BR0209963A - Derivados tricìclicos de dihidro-quinoleìnas, o respectivo processo de preparação e as composições farmacêuticas que os contêm - Google Patents
Derivados tricìclicos de dihidro-quinoleìnas, o respectivo processo de preparação e as composições farmacêuticas que os contêmInfo
- Publication number
- BR0209963A BR0209963A BR0209963-2A BR0209963A BR0209963A BR 0209963 A BR0209963 A BR 0209963A BR 0209963 A BR0209963 A BR 0209963A BR 0209963 A BR0209963 A BR 0209963A
- Authority
- BR
- Brazil
- Prior art keywords
- optionally substituted
- pharmaceutical compositions
- preparation process
- compositions containing
- hydrogen
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 125000005044 dihydroquinolinyl group Chemical class N1(CC=CC2=CC=CC=C12)* 0.000 title 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 125000006684 polyhaloalkyl group Polymers 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000005415 substituted alkoxy group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
"DERIVADOS TRICìCLICOS DE DIHIDRO-QUINOLEìNAS, O RESPECTIVO PROCESSO DE PREPARAçãO E AS COMPOSIçõES FARMACêUTICAS QUE OS CONTêM". A invenção refere-se a um composto de fórmula (1), na qual: representa uma ligação simples ou dupla, representa um ciclo escolhido dentre R~ 9a~, R~ 9b~, R~ 9c~, X e Y são tais como definidos na descrição, R~ 1~ representa um grupamento escolhido dentre hidrogênio, arila, heteroarila, cicloalquila, alquila eventualmente substituída, e COR~ 11~, no qual R~ 11~, é tal como definido na descrição, R~ 2~ a R~ 8~ representam, cada um, um grupamento escolhido dentre hidrogênio, halogênio, hidróxi, polihalogenoalquila, nitro, alquila eventualmente substituída, amino eventualmente substituído, alcóxi eventualmente substituído, -OPO(OH)~ 2~ e na qual m representa um inteiro, tal como 1 <243> m <243>, ou R~ 2~com R~ 3~, ou R~ 3~ com R~ 4~, ou R~ 4~com R~ 5~, formam juntos com os átomos de carbono que os portam um grupamento mono- ou bicíclico, contendo eventualmente 1 ou 2 heteroátomos e eventualmente substituído, R~ 16~ representa um átomo de hidrogênio ou um grupamento alquila, representa um grupamento arila, heteroarila ou arilalquila, seus isómeros ópticos, seus sais de adição a um ácido ou a uma base farmaceuticamente aceitável, assim como seus hidratos e solvatos. Medicamentos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0106791A FR2825092B1 (fr) | 2001-05-23 | 2001-05-23 | Nouveau derives trycicliques de dihydro-quinoleines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| PCT/FR2002/001716 WO2002094840A2 (fr) | 2001-05-23 | 2002-05-22 | Derives tricycliques de dihydroquinoleines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0209963A true BR0209963A (pt) | 2004-04-13 |
Family
ID=8863588
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0209963-2A BR0209963A (pt) | 2001-05-23 | 2002-05-22 | Derivados tricìclicos de dihidro-quinoleìnas, o respectivo processo de preparação e as composições farmacêuticas que os contêm |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20040180917A1 (pt) |
| EP (1) | EP1399455A2 (pt) |
| JP (1) | JP2004529191A (pt) |
| KR (1) | KR20040008190A (pt) |
| CN (1) | CN1511161A (pt) |
| AR (1) | AR033914A1 (pt) |
| BR (1) | BR0209963A (pt) |
