BR0208941A - Novos antagonistas receptores de ocitocina tocolìticos de hidróxi ciclohexenil fenil carboxamidas - Google Patents
Novos antagonistas receptores de ocitocina tocolìticos de hidróxi ciclohexenil fenil carboxamidasInfo
- Publication number
- BR0208941A BR0208941A BR0208941-6A BR0208941A BR0208941A BR 0208941 A BR0208941 A BR 0208941A BR 0208941 A BR0208941 A BR 0208941A BR 0208941 A BR0208941 A BR 0208941A
- Authority
- BR
- Brazil
- Prior art keywords
- hydroxy
- suppression
- new
- tocolytic
- receptor antagonists
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
"NOVOS ANTAGONISTAS RECEPTORES DE OCITOCINA TOCOLìTICOS DE HIDRóXI CICLOHEXENIL FENIL CARBOXAMIDAS". A presente invenção prove compostos de 10,11-dihidro-5H-pirrolo-[1,2-a][1,4]diazepina e 9,10-dihidro-4H-3a,5,9-triaza-benzo[flazuleno bem como métodos e composições farmacêuticas utilizando estes compostos para o tratamento e/ou prevenção e/ou supressão de desordens as quais podem ser remediadas ou aliviadas por atividade de antagonista de ocitocina, incluindo prevenção e/ou supressão de trabalho de parto prematuro, supressão de trabalho de parto no prazo de gravidez antes de parto por cesariana, e para o tratamento de dismenorréia. Estes compostos também são úteis para reforçar taxas de fertilidade, intensificar taxas de sobrevivência e sincronizar cio em animais de fazenda.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28331601P | 2001-04-12 | 2001-04-12 | |
PCT/US2002/011529 WO2002083679A1 (en) | 2001-04-12 | 2002-04-11 | Novel hydroxy cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0208941A true BR0208941A (pt) | 2004-08-03 |
Family
ID=23085451
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0208941-6A BR0208941A (pt) | 2001-04-12 | 2002-04-11 | Novos antagonistas receptores de ocitocina tocolìticos de hidróxi ciclohexenil fenil carboxamidas |
Country Status (8)
Country | Link |
---|---|
US (1) | US6977254B2 (pt) |
EP (1) | EP1385849A1 (pt) |
JP (1) | JP2004528326A (pt) |
CN (1) | CN1501929A (pt) |
BR (1) | BR0208941A (pt) |
CA (1) | CA2443564A1 (pt) |
MX (1) | MXPA03009336A (pt) |
WO (1) | WO2002083679A1 (pt) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7109193B2 (en) * | 2001-04-12 | 2006-09-19 | Wyeth | Tricyclic diazepines tocolytic oxytocin receptor antagonists |
US7022699B2 (en) * | 2001-04-12 | 2006-04-04 | Wyeth | Cyclohexenyl phenyl diazepines vasopressin and oxytocin receptor modulators |
US6900200B2 (en) * | 2001-04-12 | 2005-05-31 | Wyeth | Tricyclic hydroxy carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists |
US7202239B2 (en) * | 2001-04-12 | 2007-04-10 | Wyeth | Cyclohexylphenyl carboxamides tocolytic oxytocin receptor antagonists |
US7064120B2 (en) * | 2001-04-12 | 2006-06-20 | Wyeth | Tricyclic pyridyl carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists |
US7326700B2 (en) * | 2001-04-12 | 2008-02-05 | Wyeth | Cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists |
US6903087B2 (en) | 2001-04-12 | 2005-06-07 | Wyeth | Pyrido cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists |
AU2012395148B2 (en) | 2012-11-24 | 2016-10-27 | Hangzhou Dac Biotech Co., Ltd. | Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules |
ES2960619T3 (es) | 2014-02-28 | 2024-03-05 | Hangzhou Dac Biotech Co Ltd | Enlazadores cargados y sus usos para la conjugación |
NZ739830A (en) | 2015-07-12 | 2021-12-24 | Hangzhou Dac Biotech Co Ltd | Bridge linkers for conjugation of cell-binding molecules |
US9839687B2 (en) | 2015-07-15 | 2017-12-12 | Suzhou M-Conj Biotech Co., Ltd. | Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule |
