2002309420C1 (pt) |
BR (1) | BR0210153A (pt) |
CA (1) | CA2448518A1 (pt) |
IL (1) | IL158999A0 (pt) |
MX (1) | MXPA03011193A (pt) |
NO (1) | NO20035431D0 (pt) |
NZ (1) | NZ529920A (pt) |
WO (1) | WO2002100823A1 (pt) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006050472A2 (en) | 2004-11-03 | 2006-05-11 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphonous and -phosphinic acids |
WO2006050471A2 (en) * | 2004-11-03 | 2006-05-11 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs of sulfinic acids, methods of synthesis, and use |
US20060183800A1 (en) * | 2004-11-12 | 2006-08-17 | Xianqi Kong | Methods and fluorinated compositions for treating amyloid-related diseases |
US20060160777A1 (en) * | 2004-12-27 | 2006-07-20 | Anders Lehmann | New use of GABAbeta receptor agonists |
WO2006071186A1 (en) * | 2004-12-27 | 2006-07-06 | Astrazeneca Ab | Use of gabab receptor agonists |
WO2008033572A1 (en) * | 2006-09-15 | 2008-03-20 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs, methods of synthesis and use |
US20100317626A1 (en) * | 2007-07-25 | 2010-12-16 | Astrazeneca Ab | The Use Of (3-Amino-2-Fluoropropyl) Phosphinic Acid For Treatment Of NERD |
WO2011113904A1 (en) | 2010-03-17 | 2011-09-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Medicaments for the prevention and treatment of a disease associated with retinal ganglion cell degeneration |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH449046A (de) | 1963-07-09 | 1967-12-31 | Ciba Geigy | Verfahren zur Herstellung neuer Aminosäuren |
DE3326545A1 (de) * | 1983-07-22 | 1985-01-31 | Ludwig Heumann & Co GmbH, 8500 Nürnberg | Propan-2-ol-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
GB8425872D0 (en) | 1984-10-12 | 1984-11-21 | Ciba Geigy Ag | Chemical compounds |
AU594424B2 (en) | 1986-01-03 | 1990-03-08 | University Of Melbourne, The | Gastro-oesophageal reflux composition |
GB8820266D0 (en) | 1988-08-26 | 1988-09-28 | Smith Kline French Lab | Compounds |
GB8911017D0 (en) | 1989-05-13 | 1989-06-28 | Ciba Geigy Ag | Substituted aminoalkylphosphinic acids |
US5214063A (en) | 1990-06-27 | 1993-05-25 | Adir Et Compagnie | 4-aminobutyric acid compounds, compositions and methods of use for treating disorders related to a dysfunction of GABAB receptors |
FR2663934B1 (fr) | 1990-06-27 | 1994-06-03 | Adir | Nouveaux derives de l'acide 4 - amino butyrique, leur procede de preparation et les preparations pharmaceutiques qui les contiennent. |
FR2722192A1 (fr) | 1994-07-06 | 1996-01-12 | Adir | Nouveaux derives de l'acide 4-amino butyrique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
GB9420784D0 (en) | 1994-10-14 | 1994-11-30 | Glaxo Group Ltd | Medicaments |
SE9603408D0 (sv) * | 1996-09-18 | 1996-09-18 | Astra Ab | Medical use |
SE9904508D0 (sv) * | 1999-12-09 | 1999-12-09 | Astra Ab | New compounds |
-
2002
- 2002-05-28 AR ARP020101983A patent/AR033779A1/es not_active Application Discontinuation
- 2002-06-04 JP JP2003503592A patent/JP2004529982A/ja active Pending
- 2002-06-04 MX MXPA03011193A patent/MXPA03011193A/es active IP Right Grant
- 2002-06-04 AU AU2002309420A patent/AU2002309420C1/en not_active Ceased
- 2002-06-04 NZ NZ529920A patent/NZ529920A/en unknown
- 2002-06-04 CN CNA028114558A patent/CN1514825A/zh active Pending
- 2002-06-04 WO PCT/SE2002/001085 patent/WO2002100823A1/en active IP Right Grant
- 2002-06-04 KR KR10-2003-7015969A patent/KR20040007658A/ko not_active Application Discontinuation
- 2002-06-04 BR BR0210153-0A patent/BR0210153A/pt not_active IP Right Cessation
- 2002-06-04 CA CA002448518A patent/CA2448518A1/en not_active Abandoned
- 2002-06-04 EP EP02736400A patent/EP1399419A1/en not_active Withdrawn
- 2002-06-04 IL IL15899902A patent/IL158999A0/xx unknown
- 2002-06-04 US US10/479,763 patent/US6919379B2/en not_active Expired - Fee Related
-
2003
- 2003-12-05 NO NO20035431A patent/NO20035431D0/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
MXPA03011193A (es) | 2004-02-26 |
KR20040007658A (ko) | 2004-01-24 |
EP1399419A1 (en) | 2004-03-24 |
AU2002309420C1 (en) | 2008-05-29 |
NZ529920A (en) | 2005-08-26 |
IL158999A0 (en) | 2004-05-12 |
AR033779A1 (es) | 2004-01-07 |
JP2004529982A (ja) | 2004-09-30 |
AU2002309420B2 (en) | 2007-11-08 |