| CA (1) | CA2448197A1 (pt) |
| CZ (1) | CZ20033496A3 (pt) |
| EA (1) | EA200301172A1 (pt) |
| FR (1) | FR2825092B1 (pt) |
| HU (1) | HUP0401345A3 (pt) |
| MX (1) | MXPA03010597A (pt) |
| NO (1) | NO20035214L (pt) |
| PL (1) | PL364083A1 (pt) |
| SK (1) | SK16012003A3 (pt) |
| WO (1) | WO2002094840A2 (pt) |
| ZA (1) | ZA200308628B (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2013014900A (es) | 2011-06-17 | 2014-02-17 | Merck Sharp & Dohme | Tetrahidroquinolinas condensadas con cicloalquilo como moduladores de la molecula receptora homologa quimioatrayente expresada en celulas t auxiliares de tipo 2. |
| JP2017503026A (ja) | 2014-01-15 | 2017-01-26 | サントル ナシオナル ドゥ ラ ルシェルシュ シアンティフィーク（セーエヌエールエス） | 水溶性４−アザポドフィルロトキシン類似体 |
| US11731980B1 (en) | 2023-03-22 | 2023-08-22 | King Faisal University | Furo[3,4-b]quinolone compounds as antibacterial agents |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2801310B1 (fr) * | 1999-11-24 | 2004-04-16 | Adir | NOUVEAUX DERIVES DE DIHYDROFURO-[3,4-b]QUINOLEIN-1-ONES, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT |
-
2001
- 2001-05-23 FR FR0106791A patent/FR2825092B1/fr not_active Expired - Fee Related
-
2002
- 2002-05-22 PL PL02364083A patent/PL364083A1/xx not_active Application Discontinuation
- 2002-05-22 CN CNA028103483A patent/CN1511161A/zh active Pending
- 2002-05-22 JP JP2002591513A patent/JP2004529191A/ja active Pending
- 2002-05-22 US US10/477,244 patent/US20040180917A1/en not_active Abandoned
- 2002-05-22 KR KR10-2003-7015307A patent/KR20040008190A/ko not_active Application Discontinuation
- 2002-05-22 WO PCT/FR2002/001716 patent/WO2002094840A2/fr not_active Application Discontinuation
- 2002-05-22 EP EP02735551A patent/EP1399455A2/fr not_active Withdrawn
- 2002-05-22 MX MXPA03010597A patent/MXPA03010597A/es unknown
- 2002-05-22 EA EA200301172A patent/EA200301172A1/ru unknown
- 2002-05-22 SK SK1601-2003A patent/SK16012003A3/sk unknown
- 2002-05-22 BR BR0209963-2A patent/BR0209963A/pt not_active IP Right Cessation
- 2002-05-22 CA CA002448197A patent/CA2448197A1/fr not_active Abandoned
- 2002-05-22 HU HU0401345A patent/HUP0401345A3/hu unknown
- 2002-05-22 CZ CZ20033496A patent/CZ20033496A3/cs unknown
- 2002-05-23 AR ARP020101905A patent/AR033914A1/es unknown
-
2003
- 2003-11-05 ZA ZA200308628A patent/ZA200308628B/en unknown
- 2003-11-24 NO NO20035214A patent/NO20035214L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| FR2825092A1 (fr) | 2002-11-29 |
| NO20035214D0 (no) | 2003-11-24 |
| EP1399455A2 (fr) | 2004-03-24 |
| KR20040008190A (ko) | 2004-01-28 |
| CA2448197A1 (fr) | 2002-11-28 |
| CZ20033496A3 (cs) | 2004-04-14 |
| WO2002094840A3 (fr) | 2003-05-01 |
| HUP0401345A2 (hu) | 2004-11-29 |
| CN1511161A (zh) | 2004-07-07 |
| FR2825092B1 (fr) | 2005-01-14 |
| ZA200308628B (en) | 2004-11-05 |
| NO20035214L (no) | 2003-11-24 |
| WO2002094840A2 (fr) | 2002-11-28 |
| HUP0401345A3 (en) | 2006-11-28 |
| SK16012003A3 (sk) | 2004-06-08 |
| PL364083A1 (en) | 2004-12-13 |
| EA200301172A1 (ru) | 2004-04-29 |
| MXPA03010597A (es) | 2004-03-09 |
| US20040180917A1 (en) | 2004-09-16 |
| JP2004529191A (ja) | 2004-09-24 |
| AR033914A1 (es) | 2004-01-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A , 6A E 7A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2029 DE 24/11/2009. |