US20210308277A1 (en) | 2016-11-14 | 2021-10-07 | Hangzhou Dac Biotech Co., Ltd. | Conjugation linkers, cell binding molecule-drug conjugates containing the linkers, methods of making and uses such conjugates with the linkers |
CN111892569A (zh) * | 2019-05-05 | 2020-11-06 | 石家庄圣泰化工有限公司 | 4,4’-联-1,3-二氧戊环-2,2’-二酮的合成方法 |
Family Cites Families (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4766108A (en) * | 1986-12-04 | 1988-08-23 | Smith Kline Beckman Corporation | Tyr-Arg-vasopressin antagonists |
US5055448A (en) * | 1987-06-25 | 1991-10-08 | Medical College Of Ohio | Linear derivatives of arginine vasopressin antagonists |
DE69009785T2 (de) | 1989-02-10 | 1994-11-03 | Otsuka Pharma Co Ltd | Carbostyrilderivate. |
DK0450097T3 (da) | 1989-10-20 | 1996-05-20 | Otsuka Pharma Co Ltd | Benzoheterocykliske forbindelser |
US5258510A (en) * | 1989-10-20 | 1993-11-02 | Otsuka Pharma Co Ltd | Benzoheterocyclic compounds |
US5070187A (en) * | 1989-11-03 | 1991-12-03 | Trustees Of Boston University | Pharmacologically effective antagonists of arginine-vasopressin |
TW199153B (pt) | 1990-08-07 | 1993-02-01 | Dtsuka Seiyaku Kk | |
US5459131A (en) * | 1991-03-15 | 1995-10-17 | American Cyanamid Company | Renin inhibitors |
CA2066104C (en) | 1991-04-19 | 2003-05-27 | Hidenori Ogawa | Benzazepine derivatives as vasopressin antagonists |
DE69223573D1 (de) | 1991-09-16 | 1998-01-29 | Merck & Co Inc | Hydantoin und Succinimid-substituierte Spiroindanylcamphorsulfonyl als Oxytocin-Antagonisten |
EP0533242A3 (en) | 1991-09-16 | 1993-09-15 | Merck & Co. Inc. | Substituted derivatives of piperazinylcamphorsulfonyl oxytocin antagonists |
US5204349A (en) | 1991-09-16 | 1993-04-20 | Merck & Co., Inc. | Amide-substituted derivatives of spiroindanylcamphorsulfonyl oxytocin antagonists |
EP0533240A3 (en) | 1991-09-16 | 1993-09-29 | Merck & Co. Inc. | Substituted amine derivatives of piperazinylcamphorsulfonyl oxytocin antagonists |
JP2904993B2 (ja) * | 1991-10-09 | 1999-06-14 | ロート製薬株式会社 | オキシトシン受容体およびこれをコードするdna |
FR2687669B1 (fr) * | 1992-02-24 | 1997-12-19 | Guerbet Sa | Composes utilisables dans des produits de contraste pour la radiographie. |
AU657424B2 (en) | 1992-07-02 | 1995-03-09 | Otsuka Pharmaceutical Co., Ltd. | Oxytocin antagonist |
AU657431B2 (en) | 1992-08-20 | 1995-03-09 | Otsuka Pharmaceutical Co., Ltd. | Benzoheterocyclic compounds as oxytocin and vasopressin antagonists |
TW270927B (pt) * | 1992-10-16 | 1996-02-21 | Otsuka Pharma Co Ltd | |
WO1994012476A1 (en) | 1992-11-25 | 1994-06-09 | Yamanouchi Pharmaceutical Co., Ltd. | Benzanilide derivative |
AU5692094A (en) | 1992-12-21 | 1994-07-19 | Yamanouchi Pharmaceutical Co., Ltd. | Novel n-(pyridylcarbonyl)benzazepine derivative and intermediate therefor |
WO1994020473A1 (en) | 1993-03-11 | 1994-09-15 | Yamanouchi Pharmaceutical Co., Ltd. | Compound with vasopressin antagonism |
GB9307527D0 (en) | 1993-04-13 | 1993-06-02 | Fujisawa Pharmaceutical Co | New venzamide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same |
CA2166975C (en) * | 1993-07-16 | 2005-04-05 | Mark G. Bock | Benzoxazinone and benzopyrimidinone piperidinyl tocolytic oxytocin receptor antagonists |
US5516774A (en) | 1993-07-29 | 1996-05-14 | American Cyanamid Company | Tricyclic diazepine vasopressin antagonists and oxytocin antagonists |
US5968930A (en) * | 1993-07-29 | 1999-10-19 | American Cyanamid Company | Tricyclic diazepine vasopressin antagonists and oxytocin antagonists |
US5512563A (en) * | 1993-07-29 | 1996-04-30 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
US5736540A (en) * | 1993-07-29 | 1998-04-07 | American Cyanamid Company | Tricyclic diazepine vasopressin antagonists and oxytocin antagonists |