CA2448518A1 (en) | 2002-12-19 |
US6919379B2 (en) | 2005-07-19 |
NO20035431D0 (no) | 2003-12-05 |
WO2002100823A1 (en) | 2002-12-19 |
US20040152775A1 (en) | 2004-08-05 |
CN1514825A (zh) | 2004-07-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR0016253A (pt) | Composto, uso de um composto, métodos para a inibição dos relaxamentos do esfìncter esofágico inferior transientes para o tratamento da doença do refluxo gastroesofágico, da regurgitação em bebês, de nocicepção, êmese. dispepsia, ibs, soluções, adicção em cocaìna, dor, tosse, eructação, asma relacionados ou não com gord, formulação farmacêutica, e, processo para a preparação de um composto | |
IL88239A (en) | 4- (substituted- 2-benzocycloheptene -2- ylethenyl)- benzoic acid derivatives, their preparation and pharmaceutical compositions containing them | |
JPS62155205A (ja) | 抗真菌性のマニキユア液 | |
BR0016291A (pt) | Composto, uso do mesmo, métodos para a inibição das relaxações do esfìncter esofágico inferior transientes, para o tratamento da doença do refluxo gastroesofágico, da regurgitação em bebês, de nocicepção, êmese, dispepsia, ibs, soluços, adicção de cocaìna, dor, tosse, eructação, asma relacionada ou não com gord, e, formulação farmacêutica | |
BR0210153A (pt) | Composto, uso do mesmo, métodos para a inibição de relaxamentos transitórios do esfìncter esofágico inferior, para o tratamento de doença do refluxo gastro-esofágico e de regurgitação em crianças, e para o tratamento de asma, hipercinesia, eructação, tosse, dor, vìcio de cocaìna, retirada de álcool, dependência de nicotina, soluços, ibs, dispepsia, êmese ou nocicepção, e, formulação farmacêutica | |
CA3032555C (en) | Nicotine ion pair formulation neutralized with co2 and process therefor | |
MXPA04003192A (es) | Sales de acido succinico de 5, 7, 14-triazatetraciclo ?10.3.1.02,11.04,9? -hexadeca-2(11), 3, 5, 7, 9-pentaeno y composiciones farmacetucias de las mismas. | |
AR039404A1 (es) | Combinaciones de medicamentos que contienen compuestos heterociclicos y un agente anticolinergico. aerosol para su inhalacion | |
DK163185C (da) | 1h-imidazol-1-ethanol og estere deraf og deres farmaceutisk acceptable syreadditionssalte til anvendelse som talgsyntesehaemmende midler samt farmaceutiske praeparater indeholdende saadanne forbindelser | |
BR9913102A (pt) | Composto, produtos contento um composto, processo para preparação de um composto, formulação farmacêutica contento um composto, uso de um composto, processos para inibir a secreção de ácido gástrico, para o tratamento de doenças inflamatórias gastrintestinais e, para o tratamento ou profilaxia de condições que envolvam a infecção por helicobacter pylori da mucosa gástrica humana, e, formulação farmacêutica | |
DE68917937D1 (de) | Verbindungen mit magensäureinhibitorwirkung und verfahren zur herstellung. | |
ES2045083T3 (es) | Un procedimiento para preparar un compuesto quimico. | |
DK163182C (da) | Dialkylaminoalkoxybenzylalkoholderivater og farmaceutisk acceptable syreadditionssalte og kvaternaere ammoniumsalte deraf, fremgangsmaade til fremstilling deraf, farmaceutisk praeparat og fremgangsmaade til fremstilling deraf | |
DD207200A1 (de) | Verfahren zur herstellung substituierter dibenzodiazepinone | |
MY133438A (en) | Morpholinobenzamide salts | |
DE3867312D1 (de) | Spiro (4,5) decanderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen. | |
JPWO2005007191A1 (ja) | 医薬組成物 | |
EP0301474A3 (en) | New cysteine derivatives having expectorant activity | |
JPH07138139A (ja) | 口腔用組成物 | |
AU530930B2 (en) | Pharmaceutical compositions and method of treating heart disease | |
SE8204693L (sv) | Lekemedel med speciellt antiarrytmisk och understodjande verkan vid hjerthypoxi och forfarande for framstellning derav | |
GR3019970T3 (en) | Pharmaceutical compositions for use in treating aids | |
IE790237L (en) | Benzimidazol-2-ones. | |
DE3765124D1 (de) | Neue stickstoffarylmethoxy-thiophenderivate und deren saeureadditionssalze,verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate. | |
DE69008489D1 (de) | Morpholinderivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A E 9A ANUIDADE(S). |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2108 DE 31/05/2011. |