BR0208943A - Novas 10-ciclohexenil-fenil-pirrolobenzodiazepina-3-carb oxamidas e antagonistas receptores de ocitocina tocolìticos derivados das mesmas - Google Patents

Novas 10-ciclohexenil-fenil-pirrolobenzodiazepina-3-carb oxamidas e antagonistas receptores de ocitocina tocolìticos derivados das mesmas

Info

Publication number
BR0208943A
BR0208943A BR0208943-2A BR0208943A BR0208943A BR 0208943 A BR0208943 A BR 0208943A BR 0208943 A BR0208943 A BR 0208943A BR 0208943 A BR0208943 A BR 0208943A
Authority
BR
Brazil
Prior art keywords
suppression
pyrrolobenzodiazepine
oxamides
carb
cyclohexenyl
Prior art date
Application number
BR0208943-2A
Other languages
English (en)
Inventor
Amedeo Arturo Failli
William Jennings Sanders
Eugene John Trybulski
Jay Scott Shumsky
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of BR0208943A publication Critical patent/BR0208943A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)

Abstract

"NOVAS 10-CICLOHEXENIL-FENIL-PIRROLOBENZODIAZEPINA-3CARBO XAMIDAS E ANTAGONISTAS RECEPTORES DE OCITOCINA TOCOLìTICOS DERIVADOS DAS MESMAS". A presente invenção prove compostos de carboxamida tricíclicos e métodos e composições farmacêuticas para seu uso em tratamento, prevenção, ou supressão de desordens as quais podem ser remediadas ou aliviadas por atividade de antagonista de ocitocina, incluindo prevenção e/ou supressão de trabalho de parto prematuro, supressão de trabalho de parto em prazo de gravidez antes de parto por cesariana, e para o tratamento de dismenorréia. Estes compostos também são úteis na intensificação de taxas de fertilidade, reforço de taxas de sobrevivência e sincronização de cio em animais de fazenda; e podem ser úteis na prevenção e tratamento de disfunções do sistema de ocitocina no sistema nervoso central incluindo desordem compulsiva obsessiva (OCD) e desordens neuropsiquiátricas.
BR0208943-2A 2001-04-12 2002-04-11 Novas 10-ciclohexenil-fenil-pirrolobenzodiazepina-3-carb oxamidas e antagonistas receptores de ocitocina tocolìticos derivados das mesmas BR0208943A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28339201P 2001-04-12 2001-04-12
PCT/US2002/011532 WO2002083682A1 (en) 2001-04-12 2002-04-11 Novel 10-cyclohexenyl-phenyl pyrrolobenzodiazepine-3-carboxamides and derivatives thereof; tocolytic oxytocin receptor antagonists

Publications (1)

Publication Number Publication Date
BR0208943A true BR0208943A (pt) 2004-04-27

Family

ID=23085840

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0208943-2A BR0208943A (pt) 2001-04-12 2002-04-11 Novas 10-ciclohexenil-fenil-pirrolobenzodiazepina-3-carb oxamidas e antagonistas receptores de ocitocina tocolìticos derivados das mesmas

Country Status (10)

Country Link
US (1) US7326700B2 (pt)
EP (1) EP1377585B1 (pt)
JP (1) JP2004530672A (pt)
CN (1) CN1501933A (pt)
AT (1) ATE309244T1 (pt)
BR (1) BR0208943A (pt)
CA (1) CA2443566A1 (pt)
DE (1) DE60207224D1 (pt)
MX (1) MXPA03009337A (pt)
WO (1) WO2002083682A1 (pt)

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US6903087B2 (en) 2001-04-12 2005-06-07 Wyeth Pyrido cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
US6977254B2 (en) * 2001-04-12 2005-12-20 Wyeth Hydroxy cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
US7109193B2 (en) * 2001-04-12 2006-09-19 Wyeth Tricyclic diazepines tocolytic oxytocin receptor antagonists
US7064120B2 (en) * 2001-04-12 2006-06-20 Wyeth Tricyclic pyridyl carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists
US6900200B2 (en) * 2001-04-12 2005-05-31 Wyeth Tricyclic hydroxy carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists
US7202239B2 (en) * 2001-04-12 2007-04-10 Wyeth Cyclohexylphenyl carboxamides tocolytic oxytocin receptor antagonists
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JP6759326B2 (ja) 2015-07-12 2020-09-23 ハンジョウ ディーエーシー バイオテック シーオー．，エルティディ．Ｈａｎｇｚｈｏｕ Ｄａｃ Ｂｉｏｔｅｃｈ Ｃｏ．，Ｌｔｄ． 細胞結合分子の共役のための架橋連結体
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
AU2016429272A1 (en) 2016-11-14 2019-05-02 Hangzhou Dac Biotech Co., Ltd. Conjugation linkers, cell binding molecule-drug conjugates containing the likers, methods of making and uses such conjugates with the linkers
JP2018140698A (ja) * 2017-02-28 2018-09-13 本田技研工業株式会社 車両の制御装置

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Also Published As

Publication number Publication date
MXPA03009337A (es) 2004-11-12
ATE309244T1 (de) 2005-11-15
JP2004530672A (ja) 2004-10-07
CA2443566A1 (en) 2002-10-24
US7326700B2 (en) 2008-02-05
US20030004159A1 (en) 2003-01-02
EP1377585A1 (en) 2004-01-07
DE60207224D1 (de) 2005-12-15
EP1377585B1 (en) 2005-11-09
CN1501933A (zh) 2004-06-02
WO2002083682A1 (en) 2002-10-24

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A,6A E 7A ANUIDADES

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2029 DE 24/11/2009.