US5670509A (en) * | 1993-09-27 | 1997-09-23 | Merck & Co., Inc. | Tocolytic oxytocin receptor antagonists |
US5464788A (en) * | 1994-03-24 | 1995-11-07 | Merck & Co., Inc. | Tocolytic oxytocin receptor antagonists |
US5436333A (en) * | 1994-08-08 | 1995-07-25 | American Cyanamid Company | Process for the preparation of tricyclic-heterocycles |
US5599809A (en) | 1994-09-29 | 1997-02-04 | Merck & Co., Inc. | Method for improving reproductive efficiency in farm animals |
US5521173A (en) * | 1995-01-17 | 1996-05-28 | American Home Products Corporation | Tricyclic benzazepine vasopressin antagonists |
US5536718A (en) * | 1995-01-17 | 1996-07-16 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
AR002459A1 (es) | 1995-01-17 | 1998-03-25 | American Cyanamid Co | Antagonistas de vasopresina de benzacepina triciclicos, una composicion farmaceutica que los contiene, un metodo para tratar enfermedades y unprocedimiento para su preparacion. |
US5696112A (en) | 1995-01-17 | 1997-12-09 | American Cyanamid Company | Fused heterocyclic azepines as vasopressin antagonists |
US5532235A (en) * | 1995-01-17 | 1996-07-02 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
US5849735A (en) * | 1995-01-17 | 1998-12-15 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
EP0805681A4 (en) | 1995-01-24 | 1998-05-06 | Merck & Co Inc | TOCOLYTIC ANTAGONISTS OF OXYTOCIN RECEPTORS |
US5726172A (en) * | 1996-01-16 | 1998-03-10 | Merck & Co., Inc. | Tocolytic oxytocin receptor antagonists |
WO1997025992A1 (en) | 1996-01-16 | 1997-07-24 | Merck & Co., Inc. | Tocolytic oxytocin receptor antagonists |
US5756497A (en) * | 1996-03-01 | 1998-05-26 | Merck & Co., Inc. | Tocolytic oxytocin receptor antagonists |
ATE250607T1 (de) | 1996-11-01 | 2003-10-15 | Wyeth Corp | 5h pyrrolo(2,1-c)(1,4)benzodiazepin-3- carboxamidderivate |
US5880122A (en) * | 1996-11-01 | 1999-03-09 | American Home Products Corporation | 3-Carboxamide derivatives of 5H-pyrrolo 2,1-c! 1,4!-benzodiazepines |
AR011913A1 (es) * | 1997-03-06 | 2000-09-13 | Yamano Masaki | Derivados de 4,4-difluoro-2,3,4,5-tetrahidro-1h-1-benzoazepina y composiciones farmaceuticas de los mismos. |
GB2326410A (en) | 1997-06-18 | 1998-12-23 | Merck & Co Inc | Tocolytic Oxytocin Receptor Antagonists |
GB2326639A (en) | 1997-06-18 | 1998-12-30 | Merck & Co Inc | Piperazine Oxytocin Receptor Antagonists |
PT1000062E (pt) | 1997-07-30 | 2004-12-31 | Wyeth Corp | Agonistas triciclicos de vasopressina |
DE19748763A1 (de) | 1997-11-05 | 1999-05-06 | Hans Peter Zenner | Verwendung von Vasopressin-Antagonisten |
US6268359B1 (en) * | 1998-01-28 | 2001-07-31 | Senju Pharmaceutical Co., Ltd. | Preventives or remedies for vision disorders |
US6900200B2 (en) | 2001-04-12 | 2005-05-31 | Wyeth | Tricyclic hydroxy carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists |
US6903087B2 (en) * | 2001-04-12 | 2005-06-07 | Wyeth | Pyrido cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists |
US7109193B2 (en) * | 2001-04-12 | 2006-09-19 | Wyeth | Tricyclic diazepines tocolytic oxytocin receptor antagonists |
US7064120B2 (en) * | 2001-04-12 | 2006-06-20 | Wyeth | Tricyclic pyridyl carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists |
US7022699B2 (en) | 2001-04-12 | 2006-04-04 | Wyeth | Cyclohexenyl phenyl diazepines vasopressin and oxytocin receptor modulators |
US7326700B2 (en) * | 2001-04-12 | 2008-02-05 | Wyeth | Cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists |
US7202239B2 (en) * | 2001-04-12 | 2007-04-10 | Wyeth | Cyclohexylphenyl carboxamides tocolytic oxytocin receptor antagonists |
-
2002
- 2002-04-10 US US10/119,973 patent/US6977254B2/en not_active Expired - Fee Related
- 2002-04-11 CA CA002443564A patent/CA2443564A1/en not_active Abandoned
- 2002-04-11 EP EP02721727A patent/EP1385849A1/en not_active Withdrawn
- 2002-04-11 JP JP2002581434A patent/JP2004528326A/ja active Pending
- 2002-04-11 BR BR0208941-6A patent/BR0208941A/pt not_active IP Right Cessation
- 2002-04-11 MX MXPA03009336A patent/MXPA03009336A/es unknown
- 2002-04-11 CN CNA028080262A patent/CN1501929A/zh active Pending
- 2002-04-11 WO PCT/US2002/011529 patent/WO2002083679A1/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN1501929A (zh) | 2004-06-02 |
WO2002083679A1 (en) | 2002-10-24 |
JP2004528326A (ja) | 2004-09-16 |
MXPA03009336A (es) | 2004-11-12 |
US20020183311A1 (en) | 2002-12-05 |
CA2443564A1 (en) | 2002-10-24 |
US6977254B2 (en) | 2005-12-20 |
EP1385849A1 (en) | 2004-02-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR0208941A (pt) | Novos antagonistas receptores de ocitocina tocolìticos de hidróxi ciclohexenil fenil carboxamidas | |
HK1104174A1 (en) | Glucagon receptor antagonists, preparation and therapeutic uses | |
JO2371B1 (en) | 4-phenyl-pyridine derivatives | |
ATE485269T1 (de) | C-verknüpfte zyklische antagonisten des p2y1- rezeptors mit eignung bei der behandlung thrombotischer leiden | |
MY140826A (en) | Substituted pyrazoline compounds, their preparation and use as medicaments. | |
BRPI0411241A (pt) | agentes terapêuticos úteis para o tratamento de dor | |
DK1377586T3 (da) | Tricykliske diazepiner som tocolytiske oxytocinreceptorantagonister | |
UA83862C2 (ru) | Производные тиазола как модуляторы рецепторов канабиноидов | |
WO2005056524A3 (en) | Therapeutic agents useful for treating pain | |
HK1074046A1 (en) | Ccr1 antagonists for the treatment of i.a. demyelinating inflammatory disease | |
DE602004023946D1 (de) | Kombinationen aus einem arylanilin-beta-2-adrenozeptor-agonisten und einem corticosteroid | |
WO2003048164A3 (en) | Adenosine a2a receptor antagonists | |
IL162616A (en) | Benzooxazine, benzothiazine and quinoline analogues as cholinergic receptor agonists and use thereof in the preparation of medicaments for treating diseases | |
BR0209017A (pt) | Novas piridil benzazepina carboxamidas tricìclicas e antagonistas receptores de ocitocina tocolìticos derivados das mesmas | |
BR0209015A (pt) | Novas 10-ciclohexilbenzoil pirrolobenzodiazepinas substituìdas com 3-c(o)r e antagonistas receptores de ocitocina tocolìticos | |
EP1398029A8 (en) | NR3B1 nuclear receptor binding 3-substituted pyrazole derivatives | |
MXPA04003298A (es) | Compuestos de piperidina como antagonistas muscarinicos. | |
MX2007007472A (es) | Derivados de triazolona, tetrazolona e imidazolona para uso como antagonista del adrenorreceptor alfa-2c. | |
HK1090543A1 (en) | Use of carbamazepine derivatives for the treatment of agitation in dementia patients | |
BR0209016A (pt) | Novas hidróxi carboxamidas tricìclicas e antagonistas receptores de ocitocina tocolìticos derivados das mesmas | |
BR0208943A (pt) | Novas 10-ciclohexenil-fenil-pirrolobenzodiazepina-3-carb oxamidas e antagonistas receptores de ocitocina tocolìticos derivados das mesmas | |
BR0208942A (pt) | Novas 10-ciclohexilbenzoil pirrolobenzodiazepinas substituìdas com 3-c(o)r e antagonistas receptores de ocitocina tocolìticos | |
HRP20090225T1 (en) | Pharmaceutical compositions based on nk2 antagonists for pediatric use | |
WO2006138589A3 (en) | Opioid receptor ligands | |
TW200510379A (en) | 1, 4-disubstituted piperidine compounds, their preparation and use as medicaments |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A,6A E 7A ANUIDADES |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2029 DE 24/11/2009. |